Transgenerational Developmental Programming of Ovarian Reserve.

Abstract:

:Exposure to an adverse early-life environment leads to long-term health problems, many of which are recapitulated in subsequent generations. The female reproductive tract is particularly sensitive to early-life influences, and plays a pivotal role in programming the conceptus. We examine the influence of suboptimal grandmaternal diet on reproductive potential of granddaughters in the absence of any further dietary manipulations in the daughters in a rat low-protein diet model. Exposure to low-protein grand-maternal diet leads to decreased ovarian reserve and increased intra-abdominal fat mass in granddaughters, accompanied by accelerated accumulation of oxidative stress and mtDNA copy number instability in the ovaries. Ovarian telomere length declines more rapidly in the exposed granddaughters, indicating accelerated ageing in the reproductive tract. Thus, we demonstrate that suboptimal grandmaternal diet during pregnancy accelerates reproductive ageing across subsequent generations. These findings have important implications for understanding both individual rates of decline in fertility with age, and the clinical impact of current global trends towards delayed childbearing.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Aiken CE,Tarry-Adkins JL,Ozanne SE

doi

10.1038/srep16175

subject

Has Abstract

pub_date

2015-11-03 00:00:00

pages

16175

issn

2045-2322

pii

srep16175

journal_volume

5

pub_type

杂志文章
  • An Alcaligenes strain emulates Bacillus thuringiensis producing a binary protein that kills corn rootworm through a mechanism similar to Cry34Ab1/Cry35Ab1.

    abstract::Crops expressing Bacillus thuringiensis (Bt)-derived insecticidal protein genes have been commercially available for over 15 years and are providing significant value to growers. However, there remains the need for alternative insecticidal actives due to emerging insect resistance to certain Bt proteins. A screen of b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03544-9

    authors: Yalpani N,Altier D,Barry J,Kassa A,Nowatzki TM,Sethi A,Zhao JZ,Diehn S,Crane V,Sandahl G,Guan R,Poland B,Perez Ortega C,Nelson ME,Xie W,Liu L,Wu G

    更新日期:2017-06-08 00:00:00

  • Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system.

    abstract::Brown adipose tissue (BAT) plays a central role in regulating energy homeostasis, and may provide novel strategies for the treatment of human obesity. BAT-mediated thermogenesis is regulated by mitochondrial uncoupling protein 1 (UCP1) in classical brown and ectopic beige adipocytes, and is controlled by sympathetic n...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18013

    authors: Kim M,Goto T,Yu R,Uchida K,Tominaga M,Kano Y,Takahashi N,Kawada T

    更新日期:2015-12-17 00:00:00

  • In-vivo Dynamics of the Human Hippocampus across the Menstrual Cycle.

    abstract::Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32833

    authors: Barth C,Steele CJ,Mueller K,Rekkas VP,Arélin K,Pampel A,Burmann I,Kratzsch J,Villringer A,Sacher J

    更新日期:2016-10-07 00:00:00

  • ODiNPred: comprehensive prediction of protein order and disorder.

    abstract::Structural disorder is widespread in eukaryotic proteins and is vital for their function in diverse biological processes. It is therefore highly desirable to be able to predict the degree of order and disorder from amino acid sequence. It is, however, notoriously difficult to predict the degree of local flexibility wi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71716-1

    authors: Dass R,Mulder FAA,Nielsen JT

    更新日期:2020-09-08 00:00:00

  • Erratum: At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody.

    abstract::This corrects the article DOI: 10.1038/srep20029. ...

    journal_title:Scientific reports

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/srep46385

    authors: Yu C,Gao K,Zhu L,Wang W,Wang L,Zhang F,Liu C,Li M,Wormald MR,Rudd PM,Wang J

    更新日期:2017-06-30 00:00:00

  • Experience has a limited effect on humans' ability to predict the outcome of social interactions in children, dogs and macaques.

    abstract::The ability to predict others' behaviour represents a crucial mechanism which allows individuals to react faster and more appropriately. To date, several studies have investigated humans' ability to predict conspecifics' behaviour, but little is known on our ability to predict behaviour in other species. Here, we aime...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78275-5

    authors: Donnier S,Kovács G,Oña LS,Bräuer J,Amici F

    更新日期:2020-12-04 00:00:00

  • RNA-Seq and UHPLC-Q-TOF/MS Based Lipidomics Study in Lysiphlebia japonica.

    abstract::Lipids play an important role in energy storage, membrane structure stabilization and signaling. Parasitoids are excellent models to study lipidomics because a majority of them do not accumulate during their free-living life-stage. Studies on parasitoids have mostly focused on the changes in the lipids and gene transc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26139-4

    authors: Gao X,Luo J,Lü L,Zhang L,Zhang S,Cui J

    更新日期:2018-05-17 00:00:00

  • A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation.

    abstract::Gold nanoparticles (GNPs) have been demonstrated as effective radiosensitizing agents in a range of preclinical models using broad field sources of various energies. This study aimed to distinguish between these mechanisms by applying subcellular targeting using a soft X-ray microbeam in combination with GNPs. DNA dam...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44752

    authors: Ghita M,McMahon SJ,Taggart LE,Butterworth KT,Schettino G,Prise KM

    更新日期:2017-03-16 00:00:00

  • Plasma cell treatment device Plasma-on-Chip: Monitoring plasma-generated reactive species in microwells.

    abstract::We have developed a plasma cell treatment device called Plasma-on-Chip that enables the real-time monitoring of a single cell culture during plasma treatment. The device consists of three parts: 1) microwells for cell culture, 2) a microplasma device for generating reactive oxygen and nitrogen species (RONS) for use i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41953

    authors: Oh JS,Kojima S,Sasaki M,Hatta A,Kumagai S

    更新日期:2017-02-08 00:00:00

  • Author Correction: Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-68759-9

    authors: Whittington CM,O'Meally D,Laird MK,Belov K,Thompson MB,McAllan BM

    更新日期:2020-07-22 00:00:00

  • The linear artifact in enhanced depth imaging spectral domain optical coherence tomography.

    abstract::Optical coherence tomography (OCT) is a valuable ancillary test in the diagnosis and management of chorioretinal disease. The evaluation of choroid thickness using OCT has become the focus of clinical applications. We report a linear artifact that acts as a confounding factor in choroidal thickness measurements by enh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08811-3

    authors: Zuo C,Mi L,Yang S,Guo X,Xiao H,Liu X

    更新日期:2017-08-16 00:00:00

  • Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.

    abstract::The deregulation of autophagy is involved in liver regeneration. Here, we investigated the role of autophagy in the regulation of liver regeneration after partial hepatectomy (PHx) and the development of pharmacological interventions for improved liver regeneration after PHx. We show that autophagy was activated in th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15807

    authors: Lin CW,Chen YS,Lin CC,Chen YJ,Lo GH,Lee PH,Kuo PL,Dai CY,Huang JF,Chung WL,Yu ML

    更新日期:2015-10-30 00:00:00

  • Reciprocal immune benefit based on complementary production of antibiotics by the leech Hirudo verbana and its gut symbiont Aeromonas veronii.

    abstract::The medicinal leech has established a long-term mutualistic association with Aeromonas veronii, a versatile bacterium which can also display free-living waterborne and fish- or human-pathogenic lifestyles. Here, we investigated the role of antibiotics in the dynamics of interaction between the leech and its gut symbio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17498

    authors: Tasiemski A,Massol F,Cuvillier-Hot V,Boidin-Wichlacz C,Roger E,Rodet F,Fournier I,Thomas F,Salzet M

    更新日期:2015-12-04 00:00:00

  • Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells.

    abstract::Excessive Zn2+ causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H2O2/Zn2+-induced Ca2+ signalling and cell death in microglial cells. H2O2/Zn2+ induced concentration-dependent increases in cytosolic Ca2+ concentration ([Ca2+]c), which was inhibited by PJ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45032

    authors: Mortadza SS,Sim JA,Stacey M,Jiang LH

    更新日期:2017-03-21 00:00:00

  • Using nanoBRET and CRISPR/Cas9 to monitor proximity to a genome-edited protein in real-time.

    abstract::Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding G protein-coupled receptor (GPCR) function. It has been used to investigate GPCR-protein and/or -ligand interactions as well as GPCR oligomerisation. However the utility of BRET is limited by the requirement that the fusion protei...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03486-2

    authors: White CW,Vanyai HK,See HB,Johnstone EKM,Pfleger KDG

    更新日期:2017-06-09 00:00:00

  • Epidermal CD147 expression plays a key role in IL-22-induced psoriatic dermatitis.

    abstract::Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and terminal differentiation. Interleukin-22 (IL-22) and the transcription factor Stat3 play pivotal roles in the pathogenesis of psoriasis. CD147 is a transmembrane glycosylation protein that belongs to the immunoglo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44172

    authors: Peng C,Zhang S,Lei L,Zhang X,Jia X,Luo Z,Huang X,Kuang Y,Zeng W,Su J,Chen X

    更新日期:2017-03-08 00:00:00

  • Longitudinal changes in reproductive hormones through the menopause transition in the Avon Longitudinal Study of Parents and Children (ALSPAC).

    abstract::We characterised changes in reproductive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the menopause (reproductive age) in mid-life women and explored their associations with lifestyle and reproductive factors. We used data from 1608 women from a UK cohort who had repeat hormone measures and expe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77871-9

    authors: Soares AG,Kilpi F,Fraser A,Nelson SM,Sattar N,Welsh PI,Tilling K,Lawlor DA

    更新日期:2020-12-04 00:00:00

  • Social, spatial, and temporal organization in a complex insect society.

    abstract::High-density living is often associated with high disease risk due to density-dependent epidemic spread. Despite being paragons of high-density living, the social insects have largely decoupled the association with density-dependent epidemics. It is hypothesized that this is accomplished through prophylactic and induc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13393

    authors: Quevillon LE,Hanks EM,Bansal S,Hughes DP

    更新日期:2015-08-24 00:00:00

  • Hydrothermal synthesis of novel 1-aminoperylene diimide/TiO2/MoS2 composite with enhanced photocatalytic activity.

    abstract::1-aminoperylene diimide/TiO2/MoS2 composite (NH2-PDI/TiO2/MoS2) with ordered structure was prepared by hydrothermal synthesis method. The composite was characterized by XRD, SEM, FTIR, XPS, BET, DRS, PL, EIS, Raman, photocurrent, and Mott-Schottky plots spectroscopy. The potential positions of the conduction and valen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78894-y

    authors: Ma Y,Wang Y,Jiang T,Zhang F,Li X,Zhu Y

    更新日期:2020-12-15 00:00:00

  • Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands.

    abstract::The peptide nociceptin/orphanin FQ (N/OFQ) and the N/OFQ receptor (NOP) constitute a neuropeptidergic system that modulates various biological functions and is currently targeted for the generation of innovative drugs. In the present study dimeric NOP receptor ligands with spacers of different lengths were generated u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45817

    authors: Pacifico S,Carotenuto A,Brancaccio D,Novellino E,Marzola E,Ferrari F,Cerlesi MC,Trapella C,Preti D,Salvadori S,Calò G,Guerrini R

    更新日期:2017-04-06 00:00:00

  • Autonomic adaptations mediate the effect of hydration on brain functioning and mood: Evidence from two randomized controlled trials.

    abstract::Dehydration (water loss >2.0% of body weight) has significant negative effects on physical and mental performance. In two studies the effects of minor hypo-hydration (water loss <1.0% of body weight) on CNS function, mood and cardiovascular functioning were measured. Study 1: On two mornings twelve male participants w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52775-5

    authors: Young HA,Cousins A,Johnston S,Fletcher JM,Benton D

    更新日期:2019-11-11 00:00:00

  • Clinical efficacy of Professional Continuous Glucose Monitoring in improving glycemic control among children with Type 1 Diabetes Mellitus: An Open-label Randomized Control Trial.

    abstract::Frequent self-monitoring of blood glucose (SMBG) is the only accurate method available for insulin dose titration in patients with T1DM. Professional continuous glucose monitoring (p-CGM) is blinded recording of glucose trends over 5-7 days and helps physicians to guide insulin titration to patient. This study was pla...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42555-6

    authors: Raviteja KV,Kumar R,Dayal D,Sachdeva N

    更新日期:2019-04-16 00:00:00

  • Hexane-Isopropanolic Extract of Tungrymbai, a North-East Indian fermented soybean food prevents hepatic steatosis via regulating AMPK-mediated SREBP/FAS/ACC/HMGCR and PPARα/CPT1A/UCP2 pathways.

    abstract::This study for the first time examined the prophylactic role of Tungrymbai, a well-known fermented soybean food of North-East India, against hepatic steatosis. Treatment with hexane-isopropanolic (2:1, HIET) but not hydro-alcoholic (70% ethanol, HAET) extract dose-dependently (0.1, 0.2, or 0.3 µg/mL) reduced the intra...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27607-7

    authors: Dihingia A,Bordoloi J,Dutta P,Kalita J,Manna P

    更新日期:2018-07-03 00:00:00

  • Ultrahigh field MR imaging of a subconjunctival anti-glaucoma drug delivery system in a rabbit model.

    abstract::Local drug delivery systems (DDS) have become a favourable approach for the treatment of numerous diseases. Biomedical imaging techniques such as ultrahigh field magnetic resonance imaging (UHF-MRI) offer unique insight into DDS biodegradation in vivo. We describe the establishment of a 7 Tesla MRI routine for longitu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15954-w

    authors: Kopp F,Eickner T,Polei S,Falke K,Witt M,Grabow N,Stachs O,Guthoff RF,Lindner T

    更新日期:2017-11-17 00:00:00

  • Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox.

    abstract::Interleukin (IL)-27, a member of the IL-12 cytokine family, plays an important and diverse role in the function of the immune system. We have previously demonstrated that IL-27 is an anti-viral cytokine which inhibits HIV-1, HIV-2, Influenza virus and herpes simplex virus infection, and enhances the potential of react...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43441

    authors: Sowrirajan B,Saito Y,Poudyal D,Chen Q,Sui H,DeRavin SS,Imamichi H,Sato T,Kuhns DB,Noguchi N,Malech HL,Lane HC,Imamichi T

    更新日期:2017-02-27 00:00:00

  • Enhanced avidity from a multivalent fluorescent antimicrobial peptide enables pathogen detection in a human lung model.

    abstract::Rapid in situ detection of pathogens coupled with high resolution imaging in the distal human lung has the potential to provide new insights and diagnostic utility in patients in whom pneumonia is suspected. We have previously described an antimicrobial peptide (AMP) Ubiquicidin (fragment UBI29-41) labelled with an en...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44804-0

    authors: Akram AR,Avlonitis N,Scholefield E,Vendrell M,McDonald N,Aslam T,Craven TH,Gray C,Collie DS,Fisher AJ,Corris PA,Walsh T,Haslett C,Bradley M,Dhaliwal K

    更新日期:2019-06-10 00:00:00

  • Photoresponsivity of an all-semimetal heterostructure based on graphene and WTe2.

    abstract::Heterostructures based on two-dimensional (2D) materials have sparked wide interests in both fundamental physics and applied devices. Recently, Dirac/Weyl semimetals are emerging as capable functional materials for optoelectronic devices. However, thus far the interfacial coupling of an all-semimetal 2D heterostructur...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29717-8

    authors: Liu Y,Liu C,Wang X,He L,Wan X,Xu Y,Shi Y,Zhang R,Wang F

    更新日期:2018-08-27 00:00:00

  • Hormonal pleiotropy helps maintain queen signal honesty in a highly eusocial wasp.

    abstract::In insect societies, both queens and workers produce chemicals that reliably signal caste membership and reproductive status. The mechanisms that help to maintain the honesty of such queen and fertility signals, however, remain poorly studied. Here we test if queen signal honesty could be based on the shared endocrine...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01794-1

    authors: Oliveira RC,Vollet-Neto A,Akemi Oi C,van Zweden JS,Nascimento F,Sullivan Brent C,Wenseleers T

    更新日期:2017-05-10 00:00:00

  • Model-based optimization of combination protocols for irradiation-insensitive cancers.

    abstract::Alternations in the p53 regulatory network may render cancer cells resistant to the radiation-induced apoptosis. In this theoretical study we search for the best protocols combining targeted therapy with radiation to treat cancers with wild-type p53, but having downregulated expression of PTEN or overexpression of Wip...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69380-6

    authors: Hat B,Jaruszewicz-Błońska J,Lipniacki T

    更新日期:2020-07-28 00:00:00

  • Identification of DNAH6 mutations in infertile men with multiple morphological abnormalities of the sperm flagella.

    abstract::Male infertility due to spermatogenesis defects affects millions of men worldwide. However, the genetic etiology of the vast majority remains unclear. Here we describe three men with primary infertility due to multiple morphological abnormalities of the sperm flagella (MMAF) from two unrelated Han Chinese families. We...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-019-52436-7

    authors: Tu C,Nie H,Meng L,Yuan S,He W,Luo A,Li H,Li W,Du J,Lu G,Lin G,Tan YQ

    更新日期:2019-11-01 00:00:00