Abstract:
:Interaction between the epithelium and mesenchyme coordinates patterning and differentiation of oral cavity structures including teeth, palatal rugae and tongue papillae. SHH is one of the key signaling molecules for this interaction. Epithelial expression of Shh in the tooth buds and tongue papillae is regulated by at least two enhancers, MRCS1 and MFCS4. However, it is unclear how the two enhancers cooperate to regulate Shh. Here, we found that simultaneous deletion of MRCS1 and MFCS4 results in the formation of a supernumerary tooth in front of the first molar. Since deletion of either single enhancer barely affects tooth development, MRCS1 and MFCS4 evidently act in a redundant fashion. Binding motifs for WNT signaling mediators are shared by MRCS1 and MFCS4, and play a central role in regulating Shh expression, indicating that the two redundant enhancers additively exert their Shh regulation by responding to WNT signal input.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sagai T,Amano T,Maeno A,Kiyonari H,Seo H,Cho SW,Shiroishi Tdoi
10.1038/s41598-017-12532-ysubject
Has Abstractpub_date
2017-10-11 00:00:00pages
13004issue
1issn
2045-2322pii
10.1038/s41598-017-12532-yjournal_volume
7pub_type
杂志文章abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-61396-2
更新日期:2020-03-06 00:00:00
abstract::Infection after renal transplantation remains a major cause of morbidity and death, especially infection from the extensively drug-resistant bacteria, A. baumannii. A total of fourteen A. baumannii isolates were isolated from the donors' preserved fluid from DCD (donation after cardiac death) renal transplantation and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01683-7
更新日期:2017-05-16 00:00:00
abstract::The rapid spread of the SARS-CoV-2 in the COVID-19 pandemic had raised questions on the route of transmission of this disease. Initial understanding was that transmission originated from respiratory droplets from an infected host to a susceptible host. However, indirect contact transmission of viable virus by fomites ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81935-9
更新日期:2021-01-28 00:00:00
abstract::Models on how perceptual and cognitive information on others' mental states are treated by the cognitive architecture are often framed as duplex models considering two independent systems. In the context of the neuroscience of empathy analogous systems have been described. Using event-related potentials (i.e., ERPs) t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07424
更新日期:2014-12-11 00:00:00
abstract::In this contribution, a complete dissertation concerning the behavior of a Long Period Grating (LPG) inscribed in a B-Ge co-doped optical fiber by means of an excimer laser and exposed to proton irradiation during a recent extensive campaign performed at the European Organization for Nuclear Research (CERN) with a flu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58049-9
更新日期:2020-01-28 00:00:00
abstract::Increasing evidence suggest that the glucose-lowering drug metformin exerts a valuable anti-senescence role. The ability of metformin to affect the biogenesis of selected microRNAs (miRNAs) was recently suggested. MicroRNA isoforms (isomiRs) are distinct variations of miRNA sequences, harboring addition or deletion of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78871-5
更新日期:2020-12-11 00:00:00
abstract::Prescribing the right drug with the right dose is a central tenet of precision medicine. We examined the use of patients' prior Electronic Health Records to predict a reduction in drug dosage. We focus on drugs that interact with the P450 enzyme family, because their dosage is known to be sensitive and variable. We ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33980-0
更新日期:2018-10-22 00:00:00
abstract::Flat optics, which could planarize and miniaturize the traditional optical elements, possesses the features of extremely low profile and high integration for advanced manipulation of light. Here we proposed and experimentally demonstrated a planar metalens to realize an ultra-long focal length of ~240λ with a large de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09977
更新日期:2015-05-06 00:00:00
abstract::We propose a virtual sound barrier system that blocks sound transmission through openings without affecting access, light and air circulation. The proposed system applies active control technique to cancel sound transmission with a double layered loudspeaker array at the edge of the opening. Unlike traditional transpa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13546-2
更新日期:2017-10-17 00:00:00
abstract::Vitamin D may reduce mortality from prostate cancer (PC). We examined the associations of post-treatment plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations with PC mortality. Participants were PC cases from the New South Wales Prostate Cancer Care. All contactable and consenting participants, at 4.9...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62182-w
更新日期:2020-05-08 00:00:00
abstract::This study aimed to determine the clinicopathological features of the subtypes of ampullary carcinoma (AC) to explore the indications for endoscopic papillectomy (EP) in early AC. Fifty-seven patients with AC who underwent curative resection were retrospectively reviewed. The 0/IA stages were significantly more common...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79836-4
更新日期:2021-01-12 00:00:00
abstract::Myopic traction maculopathy (MTM) can cause vision disabilities in highly myopic eyes. This retrospective case series investigated the clinical outcomes of posterior scleral contraction (PSC) using genipin-cross-linked sclera as the material to treat MTM in highly myopic eyes. In total, 32 eyes from 29 highly myopic p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43256
更新日期:2017-02-21 00:00:00
abstract::Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09386-9
更新日期:2017-08-21 00:00:00
abstract::At the moment it is unknown to what extent the impaired function of T lymphocytes in ESRD patients depends on uremia, and to what extent on hemodialysis (HD) procedure. Therefore, the purpose of the study was to evaluate percentages of T lymphocyte subpopulations ex vivo, plasma concentrations of IL12p70, TNF, IL-10, ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-41619-x
更新日期:2019-03-25 00:00:00
abstract::The fine-tuning of gene expression contributes to both basic science and applications. Here, we develop a novel gene expression technology termed CRITGI (CRISPR/Transposon gene integration). CRITGI uses CRISPR/Cas9 to integrate multiple copies of the plasmid pTy1 into Ty1 loci, budding yeast retrotransposons. The pTy1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51891-6
更新日期:2019-10-25 00:00:00
abstract::Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Sp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77639-1
更新日期:2020-11-25 00:00:00
abstract::We assessed the Chinese version of the Drug Abuse Screening Test (DAST-10) for identifying illicit drug use during pregnancy among Chinese population. Chinese pregnant women attending their first antenatal visit or their first unbooked visit to the maternity ward were recruited during a 4-month study period in 2011. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11420
更新日期:2015-06-19 00:00:00
abstract::Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose concentrations affect placental lipid metabolism. Placentas from women ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50626-x
更新日期:2019-10-01 00:00:00
abstract::We present a new class of TiBw/Ti6Al4V composites with a network reinforcement architecture that exhibits a significant creep resistance compared to monolithic Ti6Al4V alloys. Creep tests performed at temperatures between 773 K and 923 K and stress range of 100 MPa-300 MPa indicate both a significant improvement of th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40823
更新日期:2017-01-17 00:00:00
abstract::A single radiation-induced superoxide ion [Formula: see text] has been observed for the first time in metal oxides. This structural defect has been revealed in fast-neutron-irradiated (6.9×1018 n/cm2) corundum (α-Al2O3) single crystals using the EPR method. Based on the angular dependence of the EPR lines at the magne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72958-9
更新日期:2020-09-28 00:00:00
abstract::Thermoelectric effects in magnetic tunnel junctions are promising to serve as the basis for logic devices or memories in a "green" information technology. However, up to now the readout contrast achieved with Seebeck effects was magnitudes smaller compared to the well-established tunnel magnetoresistance effect. Here,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08945
更新日期:2015-03-10 00:00:00
abstract::Despite the increasing number of studies conducted recently to evaluate the association between HPV infections and the risk of prostate cancer, the results remain inconclusive. Furthermore, the prevalence and distribution of overall and individual HPV types worldwide in prostate cancer has not been reported until now....
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep14667
更新日期:2015-10-06 00:00:00
abstract::Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contractile and proliferative phenotypic states. Integrins are a class of transmembrane proteins that have been implicated as novel therapeutic targets for asthma treatment. We previously showed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46260-2
更新日期:2019-07-09 00:00:00
abstract::Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and organelles to recycle their components; however, the contribution of autophagy during meiosis has not been studied in porcine oocytes maturing in vitro. In this study, we observed that the autophagy-related gene, LC3, was expressed in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29872-y
更新日期:2018-08-22 00:00:00
abstract::We show an annual overview of the sea-air CO2 exchanges and primary drivers in the Gerlache Strait, a hotspot for climate change that is ecologically important in the northern Antarctic Peninsula. In autumn and winter, episodic upwelling events increase the remineralized carbon in the sea surface, leading the region t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71814-0
更新日期:2020-09-10 00:00:00
abstract::Epidemiological knowledge of pediatric diseases may improve professionals' understanding of the pathophysiology of and risk factors for diseases and is also crucial for decision making related to workforce and resource planning in pediatric departments. In this study, a pediatric disease epidemiology knowledgebase cal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54439-w
更新日期:2019-11-28 00:00:00
abstract::Aditoprim (ADP) is a newly developed antibacterial agent in veterinary medicine. The metabolism and disposition of ADP in swine, broilers, carp and rats were investigated by using a radio tracer method combined with a radioactivity detector and a liquid chromatography/ion trap/time-of-flight mass spectrometry. After a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20370
更新日期:2016-02-03 00:00:00
abstract::Cinnabar is a natural mercury sulfide (HgS) mineral of volcanic or hydrothermal origin that is found worldwide. It has been mined prehistorically and historically in China, Japan, Europe, and the Americas to extract metallic mercury (Hg(0)) for use in metallurgy, as a medicinal, a preservative, and as a red pigment fo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14679
更新日期:2015-10-01 00:00:00
abstract:ABSTARCT:This work explores a new class of vortex/magnetite/iron oxide nanoparticles designed for magnetic hyperthermia applications. These nanoparticles, named Vortex Iron oxide Particles (VIPs), are an alternative to the traditional Superparamagnetic Iron Oxide Nanoparticles (SPIONs), since VIPs present superior heat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14633-0
更新日期:2017-11-01 00:00:00
abstract::Mediterranean Sea ecosystems are considered as hotspots of biological introductions, exposed to possible negative effects of non-indigenous species. In such temperate marine ecosystems, macroalgae may be dominant, with a great percentage of their diversity represented by introduced species. Their interaction with temp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42625
更新日期:2017-02-20 00:00:00