Cisplatin Enhances Hepatitis B Virus Replication and PGC-1α Expression through Endoplasmic Reticulum Stress.

abstract：:The capture and activation of individual T cells on functionalised surfaces enables real-time analyses of the magnitude and rhythm of intracellular calcium release. Application of Haarlet transformations generate a calcium flux 'threshold', with the frequency of the 'threshold crossings' correlating with the strength ...

journal_title：Scientific reports

authors： Christo SN,Diener KR,Nordon RE,Brown MP,Griesser HJ,Vasilev K,Christo FC,Hayball JD

更新日期：2015-01-14 00:00:00

abstract：:The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). Here we explored the effects of the...

journal_title：Scientific reports

authors： Eberhardt MJ,Schillers F,Eberhardt EM,Risser L,de la Roche J,Herzog C,Echtermeyer F,Leffler A

更新日期：2017-10-06 00:00:00

abstract：:Swarming bacteria are an example of a complex, active biological system, where high cell density and super-diffusive cell mobility confer survival advantages to the group as a whole. Previous studies on the dynamics of the swarm have been limited to easily observable regions at the advancing edge of the swarm where ce...

journal_title：Scientific reports

authors： Partridge JD,Ariel G,Schvartz O,Harshey RM,Be'er A

更新日期：2018-10-25 00:00:00

abstract：:An important step in oxide photochemistry, the loading of electrons into shallow trap states, was studied using infrared (IR) spectroscopy on both, rutile TiO2 powders and single-crystal, r-TiO2(110) oriented samples. After UV-irradiation or n-doping by exposure to H-atoms broad IR absorption lines are observed for th...

journal_title：Scientific reports

authors： Sezen H,Buchholz M,Nefedov A,Natzeck C,Heissler S,Di Valentin C,Wöll C

更新日期：2014-01-22 00:00:00

abstract：:We study universal uncertainty relations and present a method called joint probability distribution diagram to improve the majorization bounds constructed independently in [Phys. Rev. Lett. 111, 230401 (2013)] and [J. Phys. A. 46, 272002 (2013)]. The results give rise to state independent uncertainty relations satisfi...

journal_title：Scientific reports

authors： Li T,Xiao Y,Ma T,Fei SM,Jing N,Li-Jost X,Wang ZX

更新日期：2016-10-24 00:00:00

abstract：:Systemic lupus erythematosus (SLE) flares elicit progressive organ damage, leading to disability and early mortality. This study evaluated clinical and immunologic factors associated with impending flare in the Biomarkers of Lupus Disease study. Autoantibodies and 32 soluble mediators were measured by multiplex assays...

journal_title：Scientific reports

authors： Lu R,Guthridge JM,Chen H,Bourn RL,Kamp S,Munroe ME,Macwana SR,Bean K,Sridharan S,Merrill JT,James JA

更新日期：2019-06-13 00:00:00

abstract：:A toolbox for the quantum simulation of polarons in ultracold atoms is presented. Motivated by the impressive experimental advances in the area of ultracold atomic mixtures, we theoretically study the problem of ultracold atomic impurities immersed in a Bose-Einstein condensate mixture (BEC). The coupling between impu...

journal_title：Scientific reports

authors： Compagno E,De Chiara G,Angelakis DG,Palma GM

更新日期：2017-05-24 00:00:00

abstract：:The remineralization mechanism in dental caries lesions is not completely understood. This study reports on ultrastructural and chemical changes observed within arrested caries lesions. Carious human teeth were observed using scanning electron microscopy (SEM) and focused-ion-beam (FIB)-SEM. The crystals detected in t...

journal_title：Scientific reports

authors： Yoshihara K,Nagaoka N,Nakamura A,Hara T,Hayakawa S,Yoshida Y,Van Meerbeek B

更新日期：2020-03-09 00:00:00

abstract：:Interleukin-36 (IL-36) represents three cytokines, IL-36α, IL-36β and IL-36γ, which bind to the same receptor, IL-1RL2; however, their physiological function(s) remain poorly understood. Here, the role of IL-36 in immunity against HSV-1 was examined using the flank skin infection mouse model. Expression analyses revea...

journal_title：Scientific reports

authors： Milora KA,Uppalapati SR,Sanmiguel JC,Zou W,Jensen LE

更新日期：2017-07-19 00:00:00

abstract：:Breast cancer transcriptome acquires a myriad of regulation changes, and splicing is critical for the cell to "tailor-make" specific functional transcripts. We systematically revealed splicing signatures of the three most common types of breast tumors using RNA sequencing: TNBC, non-TNBC and HER2-positive breast cance...

journal_title：Scientific reports

authors： Eswaran J,Horvath A,Godbole S,Reddy SD,Mudvari P,Ohshiro K,Cyanam D,Nair S,Fuqua SA,Polyak K,Florea LD,Kumar R

更新日期：2013-01-01 00:00:00

abstract：:Hepatic encephalopathy is a neuropsychiatric syndrome evolving from cerebral osmotic disturbances and oxidative/nitrosative stress. Ammonia, the main toxin of hepatic encephalopathy, triggers astrocyte senescence in an oxidative stress-dependent way. As miRNAs are critically involved in cell cycle regulation and their...

journal_title：Scientific reports

authors： Oenarto J,Karababa A,Castoldi M,Bidmon HJ,Görg B,Häussinger D

更新日期：2016-01-12 00:00:00

abstract：:Invasive alien species are regarded a nuisance. This extends into a lack of conservation efforts in their native range. As a consequence, conservation of e.g. range-edge populations is neglected. Gobiidae have many representatives of alien species in European freshwaters, and therefore they have a bad reputation. Obje...

journal_title：Scientific reports

authors： Kukuła K,Ortyl B,Bylak A

更新日期：2019-12-23 00:00:00

abstract：:Theranostics is the emerging field of medicine that uniquely combines diagnostic techniques and active agents to diagnose and treat medical conditions simultaneously or sequentially. Finding a theranostic agent capable to cure the affected cells and being safe for the healthy ones is the key for successful treatment. ...

journal_title：Scientific reports

authors： Golubewa L,Timoshchenko I,Romanov O,Karpicz R,Kulahava T,Rutkauskas D,Shuba M,Dementjev A,Svirko Y,Kuzhir P

更新日期：2020-12-17 00:00:00

abstract：:Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional MAPKs such as ERK1/2...

journal_title：Scientific reports

authors： Alsaran H,Elkhadragy L,Shakya A,Long W

更新日期：2017-11-03 00:00:00

abstract：:Combining strong magnetic anisotropy with strong exchange interaction is a long standing goal in the design of quantum magnets. The lanthanide complexes, while exhibiting a very strong ionic anisotropy, usually display a weak exchange coupling, amounting to only a few wavenumbers. Recently, an isostructural series of ...

journal_title：Scientific reports

authors： Vieru V,Iwahara N,Ungur L,Chibotaru LF

更新日期：2016-04-18 00:00:00

abstract：:Secreted Protein Acidic and Rich in Cysteine (SPARC)-related modular calcium-binding protein-2 (SMOC2), a secreted matricellular protein, is reported to be involved in various processes related to cancer progression such as regulating the cell cycle, angiogenesis, and invasion. However, its expression and prognostic s...

journal_title：Scientific reports

authors： Kim HS,Choi JH,Lee JY,Kang J,Myung JK,Kim WH,Jang BG

更新日期：2020-03-17 00:00:00

abstract：:New techniques for the field detection of inorganic improvised explosive devices (IEDs) are urgently developed. Although ion mobility spectrometry (IMS) has been proved to be the most effective method for screening organic explosives, it still faces a major challenge to detect inorganic explosives owing to their low v...

journal_title：Scientific reports

authors： Peng L,Hua L,Wang W,Zhou Q,Li H

更新日期：2014-10-16 00:00:00

abstract：:Transport of self-propelled particles in a two-dimensional (2D) separate channel is investigated in the presence of the combined forces. By applying an ac force, the particles will be trapped by the separate walls. A dc force produces the asymmetry of the system and induces the longitudinal directed transport. Due to ...

journal_title：Scientific reports

authors： Wu JC,Ai BQ

更新日期：2016-04-01 00:00:00

abstract：:Technical guidelines for magnetic resonance imaging (MRI) of the small bowel (SB) in the setting of inflammatory bowel diseases (IBDs) were detailed in a 2017 consensus issued by European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Pediatric Radiology (ESPR); however, MRI for no...

journal_title：Scientific reports

authors： Lu J,Zhou Z,Morelli JN,Yu H,Luo Y,Hu X,Li Z,Hu D,Shen Y

更新日期：2019-10-01 00:00:00

abstract：:Insects' exoskeleton, gut, hemocoel, and cells are colonized by various microorganisms that often play important roles in their host life. Moreover, insects are frequently infected by vertically transmitted symbionts that can manipulate their reproduction. The aims of this study were the characterization of bacterial ...

journal_title：Scientific reports

authors： Kaczmarczyk A,Kucharczyk H,Kucharczyk M,Kapusta P,Sell J,Zielińska S

更新日期：2018-09-26 00:00:00

abstract：:Understanding the rhizodeposited carbon (C) dynamics of winter wheat (Triticum aestivum L.), is crucial for soil fertility and C sequestration. Pot-grown winter wheat was pulse labelled with 14CO2 at the key growth stages. 14C in the shoots, roots and soil was measured at 5 or 2 days after 14C-labelling (DAL 5/2) at e...

journal_title：Scientific reports

authors： Sun Z,Chen Q,Han X,Bol R,Qu B,Meng F

更新日期：2018-02-16 00:00:00

abstract：:The pulsed events of rainstorm erosion on the Loess Plateau are well-known, but little information is available concerning the characteristics of superficial soil erosion processes caused by heavy rainstorms at the watershed scale. This study statistically evaluated characteristics of pulsed runoff-erosion events base...

journal_title：Scientific reports

authors： Wu L,Jiang J,Li GX,Ma XY

更新日期：2018-02-27 00:00:00

abstract：:Bending light in a controllable way is desired in various applications such as beam steering, navigating and cloaking. Different from the conventional way to bend light by refractive index gradient, transformation optics or special beams through wavefront design such as Airy beams and surface plasmons, we proposed a m...

journal_title：Scientific reports

authors： Han B,Xu L,Dou Y,Xu J,Zhang G

更新日期：2015-10-29 00:00:00

abstract：:Our mind's eye and the role of internal attention in mental life and suffering has intrigued scholars for centuries. Yet, experimental study of internal attention has been elusive due to our limited capacity to control the timing and content of internal stimuli. We thus developed the Simulated Thoughts Paradigm (STP) ...

journal_title：Scientific reports

authors： Amir I,Ruimi L,Bernstein A

更新日期：2021-01-26 00:00:00

abstract：:Drug-induced cholestasis is a leading cause of drug withdrawal. However, the use of primary human hepatocytes (PHHs), the gold standard for predicting cholestasis in vitro, is limited by their high cost and batch-to-batch variability. Mature hepatocyte characteristics have been observed in human induced hepatocytes (h...

journal_title：Scientific reports

authors： Ni X,Gao Y,Wu Z,Ma L,Chen C,Wang L,Lin Y,Hui L,Pan G

更新日期：2016-12-09 00:00:00

abstract：:Vegetation buffers local diurnal land surface temperatures, however, this effect has found limited applications for remote vegetation characterization. In this work, we parameterize diurnal temperature variations as the thermal decay rate derived by using satellite daytime and nighttime land surface temperatures and m...

journal_title：Scientific reports

authors： Kumar SS,Prihodko L,Lind BM,Anchang J,Ji W,Ross CW,Kahiu MN,Velpuri NM,Hanan NP

更新日期：2020-06-17 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. PPAR agonists have well-documented anti-inflammatory and neuroprotective roles in the central nervous system. Recent evidence suggests that PPAR agonists are attractive therapeutic agen...

journal_title：Scientific reports

authors： Warden A,Truitt J,Merriman M,Ponomareva O,Jameson K,Ferguson LB,Mayfield RD,Harris RA

更新日期：2016-06-10 00:00:00

abstract：:Age-related hearing loss has been related to a compensatory increase in audio-visual integration and neural reorganization including alterations in functional resting state connectivity. How these two changes are linked in elderly listeners is unclear. The current study explored modulatory effects of hearing threshold...

journal_title：Scientific reports

authors： Schulte A,Thiel CM,Gieseler A,Tahden M,Colonius H,Rosemann S

更新日期：2020-10-12 00:00:00

abstract：:GabR from Bacillus subtilis is a transcriptional regulator of the MocR subfamily of GntR regulators. The MocR architecture is characterized by the presence of an N-terminal winged-Helix-Turn-Helix domain and a C-terminal domain folded as the pyridoxal 5'-phosphate (PLP) dependent aspartate aminotransferase (AAT). The ...

journal_title：Scientific reports

authors： Frezzini M,Guidoni L,Pascarella S

更新日期：2019-12-17 00:00:00

abstract：:Coherent, optically dressed media composed of two-level molecular systems without inversion symmetry are considered as all-optically tunable sources of coherent radiation in the microwave domain. A theoretical model and a numerical toolbox are developed to confirm the main finding: the generation of low-frequency radi...

journal_title：Scientific reports

authors： Gładysz P,Wcisło P,Słowik K

更新日期：2020-10-19 00:00:00