当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes.

Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes.

Abstract：

:Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here we used human primary myotubes (HPM) to investigate if rhythmicity of clock- and metabolic gene expression is altered in donors with obesity or type 2 diabetes compared to metabolically healthy donors. HPM were obtained from skeletal muscle biopsies of four groups: type 2 diabetic patients and their BMI- and age-matched obese controls and from lean, healthy and young endurance trained athletes and their age-matched sedentary controls. HPM were differentiated for 7 days before synchronization by serum shock followed by gene expression profiling over the next 72 hours. HPM display robust circadian rhythms in clock genes, but REVERBA displayed dampened rhythmicity in type 2 diabetes. Furthermore, rhythmicity in NAMPT and SIRT1 expression was only observed in HPM from trained athletes. Rhythmicity in expression of key-regulators of carbohydrate and lipid metabolism was modest. We demonstrate that in human skeletal muscle REVERBA/B, NAMPT and SIRT1 circadian rhythms are affected in donors of sedentary life style and poor health status.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hansen J,Timmers S,Moonen-Kornips E,Duez H,Staels B,Hesselink MK,Schrauwen P

doi

10.1038/srep35047

subject

Has Abstract

pub_date

2016-10-19 00:00:00

pages

35047

issn

2045-2322

pii

srep35047

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Genome wide association study and genomic prediction for stover quality traits in tropical maize (Zea mays L.).

    abstract：:Maize is rapidly replacing traditionally cultivated dual purpose crops of South Asia, primarily due to the better economic remuneration. This has created an impetus for improving maize for both grain productivity and stover traits. Molecular techniques can largely assist breeders in determining approaches for effectiv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80118-2

    authors： Vinayan MT,Seetharam K,Babu R,Zaidi PH,Blummel M,Nair SK

    更新日期：2021-01-12 00:00:00

  • YebC, a putative transcriptional factor involved in the regulation of the proteolytic system of Lactobacillus.

    abstract：:The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09124-1

    authors： Brown L,Villegas JM,Elean M,Fadda S,Mozzi F,Saavedra L,Hebert EM

    更新日期：2017-08-17 00:00:00

  • Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing.

    abstract：:To date, the cell and molecular mechanisms regulating tendon healing are poorly understood. Here, we establish a novel model of tendon regeneration using neonatal mice and show that neonates heal via formation of a 'neo-tendon' that differentiates along the tendon specific lineage with functional restoration of gait a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45238

    authors： Howell K,Chien C,Bell R,Laudier D,Tufa SF,Keene DR,Andarawis-Puri N,Huang AH

    更新日期：2017-03-23 00:00:00

  • Identifying microRNA determinants of human myelopoiesis.

    abstract：:Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes and granulocytes. This complex process is regulated by various extracellular a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24203-7

    authors： Rajasekhar M,Schmitz U,Flamant S,Wong JJ,Bailey CG,Ritchie W,Holst J,Rasko JEJ

    更新日期：2018-05-08 00:00:00

  • Increased pollinator service and reduced pollen limitation in the fixed dune populations of a desert shrub.

    abstract：:Evaluations of restoration success usually focus on the structural aspects of ecosystems. Pollination, as an important functional aspect, is often overlooked. Here, the shifts in pollinator assemblage and pollen limitation in the desert shrub Caragana microphylla were examined along a restoration gradient in Horqin Sa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17253-w

    authors： Pan CC,Qu H,Feng Q,Liu LD,Zhao HL,Li YL,Li YQ,Zhang TH,Liu XP

    更新日期：2017-12-04 00:00:00

  • Functional conservation of EXA1 among diverse plant species for the infection by a family of plant viruses.

    abstract：:Since the propagation of plant viruses depends on various host susceptibility factors, deficiency in them can prevent viral infection in cultivated and model plants. Recently, we identified the susceptibility factor Essential for poteXvirus Accumulation 1 (EXA1) in Arabidopsis thaliana, and revealed that EXA1-mediated...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42400-w

    authors： Yusa A,Neriya Y,Hashimoto M,Yoshida T,Fujimoto Y,Hosoe N,Keima T,Tokumaru K,Maejima K,Netsu O,Yamaji Y,Namba S

    更新日期：2019-04-11 00:00:00

  • Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin.

    abstract：:Nasopharyngeal carcinoma (NPC) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant cancer stem cells (CSC) may associate with tumor relapse and metastasis in NPC. ICG-001 is a specific CBP/β-catenin antagonist that can block CBP/β-catenin-mediated transcription of st...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09979

    authors： Chan KC,Chan LS,Ip JC,Lo C,Yip TT,Ngan RK,Wong RN,Lo KW,Ng WT,Lee AW,Tsao GS,Kahn M,Lung ML,Mak NK

    更新日期：2015-04-21 00:00:00

  • Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS.

    abstract：:Developing effective treatment strategies for neurodegenerative diseases require an understanding of the underlying cellular pathways that lead to neuronal vulnerability and progressive degeneration. To date, numerous mutations in 147 distinct genes are identified to be "associated" with, "modifier" or "causative" of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32902-4

    authors： Dervishi I,Gozutok O,Murnan K,Gautam M,Heller D,Bigio E,Ozdinler PH

    更新日期：2018-10-03 00:00:00

  • A novel method for preparing microplastic fibers.

    abstract：:Microscopic plastic (microplastic, 0.1 µm-5 mm) is a widespread pollutant impacting upon aquatic ecosystems across the globe. Environmental sampling has revealed synthetic fibers are prevalent in seawater, sediments and biota. However, microplastic fibers are rarely used in laboratory studies as they are unavailable f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34519

    authors： Cole M

    更新日期：2016-10-03 00:00:00

  • Genome and transcriptome analysis of surfactin biosynthesis in Bacillus amyloliquefaciens MT45.

    abstract：:Natural Bacillus isolates generate limited amounts of surfactin (<10% of their biomass), which functions as an antibiotic or signalling molecule in inter-/intra-specific interactions. However, overproduction of surfactin in Bacillus amyloliquefaciens MT45 was observed at a titre of 2.93 g/l, which is equivalent to hal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40976

    authors： Zhi Y,Wu Q,Xu Y

    更新日期：2017-01-23 00:00:00

  • Toxicology Study of Single-walled Carbon Nanotubes and Reduced Graphene Oxide in Human Sperm.

    abstract：:Carbon-based nanomaterials such as single-walled carbon nanotubes and reduced graphene oxide are currently being evaluated for biomedical applications including in vivo drug delivery and tumor imaging. Several reports have studied the toxicity of carbon nanomaterials, but their effects on human male reproduction have ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30270

    authors： Asghar W,Shafiee H,Velasco V,Sah VR,Guo S,El Assal R,Inci F,Rajagopalan A,Jahangir M,Anchan RM,Mutter GL,Ozkan M,Ozkan CS,Demirci U

    更新日期：2016-08-19 00:00:00

  • Analysis and Design of a Compact Leaky-Wave Antenna for Wide-Band Broadside Radiation.

    abstract：:A low-cost compact planar leaky-wave antenna (LWA) is proposed offering directive broadside radiation over a significantly wide bandwidth. The design is based on an annular metallic strip grating (MSG) configuration, placed on top of a dual-layer grounded dielectric substrate. This defines a new two-layer parallel-pla...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35480-7

    authors： Comite D,Podilchak SK,Baccarelli P,Burghignoli P,Galli A,Freundorfer AP,Antar YMM

    更新日期：2018-12-10 00:00:00

  • Bio-inspired synthesis of aqueous nanoapatite liquid crystals.

    abstract：:The macroscopically ordered structure of rod-like nanoapatites within the collagen matrix is of great significance for the mechanical performance of bones and teeth. However, the synthesis of macroscopically ordered nanoapatite remains a challenge. Inspired by the effect of citrate molecules on apatite crystals in nat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36843-w

    authors： Tan J,Jin X,Chen M

    更新日期：2019-01-24 00:00:00

  • Neurotransmitter identity and electrophysiological phenotype are genetically coupled in midbrain dopaminergic neurons.

    abstract：:Most neuronal types have a well-identified electrical phenotype. It is now admitted that a same phenotype can be produced using multiple biophysical solutions defined by ion channel expression levels. This argues that systems-level approaches are necessary to understand electrical phenotype genesis and stability. Midb...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31765-z

    authors： Tapia M,Baudot P,Formisano-Tréziny C,Dufour MA,Temporal S,Lasserre M,Marquèze-Pouey B,Gabert J,Kobayashi K,Goaillard JM

    更新日期：2018-09-11 00:00:00

  • Abrogation of type-I interferon signalling alters the microglial response to Aβ1-42.

    abstract：:Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogenesis. Critical to the process of neuroinflammation are the type-I interferon (IFN) family of cytokines. Efforts to phenotypically characterize microglia within AD identify distinct populatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59917-0

    authors： Moore Z,Mobilio F,Walker FR,Taylor JM,Crack PJ

    更新日期：2020-02-21 00:00:00

  • Element substitution of kesterite Cu2ZnSnS4 for efficient counter electrode of dye-sensitized solar cells.

    abstract：:Development of cost-effective counter electrode (CE) materials is a key issue for practical applications of photoelectrochemical solar energy conversion. Kesterite Cu2ZnSnS4 (CZTS) has been recognized as a potential CE material, but its electrocatalytic activity is still insufficient for the recovery of I-/I3- electro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26770-1

    authors： Lu S,Yang H,Li F,Wang Y,Chen S,Yang G,Liu Y,Zhang X

    更新日期：2018-06-07 00:00:00

  • Quaternary fluvial terraces of the Tiber Valley: geochronologic and geometric constraints on the back-arc magmatism-related uplift in central Italy.

    abstract：:Through a geomorphological study relying on statistically assessed classes of hilltop elevations, we reconstruct a suite of paleo-surfaces along the Tiber River Valley north of Rome that we identify as fluvial terraces formed by interplay between global sea-level fluctuations and regional upift. Using biostratigraphic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02437-1

    authors： Marra F,Florindo F,Petronio C

    更新日期：2017-05-31 00:00:00

  • Trying to see, failing to focus: near visual impairment in Down syndrome.

    abstract：:The majority of individuals with Down syndrome (DS) do not exhibit accurate accommodation, with the aetiology of this deficit unknown. This study examines the mechanism underlying hypoaccommodation in DS by simultaneously investigating the 'near triad' - accommodation, vergence and pupillary response. An objective pho...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20444

    authors： Doyle L,Saunders KJ,Little JA

    更新日期：2016-02-05 00:00:00

  • Towards ultimate low frequency air-core magnetometer sensitivity.

    abstract：:Air-core magnetometers are amongst the most commonly used magnetic field detectors in biomedical instruments. They offer excellent sensitivity, low fabrication complexity and a robust, cost-effective solution. However, air-core magnetometers must be tailored to the specific application to achieve high sensitivity, whi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02099-z

    authors： Pellicer-Guridi R,Vogel MW,Reutens DC,Vegh V

    更新日期：2017-05-23 00:00:00

  • Species identification by experts and non-experts: comparing images from field guides.

    abstract：:Accurate species identification is fundamental when recording ecological data. However, the ability to correctly identify organisms visually is rarely questioned. We investigated how experts and non-experts compared in the identification of bumblebees, a group of insects of considerable conservation concern. Experts a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33634

    authors： Austen GE,Bindemann M,Griffiths RA,Roberts DL

    更新日期：2016-09-20 00:00:00

  • Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training.

    abstract：:Regular exercise elicits advantageous metabolic adaptations in skeletal muscle, such as improved insulin sensitivity. However, the underpinning molecular mechanisms and the effect of diet on muscle exercise training benefits are unclear. We therefore characterized the skeletal muscle proteome following exercise traini...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28540-5

    authors： Kleinert M,Parker BL,Jensen TE,Raun SH,Pham P,Han X,James DE,Richter EA,Sylow L

    更新日期：2018-07-16 00:00:00

  • Identification of DNAH6 mutations in infertile men with multiple morphological abnormalities of the sperm flagella.

    abstract：:Male infertility due to spermatogenesis defects affects millions of men worldwide. However, the genetic etiology of the vast majority remains unclear. Here we describe three men with primary infertility due to multiple morphological abnormalities of the sperm flagella (MMAF) from two unrelated Han Chinese families. We...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-019-52436-7

    authors： Tu C,Nie H,Meng L,Yuan S,He W,Luo A,Li H,Li W,Du J,Lu G,Lin G,Tan YQ

    更新日期：2019-11-01 00:00:00

  • Author Correction: Artocarpus altilis extracts as a food-borne pathogen and oxidation inhibitors: RSM, COSMO RS, and molecular docking approaches.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-76567-4

    authors： Ahmad MN,Karim NU,Normaya E,Piah BM,Iqbal A,Bulat KHK

    更新日期：2020-11-05 00:00:00

  • Dispersion engineering with plasmonic nano structures for enhanced surface plasmon resonance sensing.

    abstract：:We demonstrate numerically and experimentally the enhancement of Surface Plasmon Resonance (SPR) sensing via dispersion engineering of the plasmonic response using plasmonic nanograting. Following their design and optimization, the plasmonic nanograting structures are fabricated using e-beam lithography and lift-off p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27023-x

    authors： Arora P,Talker E,Mazurski N,Levy U

    更新日期：2018-06-13 00:00:00

  • A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia.

    abstract：:Channelopathy mutations prove informative on disease causing mechanisms and channel gating dynamics. We have identified a novel heterozygous mutation in the KCNA1 gene of a young proband displaying typical signs and symptoms of Episodic Ataxia type 1 (EA1). This mutation is in the S4 helix of the voltage-sensing domai...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03041-z

    authors： Hasan S,Bove C,Silvestri G,Mantuano E,Modoni A,Veneziano L,Macchioni L,Hunter T,Hunter G,Pessia M,D'Adamo MC

    更新日期：2017-07-04 00:00:00

  • A randomised clinical study to determine the effect of a toothpaste containing enzymes and proteins on plaque oral microbiome ecology.

    abstract：:The numerous species that make up the oral microbiome are now understood to play a key role in establishment and maintenance of oral health. The ability to taxonomically identify community members at the species level is important to elucidating its diversity and association to health and disease. We report the overal...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/srep43344

    authors： Adams SE,Arnold D,Murphy B,Carroll P,Green AK,Smith AM,Marsh PD,Chen T,Marriott RE,Brading MG

    更新日期：2017-02-27 00:00:00

  • Detection of the Three Gorges Dam influence on the Changjiang (Yangtze River) submerged delta.

    abstract：:While most large river-deltas in the world are facing the risk of subsidence and erosion in the Anthropocene, it is suspected that the Changjiang submerged delta (CSD) could be subjected to the impacts of the world's largest dam, the Three Gorges Dam (TGD). Here we firstly indicate that the CSD went through high accum...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06600

    authors： Dai Z,Liu JT,Wei W,Chen J

    更新日期：2014-10-16 00:00:00

  • Face age modulates gaze following in young adults.

    abstract：:Gaze-following behaviour is considered crucial for social interactions which are influenced by social similarity. We investigated whether the degree of similarity, as indicated by the perceived age of another person, can modulate gaze following. Participants of three different age-groups (18-25; 35-45; over 65) perfor...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04746

    authors： Ciardo F,Marino BF,Actis-Grosso R,Rossetti A,Ricciardelli P

    更新日期：2014-04-22 00:00:00

  • Room temperature electrical spin injection into GaAs by an oxide spin injector.

    abstract：:Spin injection, manipulation and detection are the integral parts of spintronics devices and have attracted tremendous attention in the last decade. It is necessary to judiciously choose the right combination of materials to have compatibility with the existing semiconductor technology. Conventional metallic magnets w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05588

    authors： Bhat SG,Kumar PS

    更新日期：2014-07-07 00:00:00

  • Author Correction: Surface plasmon enhanced Organic color image sensor with Ag nanoparticles coated with silicon oxynitride.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-59906-3

    authors： Heo S,Lee J,Lee GH,Heo CJ,Kim SH,Yun DJ,Park JB,Kim K,Kim Y,Lee D,Park GS,Cho HY,Shin T,Yun SY,Kim S,Jin YW,Park KB

    更新日期：2020-02-13 00:00:00