Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin.

abstract：:Drug-resistant tuberculosis (TB) is a serious global problem, and pathogen factors involved in the transmission of isoniazid (INH)-resistant TB have not been fully investigated. We performed whole genome sequencing of 332 clinical Mycobacterium tuberculosis (Mtb) isolates collected from patients newly diagnosed with s...

journal_title：Scientific reports

authors： Hang NTL,Hijikata M,Maeda S,Thuong PH,Ohashi J,Van Huan H,Hoang NP,Miyabayashi A,Cuong VC,Seto S,Van Hung N,Keicho N

更新日期：2019-10-25 00:00:00

abstract：:Individuals who are well integrated into society have greater access to resources and tend to live longer. Why some individuals are socially isolated and others are not is therefore puzzling from an evolutionary perspective. Answering this question requires establishing the mix of intrinsic and contextual factors that...

journal_title：Scientific reports

authors： Brent LJN,Ruiz-Lambides A,Platt ML

更新日期：2017-12-19 00:00:00

abstract：:Previous trial evidence suggested potential risk of serious urinary tract infections (UTIs) and genital infections in type 2 diabetes patients using sodium glucose co-transporter-2 inhibitors (SGLT2) inhibitors. We conducted a systematic review and meta-analysis to assess the effects of SGLT2 inhibitors on UTIs and ge...

journal_title：Scientific reports

authors： Liu J,Li L,Li S,Jia P,Deng K,Chen W,Sun X

更新日期：2017-06-06 00:00:00

abstract：:Ultra-fast synchrotron radiation emission can arise from the transverse betatron motion of an electron in a laser plasma wakefield, and the radiation spectral peak is limited to tens of keV. Here, we present a new method for achieving high-energy radiation via accelerated electrons wiggling in an additional laser fiel...

journal_title：Scientific reports

authors： Feng J,Li Y,Wang J,Li D,Li F,Yan W,Wang W,Chen L

更新日期：2019-02-21 00:00:00

abstract：:The aberrant expression of human sodium iodide symporter (NIS) in breast cancer (BC) has raised the possibility of using targeted radioiodide therapy. Here we investigate modulation of endogenous, functional NIS expression by histone deacetylase inhibitors (HDACi) in vitro and in vivo. Luciferase reporter based initia...

journal_title：Scientific reports

authors： Kelkar MG,Senthilkumar K,Jadhav S,Gupta S,Ahn BC,De A

更新日期：2016-01-18 00:00:00

abstract：:Rhythms of life are dictated by oscillations, which take place in a wide rage of biological scales. In bacteria, for example, oscillations have been proven to control many fundamental processes, ranging from gene expression to cell divisions. In genetic circuits, oscillations originate from elemental block such as aut...

journal_title：Scientific reports

authors： Ruocco G,Fratalocchi A

更新日期：2014-11-18 00:00:00

abstract：:In this work, CoMoO4@NiMoO4·xH2O core-shell heterostructure electrode is directly grown on carbon fabric (CF) via a feasible hydrothermal procedure with CoMoO4 nanowires (NWs) as the core and NiMoO4 nanosheets (NSs) as the shell. This core-shell heterostructure could provide fast ion and electron transfer, a large num...

journal_title：Scientific reports

authors： Wang J,Zhang L,Liu X,Zhang X,Tian Y,Liu X,Zhao J,Li Y

更新日期：2017-01-20 00:00:00

abstract：:Most of the artificial low-pressure plasmas contact with physical walls in laboratories; the plasma loss at the wall significantly affects the plasma device performance, e.g., an electric propulsion device. Near the surface of the wall, ions are spontaneously accelerated by a sheath and deliver their momentum and ener...

journal_title：Scientific reports

authors： Takahashi K,Sugawara T,Ando A

更新日期：2020-01-23 00:00:00

abstract：:Our understanding of the interaction between the gut microbiota and host health has recently improved dramatically. However, the effects of toxic metal exposure on the gut microbiota remain poorly characterized. As this microbiota creates a critical interface between the external environment and the host's cells, it m...

journal_title：Scientific reports

authors： Richardson JB,Dancy BCR,Horton CL,Lee YS,Madejczyk MS,Xu ZZ,Ackermann G,Humphrey G,Palacios G,Knight R,Lewis JA

更新日期：2018-04-26 00:00:00

abstract：:The preparation of mesoporous iron oxides with controllable physiochemical properties for effective therapeutic drug delivery remains a formidable challenge. Herein, iron oxide mesoporous magnetic microparticles (IO-MMMs) were prepared by a modified reverse hard-templating approach using, for the first time, acid-prep...

journal_title：Scientific reports

authors： El-Boubbou K,Ali R,Al-Zahrani H,Trivilegio T,Alanazi AH,Khan AL,Boudjelal M,AlKushi A

更新日期：2019-07-01 00:00:00

abstract：:This paper presents the correlative imaging of collagen denaturation by nonlinear optical microscopy (NLO) and nanoscale infrared (IR) spectroscopy to obtain morphological and chemical information at different length scales. Such multiscale correlated measurements are applied to the investigation of ancient parchments...

journal_title：Scientific reports

authors： Latour G,Robinet L,Dazzi A,Portier F,Deniset-Besseau A,Schanne-Klein MC

更新日期：2016-05-19 00:00:00

abstract：:Macroscopic rhythms are often signatures of healthy functioning in living organisms, but they are still poorly understood on their microscopic bases. Globally interacting oscillators with heterogeneous couplings are here considered. Thorough theoretical and numerical analyses indicate the presence of multiple phase tr...

journal_title：Scientific reports

authors： Qiu T,Bonamassa I,Boccaletti S,Liu Z,Guan S

更新日期：2018-08-28 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Herrera-Nieto P,Pérez A,De Fabritiis G

更新日期：2020-09-29 00:00:00

abstract：:Giant optical transmittance changes of over 300% in wide wavelength range from 500 nm to 2500 nm were observed in LaBaCo2O5.5+δ thin films annealed in air and ethanol ambient, respectively. The reduction process induces high density of ordered oxygen vacancies and the formation of LaBaCo2O5.5 (δ = 0) structure evidenc...

journal_title：Scientific reports

authors： Cheng S,Lu J,Han D,Liu M,Lu X,Ma C,Zhang S,Chen C

更新日期：2016-11-23 00:00:00

abstract：:Bio-functionalized nanoparticles with semiconducting/metallic core encapsulated in a bio- or bio-derived materials are promising for applications in biology and especially in cancer diagnostic and healing. In this report, we report a facile, single-step, first-time synthesis and in-situ functionalization strategy for ...

journal_title：Scientific reports

authors： Liao W,Yu Z,Lin Z,Lei Z,Ning Z,Regenstein JM,Yang J,Ren J

更新日期：2015-12-21 00:00:00

abstract：:Patients with liver cirrhosis are susceptible to infections with high short-term mortalities. One CD97-related EGF-TM7 molecule, EMR2 (EGF-like molecule containing mucin-like hormone receptor 2), had been shown to regulate human neutrophil function, potentiate systemic inflammation. Nevertheless, EMR2 could also suppr...

journal_title：Scientific reports

authors： Huang CH,Jeng WJ,Ho YP,Teng W,Hsieh YC,Chen WT,Chen YC,Lin HH,Sheen IS,Lin CY

更新日期：2016-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been considered to be potent biomarkers for early disease diagnosis and for cancer therapy. The rapid and selective detection of miRNAs without reverse transcription and labelling is highly desired. Herein, we report a simple and label-free miRNA detection method that is based on the Duplex-Spe...

journal_title：Scientific reports

authors： Yan L,Yan Y,Pei L,Wei W,Zhao J

更新日期：2014-12-10 00:00:00

abstract：:The chemiresistive thin film gas sensors with fast response, high sensitivity, low power consumption and mass-produced potency, have been expected for practical application. It requires both sensitive materials, especially exquisite nanomaterials, and efficient substrate chip for heating and electrical addressing. How...

journal_title：Scientific reports

authors： Dai Z,Xu L,Duan G,Li T,Zhang H,Li Y,Wang Y,Wang Y,Cai W

更新日期：2013-01-01 00:00:00

abstract：:Metallic nanostructures are of immense scientific interest owing to unexpectedly strong interaction with light in deep subwavelength scales. Resonant excitations of surface and cavity plasmonic modes mediate strong light localization in nanoscale objects. Nevertheless, the role of surface plasmon-polaritons (SPP) in l...

journal_title：Scientific reports

authors： Yoon JW,Lee JH,Song SH,Magnusson R

更新日期：2014-07-14 00:00:00

abstract：:Carbon-based nanomaterials such as single-walled carbon nanotubes and reduced graphene oxide are currently being evaluated for biomedical applications including in vivo drug delivery and tumor imaging. Several reports have studied the toxicity of carbon nanomaterials, but their effects on human male reproduction have ...

journal_title：Scientific reports

authors： Asghar W,Shafiee H,Velasco V,Sah VR,Guo S,El Assal R,Inci F,Rajagopalan A,Jahangir M,Anchan RM,Mutter GL,Ozkan M,Ozkan CS,Demirci U

更新日期：2016-08-19 00:00:00

abstract：:The lateral motion of a magnetic skyrmion, arising because of the skyrmion Hall effect, imposes a number of restrictions on the use of this spin state in the racetrack memory. A skyrmionium is a more promising spin texture for memory applications, since it has zero total topological charge and propagates strictly alon...

journal_title：Scientific reports

authors： Kolesnikov AG,Stebliy ME,Samardak AS,Ognev AV

更新日期：2018-11-16 00:00:00

abstract：:The protective effect of estrogens against chronic glomerular diseases is admitted but remains debated during acute kidney injury (AKI). Using a model of resuscitated hemorrhagic shock in C57/Bl6 female mice, this study evaluated at 1 and 21 days the renal effect of (1) endogenous estrogen, using ovariectomized mice w...

journal_title：Scientific reports

authors： Buléon M,Cuny M,Grellier J,Charles PY,Belliere J,Casemayou A,Arnal JF,Schanstra JP,Tack I

更新日期：2020-10-14 00:00:00

abstract：:The potential of a spheroid tumor model composed of cells in different proliferative and metabolic states for the development of new anticancer strategies has been amply demonstrated. However, there is little or no information in the literature on the problems of reproducibility of data originating from experiments us...

journal_title：Scientific reports

authors： Zanoni M,Piccinini F,Arienti C,Zamagni A,Santi S,Polico R,Bevilacqua A,Tesei A

更新日期：2016-01-11 00:00:00

abstract：:We introduce a low-melting-point (MP) Sn-P-F-O glass ceramic material into the phosphor-in-glass (PIG) material to realize an 'on-chip' chip-on-board (COB) type of phosphor-converted (pc) white light-emitting diode (WLED) with green (BaSr)2SiO4:Eu2+ and red (SrCa)AlSiN3:Eu2+ (SCASN) phosphors. The optimum Sn-P-F-O-bas...

journal_title：Scientific reports

authors： Yoon HC,Yoshihiro K,Yoo H,Lee SW,Oh JH,Do YR

更新日期：2018-05-09 00:00:00

abstract：:We have prepared and studied a family of cyanobiphenyl dimers with varying linking groups with a view to exploring how molecular structure dictates the stability of the nematic and twist-bend nematic mesophases. Using molecular modelling and 1D 1H NOESY NMR spectroscopy, we determine the angle between the two aromatic...

journal_title：Scientific reports

authors： Mandle RJ,Archbold CT,Sarju JP,Andrews JL,Goodby JW

更新日期：2016-11-07 00:00:00

abstract：:It has been postulated that there is a link between age related degenerative diseases and cancer. The TNF-related apoptosis-inducing ligand (TRAIL) has been shown to selectively kill tumor cells by binding to pro-apoptotic and anti-apoptotic receptors. Our aim was to study the levels of anti-apoptotic receptor (DcR1) ...

journal_title：Scientific reports

authors： Anand A,Sharma NK,Singh R,Gupta A,Prabhakar S,Jindal N,Bhatt AK,Sharma SK,Gupta PK

更新日期：2014-02-18 00:00:00

abstract：:Waste biomass from forestry and wood processing industries is a source to obtain fine chemicals, and its processing is a good example of circular economy, but it generates secondary environmental impacts. The main objective of this study was to analyse the environmental performances of laboratory scale processes for p...

journal_title：Scientific reports

authors： Barjoveanu G,Pătrăuțanu OA,Teodosiu C,Volf I

更新日期：2020-08-12 00:00:00

abstract：:The characteristics of aortic valvular outflow jet affect aortopathy in the bicuspid aortic valve (BAV). This study aimed to elucidate the effects of BAV morphology on the aortic valvular outflow jets. Morphotype-specific valve-devising apparatuses were developed to create aortic valve models. A magnetic resonance ima...

journal_title：Scientific reports

authors： Hattori K,Nakama N,Takada J,Nishimura G,Moriwaki R,Kawasaki E,Nagao M,Goto Y,Niinami H,Iwasaki K

更新日期：2021-01-22 00:00:00

abstract：:This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall survival (OS) in a large cohort of patients. Data on efficacy and on acute/late toxicity were retrospectively col...

journal_title：Scientific reports

authors： Langrand-Escure J,Diao P,Garcia MA,Wang G,Guy JB,Espenel S,Guillaume E,Rehailia-Blanchard A,Pigné G,de Laroche G,Kaczmarek D,Muron T,Porcheron J,Phelip JM,Vallard A,Magné N

更新日期：2018-07-16 00:00:00

abstract：:What is intuitive: pro-social or anti-social behaviour? To answer this fundamental question, recent studies analyse decision times in game theory experiments under the assumption that intuitive decisions are fast and that deliberation is slow. These analyses keep track of the average time taken to make decisions under...

journal_title：Scientific reports

authors： Gallotti R,Grujić J

更新日期：2019-11-19 00:00:00