A single dose of estrogen during hemorrhagic shock protects against Kidney Injury whereas estrogen restoration in ovariectomized mice is ineffective.

Abstract:

:The protective effect of estrogens against chronic glomerular diseases is admitted but remains debated during acute kidney injury (AKI). Using a model of resuscitated hemorrhagic shock in C57/Bl6 female mice, this study evaluated at 1 and 21 days the renal effect of (1) endogenous estrogen, using ovariectomized mice with or without chronic estrogen restoration, or (2) exogenous estrogen, using a single administration of a pharmacological dose during shock resuscitation. In both ovariectomized and intact mice, hemorrhagic shock induced epithelial cell damages (assessed by KIM-1 renal expression) with secondary renal fibrosis but without significant decrease in GFR at day 21. Ovariectomy with or without estrogen restoration have no significant effect on renal damages and dysfunction. This lack of effect was associated with a marked (> 80%) reduction of total kidney GPR30 expression. By contrast, a single high dose of estradiol in intact mice reduced renal KIM-1 expression by 2/3, attenuated the severity of cell death related to pyroptosis, and prevented the increase of fibrosis by 1/3. This provides a rationale to investigate the benefits of a single administration of estrogen or estrogen modulators during acute kidney injuries in males. Furthermore, the cost/benefit ratio of such administration should be investigated in Human.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Buléon M,Cuny M,Grellier J,Charles PY,Belliere J,Casemayou A,Arnal JF,Schanstra JP,Tack I

doi

10.1038/s41598-020-73974-5

subject

Has Abstract

pub_date

2020-10-14 00:00:00

pages

17240

issue

1

issn

2045-2322

pii

10.1038/s41598-020-73974-5

journal_volume

10

pub_type

杂志文章
  • Ultralow Lattice Thermal Conductivity of the Random Multilayer Structure with Lattice Imperfections.

    abstract::Randomizing the layer thickness of superlattices (SL) can lead to localization of coherent phonons and thereby reduces the lattice thermal conductivity κ l . In this work, we propose strategies that can suppress incoherent phonon transport in the above random multilayer (RML) structure to further reduce κ l . Molecula...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08359-2

    authors: Chakraborty P,Cao L,Wang Y

    更新日期:2017-08-15 00:00:00

  • The synergy between the insect-inspired claws and adhesive pads increases the attachment ability on various rough surfaces.

    abstract::To attach reliably on various inclined rough surfaces, many insects have evolved both claws and adhesive pads on their feet. However, the interaction between these organs still remains unclear. Here we designed an artificial attachment device, which mimics the structure and function of claws and adhesive pads, and tes...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26219

    authors: Song Y,Dai Z,Wang Z,Ji A,Gorb SN

    更新日期:2016-05-20 00:00:00

  • Evaluation of reproductive performances of the common octopus (Octopus vulgaris) reared in water recirculation systems and fed different diets.

    abstract::The reproductive performance of Octopus vulgaris broodstocks fed two different diets (mixed fish [F group, BW 1,048.14 g] or mixed crustaceans [C group, BW 998.44 g]) was analyzed using an experimental recirculating aquaculture system consisting of a tank equipped with spawning and incubation chambers. A total of 8 fe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72151-y

    authors: Casalini A,Roncarati A,Emmanuele P,Guercilena N,Bonaldo A,Parma L,Mordenti O

    更新日期:2020-09-17 00:00:00

  • Optical coherence tomographic features of macular telangiectasia type 2: Korean Macular Telangiectasia Type 2 Study-Report No. 1.

    abstract::We analysed the imaging findings of macular telangiectasia (MacTel) type 2 in Korea using spectral domain optical coherence tomography (SD-OCT) and investigated their relationship with visual acuity and clinical stages. A retrospective multicentre cross-sectional study was conducted in six tertiary hospitals in Korea ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-73803-9

    authors: Kim YH,Chung YR,Oh J,Kim SW,Lee CS,Yun C,Lee B,Ahn SM,Choi EY,Jang S,Lee K

    更新日期:2020-10-06 00:00:00

  • Amorphous solid dispersions of enzalutamide and novel polysaccharide derivatives: investigation of relationships between polymer structure and performance.

    abstract::Amorphous solid dispersion (ASD) is a widely employed formulation technique for drugs with poor aqueous solubility. Polymers are integral components of ASDs, but mechanisms by which polymers lead to the generation and maintenance of supersaturated solutions, which enhance oral absorption in vivo, are poorly understood...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75077-7

    authors: Wilson VR,Lou X,Osterling DJ,Stolarik DF,Jenkins GJ,Nichols BLB,Dong Y,Edgar KJ,Zhang GGZ,Taylor LS

    更新日期:2020-10-28 00:00:00

  • Electrode-free visual prosthesis/exoskeleton control using augmented reality glasses in a first proof-of-technical-concept study.

    abstract::In the field of neuroprosthetics, the current state-of-the-art method involves controlling the prosthesis with electromyography (EMG) or electrooculography/electroencephalography (EOG/EEG). However, these systems are both expensive and time consuming to calibrate, susceptible to interference, and require a lengthy lea...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-73250-6

    authors: Hazubski S,Hoppe H,Otte A

    更新日期:2020-10-01 00:00:00

  • A new semi-supervised learning model combined with Cox and SP-AFT models in cancer survival analysis.

    abstract::Gene selection is an attractive and important task in cancer survival analysis. Most existing supervised learning methods can only use the labeled biological data, while the censored data (weakly labeled data) far more than the labeled data are ignored in model building. Trying to utilize such information in the censo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13133-5

    authors: Chai H,Li ZN,Meng DY,Xia LY,Liang Y

    更新日期:2017-10-12 00:00:00

  • Quorum sensing in Pseudomonas aeruginosa mediated by RhlR is regulated by a small RNA PhrD.

    abstract::Pseudomonas aeruginosa is a highly invasive human pathogen in spite of the absence of classical host specific virulence factors. Virulence factors regulated by quorum sensing (QS) in P. aeruginosa cause acute infections to shift to chronic diseases. Several small regulatory RNAs (sRNAs) mediate fine-tuning of bacteria...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36488-9

    authors: Malgaonkar A,Nair M

    更新日期:2019-01-23 00:00:00

  • Low energy cost for cultured pearl formation in grafted chimeric Pinctada margaritifera.

    abstract::The pearl oyster is one of the rare animal models that support two distinct genomes, through the surgical graft process operated for culture pearl production. This grafted organism is assimilated to a chimera whose physiological functioning remains poorly known. The question of the energy expenditure comparison betwee...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25360-5

    authors: Le Moullac G,Soyez C,Ky CL

    更新日期:2018-05-14 00:00:00

  • Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2.

    abstract::Cardiac contractility is enhanced by phosphorylation of myosin light chain 2 (MLC2) by cardiac-specific MLC kinase (cMLCK), located at the neck region of myosin heavy chain. In normal mouse and human hearts, the level of phosphorylation is maintained relatively constant, at around 30-40% of total MLC2, likely by well-...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48884-w

    authors: X Cai L,Tanada Y,D Bello G,C Fleming J,F Alkassis F,Ladd T,Golde T,Koh J,Chen S,Kasahara H

    更新日期:2019-08-29 00:00:00

  • Controlled synthesis of Ni/CuOx/Ni nanowires by electrochemical deposition with self-compliance bipolar resistive switching.

    abstract::We demonstrate synthesis of Ni/CuOx/Ni nanowires (NWs) by electrochemical deposition on anodized aluminum oxide (AAO) membranes. AAO with pore diameter of ~70 nm and pore length of ~50 μm was used as the template for synthesis of NWs. After deposition of Au as the seed layer, NWs with a structure of Ni/CuOx/Ni were gr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23069

    authors: Park K,Lee JS

    更新日期:2016-03-15 00:00:00

  • Dynamical Casimir-Polder force on a two-level atom with superposition state in a cavity comprising a dielectric.

    abstract::We study the dynamical Casimir-Polder force on a two-level atom with different initial states in the one-dimensional dielectric cavity with output coupling, and obtain the analytical expression of the expectation value of dynamical Casimir-Polder force. Results show that the expectation values of dynamical Casimir-Pol...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68546-6

    authors: Long Y,Wang W,Zhang X,Yang H,Zheng T

    更新日期:2020-07-20 00:00:00

  • TM4SF1 Promotes Metastasis of Pancreatic Cancer via Regulating the Expression of DDR1.

    abstract::Transmembrane-4-L-six-family-1(TM4SF1), a four-transmembrane L6 family member, is highly expressed in various pancreatic cancer cell lines and promotes cancer cells metastasis. However, the TM4SF1-associated signaling network in metastasis remains unknown. In the present study, we found that TM4SF1 affected the format...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45895

    authors: Yang JC,Zhang Y,He SJ,Li MM,Cai XL,Wang H,Xu LM,Cao J

    更新日期:2017-04-03 00:00:00

  • Faithful animal modelling of human glioma by using primary initiating cells and its implications for radiosensitization therapy [ARRIVE 1].

    abstract::It has been reported that the ATM kinase inhibitor KU60019 preferentially radiosensitizes orthotopic high grade gliomas (HGG) driven by established U87 and U1242 cell lines bearing specific TP53 mutations. We wished to determine whether those results could be extended to tumors driven by primary glioma initiating cell...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32578-w

    authors: Frosina G,Ravetti JL,Corvò R,Fella M,Garrè ML,Levrero F,Marcello D,Marubbi D,Morana G,Mussap M,Neumaier CE,Profumo A,Raso A,Rosa F,Vagge S,Vecchio D,Verrico A,Zona G,Daga A

    更新日期:2018-09-21 00:00:00

  • Sex-biased patterns shaped the genetic history of Roma.

    abstract::The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous geneti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71066-y

    authors: García-Fernández C,Font-Porterias N,Kučinskas V,Sukarova-Stefanovska E,Pamjav H,Makukh H,Dobon B,Bertranpetit J,Netea MG,Calafell F,Comas D

    更新日期:2020-09-02 00:00:00

  • Kunitz type protease inhibitor from the canine tapeworm as a potential therapeutic for melanoma.

    abstract::Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have recently been extensively researched as potential therapeutic agents against var...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52609-4

    authors: Ranasinghe SL,Rivera V,Boyle GM,McManus DP

    更新日期:2019-11-07 00:00:00

  • A Pilot Study Comparing Aortic Valve Area Estimates Derived from Fick Cardiac Output with Estimates Based on Cheetah-NICOM Cardiac Output.

    abstract::Cardiac output during cardiac catheterization is often estimated using the modified Fick method (COFick). In this proof-of-concept, prospective non-randomized study carried out in a single academic healthcare centre, we examined whether replacing COFick in the Gorlin formula with Cheetah-NICOM monitor cardiac output (...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64753-3

    authors: Mitrev L,van Helmond N,Kaddissi G,Awad A,Patel K,Aji J,Ogbara J,Rafeq Z,Nagubandi V,Orr D,Gaughan J,Rosenbloom M

    更新日期:2020-05-12 00:00:00

  • Non-iridescent transmissive structural color filter featuring highly efficient transmission and high excitation purity.

    abstract::Nanostructure based color filtering has been considered an attractive replacement for current colorant pigmentation in the display technologies, in view of its increased efficiencies, ease of fabrication and eco-friendliness. For such structural filtering, iridescence relevant to its angular dependency, which poses a ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04921

    authors: Shrestha VR,Lee SS,Kim ES,Choi DY

    更新日期:2014-05-12 00:00:00

  • Dysmenorrhea increased the risk of postpartum depression in Chinese Han parturients.

    abstract::Several studies have shown that dysmenorrhea increased the risk of depression. However, the association between dysmenorrhea and postpartum depression (PPD) is unclear. The purpose of this study is to evaluate the effects of dysmenorrhea on the development of PPD among Chinese women. A case-control study was performed...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53059-8

    authors: Meng L,Li J,Cheng Y,Wei T,Du Y,Peng S

    更新日期:2019-11-12 00:00:00

  • Design and manufacture of 3D cell culture plate for mass production of cell-spheroids.

    abstract::A 3D cell culture is preferred to 2D cell culture since it allows cells to grow in all directions in vitro, similar to how they would in vivo. 3D cell culture plates currently used in tissue engineering research have limited access to control the geometry. Furthermore, 3D cell culture plate manufacturing methods are r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50186-0

    authors: Lee D,Pathak S,Jeong JH

    更新日期:2019-09-27 00:00:00

  • Estimating sleep parameters using an accelerometer without sleep diary.

    abstract::Wrist worn raw-data accelerometers are used increasingly in large-scale population research. We examined whether sleep parameters can be estimated from these data in the absence of sleep diaries. Our heuristic algorithm uses the variance in estimated z-axis angle and makes basic assumptions about sleep interruptions. ...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1038/s41598-018-31266-z

    authors: van Hees VT,Sabia S,Jones SE,Wood AR,Anderson KN,Kivimäki M,Frayling TM,Pack AI,Bucan M,Trenell MI,Mazzotti DR,Gehrman PR,Singh-Manoux BA,Weedon MN

    更新日期:2018-08-28 00:00:00

  • Thermoelectric performance of n-type Mg2Ge.

    abstract::Magnesium-based thermoelectric materials (Mg2X, X = Si, Ge, Sn) have received considerable attention due to their availability, low toxicity, and reasonably good thermoelectric performance. The synthesis of these materials with high purity is challenging, however, due to the reactive nature and high vapour pressure of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04348-7

    authors: Santos R,Nancarrow M,Dou SX,Aminorroaya Yamini S

    更新日期:2017-06-21 00:00:00

  • Intraperitoneal and subcutaneous glucagon delivery in anaesthetized pigs: effects on circulating glucagon and glucose levels.

    abstract::Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals with diabetes. Artificial pancreas systems have been developed for use in the subcutaneous tissue...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70813-5

    authors: Åm MK,Dirnena-Fusini I,Fougner AL,Carlsen SM,Christiansen SC

    更新日期:2020-08-13 00:00:00

  • Effects of Black Raspberries and Their Ellagic Acid and Anthocyanin Constituents on Taxane Chemotherapy of Castration-Resistant Prostate Cancer Cells.

    abstract::Cancer patients often use dietary supplements while on therapy, but little is known about interactions of supplements with cancer chemotherapy. Black raspberries (BRB) have anti-cancer effects, but have not been evaluated for interference with chemotherapy for castrate-resistant prostate cancer (CRPC). Here we studied...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39589-1

    authors: Eskra JN,Schlicht MJ,Bosland MC

    更新日期:2019-03-13 00:00:00

  • Association between Int7G24A rs334354 polymorphism and cancer risk: a meta-analysis of case-control studies.

    abstract::Accumulating evidences have suggested the potential association between Int7G24A (rs334354) polymorphism and cancer risk. However, results from epidemiological studies are controversial. We thus conducted this meta-analysis to clarify the association. Relevant studies were identified on electronic databases according ...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/srep11350

    authors: Wu W,Tong Y,Wei X,Zhao Q,Pan X,Yu G,Lu Q

    更新日期:2015-06-15 00:00:00

  • Synergistic effect of N-decorated and Mn(2+) doped ZnO nanofibers with enhanced photocatalytic activity.

    abstract::Here we report a high efficiency photocatalyst, i.e., Mn(2+)-doped and N-decorated ZnO nanofibers (NFs) enriched with vacancy defects, fabricated via electrospinning and a subsequent controlled annealing process. This nanocatalyst exhibits excellent visible-light photocatalytic activity and an apparent quantum efficie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32711

    authors: Wang Y,Cheng J,Yu S,Alcocer EJ,Shahid M,Wang Z,Pan W

    更新日期:2016-09-07 00:00:00

  • Target-distractor competition cannot be resolved across a saccade.

    abstract::When a distractor is presented in close spatial proximity to a target, a saccade tends to land in between the two objects rather than on the target. This robust phenomenon (also referred to as the global effect) is thought to reflect unresolved competition between target and distractor. It is unclear whether this land...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34120-4

    authors: Arkesteijn K,Smeets JBJ,Donk M,Belopolsky AV

    更新日期:2018-10-24 00:00:00

  • The oldest freshwater crabs: claws on dinosaur bones.

    abstract::With approximately 1,500 extant species, freshwater crabs (Decapoda: Brachyura) are among the most diverse decapod crustaceans. Nevertheless, their fossil record is extremely limited: only Potamidae, Potamonautidae and Trichodactylidae are reported up to the Eocene of the Neotropics so far. This work documents unusual...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56180-w

    authors: Robin N,van Bakel BWM,Hyžný M,Cincotta A,Garcia G,Charbonnier S,Godefroit P,Valentin X

    更新日期:2019-12-27 00:00:00

  • Direct Conversion of CH3NH3PbI3 from Electrodeposited PbO for Highly Efficient Planar Perovskite Solar Cells.

    abstract::Organic-inorganic hybrid perovskite materials have recently been identified as a promising light absorber for solar cells. In the efficient solar cells, the perovskite active layer has generally been fabricated by either vapor deposition or two-step sequential deposition process. Herein, electrochemically deposited Pb...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15889

    authors: Huang JH,Jiang KJ,Cui XP,Zhang QQ,Gao M,Su MJ,Yang LM,Song Y

    更新日期:2015-10-29 00:00:00

  • M2 macrophages predict worse long-term outcomes in human acute tubular necrosis.

    abstract::Although macrophages are important players in the injury/repair processes in animal models of acute kidney injury (AKI), their roles in human AKI remains uncertain owing to a paucity of human biopsy studies. We investigated the role of macrophages in 72 cases of biopsy-proven acute tubular necrosis (ATN) and six cases...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58725-w

    authors: Kim MG,Lim K,Lee YJ,Yang J,Oh SW,Cho WY,Jo SK

    更新日期:2020-02-07 00:00:00