Abstract：
:Transmembrane-4-L-six-family-1(TM4SF1), a four-transmembrane L6 family member, is highly expressed in various pancreatic cancer cell lines and promotes cancer cells metastasis. However, the TM4SF1-associated signaling network in metastasis remains unknown. In the present study, we found that TM4SF1 affected the formation and function of invadopodia. Silencing of TM4SF1 reduced the expression of DDR1 significantly in PANC-1 and AsPC-1 cells. Through double fluorescence immuno-staining and Co-immunoprecipitation, we also found that TM4SF1 colocalized with DDR1 and had an interaction with DDR1. In addition, upregulating the expression of DDR1 rescued the inhibitory effects of cell migration and invasion, the expression of MMP2 and MMP9 and the formation and function of invadopodia when TM4SF1 silenced. In pancreatic cancer tissues, qRT-PCR and scatter plots analysis further determined that TM4SF1 had a correlation with DDR1. Collectively, our study provides a novel regulatory pathway involving TM4SF1, DDR1, MMP2 and MMP9, which promotes the formation and function of invadopodia to support cell migration and invasion in pancreatic cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yang JC,Zhang Y,He SJ,Li MM,Cai XL,Wang H,Xu LM,Cao Jdoi
10.1038/srep45895subject
Has Abstractpub_date
2017-04-03 00:00:00pages
45895issn
2045-2322pii
srep45895journal_volume
7pub_type
杂志文章abstract：:Endonuclease V (EndoV) is a ubiquitous protein present in all three kingdoms of life, responsible for the specific cleavages at the second phosphodiester bond 3' to inosine. E. coli EndoV (EcEndoV) is the first member discovered in the EndoV family. It is a small protein with a compact gene organization, yet with a wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12754
更新日期：2015-08-05 00:00:00
abstract：:Survival analyses for malignancies, including renal cell carcinoma (RCC), have primarily been conducted using the Cox proportional hazards (CPH) model. We compared the random survival forest (RSF) and DeepSurv models with the CPH model to predict recurrence-free survival (RFS) and cancer-specific survival (CSS) in non...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80262-9
更新日期：2021-01-13 00:00:00
abstract：:Glutamine (Gln) is converted to excitatory (glutamate, aspartate) and inhibitory (γ-amino butyric acid) amino acid neurotransmitters in brain, and is a source of energy during glucose deprivation. Current research utilized an Analytical Quality by Design approach to optimize levels and combinations of critical gas pre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64099-w
更新日期：2020-04-28 00:00:00
abstract：:Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of these lines with their other properties. The analysis revealed a r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41241
更新日期：2017-01-25 00:00:00
abstract：:Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23500-5
更新日期：2018-03-26 00:00:00
abstract：:Patient-matched transcriptomic studies using tumour samples before and after treatment allow inter-patient heterogeneity to be controlled, but tend not to include an untreated comparison. Here, Illumina BeadArray technology was used to measure dynamic changes in gene expression from thirty-seven paired diagnostic core...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29434
更新日期：2016-07-07 00:00:00
abstract：:In this study, a novel method based on the transfer of graphene patterns from a rigid or flexible substrate onto a polymeric film surface via solvent casting was developed. The method involves the creation of predetermined graphene patterns on the substrate, casting a polymer solution, and directly transferring the gr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46978-z
更新日期：2019-07-22 00:00:00
abstract：:In this study, the effects of acetyl-xylogalactan extracted from Sarcodia suieae on RAW 264.7 macrophage polarisation were evaluated. This extracted acetyl-xylogalactan had a monosaccharide composition of 91% galactose and 9% xylose, with polysaccharide and acetyl contents of 80.6% and 19.3%, respectively. MALDI-TOF m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56246-9
更新日期：2019-12-23 00:00:00
abstract：:In a haptic search task, one has to detect the presence of a target among distractors using the sense of touch. A salient target can be detected faster than a non-salient target. However, little is known about the exploration strategies that are used, especially in 3D search tasks where items are held in the hand. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06254
更新日期：2014-09-03 00:00:00
abstract：:Horizontal transfer of antibiotic resistance determinants contributes to dissemination of antibiotic resistance. Such transfer of resistance genes within the human gut has been documented in some in vivo studies. The present study investigated seven bla CTX-M-1-carrying Escherichia coli isolates from three consecutive...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18659-2
更新日期：2018-01-10 00:00:00
abstract：:Actinidia arguta 'Tianyuanhong' is a new kiwifruit variety with an all-red pericarp and pulp, in contrast to the all-green pulp of A. arguta 'Yongfengyihao'. Transcriptome profile analysis of fruit color has been reported, however, the metabolic mechanisms producing red flesh remain unknown, and it is unclear why the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06074-6
更新日期：2017-07-18 00:00:00
abstract：:Temporal fluctuation of neural activity in the brain has an important function in optimal information processing. Spontaneous activity is a source of such fluctuation. The distribution of excitatory postsynaptic potentials (EPSPs) between cortical pyramidal neurons can follow a log-normal distribution. Recent studies ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49286-8
更新日期：2019-09-04 00:00:00
abstract：:The human brain contains areas that respond selectively to faces, bodies and scenes. Neuroimaging studies have shown that a subset of these areas preferentially respond more to moving than static stimuli, but the reasons for this functional dissociation remain unclear. In the present study, we simultaneously mapped th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44663-9
更新日期：2019-06-03 00:00:00
abstract：:The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver microenvironment and its peripheral blood counterpart in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13777-3
更新日期：2017-10-16 00:00:00
abstract：:Laser-driven ion acceleration is often analyzed assuming that ionization reaches a steady state early in the interaction of the laser pulse with the target. This assumption breaks down for materials of high atomic number for which the ionization occurs concurrently with the acceleration process. Using particle-in-cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37085-6
更新日期：2019-01-24 00:00:00
abstract：:A current threat to the marine ecosystem is the high level of solar ultraviolet radiation (UV). Large whales have recently been shown to suffer sun-induced skin damage from continuous UV exposure. Genotoxic consequences of such exposure remain unknown for these long-lived marine species, as does their capacity to coun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02386
更新日期：2013-01-01 00:00:00
abstract：:The content of intrinsically disordered protein (IDP) is related to organism complexity, evolution, and regulation. In the Plantae, despite their high complexity, experimental investigation of IDP content is lacking. We identified by mass spectrometry 682 heat-resistant proteins from the green alga, Chlamydomonas rein...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24772-7
更新日期：2018-05-01 00:00:00
abstract：:Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer therapy. The 111In-labelled DOTA-conjugated ZEGFR:2377 Affibody molecule was successfully used for imaging of EGFR-expressing xenografts in mice. A...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05700-7
更新日期：2017-07-20 00:00:00
abstract：:The Toarcian Oceanic Anoxic Event (TOAE, Early Jurassic, ~182 Ma ago) was characterised by severe environmental perturbations which led to habitat degradation and extinction of marine species. Warming-induced anoxia is usually identified as main driver, but because marine life was also affected in oxygenated environme...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61393-5
更新日期：2020-03-13 00:00:00
abstract：:The objective of this study was to investigate the effects of slightly elevated atmospheric temperature in the spring on photosynthetic products in wheat seedlings and on organic compounds and biological activity in rhizosphere soil under cadmium (Cd) stress. Elevated temperature was associated with increased soluble ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14426
更新日期：2015-09-23 00:00:00
abstract：:Noise-induced hearing loss (NIHL) is a common health concern with significant social, psychological, and cognitive implications. Moderate levels of acoustic overstimulation associated with tinnitus and impaired speech perception cause cochlear synaptopathy, characterized physiologically by reduction in wave I of the s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75058-w
更新日期：2020-10-22 00:00:00
abstract：:The present study used 16S rRNA gene amplicon sequencing to assess the impact on salivary microbiome of different grades of dental and periodontal disease and the combination of both (hereinafter referred to as oral disease), in terms of bacterial diversity, co-occurrence network patterns and predictive models. Our sc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79875-x
更新日期：2021-01-13 00:00:00
abstract：:Studies on dsDNA bacteriophages have revealed that a DNA packaging complex assembles at a special vertex called the 'portal vertex' and consists of a portal, a DNA packaging ATPase and other components. AdV protein IVa2 is presumed to function as a DNA packaging ATPase. However, a protein that functions as a portal is...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07997-w
更新日期：2017-08-08 00:00:00
abstract：:Stable isotope mixing models are regularly used to provide probabilistic estimates of source contributions to dietary mixtures. Whilst Bayesian implementations of isotope mixing models have become prominent, the use of appropriate diet-tissue discrimination factors (DTDFs) remains as the least resolved aspect. The DTD...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73019-x
更新日期：2020-09-25 00:00:00
abstract：:Programmed death-1 (PD-1) is an immunosuppressive receptor functionally bound with programmed death-ligand 1 (PD-L1), which has been reported in various malignancies. However, only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). In this study, we aim to invest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43627
更新日期：2017-03-03 00:00:00
abstract：:For augmentation or reconstruction of urinary bladder after cystectomy, bladder urothelium derived from human induced pluripotent stem cells (hiPSCs) has recently received focus. However, previous studies have only shown the emergence of cells expressing some urothelial markers among derivatives of hiPSCs, and no repo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46848-8
更新日期：2019-07-19 00:00:00
abstract：:Graphene grown by high temperature molecular beam epitaxy on hexagonal boron nitride (hBN) forms continuous domains with dimensions of order 20 μm, and exhibits moiré patterns with large periodicities, up to ~30 nm, indicating that the layers are highly strained. Topological defects in the moiré patterns are observed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22440
更新日期：2016-03-01 00:00:00
abstract：:Increased prostaglandin E2 (PGE2) levels were detected in mitochondrial disease patient cells harboring nuclear gene mutations in structural subunits of complex I, using a metabolomics screening approach. The increased levels of this principal inflammation mediator normalized following exposure of KH176m, an active re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79466-w
更新日期：2021-01-13 00:00:00
abstract：:Clonal cell analysis defines the potential of single cells and the diversity they can produce. To achieve this, we have developed a novel adaptation of the genetic tracing strategy, UbC-StarTrack, which attributes a specific and unique color-code to single neural precursors, allowing all their progeny to be tracked. W...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33896
更新日期：2016-09-22 00:00:00
abstract：:Sand temperatures at nest depths and implications for hatchling sex ratios of hawksbill turtles (Eretmochelys imbricata) and green turtles (Chelonia mydas) nesting in the Chagos Archipelago, Indian Ocean are reported and compared to similar measurements at rookeries in the Atlantic and Caribbean. During 2012-2014, tem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20339
更新日期：2016-02-02 00:00:00
