Whales use distinct strategies to counteract solar ultraviolet radiation.

Abstract:

:A current threat to the marine ecosystem is the high level of solar ultraviolet radiation (UV). Large whales have recently been shown to suffer sun-induced skin damage from continuous UV exposure. Genotoxic consequences of such exposure remain unknown for these long-lived marine species, as does their capacity to counteract UV-induced insults. We show that UV exposure induces mitochondrial DNA damage in the skin of seasonally sympatric fin, sperm, and blue whales and that this damage accumulates with age. However, counteractive molecular mechanisms are markedly different between species. For example, sperm whales, a species that remains for long periods at the sea surface, activate genotoxic stress pathways in response to UV exposure whereas the paler blue whale relies on increased pigmentation as the season progresses. Our study also shows that whales can modulate their responses to fluctuating levels of UV, and that different evolutionary constraints may have shaped their response strategies.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Martinez-Levasseur LM,Birch-Machin MA,Bowman A,Gendron D,Weatherhead E,Knell RJ,Acevedo-Whitehouse K

doi

10.1038/srep02386

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

2386

issn

2045-2322

pii

srep02386

journal_volume

3

pub_type

杂志文章
  • Effect of Fluoride Doping in Laponite Nanoplatelets on Osteogenic Differentiation of Human Dental Follicle Stem Cells (hDFSCs).

    abstract::Bioactive nanosilicates are emerging prominent next generation biomaterials due to their intrinsic functional properties such as advanced biochemical and biophysical cues. Recent studies show interesting dose-dependent effect of fluoride ions on the stem cells. Despite of interesting properties of fluoride ions as wel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37327-7

    authors: Veernala I,Giri J,Pradhan A,Polley P,Singh R,Yadava SK

    更新日期:2019-01-29 00:00:00

  • A simple optimization approach for improving target dose homogeneity in intensity-modulated radiotherapy for sinonasal cancer.

    abstract::Homogeneous target dose distribution in intensity-modulated radiotherapy (IMRT) for sinonasal cancer (SNC) is challenging to achieve. To solve this problem, we established and evaluated a basal-dose-compensation (BDC) optimization approach, in which the treatment plan is further optimized based on the initial plans. G...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15361

    authors: Lu JY,Zhang JY,Li M,Cheung ML,Li YK,Zheng J,Huang BT,Zhang WZ

    更新日期:2015-10-26 00:00:00

  • Gearing Up the Human Ankle-Foot System to Reduce Energy Cost of Fast Walking.

    abstract::During locomotion, the human ankle-foot system dynamically alters its gearing, or leverage of the ankle joint on the ground. Shifting ankle-foot gearing regulates speed of plantarflexor (i.e., calf muscle) contraction, which influences economy of force production. Here, we tested the hypothesis that manipulating ankle...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65626-5

    authors: Ray SF,Takahashi KZ

    更新日期:2020-05-29 00:00:00

  • Functional dichotomy of Vδ2 γδ T cells in chronic hepatitis C virus infections: role in cytotoxicity but not for IFN-γ production.

    abstract::Vδ2 γδ (Vδ2) T cells, a major human γδ T cell subset, exhibit broad anti-tumor and anti-infective activity; however, their precise role in chronic hepatitis C virus (HCV) infections remains unclear. In this study, we analyzed the phenotype and function of Vδ2 T cells in 43 HCV-infected patients compared to 39 healthy ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26296

    authors: Yin W,Tong S,Zhang Q,Shao J,Liu Q,Peng H,Hu H,Peng M,Hu P,Ren H,Tian Z,Zhang D

    更新日期:2016-05-19 00:00:00

  • Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer.

    abstract::Colorectal cancer is one of the main causes of cancer death worldwide, and novel biomarkers are urgently needed for its early diagnosis and treatment. The utilization of metabolomics to identify and quantify metabolites in body fluids may allow the detection of changes in their concentrations that could serve as diagn...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55952-8

    authors: Martín-Blázquez A,Díaz C,González-Flores E,Franco-Rivas D,Jiménez-Luna C,Melguizo C,Prados J,Genilloud O,Vicente F,Caba O,Pérez Del Palacio J

    更新日期:2019-12-27 00:00:00

  • C70 Fullerene Cage as a Novel Catalyst for Efficient Proton Transfer Reactions between Small Molecules: A Theoretical study.

    abstract::When acids are supplied with an excess electron (or placed in an Ar or the more polarizable N2 matrix) in the presence of species such as NH3, the formation of ion-pairs is a likely outcome. Using density functional theory and first-principles calculations, however, we show that, without supplying an external electron...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46725-4

    authors: Varadwaj PR,Varadwaj A,Marques HM

    更新日期:2019-07-23 00:00:00

  • Effects of sublethal doses of clothianidin and/or V. destructor on honey bee (Apis mellifera) self-grooming behavior and associated gene expression.

    abstract::Little is known about the combined effects of stressors on social immunity of honey bees (Apis mellifera) and related gene expression. The interaction between sublethal doses of a neurotoxin, clothianidin, and the ectoparasite, Varroa destructor, was examined by measuring differentially expressed genes (DEGs) in brain...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41365-0

    authors: Morfin N,Goodwin PH,Hunt GJ,Guzman-Novoa E

    更新日期:2019-03-26 00:00:00

  • Competitive non-SELEX for the selective and rapid enrichment of DNA aptamers and its use in electrochemical aptasensor.

    abstract::The SELEX (Systematic Evolution of Ligands by EXponential enrichment) method has been used successfully since 1990, but work is still required to obtain highly specific aptamers. Here, we present a novel approach called 'Competitive non-SELEX' (and termed as 'SELCOS' (Systematic Evolution of Ligands by COmpetitive Sel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43187-6

    authors: Kushwaha A,Takamura Y,Nishigaki K,Biyani M

    更新日期:2019-04-30 00:00:00

  • Characterization of a New Protein Family Associated With the Silica Deposition Vesicle Membrane Enables Genetic Manipulation of Diatom Silica.

    abstract::Diatoms are known for their intricate, silicified cell walls (frustules). Silica polymerization occurs in a compartment called the silica deposition vesicle (SDV) and it was proposed that the cytoskeleton influences silica patterning through the SDV membrane (silicalemma) via interactions with transmembrane proteins. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13613-8

    authors: Tesson B,Lerch SJL,Hildebrand M

    更新日期:2017-10-18 00:00:00

  • Hepatocytic parental progenitor cells of rat small hepatocytes maintain self-renewal capability after long-term culture.

    abstract::The liver has a variety of functions for maintaining homeostasis, and hepatocytes play a major role. In contrast with the high regenerative capacity of mature hepatocytes (MHs) in vivo, they have not been successfully expanded ex vivo. Here we demonstrate that CD44-positive cells sorted from small hepatocyte (SH) colo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46177

    authors: Ishii M,Kino J,Ichinohe N,Tanimizu N,Ninomiya T,Suzuki H,Mizuguchi T,Hirata K,Mitaka T

    更新日期:2017-04-11 00:00:00

  • Arx Expression Suppresses Ventralization of the Developing Dorsal Forebrain.

    abstract::Early brain development requires a tight orchestration between neural tube patterning and growth. How pattern formation and brain growth are coordinated is incompletely understood. Previously we showed that aristaless-related homeobox (ARX), a paired-like transcription factor, regulates cortical progenitor pool expans...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36194-6

    authors: Lim Y,Cho IT,Shi X,Grinspan JB,Cho G,Golden JA

    更新日期:2019-01-18 00:00:00

  • Nutrient removal and microalgal biomass production from different anaerobic digestion effluents with Chlorella species.

    abstract::Potential of microalgal cultivation as an alternative approach to the treatment of anaerobic digestion (AD) effluents was examined using two representative Chlorella species, Chlorella vulgaris (CV) and Chlorella protothecoides (CP). Both species effectively removed NH4+-N from the AD effluents from four digesters tre...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42521-2

    authors: Yu H,Kim J,Lee C

    更新日期:2019-04-16 00:00:00

  • Integrin α7 expression is increased in asthmatic patients and its inhibition reduces Kras protein abundance in airway smooth muscle cells.

    abstract::Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contractile and proliferative phenotypic states. Integrins are a class of transmembrane proteins that have been implicated as novel therapeutic targets for asthma treatment. We previously showed ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46260-2

    authors: Teoh CM,Tan SSL,Langenbach SY,Wong AH,Cheong DHJ,Tam JKC,New CS,Tran T

    更新日期:2019-07-09 00:00:00

  • Plasticity of the inner cell mass in mouse blastocyst is restricted by the activity of FGF/MAPK pathway.

    abstract::In order to ensure successful development, cells of the early mammalian embryo must differentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by epiblast (EPI) or primitive endoderm (PE) specification within the ICM. Here, we deciphered the mechanism that assures the correct order of these sequenti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15427-0

    authors: Wigger M,Kisielewska K,Filimonow K,Plusa B,Maleszewski M,Suwińska A

    更新日期:2017-11-09 00:00:00

  • Controlling the impact of the managed honeybee on wild bees in protected areas.

    abstract::In recent years, conservation biologists have raised awareness about the risk of ecological interference between massively introduced managed honeybees and the native wild bee fauna in protected natural areas. In this study, we surveyed wild bees and quantified their nectar and pollen foraging success in a rosemary Me...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27591-y

    authors: Henry M,Rodet G

    更新日期:2018-06-18 00:00:00

  • Projected change in global fisheries revenues under climate change.

    abstract::Previous studies highlight the winners and losers in fisheries under climate change based on shifts in biomass, species composition and potential catches. Understanding how climate change is likely to alter the fisheries revenues of maritime countries is a crucial next step towards the development of effective socio-e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32607

    authors: Lam VW,Cheung WW,Reygondeau G,Sumaila UR

    更新日期:2016-09-07 00:00:00

  • Controllable thermal rectification realized in binary phase change composites.

    abstract::Phase transition is a natural phenomenon happened around our daily life, represented by the process from ice to water. While melting and solidifying at a certain temperature, a high heat of fusion is accompanied, classified as the latent heat. Phase change material (PCM) has been widely applied to store and release la...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08884

    authors: Chen R,Cui Y,Tian H,Yao R,Liu Z,Shu Y,Li C,Yang Y,Ren T,Zhang G,Zou R

    更新日期:2015-03-09 00:00:00

  • Compact Shielding of Graphene Monolayer Leads to Extraordinary SERS-Active Substrate with Large-Area Uniformity and Long-Term Stability.

    abstract::Surface-enhanced Raman scattering (SERS) can significantly boost the inherently weak Raman scattering signal and provide detailed structural information and binding nature of the molecules on the surface. Despite the long history of this technology, SERS has yet to become a sophisticated analytical tool in practical a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17167

    authors: Liu X,Wang J,Wu Y,Fan T,Xu Y,Tang L,Ying Y

    更新日期:2015-11-30 00:00:00

  • Phenotypic diversity identified by cardiac magnetic resonance in a large hypertrophic cardiomyopathy family with a single MYH7 mutation.

    abstract::Limited data is available on phenotypic variations with the same genotype in hypertrophic cardiomyopathy (HCM). The present study aims to explore the relationship between genotype and phenotype characterized by cardiovascular magnetic resonance (CMR) in a large Chinese family. A proband diagnosed with HCM from a multi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19372-4

    authors: Wang J,Wan K,Sun J,Li W,Liu H,Han Y,Chen Y

    更新日期:2018-01-17 00:00:00

  • Noise Reduction in Complex Biological Switches.

    abstract::Cells operate in noisy molecular environments via complex regulatory networks. It is possible to understand how molecular counts are related to noise in specific networks, but it is not generally clear how noise relates to network complexity, because different levels of complexity also imply different overall number o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20214

    authors: Cardelli L,Csikász-Nagy A,Dalchau N,Tribastone M,Tschaikowski M

    更新日期:2016-02-08 00:00:00

  • The biological role of N-acyl-homoserine lactone-based quorum sensing (QS) in EPS production and microbial community assembly during anaerobic granulation process.

    abstract::Although N-acyl-L-homoserine lactone (AHL) based quorum sensing (QS) phenomenon has been observed in mature anaerobic granules, the biological role of AHL-based QS system in anaerobic granulation process remains unexplored. For the first time, a long-term anaerobic bioreactor was operated for 168 days to investigate t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34183-3

    authors: Ma H,Ma S,Hu H,Ding L,Ren H

    更新日期:2018-10-25 00:00:00

  • LKB1/p53/TIGAR/autophagy-dependent VEGF expression contributes to PM2.5-induced pulmonary inflammatory responses.

    abstract::One of the health hazards of PM2.5 exposure is to induce pulmonary inflammatory responses. In our previous study, we demonstrated that exposing both the immortalized and primary human bronchial epithelial cells to PM2.5 results in a significant upregulation of VEGF production, a typical signaling event to trigger chro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53247-6

    authors: Xu H,Xu X,Wang H,Qimuge A,Liu S,Chen Y,Zhang C,Hu M,Song L

    更新日期:2019-11-12 00:00:00

  • Genome analysis and genetic transformation of a water surface-floating microalga Chlorococcum sp. FFG039.

    abstract::Microalgal harvesting and dewatering are the main bottlenecks that need to be overcome to tap the potential of microalgae for production of valuable compounds. Water surface-floating microalgae form robust biofilms, float on the water surface along with gas bubbles entrapped under the biofilms, and have great potentia...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47612-8

    authors: Maeda Y,Nojima D,Sakurai M,Nomaguchi T,Ichikawa M,Ishizuka Y,Tanaka T

    更新日期:2019-08-01 00:00:00

  • Contextual experience modifies functional connectome indices of topological strength and efficiency.

    abstract::Stimuli presented at short temporal delays before functional magnetic resonance imaging (fMRI) can have a robust impact on the organization of synchronous activity in resting state networks. This presents an opportunity to investigate how sensory, affective and cognitive stimuli alter functional connectivity in rodent...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76935-0

    authors: Pompilus M,Colon-Perez LM,Grudny MM,Febo M

    更新日期:2020-11-16 00:00:00

  • Characterization of the Escherichia coli σ(S) core regulon by Chromatin Immunoprecipitation-sequencing (ChIP-seq) analysis.

    abstract::In bacteria, selective promoter recognition by RNA polymerase is achieved by its association with σ factors, accessory subunits able to direct RNA polymerase "core enzyme" (E) to different promoter sequences. Using Chromatin Immunoprecipitation-sequencing (ChIP-seq), we searched for promoters bound by the σ(S)-associa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10469

    authors: Peano C,Wolf J,Demol J,Rossi E,Petiti L,De Bellis G,Geiselmann J,Egli T,Lacour S,Landini P

    更新日期:2015-05-28 00:00:00

  • Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure.

    abstract::Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is de...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01521-w

    authors: Cao S,Wang T,Yang J,Hu B,Levy U,Yu W

    更新日期:2017-05-02 00:00:00

  • Oxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XFe96 Extracellular Flux Analyzer.

    abstract::Caenorhabditis elegans presents functioning, biologically relevant phenotypes and is frequently used as a bioindicator of toxicity. However, most C. elegans in vivo effect-assessment methods are laborious and time consuming. Therefore, we developed a novel method to measure the oxygen consumption rate of C. elegans as...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61054-7

    authors: Preez GD,Fourie H,Daneel M,Miller H,Höss S,Ricci C,Engelbrecht G,Zouhar M,Wepener V

    更新日期:2020-03-06 00:00:00

  • Surviving salt fluctuations: stress and recovery in Halobacterium salinarum, an extreme halophilic Archaeon.

    abstract::Halophilic proteins subjected to below about 15% salt in vitro denature through misfolding, aggregation and/or precipitation. Halobacteria, however, have been detected in environments of fluctuating salinity such as coastal salterns and even around fresh water springs in the depths of the Dead Sea. In order to identif...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59681-1

    authors: Vauclare P,Natali F,Kleman JP,Zaccai G,Franzetti B

    更新日期:2020-02-24 00:00:00

  • Tumour Necrosis Factor-α Inhibition Improves Stroke Outcome in a Mouse Model of Rheumatoid Arthritis.

    abstract::Rheumatoid Arthritis (RA) is a chronic inflammatory disorder where incidence and severity of myocardial infarction are increased. Data on the incidence and outcome of stroke are conflicting. Thus, we investigated outcome after Ischemia/Reperfusion (I/R) brain injury in a mouse model of RA and assessed for the role of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-38670-z

    authors: Bonetti NR,Diaz-Cañestro C,Liberale L,Crucet M,Akhmedov A,Merlini M,Reiner MF,Gobbato S,Stivala S,Kollias G,Ruschitzka F,Lüscher TF,Beer JH,Camici GG

    更新日期:2019-02-18 00:00:00

  • Author Correction: In situ assembly of Ag nanoparticles (AgNPs) on porous silkworm cocoon-based wound film: enhanced antimicrobial and wound healing activity.

    abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41598-018-19257-6

    authors: Yu K,Lu F,Li Q,Chen H,Lu B,Liu J,Li Z,Dai F,Wu D,Lan G

    更新日期:2018-01-22 00:00:00