Deep learning based prediction of prognosis in nonmetastatic clear cell renal cell carcinoma.

Abstract:

:Survival analyses for malignancies, including renal cell carcinoma (RCC), have primarily been conducted using the Cox proportional hazards (CPH) model. We compared the random survival forest (RSF) and DeepSurv models with the CPH model to predict recurrence-free survival (RFS) and cancer-specific survival (CSS) in non-metastatic clear cell RCC (nm-cRCC) patients. Our cohort included 2139 nm-cRCC patients who underwent curative-intent surgery at six Korean institutions between 2000 and 2014. The data of two largest hospitals' patients were assigned into the training and validation dataset, and the data of the remaining hospitals were assigned into the external validation dataset. The performance of the RSF and DeepSurv models was compared with that of CPH using Harrel's C-index. During the follow-up, recurrence and cancer-specific deaths were recorded in 190 (12.7%) and 108 (7.0%) patients, respectively, in the training-dataset. Harrel's C-indices for RFS in the test-dataset were 0.794, 0.789, and 0.802 for CPH, RSF, and DeepSurv, respectively. Harrel's C-indices for CSS in the test-dataset were 0.831, 0.790, and 0.834 for CPH, RSF, and DeepSurv, respectively. In predicting RFS and CSS in nm-cRCC patients, the performance of DeepSurv was superior to that of CPH and RSF. In no distant time, deep learning-based survival predictions may be useful in RCC patients.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Byun SS,Heo TS,Choi JM,Jeong YS,Kim YS,Lee WK,Kim C

doi

10.1038/s41598-020-80262-9

subject

Has Abstract

pub_date

2021-01-13 00:00:00

pages

1242

issue

1

issn

2045-2322

pii

10.1038/s41598-020-80262-9

journal_volume

11

pub_type

杂志文章
  • Seed yield can be explained by altered yield components in field-grown western wheatgrass (Pascopyrum smithii Rydb.).

    abstract::Western wheatgrass (Pascopyrum smithii Rydb.) is an important cool-season forage and turfgrass. However, due to seed dormancy and poor seedling vigor, it is difficult to develop high seed yield production systems, and assessing these components in response to seed yield. Based on multifactor orthogonally designed fiel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54586-0

    authors: Chen Z,Niu J,Cao X,Jiang W,Cui J,Wang Q,Zhang Q

    更新日期:2019-11-29 00:00:00

  • Anomalous bond length behavior and a new solid phase of bromine under pressure.

    abstract::The behavior of diatomic molecular solids under pressure have attracted great interest and been extensively studied. Under ambient pressure, the structure of bromine is known to be a molecular phase (phase I). With increasing pressure, it transforms into an incommensurate phase (phase V) before eventually to a monoato...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25649

    authors: Wu M,Tse JS,Pan Y

    更新日期:2016-05-09 00:00:00

  • Mesenchymal stem cell-mediated Notch2 activation overcomes radiation-induced injury of the hematopoietic system.

    abstract::Radiation exposure severely damages the hematopoietic system. Although several radio-protectors have been proposed to prevent radiation-induced damage, most agents have limited efficacy. In the present study, we investigated whether mesenchymal stem cells (MSCs) could contribute to the expansion of hematopoietic cells...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27666-w

    authors: Kim A,Shim S,Kim MJ,Myung JK,Park S

    更新日期:2018-06-18 00:00:00

  • Chain-like structure elements in Ni40Ta60 metallic glasses observed by scanning tunneling microscopy.

    abstract::The structure of metallic glasses is a long-standing question because the lack of long-range order makes diffraction based techniques difficult to be applied. Here, we used scanning tunneling microscopy with large tunneling resistance of 6 GΩ at low temperature in order to minimize forces between probe and sample and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13143

    authors: Pawlak R,Marot L,Sadeghi A,Kawai S,Glatzel T,Reimann P,Goedecker S,Güntherodt HJ,Meyer E

    更新日期:2015-08-13 00:00:00

  • GLCCI1 rs37973: a potential genetic predictor of therapeutic response to inhaled corticosteroids in Chinese chronic obstructive pulmonary disease patients.

    abstract::Inhaled corticosteroids (ICSs) are widely prescribed in chronic obstructive pulmonary disease (COPD). However, little is known about predictors of ICSs therapeutic response. To investigate whether the variation in glucocorticoid-induced transcript 1 (GLCCI1) rs37973 is associated with ICS efficacy. A total of 204 clin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42552

    authors: Lei Y,Gao Y,Chen J,Li M,Wu X,Ning Q,Zhao J,Xiong W,Xu Y,Xie J

    更新日期:2017-02-10 00:00:00

  • Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.

    abstract::Fibulins are extracellular matrix proteins associated with elastic fibres. Homozygous Fibulin-4 mutations lead to life-threatening abnormalities such as aortic aneurysms. Aortic aneurysms in Fibulin-4 mutant mice were associated with upregulation of TGF-β signalling. How Fibulin-4 deficiency leads to deregulation of t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16872

    authors: Ramnath NW,Hawinkels LJ,van Heijningen PM,te Riet L,Paauwe M,Vermeij M,Danser AH,Kanaar R,ten Dijke P,Essers J

    更新日期:2015-11-26 00:00:00

  • Highly hard yet toughened bcc-W coating by doping unexpectedly low B content.

    abstract::Either hardness or toughness has been the core interest in scientific exploration and technological pursuit for a long time. However, it is still a big challenge to enhance the hardness and toughness at the same time, since the improvement of one side is always at the expense of the other one. Here, we have succeeded ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09807-9

    authors: Yang L,Zhang K,Wen M,Hou Z,Gong C,Liu X,Hu C,Cui X,Zheng W

    更新日期:2017-08-24 00:00:00

  • Systematic Review with Network Meta-Analysis: Antidiabetic Medication and Risk of Hepatocellular Carcinoma.

    abstract::Antidiabetic medication may modify the incidence of hepatocellular carcinoma (HCC). We aimed to compare the use of different antidiabetic strategies and the incidence of HCC. PubMed, Embase.com and Cochrane Library databases were searched up to 31 October 2015 and randomized controlled trials (RCTs), cohort studies or...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1038/srep33743

    authors: Zhou YY,Zhu GQ,Liu T,Zheng JN,Cheng Z,Zou TT,Braddock M,Fu SW,Zheng MH

    更新日期:2016-09-19 00:00:00

  • Damage severity of wood-destroying insects according to the Bevan damage classification system in log depots of Northwest Turkey.

    abstract::The aim of the study was to determine damage severity of wood-destroying insects on logs stored in forest depots. The Bevan damage classification (BDC) system, developed in 1987, was utilized to determine damage severity in log depots in 21 locations throughout seven provinces in Turkey. Pheromone traps were placed in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70696-6

    authors: Yalcin M,Akcay C,Tascioglu C,Yuksel B,Ozbayram AK

    更新日期:2020-08-13 00:00:00

  • An extraterrestrial trigger for the Early Cretaceous massive volcanism? Evidence from the paleo-Tethys Ocean.

    abstract::The Early Cretaceous Greater Ontong Java Event in the Pacific Ocean may have covered ca. 1% of the Earth's surface with volcanism. It has puzzled scientists trying to explain its origin by several mechanisms possible on Earth, leading others to propose an extraterrestrial trigger to explain this event. A large oceanic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00268

    authors: Tejada ML,Ravizza G,Suzuki K,Paquay FS

    更新日期:2012-01-01 00:00:00

  • A novel method for preparing microplastic fibers.

    abstract::Microscopic plastic (microplastic, 0.1 µm-5 mm) is a widespread pollutant impacting upon aquatic ecosystems across the globe. Environmental sampling has revealed synthetic fibers are prevalent in seawater, sediments and biota. However, microplastic fibers are rarely used in laboratory studies as they are unavailable f...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34519

    authors: Cole M

    更新日期:2016-10-03 00:00:00

  • Temperature-dependent Schottky barrier in high-performance organic solar cells.

    abstract::Organic solar cells (OSCs) have attracted great attention in the past 30 years, and the power conversion efficiency (PCE) now reaches around 10%, largely owning to the rapid material developments. Meanwhile with the progress in the device performance, more and more interests are turning to understanding the fundamenta...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40134

    authors: Li H,He D,Zhou Q,Mao P,Cao J,Ding L,Wang J

    更新日期:2017-01-10 00:00:00

  • Solving the controversy of healthier organic fruit: Leaf wounding triggers distant gene expression response of polyphenol biosynthesis in strawberry fruit (Fragaria x ananassa).

    abstract::The claim that organic agriculture produces higher levels of phytochemicals has been controversial for decades. Using strawberries as a model crop in field conditions, a preharvest leaf wounding stress was applied to study the production of phytochemicals in fruits. As a result phenolic compounds (PCs) and total solub...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55033-w

    authors: Ibanez F,Bang WY,Lombardini L,Cisneros-Zevallos L

    更新日期:2019-12-17 00:00:00

  • Design, transform and control of optical field in discrete optical system: an example.

    abstract::A discrete optical system can broaden the spatial distribution of the input light through optical coupling in array waveguides, just like diffraction in continuous media. Here, we theoretically demonstrate several kinds of control methods of optical field propagation in a discrete optical system, which is composed of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05414-w

    authors: Deng H,Yuan Y,Yuan L

    更新日期:2017-07-12 00:00:00

  • Author Correction: Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-53132-2

    authors: Ihara T,Nakamura Y,Mitsui T,Tsuchiya S,Kanda M,Kira S,Nakagomi H,Sawada N,Kamiyama M,Shigetomi E,Shinozaki Y,Yoshiyama M,Nakao A,Koizumi S,Takeda M

    更新日期:2019-11-08 00:00:00

  • Author Correction: Phonological network fluency identifies phonological restructuring through mental search.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-55966-2

    authors: Neergaard KD,Luo J,Huang CR

    更新日期:2020-01-14 00:00:00

  • Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population.

    abstract::Obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAT) compared to subcutaneous sites (SAT) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58430-8

    authors: Otto L,Budde K,Kastenmüller G,Kaul A,Völker U,Völzke H,Adamski J,Kühn JP,Krumsiek J,Artati A,Nauck M,Friedrich N,Pietzner M

    更新日期:2020-01-30 00:00:00

  • Laparoscopic Resection of Residual Retroperitoneal Tumor Mass in Advanced Nonseminomatous Testicular Germ Cell Tumors; a Feasible and Safe Oncological Procedure.

    abstract::Ten-year oncological experience of the University Medical Center Groningen with conventional laparotomy (C-RRRTM) and laparoscopy (L-RRRTM) is described concerning resection of residual retroperitoneal tumor masses (RRTM) in a large series of patients with advanced nonseminomatous testicular germ cell tumors (NSTGCT)....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52109-5

    authors: Öztürk Ç,Been LB,van Ginkel RJ,Gietema JA,Hoekstra HJ

    更新日期:2019-11-01 00:00:00

  • Ultrasound modulates ion channel currents.

    abstract::Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in animals and humans, but the mechanism of this effect is unknown. It has been hypothesized that US, a mechanical stimulus, may mediate cellular discharge by activating mechanosensitive ion channels embedded within cellular membranes. To ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24170

    authors: Kubanek J,Shi J,Marsh J,Chen D,Deng C,Cui J

    更新日期:2016-04-26 00:00:00

  • Pet dogs' relationships vary rather individually than according to partner's species.

    abstract::Most dogs worldwide are free-ranging animals that form relationships mainly with conspecifics, yet research has focused mainly on the dog-human bond, leading to the hypothesis that dogs evolved specific abilities to form a unique relationship with humans. Although widespread, this hypothesis has not, as yet, been test...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40164-x

    authors: Cimarelli G,Marshall-Pescini S,Range F,Virányi Z

    更新日期:2019-03-05 00:00:00

  • Methane formation and consumption processes in Xiangxi Bay of the Three Gorges Reservoir.

    abstract::Indoor simulation experiment was carried out to evaluate the formation and consumption rates of methane (CH4) in Xiangxi Bay of the Three Gorges Reservoir (TGR), China. The results show that both the CH4 formation and consumption rates were significantly positively correlated with temperature. CH4 efflux decreased wit...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04449

    authors: Wang C,Xiao S,Li Y,Zhong H,Li X,Peng F

    更新日期:2014-03-24 00:00:00

  • A nomogram for predicting cancer-specific survival in patients with osteosarcoma as secondary malignancy.

    abstract::The prognostic factors for survival among patients with secondary osteosarcoma remain unclear. The aim of this study was to develop a practical nomogram for predicting cancer-specific survival (CSS) in patients with osteosarcoma as a secondary malignancy. The surveillance, epidemiology, and end results database was us...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69740-2

    authors: He Y,Liu H,Wang S,Zhang J

    更新日期:2020-07-30 00:00:00

  • Restricted regions of enhanced growth of Antarctic krill in the circumpolar Southern Ocean.

    abstract::Food webs in high-latitude oceans are dominated by relatively few species. Future ocean and sea-ice changes affecting the distribution of such species will impact the structure and functioning of whole ecosystems. Antarctic krill (Euphausia superba) is a key species in Southern Ocean food webs, but there is little und...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07205-9

    authors: Murphy EJ,Thorpe SE,Tarling GA,Watkins JL,Fielding S,Underwood P

    更新日期:2017-07-31 00:00:00

  • Performance of a Heating Block System Designed for Studying the Heat Resistance of Bacteria in Foods.

    abstract::Knowledge of bacteria's heat resistance is essential for developing effective thermal treatments. Choosing an appropriate test method is important to accurately determine bacteria's heat resistances. Although being a major factor to influence the thermo-tolerance of bacteria, the heating rate in samples cannot be cont...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30758

    authors: Kou XX,Li R,Hou LX,Huang Z,Ling B,Wang SJ

    更新日期:2016-07-28 00:00:00

  • A Systematic Review and Meta-analysis of the Topical Administration of Fibrin Sealant in Total Hip Arthroplasty.

    abstract::Patients who undergo total hip arthroplasty (THA) may experience a large amount of blood loss. The objective of our study is to include randomized controlled trials (RCTs) and compare the clinical outcomes of fibrin sealant (FS) versus placebo after a THA. In October 2015, we searched the following databases: Medline,...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1038/s41598-017-16779-3

    authors: Zhao Z,Ma X,Ma J,Sun X,Li F,Lv J

    更新日期:2018-01-08 00:00:00

  • Antitumor activities of Liver-targeting peptide modified Recombinant human Endostatin in BALB/c-nu mice with Hepatocellular carcinoma.

    abstract::In our previous study, a liver-targeting peptide CSP I-plus modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed and showed potent antiangiogenic capability and could specifically bind to human hepatocellular carcinoma cells to make a direct inhibition in vitro. In this study, the bi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14320-0

    authors: Yan M,Dongmei B,Jingjing Z,Xiaobao J,Jie W,Yan W,Jiayong Z

    更新日期:2017-10-26 00:00:00

  • Extrapyramidal plasticity predicts recovery after spinal cord injury.

    abstract::Spinal cord injury (SCI) leads to wide-spread neurodegeneration across the neuroaxis. We explored trajectories of surface morphology, demyelination and iron concentration within the basal ganglia-thalamic circuit over 2 years post-SCI. This allowed us to explore the predictive value of neuroimaging biomarkers and dete...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70805-5

    authors: Huber E,Patel R,Hupp M,Weiskopf N,Chakravarty MM,Freund P

    更新日期:2020-08-24 00:00:00

  • The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation.

    abstract::The renal sodium chloride cotransporter, NCC, in the distal convoluted tubule is important for maintaining body Na+ and K+ homeostasis. Endogenous NCC is highly ubiquitylated, but the role of individual ubiquitylation sites is not established. Here, we assessed the role of 10 ubiquitylation sites for NCC function. Tra...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12819-0

    authors: Rosenbaek LL,Rizzo F,Wu Q,Rojas-Vega L,Gamba G,MacAulay N,Staub O,Fenton RA

    更新日期:2017-10-11 00:00:00

  • Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis.

    abstract::Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although trabecular bone involvement in ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00162-3

    authors: Pascart T,Falgayrac G,Migaud H,Quinchon JF,Norberciak L,Budzik JF,Paccou J,Cotten A,Penel G,Cortet B

    更新日期:2017-03-07 00:00:00

  • Network-based proteomic approaches reveal the neurodegenerative, neuroprotective and pain-related mechanisms involved after retrograde axonal damage.

    abstract::Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to a retrograde degenerative process or to a regenerative reaction, depending injury proximity among other factors. Distinguished key events as...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09185

    authors: Casas C,Isus L,Herrando-Grabulosa M,Mancuso FM,Borrás E,Sabidó E,Forés J,Aloy P

    更新日期:2015-03-18 00:00:00