Abstract：
:Cardiac output during cardiac catheterization is often estimated using the modified Fick method (COFick). In this proof-of-concept, prospective non-randomized study carried out in a single academic healthcare centre, we examined whether replacing COFick in the Gorlin formula with Cheetah-NICOM monitor cardiac output (COCheetah) could produce an accurate and precise estimate of aortic valve area in patients with severe aortic stenosis. In twenty-six subjects, COFick and COCheetah were obtained concurrently. A spot and 3-minute running average of COCheetah was used. Bland and Altman analysis was used to derive bias, 95% limits of agreement (LOA) and confidence intervals (CI). The mean difference (bias) between AVACheetah (average) and AVAFick was 0.11 cm2 and the 95% LOA were ±0.42 cm2. The 95% CI of the bias was 0.02-0.2 cm2. The bias and 95% LOA of AVACheetah (spot value) were 0.14 ± 0.42cm2, with a 95% CI of 0.06-0.23 cm2. No proportional bias was present. AVACheetah thus appears to be a reasonably accurate measure of AVA in patients with severe aortic stenosis compared to AVAFick measured using a modified Fick CO. However, the limits of agreement were not narrow enough to consider AVACheetah and AVAFick interchangeable.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mitrev L,van Helmond N,Kaddissi G,Awad A,Patel K,Aji J,Ogbara J,Rafeq Z,Nagubandi V,Orr D,Gaughan J,Rosenbloom Mdoi
10.1038/s41598-020-64753-3subject
Has Abstractpub_date
2020-05-12 00:00:00pages
7852issue
1issn
2045-2322pii
10.1038/s41598-020-64753-3journal_volume
10pub_type
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