Abstract：
:Platelet-driven reduction in blood clot volume (clot contraction or retraction) has been implicated to play a role in hemostasis and thrombosis. Although these processes are often linked with inflammation, the role of inflammatory cells in contraction of blood clots and thrombi has not been investigated. The aim of this work was to study the influence of activated monocytes on clot contraction. The effects of monocytes were evaluated using a quantitative optical tracking methodology to follow volume changes in a blood clot formed in vitro. When a physiologically relevant number of isolated human monocytes pre-activated with phorbol-12-myristate-13-acetate (PMA) were added back into whole blood, the extent and rate of clot contraction were increased compared to addition of non-activated cells. Inhibition of tissue factor expression or its inactivation on the surface of PMA-treated monocytes reduced the extent and rate of clot contraction back to control levels with non-activated monocytes. On the contrary, addition of tissue factor enhanced clot contraction, mimicking the effects of tissue factor expressed on the activated monocytes. These data suggest that the inflammatory cells through their expression of tissue factor can directly affect hemostasis and thrombosis by modulating the size and density of intra- and extravascular clots and thrombi.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Peshkova AD,Le Minh G,Tutwiler V,Andrianova IA,Weisel JW,Litvinov RIdoi
10.1038/s41598-017-05601-9subject
Has Abstractpub_date
2017-07-11 00:00:00pages
5149issue
1issn
2045-2322pii
10.1038/s41598-017-05601-9journal_volume
7pub_type
杂志文章abstract：:The impact of obesity on health-related quality of life (HRQoL) in chronic kidney disease (CKD) population has not been elucidated, despite the impairment of HRQoL in the obese among general population. We hypothesized that the impact of obesity on HRQoL might be confounded by impaired renal function in CKD population...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59382-9
更新日期：2020-02-11 00:00:00
abstract：:Recent studies have shown that the representation of an item in visual working memory (VWM) can bias the deployment of attention to stimuli in the visual scene possessing the same features. When multiple item representations are simultaneously held in VWM, whether these representations, especially those held in a non-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32144-4
更新日期：2018-09-17 00:00:00
abstract：:Comparable taxonomic ranks within clades can facilitate more consistent classifications and objective comparisons among taxa. Here we use a temporal approach to identify taxonomic ranks. This is an extension of the temporal banding approach including a Temporal Error Score that finds an objective cut-off for each taxo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02477-7
更新日期：2017-05-23 00:00:00
abstract：:Cerebrospinal fluid (CSF) biomarkers are useful in the diagnosis and the prediction of progression of several neurodegenerative diseases. Among them, CSF neurofilament light (NfL) protein has particular interest, as its levels reflect neuroaxonal degeneration, a common feature in various neurodegenerative diseases. In...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66090-x
更新日期：2020-06-08 00:00:00
abstract：:Metabolomics studies of diseases associated with chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways. Moreover, the holistic approach of such studies gives insights into the pathophysiological risk factors associated with chronic alcohol-induced disability, morbidity and mor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24128-1
更新日期：2018-04-10 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-36257-8
更新日期：2018-11-27 00:00:00
abstract：:The ionizing radiation in aqueous solutions of gold nanoparticles, stabilized by electrostatic non-covalent intermolecular forces and steric interactions, with antimicrobial compounds, are investigated with picosecond pulse radiolysis techniques. Upon pulse radiolysis of an aqueous solution containing very low concent...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25711-2
更新日期：2018-05-08 00:00:00
abstract：:Geographical origin determination of white rice has become the major issue of food industry. However, there is still lack of a high-throughput method for rapidly and reproducibly differentiating the geographical origins of commercial white rice. In this study, we developed a method that employed lipidomics and deep le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08892-0
更新日期：2017-08-17 00:00:00
abstract：:Although thimerosal, an ethylmercury-based preservative, has been removed from most pediatric vaccines in the United States, some multidose vaccines, such as influenza vaccines, still contain thimerosal. Considering that a growing number of studies indicate involvement of the gut microbiome in infant immune developmen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34019-0
更新日期：2018-10-26 00:00:00
abstract：:Doping with the optimum concentration of carriers (electrons or holes) can modify the physical properties of materials. Therefore, improved ways to achieve carrier doping have been pursued extensively for more than 50 years. Metal-intercalation is one of the most important techniques for electron doping of organic / i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18931
更新日期：2016-01-06 00:00:00
abstract：:We aimed to establish a high-performing and robust classification strategy, using magnetic resonance imaging (MRI), along with combinations of feature extraction and selection in human and machine learning using radiomics or deep features by employing a small dataset. Using diffusion and contrast-enhanced T1-weighted ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42276-w
更新日期：2019-04-05 00:00:00
abstract：:Epigenetic deregulation, such as the reduction of histone acetylation levels, is thought to be causally linked to various maladies associated with aging. Consequently, histone deacetylase inhibitors are suggested to serve as epigenetic therapy by increasing histone acetylation. However, previous work suggests that man...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22674-2
更新日期：2018-03-08 00:00:00
abstract：:Different classical theories are commonly applied in various branches of physics to describe the relativistic dynamics of electrons by coupled equations for the orbital motion and spin precession. Exemplarily, we benchmark the Frenkel model and the classical Foldy-Wouthuysen model with spin-dependent forces (Stern-Ger...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31624
更新日期：2016-08-22 00:00:00
abstract：:Here we present the first report of a carbon-γ-Fe₂O₃ nanoparticle composite of mesoporous carbon, bearing COOH- and phenolic OH- functional groups on its surface, a remarkable and magnetically separable adsorbent, for the radioactive material emitted by the Fukushima Daiichi nuclear power plant accident. Contaminated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06053
更新日期：2014-08-13 00:00:00
abstract：:Patients with asymptomatic occlusion in the internal carotid arteries (ICA) have been shown to have a better preserved hemodynamic status of the brain as compared to patients with symptoms. This study was aimed to explore the cerebral perfusion alterations in asymptomatic patients using multi-parametric arterial spin-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02094-4
更新日期：2017-05-12 00:00:00
abstract：:Excessive activation of inflammation and the accompanying lung vascular endothelial barrier disruption are primary pathogenic features of acute lung injury (ALI). Microtubule-associated protein 4 (MAP4), a tubulin assembly-promoting protein, is important for maintaining the microtubule (MT) cytoskeleton and cell-cell ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08895
更新日期：2015-03-09 00:00:00
abstract：:Clostridium difficile hyper-virulent ribotype 027 strain has become a significant concern globally, but has rarely been reported in Asian countries including China. Recently, a retrospective single-center study in Beijing, China, detected two ribotype 027 C. difficile isolates from two patients coming for outpatient v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18834
更新日期：2016-01-07 00:00:00
abstract：:Magnolia sirindhorniae Noot. & Chalermglin is an endangered species with high ornamental and commercial value that needs to be urgently protected and judiciously commercialized. In this study, a protocol for efficient regeneration of this species is standardized. The lateral buds of the M. sirindhorniae plant were use...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46050-w
更新日期：2019-07-03 00:00:00
abstract：:Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially expressed genes (DEGs) were ann...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19010-5
更新日期：2018-01-31 00:00:00
abstract：:Pancreas development requires restrained Hedgehog (Hh) signaling activation. While deregulated Hh signaling in the pancreatic mesenchyme has been long suggested to be detrimental for proper organogenesis, this association was not directly shown. Here, we analyzed the contribution of mesenchymal Hh signaling to pancrea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38008
更新日期：2016-11-28 00:00:00
abstract：:Friction stir processing (FSP) was used to achieve grain refinement on Mg-Al-Zn alloys, which also brought in significant texture modification. The different micro-texture characteristics were found to cause irregular micro-hardness distribution in FSPed region. The effects of texture and grain size were investigated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22344-3
更新日期：2018-03-08 00:00:00
abstract：:We engineered a transdermal neuromodulation approach that targets peripheral (cranial and spinal) nerves and utilizes their afferent pathways as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) method on sympathetic physiology under differe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13865
更新日期：2015-09-10 00:00:00
abstract：:Light-sheet fluorescence microscopy has emerged as a powerful platform for 3-D volumetric imaging in the life sciences. Here, we introduce an important step towards its use deep inside biological tissue. Our new technique, based on digital holography, enables delivery of the light-sheet through a multimode optical fib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18050
更新日期：2015-12-14 00:00:00
abstract：:Leiomyomas, adenomyosis, and endometriosis are reported to be risk factors for endometrial carcinoma (EC), and adenomyosis and endometriosis also for ovarian carcinoma (OC). We aimed to describe the prevalence of these conditions in EC patients with or without an OC diagnosis, and to investigate their relationship wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59916-1
更新日期：2020-02-27 00:00:00
abstract：:Tomatoes are known to have ameliorative effects on cardiovascular disease and cancer. The nutritional value of tomatoes can be enhanced by increasing flavonoids content through genetic modification. The regulatory gene PAP1 (production of anthocyanin pigment 1) from Arabidopsis is reported to increase initial flavonoi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12355-x
更新日期：2017-09-28 00:00:00
abstract：:Figure-ground segregation is the process by which the visual system identifies image elements of figures and segregates them from the background. Previous studies examined figure-ground segregation in the visual cortex of monkeys where figures elicit stronger neuronal responses than backgrounds. It was demonstrated in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36087-8
更新日期：2018-12-12 00:00:00
abstract：:Tropical carnivorous plant, Nepenthes, locally known as "monkey cup", utilises its pitcher as a passive trap to capture insects. It then secretes enzymes into the pitcher fluid to digest the insects for nutrients acquisition. However, little is known about the microbiota and their activity in its pitcher fluid. Eighte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20016
更新日期：2016-01-28 00:00:00
abstract：:The fusion of villous cytotrophoblasts into the multinucleated syncytiotrophoblast is critical for the essential functions of the mammalian placenta. Using RNA-Seq gene expression and quantitative protein expression, we identified genes and their cognate proteins which are coordinately up- or down-regulated in two cel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23379-2
更新日期：2018-03-23 00:00:00
abstract：:Diamond attracts considerable attention as a versatile and technologically useful material. For many demanding applications, such as recently emerged quantum optics and sensing, it is important to develop new routes for fabrication of diamond containing defects with specific optical, electronic and magnetic properties...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14789
更新日期：2015-10-05 00:00:00
abstract：:Transport of mesoscale particles due to driving flow fields or external forces on a periodic surface appears in many areas. Geometrical and physical characteristics of particles affect the velocities of the particles in these periodic landscapes. In this paper, we present a numerical simulation based on solving the La...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75187-2
更新日期：2020-10-26 00:00:00
