Transdermal neuromodulation of noradrenergic activity suppresses psychophysiological and biochemical stress responses in humans.

Abstract:

:We engineered a transdermal neuromodulation approach that targets peripheral (cranial and spinal) nerves and utilizes their afferent pathways as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) method on sympathetic physiology under different experimental conditions. The TEN method involved delivering high-frequency pulsed electrical currents to ophthalmic and maxillary divisions of the right trigeminal nerve and cervical spinal nerve afferents. Under resting conditions, TEN significantly suppressed basal sympathetic tone compared to sham as indicated by functional infrared thermography of facial temperatures. In a different experiment, subjects treated with TEN reported significantly lower levels of tension and anxiety on the Profile of Mood States scale compared to sham. In a third experiment when subjects were experimentally stressed TEN produced a significant suppression of heart rate variability, galvanic skin conductance, and salivary α-amylase levels compared to sham. Collectively these observations demonstrate TEN can dampen basal sympathetic tone and attenuate sympathetic activity in response to acute stress induction. Our physiological and biochemical observations are consistent with the hypothesis that TEN modulates noradrenergic signaling to suppress sympathetic activity. We conclude that dampening sympathetic activity in such a manner represents a promising approach to managing daily stress.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Tyler WJ,Boasso AM,Mortimore HM,Silva RS,Charlesworth JD,Marlin MA,Aebersold K,Aven L,Wetmore DZ,Pal SK

doi

10.1038/srep13865

subject

Has Abstract

pub_date

2015-09-10 00:00:00

pages

13865

issn

2045-2322

pii

srep13865

journal_volume

5

pub_type

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