Abstract:
:To investigate confounding factors of real-time ultrasound elastography (RTE) and to evaluate the diagnostic performance of ultrasound (US)-guided FNA for thyroid nodules with indeterminate elastography compared with conventional US. This study included 244 nodules with indeterminate elastography caused by several confounding factors (large or small size, deep location, isthmic or paratracheal location, calcification, thyroiditis, conflicting results between conventional US and RTE), and corresponding prevalences of malignancy were calculated. Additionally, conventional US and US-FNA data were collected and compared. The prevalences of malignancy of confounding factors were 74.1%, 75.0%, 73.3%, 46.2%, 27.3%, and 53.2%, respectively. Sonographic features (border, margin, echogenicity, echohomogeneity, and microcalcification) were significantly different between benign and malignant thyroid nodules (p < 0.05), and most of them exhibited good sensitivity but unsatisfactory specificity and accuracy. While US-FNA exhibited better performance with a sensitivity of 96.9%, a specificity of 99.1% and an accuracy of 98.0% in the diagnosis of malignancy. Given that indeterminate RTE is inevitable with a rather high malignant risk due to several confounding factors, our study revealed that US-FNA was a valuable tool in nodules with indeterminate elastography by increasing the detection rate of thyroid malignancy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wu Q,Qu Y,Zang X,Li Y,Yi X,Wang Y,Hu Bdoi
10.1038/s41598-017-18121-3subject
Has Abstractpub_date
2017-12-21 00:00:00pages
18005issue
1issn
2045-2322pii
10.1038/s41598-017-18121-3journal_volume
7pub_type
杂志文章abstract::Biomodels made of poly(vinyl alcohol) (PVA) are demanded because they can represent the geometries and mechanical properties of human tissues realistically. Injecting and molding, commonly used in three-dimensional (3D) modeling, help to represent the blood vessels accurately. However, these techniques sometimes requi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34986-4
更新日期:2018-11-08 00:00:00
abstract::Machine learning algorithms have recently shown their precision and potential in many different use cases and fields of medicine. Most of the algorithms used are supervised and need a large quantity of labeled data to achieve high accuracy. Also, most applications of machine learning in medicine are attempts to mimic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73902-7
更新日期:2020-10-12 00:00:00
abstract::The major human pathogen Streptococcus pneumoniae is a leading cause of disease and death worldwide. Pneumococcal biofilm formation within the nasopharynx leads to long-term colonization and persistence within the host. We have previously demonstrated that the capsular surface-associated pneumococcal serine rich repea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32371
更新日期:2016-09-01 00:00:00
abstract::The monitoring and early detection of abnormalities or variations in the cardiac cycle functionality are very critical practices and have significant impact on the prevention of heart diseases and their associated complications. Currently, in the field of biomedical engineering, there is a growing need for devices cap...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37093
更新日期:2016-11-17 00:00:00
abstract::Balance is a very important function that allows maintaining a stable stance needed for many daily life activities and for preventing falls. We investigated whether balance control could be improved by a placebo procedure consisting of verbal suggestion. Thirty healthy volunteers were randomized in two groups (placebo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42888-2
更新日期:2019-04-23 00:00:00
abstract::Transforming growth factor-β/Smad3 signaling plays a critical role in the process of chronic kidney disease (CKD), but targeting Smad3 systematically may cause autoimmune disease by impairing immunity. In this study, we used whole-transcriptome RNA-sequencing to identify the differential gene expression profile, gene ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17901
更新日期:2015-12-09 00:00:00
abstract::Mutations in genes that encode components of tuberous sclerosis complex 2 (TSC2) are associated with tuberous sclerosis complex disease. TSC2 interacts with tuberous sclerosis complex 1 to form a complex that negatively regulates cell growth and proliferation via the inactivation of mechanistic target of rapamycin com...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78274-6
更新日期:2020-12-03 00:00:00
abstract::Microbial rhodopsin is a photoreceptor protein found in various bacteria and archaea, and it is considered to be a light-utilization device unique to heterotrophs. Recent studies have shown that several cyanobacterial genomes also include genes that encode rhodopsins, indicating that these auxiliary light-utilizing pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73606-y
更新日期:2020-10-07 00:00:00
abstract::N(1)-methyladenosine (m(1)A) is a prominent RNA modification involved in many biological processes. Accurate identification of m(1)A site is invaluable for better understanding the biological functions of m(1)A. However, limitations in experimental methods preclude the progress towards the identification of m(1)A site...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31080
更新日期:2016-08-11 00:00:00
abstract::The ability to induce reversible phase transitions between homogeneous solutions and biphasic liquid-liquid systems, at pre-defined and suitable operating temperatures, is of crucial relevance in the design of separation processes. Ionic-liquid-based aqueous biphasic systems (IL-based ABS) have demonstrated superior p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20276
更新日期:2016-02-04 00:00:00
abstract::Beneficial effects of CO2 on photosynthetic organisms will be a key driver of ecosystem change under ocean acidification. Predicting the responses of macroalgal species to ocean acidification is complex, but we demonstrate that the response of assemblages to elevated CO2 are correlated with inorganic carbon physiology...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46297
更新日期:2017-04-18 00:00:00
abstract::Shape memory alloys are typical temperature-sensitive metallic functional materials due to superelasticity and shape recovery characteristics. The conventional shape memory effect involves the formation and deformation of thermally induced martensite and its reverse transformation. The shape recovery process usually t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21754
更新日期:2016-02-16 00:00:00
abstract::Glioma is the most common primary intracranial tumor and is associated with very low survival rates. The development of reliable biomarkers can help to elucidate the molecular mechanisms involved in glioma development. Here the expression of ABCC8 mRNA, clinical characteristics, and survival information based on 1893 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69676-7
更新日期:2020-07-29 00:00:00
abstract::This article presents the homodyne detection in a self-oscillation system, which represented by a short-range radar (SRR) circuit, that is analysed using a multi-time forced oscillator (MTFO) model. The MTFO model is based on a forced oscillation perspective with the signal and system theory, a second-order differenti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43680
更新日期:2017-03-02 00:00:00
abstract::The finding that mature forest ecosystems increase carbon in woody tissues and mineral soils indicates that the original equilibriums are being pushed to a higher state. The final driving forces will probably be increasing CO2 and nitrogen deposition, global warming, and changes to precipitation patterns. However, whi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03681
更新日期:2014-01-14 00:00:00
abstract::Prasinophytes are a paraphyletic group of nine lineages of green microalgae that are currently classified either at the class or order level or as clades without formal taxonomic description. Prasinophyte clade VII comprises picoplanktonic algae that are important components of marine phytoplankton communities, partic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12412-5
更新日期:2017-10-25 00:00:00
abstract::Chronic suppurative otitis media (CSOM) is one of the most common infectious diseases of the middle ear especially affecting children, leading to delay in language development and communication. Although Staphylococcus aureus is the most common pathogen associated with CSOM, its interaction with middle ear epithelial ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47079-7
更新日期:2019-07-25 00:00:00
abstract::In the current report, we describe the identification of three genetically distinct groups of prophages integrated into three different chromosomal sites of human gut-associated Bifidobacterium breve and Bifidobacterium longum strains. These bifidobacterial prophages are distantly related to temperate actinobacterioph...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31181-3
更新日期:2018-08-24 00:00:00
abstract::It is estimated from twin studies that heritable factors account for at-least half of asthma-risk, of which genetic variants identified through population studies explain only a small fraction. Multi-generation large families with high asthma prevalence can serve as a model to identify highly penetrant genetic variant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54718-6
更新日期:2019-12-13 00:00:00
abstract::Neovascularization of the erectile tissue emerges as a beneficial curative approach to treat erectile dysfunction (ED). Here we for the first time report the unexpected role of vasohibin-1 (VASH1), mainly known as an anti-angiogenic factor, in restoring erectile function in diabetic mice. A diabetic patient has lower ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80925-7
更新日期:2021-01-13 00:00:00
abstract::Cnidarians, in general, are long-lived organisms and hence may repeatedly encounter common pathogens during their lifespans. It remains unknown whether these early diverging animals possess some type of immunological reaction that strengthens the defense response upon repeated infections, such as that described in mor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17425
更新日期:2015-12-02 00:00:00
abstract::The structure of bonds in biomolecules, such as base pairs in RNA chains or native interactions in proteins, can be presented in the form of a chord diagram. A given biomolecule is then characterized by the genus of an auxiliary two-dimensional surface associated to such a diagram. In this work we introduce the notion...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35557-3
更新日期:2018-12-03 00:00:00
abstract::Essential oils are volatile compounds commonly used by several industries, easily degradable, which restrains their applications. Therefore, we developed and validated a methodology for producing microcapsules loaded with orange essential oil, using a spray-drying process. The experimental design results showed that t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68823-4
更新日期:2020-07-16 00:00:00
abstract::Coral reefs face a crisis due to local and global anthropogenic stressors. A large proportion of the ~50% coral loss on the Great Barrier Reef has been attributed to outbreaks of the crown-of-thorns-seastar (COTS). A widely assumed cause of primary COTS outbreaks is increased larval survivorship due to higher food ava...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08402
更新日期:2015-02-12 00:00:00
abstract::Several systems can be represented as multiplex networks, i.e. in terms of a superposition of various graphs, each related to a different mode of connection between nodes. Hence, the definition of proper mathematical quantities aiming at capturing the added level of complexity of those systems is required. Various ste...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09120
更新日期:2015-03-13 00:00:00
abstract::Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse BoNT-induced blockade of neuromuscular transmission. While aminopyridines have ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16064-3
更新日期:2017-11-20 00:00:00
abstract::Porphyry deposits are copper-rich orebodies formed by precipitation of metal sulphides from hydrothermal fluids released from magmatic intrusions that cooled at depth within the Earth's crust. Finding new porphyry deposits is essential because they are our largest source of copper and they also contain other strategic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40566
更新日期:2017-01-12 00:00:00
abstract::Detailed structural analyses of the mushroom body which plays critical roles in olfactory learning and memory revealed that it is directly connected with multiple primary sensory centers in Drosophila. Connectivity patterns between the mushroom body and primary sensory centers suggest that each mushroom body lobe proc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29481
更新日期:2016-07-11 00:00:00
abstract::Drug-based treatments are the most widely used interventions for cancer management. Personalized drug response profiling remains inherently challenging with low cell count harvested from tumour sample. We present a 96well-formatted microfluidic plate with built-in micro-gap that preserves up to 99.2% of cells during m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09656
更新日期:2015-04-13 00:00:00
abstract::Using census data we identify geographic patterns in residency changes in Lesotho over a decade. Using kriging to spatially interpolate data from 8,510 households we identify regions where households have members temporarily living away from home (divided households). Further, using a multivariate analysis and data fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17598
更新日期:2015-12-02 00:00:00