Abstract：
:This study used resting-state functional MRI (r-fMRI) to evaluate intrinsic brain activity in drug-naive patients with essential tremor (ET) with and without head tremor. We enrolled 20 patients with ET with hand and head tremor (h-ET), 27 patients with ET without head tremor (a-ET), and 27 healthy controls (HCs). All participants underwent r-fMRI scans on a 3-T MR system. The amplitude of low-frequency fluctuation (ALFF) of blood oxygen level-dependent signals was used to characterize regional cerebral function. We identified increased ALFF value in the bilateral posterior lobe of cerebellum in the h-ET patients relative to a-ET and HCs and demonstrated that h-ET is related to abnormalities in the cerebello-cortical areas, while the a-ET is related to abnormalities in the thalamo-cortical areas. In addition, we observed the ALFF abnormality in the cerebellum (left cerebellum VIII and right cerebellum VI) correlated with the tremor score in h-ET patients and abnormal ALFF in the left precentral gyrus correlated with the age at onset and disease duration in h-ET patients. These findings may be helpful for facilitating further understanding of the potential mechanisms underlying different subtypes of ET.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang L,Lei D,Suo X,Li N,Lu Z,Li J,Peng J,Gong Q,Peng Rdoi
10.1038/s41598-018-28778-zsubject
Has Abstractpub_date
2018-07-12 00:00:00pages
10580issue
1issn
2045-2322pii
10.1038/s41598-018-28778-zjournal_volume
8pub_type
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