当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Isolation, characterization and antifungal docking studies of wortmannin isolated from Penicillium radicum.

Isolation, characterization and antifungal docking studies of wortmannin isolated from Penicillium radicum.

Abstract：

:During the search for a potent antifungal drug, a cell-permeable metabolite was isolated from a soil isolate taxonomically identified as Penicillium radicum. The strain was found to be a potent antifungal agent. Production conditions of the active compound were optimized and the active compound was isolated, purified, characterized and identified as a phosphoinositide 3-kinase (PI3K) inhibitor, commonly known as wortmannin (Wtmn). This is very first time we are reporting the production of Wtmn from P. radicum. In addition to its previously discovered anticancer properties, the broad spectrum antifungal property of Wtmn was re-confirmed using various fungal strains. Virtual screening was performed through molecular docking studies against potential antifungal targets, and it was found that Wtmn was predicted to impede the actions of these targets more efficiently than known antifungal compounds such as voriconazole and nikkomycin i.e. 1) mevalonate-5-diphosphate decarboxylase (1FI4), responsible for sterol/isoprenoid biosynthesis; 2) exocyst complex component SEC3 (3A58) where Rho- and phosphoinositide-dependent localization is present and 3) Kre2p/Mnt1p a Golgi alpha1,2-mannosyltransferase (1S4N) involved in the biosynthesis of yeast cell wall glycoproteins). We conclude that Wtmn produced from P. radicum is a promising lead compound which could be potentially used as an efficient antifungal drug in the near future after appropriate structural modifications to reduce toxicity and improve stability.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Singh V,Praveen V,Tripathi D,Haque S,Somvanshi P,Katti SB,Tripathi CK

doi

10.1038/srep11948

subject

Has Abstract

pub_date

2015-07-10 00:00:00

pages

11948

issn

2045-2322

pii

srep11948

journal_volume

5

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Growth and development of the third permanent molar in Paranthropus robustus from Swartkrans, South Africa.

    abstract：:Third permanent molars (M3s) are the last tooth to form but have not been used to estimate age at dental maturation in early fossil hominins because direct histological evidence for the timing of their growth has been lacking. We investigated an isolated maxillary M3 (SK 835) from the 1.5 to 1.8-million-year-old (Mya)...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76032-2

    authors： Dean C,Zanolli C,Le Cabec A,Tawane M,Garrevoet J,Mazurier A,Macchiarelli R

    更新日期：2020-11-04 00:00:00

  • Phenotypic Characterization Analysis of Human Hepatocarcinoma by Urine Metabolomics Approach.

    abstract：:Hepatocarcinoma (HCC) is one of the deadliest cancers in the world and represents a significant disease burden. Better biomarkers are needed for early detection of HCC. Metabolomics was applied to urine samples obtained from HCC patients to discover noninvasive and reliable biomarkers for rapid diagnosis of HCC. Metab...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19763

    authors： Liang Q,Liu H,Wang C,Li B

    更新日期：2016-01-25 00:00:00

  • Apoptotic effect of novel Schiff based CdCl₂(C₁₄H₂₁N₃O₂) complex is mediated via activation of the mitochondrial pathway in colon cancer cells.

    abstract：:The development of metal-based agents has had a tremendous role in the present progress in cancer chemotherapy. One well-known example of metal-based agents is Schiff based metal complexes, which hold great promise for cancer therapy. Based on the potential of Schiff based complexes for the induction of apoptosis, thi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09097

    authors： Hajrezaie M,Paydar M,Looi CY,Moghadamtousi SZ,Hassandarvish P,Salga MS,Karimian H,Shams K,Zahedifard M,Majid NA,Ali HM,Abdulla MA

    更新日期：2015-03-13 00:00:00

  • CRISRP/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat.

    abstract：:Thyroid hormone (TH) has long been believed to play a minor role in male reproduction. However, evidences from experimental model of thyrotoxicosis or hypothyroidism suggests its role in spermatogenesis. Cellular action of TH requires membrane transport via specific transporters such as monocarboxylate transporter 8 (...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67594-2

    authors： Bae HS,Jin YK,Ham S,Kim HK,Shin H,Cho GB,Lee KJ,Lee H,Kim KM,Koo OJ,Jang G,Lee JM,Lee JY

    更新日期：2020-07-07 00:00:00

  • Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice.

    abstract：:Chronic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney disease (CKD). The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model. Nuclear factor erythroid 2-related factor 2 (Nrf...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08054-2

    authors： Sogawa Y,Nagasu H,Iwase S,Ihoriya C,Itano S,Uchida A,Kidokoro K,Taniguchi S,Takahashi M,Satoh M,Sasaki T,Suzuki T,Yamamoto M,Horng T,Kashihara N

    更新日期：2017-08-18 00:00:00

  • Post-treatment levels of plasma 25- and 1,25-dihydroxy vitamin D and mortality in men with aggressive prostate cancer.

    abstract：:Vitamin D may reduce mortality from prostate cancer (PC). We examined the associations of post-treatment plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations with PC mortality. Participants were PC cases from the New South Wales Prostate Cancer Care. All contactable and consenting participants, at 4.9...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62182-w

    authors： Nair-Shalliker V,Bang A,Egger S,Clements M,Gardiner RA,Kricker A,Seibel MJ,Chambers SK,Kimlin MG,Armstrong BK,Smith DP

    更新日期：2020-05-08 00:00:00

  • Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

    abstract：:We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26217-7

    authors： Sawai H,Nishida N,Khor SS,Honda M,Sugiyama M,Baba N,Yamada K,Sawada N,Tsugane S,Koike K,Kondo Y,Yatsuhashi H,Nagaoka S,Taketomi A,Fukai M,Kurosaki M,Izumi N,Kang JH,Murata K,Hino K,Nishina S,Matsumoto A,Tanaka

    更新日期：2018-05-21 00:00:00

  • SERS activity of hybrid nano/microstructures Ag-Fe3O4 based on Dimorphotheca ecklonis pollen grains as bio-template.

    abstract：:Nature provides remarkable examples of mass-produced microscale particles with structures and chemistries optimized by evolution for particular functions. Synthetic chemical tailoring of such sustainable biogenic particles may be used to generate new multifunctional materials. Herein, we report a facile method for the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73615-x

    authors： Ávila-Avilés RD,Torres-Gómez N,Camacho-López MA,Vilchis-Nestor AR

    更新日期：2020-10-06 00:00:00

  • Green Reduction of Graphene Oxide using Kaffir Lime Peel Extract (Citrus hystrix) and Its Application as Adsorbent for Methylene Blue.

    abstract：:Green reduction of graphene oxide (GO) by phytochemicals was explored using the aqueous extract of kaffir lime peels. The research methods included preparation of extracts, preparation of GO, preparation and characterization of reduced-GO (RGO) using Fourier Transform Infrared (FTIR), X-ray diffraction (XRD), and UV-V...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-57433-9

    authors： Wijaya R,Andersan G,Permatasari Santoso S,Irawaty W

    更新日期：2020-01-20 00:00:00

  • Light absorption enhancement in ultrathin film solar cell with embedded dielectric nanowires.

    abstract：:A novel design of thin-film crystalline silicon solar cell (TF C-Si-SC) is proposed and numerically analyzed. The reported SC has 1.0 µm thickness of C-Si with embedded dielectric silicon dioxide nanowires (NWs). The introduced NWs increase the light scattering in the active layer which improves the optical path lengt...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74453-7

    authors： Elrabiaey MA,Hussein M,Hameed MFO,Obayya SSA

    更新日期：2020-10-16 00:00:00

  • Activity-dependent changes in synaptic protein complex composition are consistent in different detergents despite differential solubility.

    abstract：:At the post-synaptic density (PSD), large protein complexes dynamically form and dissociate in response to synaptic activity, comprising the biophysical basis for learning and memory. The use of detergents to isolate the PSD and release its membrane-associated proteins complicates studies of these activity-dependent p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46690-y

    authors： Lautz JD,Gniffke EP,Brown EA,Immendorf KB,Mendel RD,Smith SEP

    更新日期：2019-07-26 00:00:00

  • Detection of genomic regions associated with tiller number in Iranian bread wheat under different water regimes using genome-wide association study.

    abstract：:Two of the important traits for wheat yield are tiller and fertile tiller number, both of which have been thought to increase cereal yield in favorable and unfavorable environments. A total of 6,349 single nucleotide polymorphism (SNP) markers from the 15 K wheat Infinium array were employed for genome-wide associatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69442-9

    authors： Bilgrami SS,Ramandi HD,Shariati V,Razavi K,Tavakol E,Fakheri BA,Mahdi Nezhad N,Ghaderian M

    更新日期：2020-08-20 00:00:00

  • Transdermal neuromodulation of noradrenergic activity suppresses psychophysiological and biochemical stress responses in humans.

    abstract：:We engineered a transdermal neuromodulation approach that targets peripheral (cranial and spinal) nerves and utilizes their afferent pathways as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) method on sympathetic physiology under differe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13865

    authors： Tyler WJ,Boasso AM,Mortimore HM,Silva RS,Charlesworth JD,Marlin MA,Aebersold K,Aven L,Wetmore DZ,Pal SK

    更新日期：2015-09-10 00:00:00

  • Increased systolic blood pressure reactivity to acute stress is related with better self-reported health.

    abstract：:The stress reactivity hypothesis posits that the magnitude of cardiovascular reactions to acute stress tasks is related with future blood pressure status, heart hypertrophy, and atherosclerosis. We assessed the stress reactivity hypothesis and aimed to identify which physiological indices (blood pressure, heart-rate, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06882

    authors： Wright BJ,O'Brien S,Hazi A,Kent S

    更新日期：2014-11-13 00:00:00

  • Effect of 6p21 region on lung function is modified by smoking: a genome-wide interaction study.

    abstract：:Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD); however, more than 25% of COPD patients are non-smokers, and gene-by-smoking interactions are expected to affect COPD onset. We aimed to identify the common genetic variants interacting with pack-years of smoking on FEV1/FVC ratios in ind...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70092-0

    authors： Park B,An J,Kim W,Kang HY,Koh SB,Oh B,Jung KJ,Jee SH,Kim WJ,Cho MH,Silverman EK,Park T,Won S

    更新日期：2020-08-04 00:00:00

  • Close relationship between a dry-wet transition and a bubble rearrangement in two-dimensional foam.

    abstract：:Liquid foams are classified into a dry foam and a wet foam, empirically judging from the liquid fraction or the shape of the gas bubbles. It is known that physical properties such as elasticity and diffusion are different between the dry foam and the wet foam. Nevertheless, definitions of those states have been vague ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37506

    authors： Furuta Y,Oikawa N,Kurita R

    更新日期：2016-11-22 00:00:00

  • Impact of the secretome of activated pancreatic stellate cells on growth and differentiation of pancreatic tumour cells.

    abstract：:Pancreatic ductal adenocarcinoma (PDAC) exists in a complex desmoplastic microenvironment. As part of it, pancreatic stellate cells (PSCs) provide a fibrotic niche, stimulated by a dynamic communication between activated PSCs and tumour cells. Investigating how PSCs contribute to tumour development and for identifying...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41740-x

    authors： Marzoq AJ,Mustafa SA,Heidrich L,Hoheisel JD,Alhamdani MSS

    更新日期：2019-03-28 00:00:00

  • An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model.

    abstract：:The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZIKV's neurotropic effects in the course of fetal development. Vaccine candidates against ZIKV are coming online, but immunological tools to study anti-ZIKV responses in preclinical models, particular...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00193-w

    authors： Chahal JS,Fang T,Woodham AW,Khan OF,Ling J,Anderson DG,Ploegh HL

    更新日期：2017-03-21 00:00:00

  • Management of soil pH promotes nitrous oxide reduction and thus mitigates soil emissions of this greenhouse gas.

    abstract：:While concerns about human-induced effects on the Earth's climate have mainly concentrated on carbon dioxide (CO2) and methane (CH4), reducing anthropogenic nitrous oxide (N2O) flux, mainly of agricultural origin, also represents an opportunity for substantial mitigation. To develop a solution that induces neither the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56694-3

    authors： Hénault C,Bourennane H,Ayzac A,Ratié C,Saby NPA,Cohan JP,Eglin T,Gall CL

    更新日期：2019-12-27 00:00:00

  • Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae.

    abstract：:Zika virus (ZIKV) causes significant public health concerns because of its association with congenital malformations, neurological disorders in adults, and, more recently, death. Considering the necessity to mitigate ZIKV-associated diseases, antiviral interventions are an urgent necessity. Sofosbuvir, a drug in clini...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09797-8

    authors： Ferreira AC,Zaverucha-do-Valle C,Reis PA,Barbosa-Lima G,Vieira YR,Mattos M,Silva PP,Sacramento C,de Castro Faria Neto HC,Campanati L,Tanuri A,Brüning K,Bozza FA,Bozza PT,Souza TML

    更新日期：2017-08-25 00:00:00

  • Electrochemical degradation and saponification of porcine adipose tissue.

    abstract：:Body contouring achieved via subcutaneous adipose tissue reduction has notably advanced over the past century, from suction assisted lipectomy to techniques with reduced degrees of invasiveness including laser, radiofrequency, high frequency focused ultrasound, cryolipolysis, and drug-based injection approaches. These...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76678-y

    authors： Pham TT,Stokolosa AM,Borden PA,Hansen KD,Hong EM,Krasieva TB,Sivoraphonh RH,Moy WJ,Heidari AE,Lee LH,Kim EH,Sun CH,Jia W,Mo J-,Kim S,Hill MG,Wong BJF

    更新日期：2020-11-27 00:00:00

  • Study of Structural stability and formation mechanisms in DSPC and DPSM liposomes: A coarse-grained molecular dynamics simulation.

    abstract：:Liposomes or biological vesicles can be created from cholesterol, phospholipid, and water. Their stability is affected by their phospholipid composition which can influence disease treatment and drug delivery efficacy. In this study, the effect of phospholipid type on the formation and stability of liposomes using coa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58730-z

    authors： Hashemzadeh H,Javadi H,Darvishi MH

    更新日期：2020-02-04 00:00:00

  • Toward a nanopaper-based and solid phase immunoassay using FRET for the rapid detection of bacteria.

    abstract：:In this study, we propose a novel sensitive solid-based immunosensor developed on a plasmonic nanopaper platform for the detection of Escherichia coli (E. coli) bacteria. This plasmonic nanopaper that comprises of carboxylated bacterial cellulose (CBC) impregnated with gold nanoparticles (AuNP-CBC), employed as a quen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71285-3

    authors： Heli B,Ajji A

    更新日期：2020-09-01 00:00:00

  • Inhibition of hypoxia inducible factor-1α attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases.

    abstract：:Hypoxia inducible factor-1α (HIF-1α) pathway is associated with many vascular diseases, including atherosclerosis, arterial aneurysms, pulmonary hypertension and chronic venous diseases. Significant HIF-1α expression could be found at the rupture edge at human abdominal aortic aneurysm (AAA) tissues. While our initial...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28612

    authors： Tsai SH,Huang PH,Hsu YJ,Peng YJ,Lee CH,Wang JC,Chen JW,Lin SJ

    更新日期：2016-07-01 00:00:00

  • Evidence that ERF transcriptional regulators serve as possible key molecules for natural variation in defense against herbivores in tall goldenrod.

    abstract：:We collected Solidago altissima clones to explore their leaf damage resistance, and as a result identified five accessions that exhibited variable defense abilities against the generalist herbivore Spodoptera litura. In order to characterize molecules involved in such natural variation, we focused on ethylene response...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62142-4

    authors： Takafuji K,Rim H,Kawauchi K,Mujiono K,Shimokawa S,Ando Y,Shiojiri K,Galis I,Arimura GI

    更新日期：2020-03-24 00:00:00

  • Tension-type headache in the Emergency Department Diagnosis and misdiagnosis: The TEDDi study.

    abstract：:Headache is a common reason to visit the emergency department (ED). Tension-type headache (TTH) is the commonest headache. The diagnosis of TTH implies a mild condition, with no need for special tests. We evaluated the use of the International Classification of Headache Disorders (ICHD) criteria for TTH in the ED. We ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59171-4

    authors： García-Azorín D,Farid-Zahran M,Gutiérrez-Sánchez M,González-García MN,Guerrero AL,Porta-Etessam J

    更新日期：2020-02-12 00:00:00

  • Alcohol consumption is associated with glaucoma severity regardless of ALDH2 polymorphism.

    abstract：:The present study investigated the effect of aldehyde dehydrogenase2 (ALDH2) rs671 polymorphism and alcohol consumption on the severity of primary open-angle glaucoma (POAG). The questionnaire for alcohol consumption pattern and targeted genotyping for ALDH2 rs671 polymorphism was performed from 445 Korean POAG patien...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74470-6

    authors： Han YS,Kim YW,Kim YJ,Park KH,Jeoung JW

    更新日期：2020-10-15 00:00:00

  • Peculiarity of Two Thermodynamically-Stable Morphologies and Their Impact on the Efficiency of Small Molecule Bulk Heterojunction Solar Cells.

    abstract：:Structural characteristics of the active layers in organic photovoltaic (OPV) devices play a critical role in charge generation, separation and transport. Here we report on morphology and structural control of p-DTS(FBTTh2)2:PC71BM films by means of thermal annealing and 1,8-diiodooctane (DIO) solvent additive process...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13407

    authors： Herath N,Das S,Keum JK,Zhu J,Kumar R,Ivanov IN,Sumpter BG,Browning JF,Xiao K,Gu G,Joshi P,Smith S,Lauter V

    更新日期：2015-08-28 00:00:00

  • Large seasonal and spatial variation in nano- and microphytoplankton diversity along a Baltic Sea-North Sea salinity gradient.

    abstract：:Aquatic phytoplankton experience large fluctuations in environmental conditions during seasonal succession and across salinity gradients, but the impact of this variation on their diversity is poorly understood. We examined spatio-temporal variation in nano- and microphytoplankton (> 2 µm) community structure using al...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74428-8

    authors： Olofsson M,Hagan JG,Karlson B,Gamfeldt L

    更新日期：2020-10-19 00:00:00

  • In vivo imaging of bacterial colonization of the lower respiratory tract in a baboon model of Bordetella pertussis infection and transmission.

    abstract：:Recent whooping cough (pertussis) outbreaks in many countries highlight the crucial need for a better understanding of the pathogenesis of Bordetella pertussis infection of the respiratory tract. The baboon is a recently described preclinical model for the study of B. pertussis infection and may be ideal for the evalu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30896-7

    authors： Naninck T,Coutte L,Mayet C,Contreras V,Locht C,Le Grand R,Chapon C

    更新日期：2018-08-16 00:00:00