CRISRP/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat.

abstract：:Tropical Pacific stalagmites are commonly affected by dating uncertainties because of their low U concentration and/or elevated initial 230Th content. This poses problems in establishing reliable trends and periodicities for droughts and pluvial episodes in a region vulnerable to climate change. Here we constrain the ...

journal_title：Scientific reports

authors： Faraji M,Borsato A,Frisia S,Hellstrom JC,Lorrey A,Hartland A,Greig A,Mattey DP

更新日期：2021-01-26 00:00:00

abstract：:Traditional diagnostic detection of chronic wasting disease (CWD) relies on immunodetection of misfolded CWD prion protein (PrP(CWD)) by western blotting, ELISA, or immunohistochemistry (IHC). These techniques require separate sample collections (frozen and fixed) which may result in discrepancies due to variation in ...

journal_title：Scientific reports

authors： Hoover CE,Davenport KA,Henderson DM,Pulscher LA,Mathiason CK,Zabel MD,Hoover EA

更新日期：2016-05-09 00:00:00

abstract：:Differential vulnerability among motor neuron (MN) subtypes is a fundamental feature of amyotrophic lateral sclerosis (ALS): fast-fatigable (FF) MNs are more vulnerable than fast fatigue-resistant (FR) or slow (S) MNs. The reason for this selective vulnerability remains enigmatic. We report here that the extracellular...

journal_title：Scientific reports

authors： Morisaki Y,Niikura M,Watanabe M,Onishi K,Tanabe S,Moriwaki Y,Okuda T,Ohara S,Murayama S,Takao M,Uchida S,Yamanaka K,Misawa H

更新日期：2016-06-06 00:00:00

abstract：:Polypoidal choroidal vasculopathy (PCV) is a degenerative macular disease. The study determined the topographical concordance in the areal extent of PCV, defined by indocyanine green angiography (ICGA), and the corresponding outcomes from spectral-domain optical coherence tomography (SD-OCT) and microperimetry, in 25 ...

journal_title：Scientific reports

authors： Acton JH,Ogino K,Akagi Y,Wild JM,Yoshimura N

更新日期：2018-10-25 00:00:00

abstract：:During mouse preimplantation embryo development, three distinct cell lineages are formed, represented by the differentiating trophectoderm (TE), primitive endoderm (PrE) and the pluripotent epiblast (EPI). Classically, lineage derivation has been presented as a two-step process whereby outer TE cells are first segrega...

journal_title：Scientific reports

authors： Mihajlović AI,Thamodaran V,Bruce AW

更新日期：2015-10-13 00:00:00

abstract：:A crystalline solid exhibits thermally induced localised non-affine droplets in the absence of external stress. Here we show that upon an imposed shear, the size of these droplets grow until they percolate at a critical strain, well below the value at which the solid begins to yield. This critical point does not manif...

journal_title：Scientific reports

authors： Das T,Ganguly S,Sengupta S,Rao M

更新日期：2015-06-03 00:00:00

abstract：:α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type 1D (MDC1D), etc. LARGE, the causative gene f...

journal_title：Scientific reports

authors： Ohtsuka Y,Kanagawa M,Yu CC,Ito C,Chiyo T,Kobayashi K,Okada T,Takeda S,Toda T

更新日期：2015-02-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Delplancke TDJ,de Seymour JV,Tong C,Sulek K,Xia Y,Zhang H,Han TL,Baker PN

更新日期：2020-02-21 00:00:00

abstract：:In higher plants, L-galactono-1,4-lactone dehydrogenase (GLDH) plays important roles in ascorbic acid (AsA) biosynthesis and assembly of respiration complex I. Here we report three homoeologous genes (TaGLDH-A1, -B1 and -D1) encoding common wheat GLDH isozymes and a unique allelic variant (TaGLDH-A1b) associated with ...

journal_title：Scientific reports

authors： Zhang J,Li B,Yang Y,Mu P,Qian W,Dong L,Zhang K,Liu X,Qin H,Ling H,Wang D

更新日期：2016-07-22 00:00:00

abstract：:The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is considered as a human carcinogenic or mutagenic compound that is produced from the co-condensation of creatinine and amino acids as meats cook at high temperatures. The cooking of meats at high temperatures produces fumes, and these fumes...

journal_title：Scientific reports

authors： Poudel BK,Choi J,Park JH,Doh KO,Byeon JH

更新日期：2017-09-07 00:00:00

abstract：:Truffles (Tuber spp.) are the fruiting bodies of symbiotic fungi, which are prized food delicacies. The marked aroma variability observed among truffles of the same species has been attributed to a series of factors that are still debated. This is because factors (i.e. genetics, maturation, geographical location and t...

journal_title：Scientific reports

authors： Vahdatzadeh M,Splivallo R

更新日期：2018-06-18 00:00:00

abstract：:Mitochondria behave as functional and structural hubs for innate defense against intracellular infection. While the mitochondrial membrane serves as a platform for the assembly of signaling complexes activated by intracellular infection, various danger molecules derived from impaired mitochondria activate innate signa...

journal_title：Scientific reports

authors： Seo JH,Hwang CS,Yoo JY

更新日期：2020-07-07 00:00:00

abstract：:Ratchet is a device that produces direct current of particles when driven by an unbiased force. We demonstrate a simple scattering quantum ratchet based on an asymmetrical quantum tunneling effect in two-dimensional electron gas with Rashba spin-orbit interaction (R2DEG). We consider the tunneling of electrons across ...

journal_title：Scientific reports

authors： Ang YS,Ma Z,Zhang C

更新日期：2015-01-19 00:00:00

abstract：:De novo mutations (DNMs), including germinal and postzygotic mutations (PZMs), are a strong source of causality for Autism Spectrum Disorder (ASD). However, the biological processes involved behind them remain unexplored. Our aim was to detect DNMs (germinal and PZMs) in a Spanish ASD cohort (360 trios) and to explore...

journal_title：Scientific reports

authors： Alonso-Gonzalez A,Calaza M,Amigo J,González-Peñas J,Martínez-Regueiro R,Fernández-Prieto M,Parellada M,Arango C,Rodriguez-Fontenla C,Carracedo A

更新日期：2021-01-11 00:00:00

abstract：:SIRT1, the NAD+-dependent protein deacetylase, controls cell-cycle progression and apoptosis by suppressing p53 tumour suppressor. Although SIRT1 is known to be phosphorylated by JNK1 upon oxidative stress and subsequently down-regulated, it still remains elusive how SIRT1 stability and activity are controlled. Here, ...

journal_title：Scientific reports

authors： Kim M,Kwon YE,Song JO,Bae SJ,Seol JH

更新日期：2016-11-24 00:00:00

abstract：:Recent studies including the SPRINT trial have shown beneficial effects of intensive systolic blood pressure reduction over the standard approach. The awareness of the J-curve for diastolic blood pressure (DBP) causes some uncertainty regarding the net clinical effects of blood pressure reduction. The current analysis...

journal_title：Scientific reports

authors： Sobieraj P,Lewandowski J,Siński M,Gaciong Z

更新日期：2019-09-10 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolism. The importance of mTORC1 signaling in neuronal development and functions has been highlighted by its strong relationship with many neurological and neuropsychiatric diseases. Previous studies demonstrated that hyperactivation of mTORC1...

journal_title：Scientific reports

authors： Sakai Y,Kassai H,Nakayama H,Fukaya M,Maeda T,Nakao K,Hashimoto K,Sakagami H,Kano M,Aiba A

更新日期：2019-02-26 00:00:00

abstract：:Quaternary ammonium compounds (QACs) are classified as cationic surfactants, and are known for their biocidal activity. However, their modes of action are thus far not completely understood. In this study, we synthesized a gemini QAC, PMT12-BF4 and found that it exerted unsurpassed broad-spectrum antifungal activity a...

journal_title：Scientific reports

authors： Hsu LH,Kwaśniewska D,Wang SC,Shen TL,Wieczorek D,Chen YL

更新日期：2020-02-19 00:00:00

abstract：:Understanding the traits that might be linked with biological invasions represents a great challenge for preventing non-target effects on local biodiversity. In predatory insects, the ability to exploit habitats for oviposition and the physiological response to prey availability differs between species. Those species ...

journal_title：Scientific reports

authors： Rondoni G,Ielo F,Ricci C,Conti E

更新日期：2017-06-16 00:00:00

abstract：:Platelet Derived Growth Factor Receptor (PDGFR) signaling is a central mitogenic pathway in development, as well as tissue repair and homeostasis. The rules governing the binding of PDGF ligand to the receptor to produce activation and downstream signaling have been well defined over the last several decades. In cultu...

journal_title：Scientific reports

authors： Kadrmas JL,Beckerle MC,Yoshigi M

更新日期：2020-11-09 00:00:00

abstract：:We adopted a vision-based tracking system for augmented reality (AR), and evaluated whether it helped surgeons to localize the recurrent laryngeal nerve (RLN) during robotic thyroid surgery. We constructed an AR image of the trachea, common carotid artery, and RLN using CT images. During surgery, an AR image of the tr...

journal_title：Scientific reports

authors： Lee D,Yu HW,Kim S,Yoon J,Lee K,Chai YJ,Choi JY,Kong HJ,Lee KE,Cho HS,Kim HC

更新日期：2020-05-21 00:00:00

abstract：:Ion pumps and channels are responsible for a wide variety of biological functions. Ion pumps transport only one ion during each stimulus-dependent reaction cycle, whereas ion channels conduct a large number of ions during each cycle. Ion pumping rhodopsins such as archaerhodopsin-3 (Arch) are often utilized as light-d...

journal_title：Scientific reports

authors： Yamanashi T,Maki M,Kojima K,Shibukawa A,Tsukamoto T,Chowdhury S,Yamanaka A,Takagi S,Sudo Y

更新日期：2019-05-27 00:00:00

abstract：:For infants with acute progressive hydrocephalus, invasive drainage of cerebrospinal fluid (CSF) is performed until a ventriculo-peritoneal shunt can be inserted. Surrogate markers of intracranial pressure (ICP) may help optimise the timing of invasive procedures. To assess whether RI with/without fontanel compression...

journal_title：Scientific reports

authors： Yoshizuka T,Kinoshita M,Iwata S,Tsuda K,Kato T,Saikusa M,Shindou R,Hara N,Harada E,Takashima S,Takeshige N,Saitoh S,Yamashita Y,Iwata O

更新日期：2018-08-07 00:00:00

abstract：:Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...

journal_title：Scientific reports

authors： Extramiana F,Milleron O,Elbitar S,Uccellini A,Langeois M,Spentchian M,Delorme G,Arnoult F,Denjoy I,Bouleti C,Fressart V,Iserin F,Maison-Blanche P,Abifadel M,Leenhardt A,Boileau C,Jondeau G

更新日期：2018-08-29 00:00:00

abstract：:After prolonged stay in an intensive care unit (ICU) patients often complain about cognitive impairments that affect health-related quality of life after discharge. The aim of this proof-of-concept study was to test the feasibility and effects of controlled visual and acoustic stimulation in a virtual reality (VR) set...

journal_title：Scientific reports

authors： Gerber SM,Jeitziner MM,Wyss P,Chesham A,Urwyler P,Müri RM,Jakob SM,Nef T

更新日期：2017-10-16 00:00:00

abstract：:The lignite biodegradation procedure to produce water-soluble humic materials (WSHM) with a Penicillium stain was established by previous studies in our laboratory. This study researched the effects of WSHM on the growth of Bradyrhizobium liaoningense CCBAU05525 and its nodulation on soybean. Results showed that WSHM ...

journal_title：Scientific reports

authors： Guo Gao T,Yuan Xu Y,Jiang F,Zhen Li B,Shui Yang J,Tao Wang E,Li Yuan H

更新日期：2015-06-08 00:00:00

abstract：:Drosophila melanogaster is a promiscuous species that inhabits a large range of harsh environments including flooded habitats and varying temperature changes. To survive these environments, fruit flies have adapted mechanisms of tolerance that allow them to thrive. During exposure to anoxic stress, fruit flies and oth...

journal_title：Scientific reports

authors： Benasayag-Meszaros R,Risley MG,Hernandez P,Fendrich M,Dawson-Scully K

更新日期：2015-03-17 00:00:00

abstract：:Diarrhea is a leading cause of death among young mammals, especially during weaning. Here, we investigated the effects of Cathelicidin-WA (CWA) on diarrhea, intestinal morphology, inflammatory responses, epithelial barrier and microbiota in the intestine of young mammals during weaning. Piglets with clinical diarrhea ...

journal_title：Scientific reports

authors： Yi H,Zhang L,Gan Z,Xiong H,Yu C,Du H,Wang Y

更新日期：2016-05-16 00:00:00

abstract：:Although thimerosal, an ethylmercury-based preservative, has been removed from most pediatric vaccines in the United States, some multidose vaccines, such as influenza vaccines, still contain thimerosal. Considering that a growing number of studies indicate involvement of the gut microbiome in infant immune developmen...

journal_title：Scientific reports

authors： Hasegawa Y,Curtis B,Yutuc V,Rulien M,Morrisroe K,Watkins K,Ferrier C,English C,Hewitson L,Slupsky CM

更新日期：2018-10-26 00:00:00

abstract：:We report the high susceptibility of several clinical isolates of Propionibacterium acnes from different sources (skin, bone, wound exudates, abscess or blood contamination) to the head-to-tail cyclized bacteriocin AS-48. This peptide is a feasible candidate for further pharmacological development against this bacteri...

journal_title：Scientific reports

authors： Cebrián R,Arévalo S,Rubiño S,Arias-Santiago S,Rojo MD,Montalbán-López M,Martínez-Bueno M,Valdivia E,Maqueda M

更新日期：2018-08-06 00:00:00