Abstract：
:Generating a protective and long-lasting immune response is the primary goal in the expanding field of immunotherapeutic research. In current study we designed an immunogenic bacteriophage- based vaccine to induce a cytotoxic T lymphocyte activity against a mice tumor model over-expressing HER2/neu. Bacteriophage λ displaying a HER2/neu derived peptide GP2 was constructed and used as an anti-cancer vaccine in a BALB/c mouse xenograft tumor model. The results of our study indicated that phage nanoparticles displaying GP2 as a fused peptide to the gpD phage capsid protein induced a robust CTL response. Furthermore, the chimeric phage nanoparticles protected mice against HER2/neu-positive tumor challenge in both prophylactic and therapeutic settings. In conclusion, we propose that λ phage nanoparticles decorated with GP2 peptide merit further investigation for the development of peptide-based vaccines against HER2/neu overexpressing tumors.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Razazan A,Nicastro J,Slavcev R,Barati N,Arab A,Mosaffa F,Jaafari MR,Behravan Jdoi
10.1038/s41598-018-38371-zsubject
Has Abstractpub_date
2019-02-18 00:00:00pages
2221issue
1issn
2045-2322pii
10.1038/s41598-018-38371-zjournal_volume
9pub_type
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