Abstract:
:In present study, transmission electron microscopy and flow cytometry were utilized to investigate the classification, characterization and immune functions of hemocytes from horseshoe crab, Tachypleus tridentatus and Carcinoscorpius rotundicauda. Three types of hemocytes were distinguished respectively: the granular cell, the semi-granular cell and the hyaline cell by transmission electron microscopy, while three hemocyte subpopulations (Gate 1 cell, Gate 2 cell, Gate 3 cell) were classified by flow cytometry. Hyaline cell was the major cell type with the highest nuclear-cytoplasmic ratio and granular cell and semi-granular cell showed lower ratios. Immune parameters of hemocytes in horseshoe crabs were investigated by flow cytometry. Different hemocyte subpopulations respond for diverse functions. Lysosomal contents and hemocyte mortality in Gate 3 cell subpopulation were higher than that in other subpopulations, while reactive oxygen species, phagocytosis and non-specific esterase, in Gate 1 cell subpopulation, were higher than those in other subpopulations. The hemocyte types between the two species had no significant differences in staining or morphology.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wu F,Xie Z,Yan M,Li Q,Song J,Hu M,Wang Ydoi
10.1038/s41598-019-43630-8subject
Has Abstractpub_date
2019-05-08 00:00:00pages
7095issue
1issn
2045-2322pii
10.1038/s41598-019-43630-8journal_volume
9pub_type
杂志文章abstract::To further expand the substrate range of the cyclohexylamine oxidase (CHAO) from Brevibacterium oxydans, a library of diverse mutants was created and assayed toward a group of structurally diverse substrates. Among them, mutants T198A and M226A exhibited enhanced activity relative to wt CHAO for most (S)-enantiomers o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24973
更新日期:2016-05-03 00:00:00
abstract::Nanospheres of lead (Pb) have recently been identified in zircon (ZrSiO4) with the potential to compromise the veracity of U-Pb age determinations. The key assumption that the determined age is robust against the effects of Pb mobility, as long as Pb is not lost from the zircon during subsequent geological events, is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49882-8
更新日期:2019-09-23 00:00:00
abstract::Congenital reproductive tract anomalies could impair fertility. Female and male reproductive tracts are developed from Müllerian ducts and Wolffian ducts, respectively, involving initiation, elongation and differentiation. Genetic basis solely for distal reproductive tract development is largely unknown. Lhfpl2 (lipom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23037
更新日期:2016-03-11 00:00:00
abstract::In the last forty years therapy outcomes for depression have remained the same with approximately 50% of patients responding to treatments. Advances are urgently required. We hypothesised that a recent treatment, metacognitive therapy (MCT), might be more effective, by targeting mental control processes that directly ...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-64577-1
更新日期:2020-05-12 00:00:00
abstract::Autophagy is known to be implicated in the pathogenesis of Sjögren syndrome (SS), but evidences are limited. We aimed to examine the levels of autophagy markers in tear film and conjunctival epithelial cells from SS dry eye patients, and analyze their correlations with clinical features. Patients with SS dry eye exhib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17128-0
更新日期:2017-12-08 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-22724-9
更新日期:2018-03-13 00:00:00
abstract::A better understanding of the mechanisms underlying cell tropisms and the efficiency of viral infection is critical for the development of vaccines and antiviral drugs for viral diseases. In this study, we worked on the entry mechanisms of guinea pig cytomegalovirus and found that endogenous expression of a combinatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65545-5
更新日期:2020-05-22 00:00:00
abstract::Lepus yarkandensis is a desert hare of the Tarim Basin in western China, and it has strong adaptability to arid environments. Aquaporins (AQPs) are a family of water channel proteins that facilitate transmembrane water transport. Gastrointestinal tract AQPs are involved in fluid absorption in the small intestine and c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53291-2
更新日期:2019-11-12 00:00:00
abstract::This corrects the article DOI: 10.1038/srep44888. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/srep46881
更新日期:2017-08-29 00:00:00
abstract::The alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is known to trigger the adaptive response by inducing the ada-regulon - consisting of three DNA repair enzymes Ada, AlkB, AlkA and the enigmatic AidB. We have applied custom designed tiling arrays to study transcriptional changes in Escherichia coli foll...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03053
更新日期:2013-10-25 00:00:00
abstract::Human papillomavirus (HPV) is the most common sexually transmitted infection in the world and the main cause of cervical cancer. Nowadays, the virus-like particles (VLPs) based on L1 proteins have been considered as the best candidate for vaccine development against HPV infections. Two commercial HPV (Gardasil and Cer...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51679-8
更新日期:2019-10-23 00:00:00
abstract::Myocardial ischemia/reperfusion (I/R) injury detrimentally alters the prognosis of patients undergoing revascularization after acute myocardial infarction. Our previous study demonstrated that NF-κB-induced autophagy plays a detrimental role in cardiac I/R injury using a rabbit myocardial I/R model. In this study, we ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37448
更新日期:2016-11-18 00:00:00
abstract::Elastic waves are guided along finite structures such as cylinders, plates, or rods through reflection, refraction, and mode conversion at the interfaces. Such wave propagation is ubiquitous in the world around us, and studies of elastic waveguides first emerged in the later part of the 19(th) century. Early work on e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11112
更新日期:2015-06-08 00:00:00
abstract::The structure of bonds in biomolecules, such as base pairs in RNA chains or native interactions in proteins, can be presented in the form of a chord diagram. A given biomolecule is then characterized by the genus of an auxiliary two-dimensional surface associated to such a diagram. In this work we introduce the notion...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35557-3
更新日期:2018-12-03 00:00:00
abstract::When coming to identify new 2D materials, our intuition would suggest us to look from layered instead of 3D materials. However, since graphite can be hypothetically derived from diamond by stretching it along its [111] axis, many 3D materials can also potentially be explored as new candidates for 2D materials. Using a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24660
更新日期:2016-04-19 00:00:00
abstract::The indirect interactions between insect vectors, such as whiteflies, and the viruses they transmit, such as begomoviruses, via host plants may produce a range of outcome depending on the species/strain of each of the three organisms involved, and the mechanisms underlying the variations are not well understood. Here,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00692-w
更新日期:2017-04-03 00:00:00
abstract::We evaluated regression of iris neovascularization (INV) using en-face anterior-segment optical coherence tomography angiography (AS-OCTA) after anti-vascular endothelial growth factor (VEGF) therapy. Seven consecutive eyes with INV were examined before and after anti-VEGF therapy, and all AS-OCTA scans were obtained ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46514-z
更新日期:2019-07-16 00:00:00
abstract::While molecular-targeted drugs have demonstrated strong therapeutic efficacy against diverse diseases such as cancer and infection, the appearance of drug resistance associated with genetic variations in individual patients or pathogens has severely limited their clinical efficacy. Therefore, precision medicine approa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58877-9
更新日期:2020-02-07 00:00:00
abstract::Humans bargaining over money tend to reject unfair offers, whilst chimpanzees bargaining over primary rewards of food do not show this same motivation to reject. Whether such reciprocal fairness represents a predominantly human motivation has generated considerable recent interest. We induced either moderate or severe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00593
更新日期:2012-01-01 00:00:00
abstract::We investigated the association between impulsivity related traits and BMI at the observational and genetic epidemiology level in a cross-sectional population of healthy young American-European adults. We studied 998 students and university staff of European ancestry recruited from Chicago (Illinois) and Athens (Georg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53922-8
更新日期:2019-11-26 00:00:00
abstract::Living organisms have to adjust to their surrounding in order to survive in stressful conditions. We study this mechanism in one of most primitive creatures - photosynthetic green sulfur bacteria. These bacteria absorb photons very efficiently using the chlorosome antenna complexes and perform photosynthesis in extrem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05057
更新日期:2014-05-27 00:00:00
abstract::Image enhancement techniques are able to improve the contrast and visual quality of magnetic resonance (MR) images. However, conventional methods cannot make up some deficiencies encountered by respective brain tumor MR imaging modes. In this paper, we propose an adaptive intuitionistic fuzzy sets-based scheme, called...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35760
更新日期:2016-10-27 00:00:00
abstract::Novelty seeking (NS) is a personality trait reflecting excitement in response to novel stimuli. High NS is usually a predictor of risky behaviour such as drug abuse. However, the relationships between NS and risk-related cognitive processes, including individual risk preference and the brain activation associated with...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep10534
更新日期:2015-06-11 00:00:00
abstract::Ganoderma lucidum polysaccharide peptide (GLPP) scavenges oxygen free radicals that are a key factor in the pathogenesis of renal ischemia reperfusion injury (RIRI). The aim of this study was to determine whether GLPP could attenuate RIRI by counteracting the oxidative stress. The mechanism involved was assessed by an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16910
更新日期:2015-11-25 00:00:00
abstract::Just as the topology of the Fermi surface defines the properties of the free electrons in metals and semiconductors, the geometry of the iso-frequency surface in the phase space of the propagating electromagnetic waves, determines the optical properties of the corresponding optical materials. Furthermore, in the direc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17824
更新日期:2015-12-16 00:00:00
abstract::Pupillary light reflex (PLR) is an involuntary response where the pupil size changes with luminance. Studies have shown that PLR response was altered in children with autism spectrum disorders (ASDs) and other neurological disorders. However, PLR in infants and toddlers is still understudied. We conducted a longitudin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58254-6
更新日期:2020-01-27 00:00:00
abstract::Alterations in the gut microbiota play a crucial role in host physiology and metabolism; however, the molecular pathways underlying these changes in diet-induced obesity are unclear. Mechanistic target of rapamycin (mTOR) signaling pathway is associated with metabolic disorders such as obesity and type 2 diabetes (T2D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30887
更新日期:2016-07-29 00:00:00
abstract::Nitrogen-doped hierarchical porous carbons were synthesized successfully by a controllable one-pot method using glucose and dicyandiamide as carbon source and nitrogen source via hydrothermal carbonization process. The nitrogen-doped materials, possessing high nitrogen content (up to 7 wt%), large surface area (>320 m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21365
更新日期:2016-02-25 00:00:00
abstract::Most of the current studies on myocardial strain are mainly applied in patients with sinus rhythm because the image quality of arrhythmias obtained with conventional scanning sequences does not meet diagnostic needs. Here, we intend to assess left ventricular (LV) global myocardial strain in patients with arrhythmias ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66315-z
更新日期:2020-06-09 00:00:00
abstract::Eurasian Jay (Garrulus glandarius) feathers display periodic variations in the reflected colour from white through light blue, dark blue and black. We find the structures responsible for the colour are continuous in their size and spatially controlled by the degree of spinodal phase separation in the corresponding reg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18317
更新日期:2015-12-21 00:00:00