Abstract：
:Lepus yarkandensis is a desert hare of the Tarim Basin in western China, and it has strong adaptability to arid environments. Aquaporins (AQPs) are a family of water channel proteins that facilitate transmembrane water transport. Gastrointestinal tract AQPs are involved in fluid absorption in the small intestine and colon. This study aimed to determine the distribution of AQPs and sodium transporters in the gastrointestinal tract of L. yarkandensis and to compare the expression of these proteins with that in Oryctolagus cuniculus. Immunohistochemistry was performed to analyse the cellular distribution of these proteins, and the acquired images were analysed with IpWin32 software. Our results revealed that AQP1 was located in the colonic epithelium, central lacteal cells, fundic gland parietal cells, and capillary endothelial cells; AQP3 was located in the colonic epithelium, small intestinal villus epithelium, gastric pit and fundic gland; AQP4 was located in the fundic gland, small intestinal gland and colonic epithelium; and epithelial sodium channel (ENaC) and Na+-K+-ATPase were located in the epithelial cells, respectively. The higher expression levels of AQP1, AQP3, ENaC and Na+-K+-ATPase in the colon of L. yarkandensis compared to those in O. cuniculus suggested that L. yarkandensis has a higher capacity for faecal dehydration.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang J,Li S,Deng F,Baikeli B,Yu W,Liu Gdoi
10.1038/s41598-019-53291-2subject
Has Abstractpub_date
2019-11-12 00:00:00pages
16639issue
1issn
2045-2322pii
10.1038/s41598-019-53291-2journal_volume
9pub_type
杂志文章abstract：:Private Set Intersection Cardinality (PSI-CA) and Private Set Union Cardinality (PSU-CA) are two cryptographic primitives whereby two or more parties are able to obtain the cardinalities of the intersection and the union of their respective private sets, and the privacy of their sets is preserved. In this paper, we pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77579-w
更新日期：2020-12-17 00:00:00
abstract：:Recombinant protein and virus-like particle (VLP) production based on the baculovirus expression vector system is fast, flexible, and offers high yields. Independent from the product, a multitude of parameters are screened during process development/optimisation. Early development acceleration is a key requirement for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57761-w
更新日期：2020-01-23 00:00:00
abstract：:Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhanc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02940
更新日期：2013-10-15 00:00:00
abstract：:The extreme miniaturization of biological and chemical assays in aqueous-droplet compartments enables spatiotemporal control for large-scale parallel experimentation and can thus permit new capabilities for "digitizing" directed molecular evolution methodologies. We report a remarkably facile bulk method to generate m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26257
更新日期：2016-05-20 00:00:00
abstract：:Climate change significantly affects geographic distribution of plants pests and diseases worldwide. Understanding the influence of future climate change on the suitable areas of Diaphorina citri (Kuwayama) in our country and taking timely countermeasures are crucial for improving the effectiveness of control of pest....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66274-5
更新日期：2020-06-08 00:00:00
abstract：:The exact extent, by which the hydrologic cycle in the Neotropics was affected by external forcing during the last deglaciation, remains poorly understood. Here we present a new paleo-rainfall reconstruction based on high-resolution speleothem δ18O records from the core region of the South American Monsoon System (SAM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44267
更新日期：2017-03-10 00:00:00
abstract：:Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders. Mutations of the chromatin remodeling protein Lsh/HELLS can cause the human Immunodeficiency, Centromere instability and Facial ano...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00804-6
更新日期：2017-04-25 00:00:00
abstract：:For the past 30 years, oocytes from Xenopus laevis have been extensively used to express and characterise ion channels in an easily controlled environment. Here we report the first use of oocytes from the closely related species Xenopus borealis as an alternative expression system for neuronal ion channels. Using the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14763
更新日期：2015-10-06 00:00:00
abstract：:Models of biological processes are often subject to different sources of noise. Developing an understanding of the combined effects of different types of uncertainty is an open challenge. In this paper, we study a variant of the susceptible-infective-recovered model of epidemic spread, which combines both agent-to-age...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12606-x
更新日期：2017-10-11 00:00:00
abstract：:To compare the soil water balance, yield and water use efficiency (WUE) of spring maize under different mulching types in the Loess Plateau, a 7-year field experiment was conducted in the Changwu region of the Loess Plateau. Three treatments were used in this experiment: straw mulch (SM), plastic film mulch (PM) and c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38995
更新日期：2016-12-15 00:00:00
abstract：:The transcriptome of the endometrium early postpartum was profiled to determine if inflammatory gene expression was elevated in cows which subsequently developed uterine disease. Endometrial cytobrush samples were collected at 7 days postpartum (DPP) from 112 Holstein-Friesian dairy cows, from which 27 were retrospect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75104-7
更新日期：2020-10-26 00:00:00
abstract：:CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F0 animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes after double strand break (DSB) repair. Even with high efficiency levels of genome editing, phenotyp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71412-0
更新日期：2020-09-04 00:00:00
abstract：:Although most nanofabrication techniques can control nano/micro particle (NMP) size over a wide range, the majority of NMPs for biomedical applications exhibits a diameter of ~100 nm. Here, the vascular distribution of spherical particles, from 10 to 1,000 nm in diameter, is studied using intravital microscopy and com...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02079
更新日期：2013-01-01 00:00:00
abstract：:Learning a skilled movement often requires changing multiple dimensions of movement in a coordinated manner. Serial training is one common approach to learning a new movement pattern, where each feature is learned in isolation from the others. Once one feature is learned, we move on to the next. However, when learning...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56319-9
更新日期：2019-12-24 00:00:00
abstract：:Agriculture resulted in extensive population growths and human activities. However, whether major human expansions started after Neolithic Time still remained controversial. With the benefit of 1000 Genome Project, we were able to analyze a total of 910 samples from 11 populations in Africa, Europe and Americas. From ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00745
更新日期：2012-01-01 00:00:00
abstract：:Lung cancer is the foremost cause of cancer related deaths in the U.S. It is a heterogeneous disease composed of genetically and phenotypically distinct tumor cells surrounded by heterotypic cells and extracellular matrix dynamically interacting with the tumor cells. Research in lung cancer is often restricted to pati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41301-2
更新日期：2019-03-20 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep25577. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46944
更新日期：2018-02-16 00:00:00
abstract：:Functional reactivation of p53 pathway, although arduous, can potentially provide a broad-based strategy for cancer therapy owing to frequent p53 inactivation in human cancer. Using a phosphoprotein-screening array, we found that Benzyl Isothiocynate, (BITC) increases p53 phosphorylation in breast cancer cells and rev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40070
更新日期：2017-01-10 00:00:00
abstract：:Spatial organization of G-protein coupled receptors (GPCRs) into dimers and higher order oligomers has been demonstrated in vitro and in vivo. The pharmacological readout was shown to depend on the specific interfaces, but why particular regions of the GPCR structure are involved, and how ligand-determined states chan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02909
更新日期：2013-10-09 00:00:00
abstract：:Arthroplasty is a surgical procedure to restore the function of the joint of patient suffering from knee osteoarthritis. However, postoperative functional deficits are reported even after a rehabilitation program. In order to determine the origin of functional deficits of patient suffering from knee osteoarthritis and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62146-0
更新日期：2020-03-24 00:00:00
abstract：:Epigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a novel epigenetically silenced target gene. We investigated the epigenetic regulation of ABCB4 in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06899
更新日期：2014-11-04 00:00:00
abstract：:Even though a number of different in vitro fusion assays have been developed to analyze protein mediated fusion, they still only partially capture the essential features of the in vivo situation. Here we established an in vitro fusion assay that mimics the fluidity and planar geometry of the cellular plasma membrane t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12006
更新日期：2015-07-13 00:00:00
abstract：:Group-IVa elements silicon and germanium are known for their semiconducting properties at room temperature, which are technologically critical. Metallicity and superconductivity are found at higher pressures only, Ge β-tin (tI4) being the first high-pressure metallic phase in the phase diagram. However, recent experim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01466
更新日期：2013-01-01 00:00:00
abstract：:In this study, we report on a new approach for remote temperature probing that provides accuracy as good as 0.017°C (0.0055% accuracy) by measuring the magnetisation curve of magnetic nanoparticles. We included here the theoretical model construction and the inverse calculation method, and explored the impact caused b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06338
更新日期：2014-10-15 00:00:00
abstract：:Chemical separation has great importance in industrial applications. Separation of xylene isomers still prevails to be one of the most important challenges in chemical industry, due to the large amount of commercial use of p-xylene in the production of beverage bottles, fibers and films. A novel Zn(II)-based dynamic c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05761
更新日期：2014-07-21 00:00:00
abstract：:The renin-angiotensin system (RAS) plays a key role in the control of vasoconstriction as well as sodium and fluid retention mediated mainly by angiotensin (Ang) II acting at the AT1 receptor (AT1R). Ang-(1-7) is another RAS peptide, identified as the endogenous ligand of the Mas receptor and known to counterbalance m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12074-3
更新日期：2017-09-19 00:00:00
abstract：:We present a detailed study to resolve the discrepancy between the existing theoretically estimated oscillator strengths and the recently observed result from the X-ray free electron laser (XFEL) experiment performed at the Linac Coherent Light Source (LCLS) for the intensity ratio between two of the strongest emissio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43916-x
更新日期：2019-05-16 00:00:00
abstract：:This study aimed to explore the development of mental rotation ability throughout life by comparing different kinds of stimuli. Thirty-six children (6-9 years-old), 30 young (20-28 years-old) and 30 elderly people (60-82 years-old) performed mental rotation tasks with abstract (i.e. two-dimensional lines) and concrete...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37729-7
更新日期：2019-02-04 00:00:00
abstract：:The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) in both DNA and RNA. AlkB homolog 3 (ALKBH3) was als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42271
更新日期：2017-02-13 00:00:00
abstract：:Aerogels have numerous applications due to their high surface area and low densities. However, creating aerogels from a large variety of materials has remained an outstanding challenge. Here, we report a new methodology to enable aerogel production with a wide range of materials. The method is based on the assembly of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00849
更新日期：2012-01-01 00:00:00
