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Accuracy of Two Point-of-Care Tests for Rapid Diagnosis of Bovine Tuberculosis at Animal Level using Non-Invasive Specimens.

Abstract：

:Bovine tuberculosis (BTB) testing in cattle requires a significant investment of time, equipment, and labor. Novel, rapid, cheaper and accurate methods are needed. The Alere Determine TB lipoarabinomannan antigen (LAM-test) is a World Health Organization-endorsed point-of-care urine test designed to detect active TB disease in humans. The Lionex Animal TB Rapid Test (Lionex-test) is a novel animal specific TB diagnostic blood test. An animal level analysis was performed using urine (n = 141) and milk (n = 63) samples from depopulated BTB-suspected cattle to test the accuracy of the LAM-test when compared to results of positive TB detection by any routine BTB tests (BOVIGAM, necropsy, histology, culture, PCR) that are regularly performed by the United States Department of Agriculture (USDA). The agreement between the urine LAM-test and USDA standard tests were poor at varying testing time points. The same milk samples did not elicit statistically significant agreement with the Lionex-test, although positive trends were present. Hence, we cannot recommend the LAM-test as a valid BTB diagnostic test in cattle using either urine or milk. The Lionex-test's production of positive trends using milk samples suggests larger sample sizes may validate the Lionex-test in accurately diagnosing BTB in cattle using milk samples, potentially providing a quick and reliable field test for BTB.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kelley HV,Waibel SM,Sidiki S,Tomatis-Souverbielle C,Scordo JM,Hunt WG,Barr N,Smith R,Silwani SN,Averill JJ,Baer S,Hengesbach J,Yildiz VO,Pan X,Gebreyes WA,Balada-Llasat JM,Wang SH,Torrelles JB

doi

10.1038/s41598-020-62314-2

subject

Has Abstract

pub_date

2020-03-25 00:00:00

pages

5441

issue

1

issn

2045-2322

pii

10.1038/s41598-020-62314-2

journal_volume

10

pub_type

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