Non-invasive nanosecond electroporation for biocontrol of surface infections: an in vivo study.

abstract：:Escherichia coli lac repressor (LacI) is a paradigmatic transcriptional factor that controls the expression of lacZYA in the lac operon. This tetrameric protein specifically binds to the O1, O2 and O3 operators of the lac operon and forms a DNA loop to repress transcription from the adjacent lac promoter. In this arti...

journal_title：Scientific reports

authors： Fulcrand G,Dages S,Zhi X,Chapagain P,Gerstman BS,Dunlap D,Leng F

更新日期：2016-01-14 00:00:00

abstract：:Anti-mucin1 (MUC1) antibodies have long been used clinically in cancer diagnosis and therapy and specific bindings of some of them are known to be dependent on the differential glycosylation of MUC1. However, a systematic comparison of the binding specificities of anti-MUC1 antibodies was not previously conducted. Her...

journal_title：Scientific reports

authors： Yoshimura Y,Denda-Nagai K,Takahashi Y,Nagashima I,Shimizu H,Kishimoto T,Noji M,Shichino S,Chiba Y,Irimura T

更新日期：2019-11-12 00:00:00

abstract：:The use of anti-cancer adjuvant therapy is rationalized by potentiating the efficacy, and/or protecting from major side effects of chemotherapeutics. Thymoquinone (TQ) is a naturally occurring compound with cumulative evidence of anti-cancer properties. In this study, we assessed the chemomodulatory potential of TQ to...

journal_title：Scientific reports

authors： Bashmail HA,Alamoudi AA,Noorwali A,Hegazy GA,AJabnoor G,Choudhry H,Al-Abd AM

更新日期：2018-08-03 00:00:00

abstract：:Nanothermometry methods with intracellular sensitivities have the potential to make important contributions to fundamental cell biology and medical fields, as temperature is a relevant physical parameter for molecular reactions to occur inside the cells and changes of local temperature are well identified therapeutic ...

journal_title：Scientific reports

authors： Savchuk OA,Silvestre OF,Adão RMR,Nieder JB

更新日期：2019-05-17 00:00:00

abstract：:The sensing properties of monolayer arsenic phosphorus (AsP) for the adsorption of SF6, H2O, O2, and SF6 decomposition gases (SO2 and H2S) are theoretically investigated by the first-principle calculations. We calculate the adsorption energy, equilibrium distance, Mulliken charge transfer, and electron localization fu...

journal_title：Scientific reports

authors： Jin W,Guofeng Y,Junjun X,Jianming L,Qing C,Dunjun C,Hai L,Rong Z,Youdou Z

更新日期：2018-08-13 00:00:00

abstract：:Podocyte loss is the initial event in the development of glomerulosclerosis, the structural hallmark of progressive proteinuric nephropathies. Understanding mechanisms underlying glomerular injury is the key challenge for identifying novel therapeutic targets. In mice with protein-overload induced by bovine serum albu...

journal_title：Scientific reports

authors： Morigi M,Locatelli M,Rota C,Buelli S,Corna D,Rizzo P,Abbate M,Conti D,Perico L,Longaretti L,Benigni A,Zoja C,Remuzzi G

更新日期：2016-06-27 00:00:00

abstract：:Correlations between fluctuations in resting state BOLD fMRI signals are interpreted as measures of functional connectivity (FC), but the neural basis of their origins and their relationships to specific features of underlying electrophysiologic activity, have not been fully established. In particular, the dependence ...

journal_title：Scientific reports

authors： Shi Z,Wilkes DM,Yang PF,Wang F,Wu R,Wu TL,Chen LM,Gore JC

更新日期：2019-06-20 00:00:00

abstract：:The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a potential therapeutic target for endocrine, metabolic and stress-related disorders. However, many questions regarding the protein structure and dynamics of PAC1R remain largely unanswered. Using microsecond-long simulations,...

journal_title：Scientific reports

authors： Liao C,Zhao X,Brewer M,May V,Li J

更新日期：2017-07-14 00:00:00

abstract：:Bile acids (BAs) are key mediators of the glycemic control after bariatric surgeries. Cholecystectomy modifies the kinetics of BAs, and whether this procedure influences the BAs pool and its metabolic response to bariatric surgeries is not known. We used targeted and untargeted metabolomics to assess whether cholecyst...

journal_title：Scientific reports

authors： Machado NM,Cardinelli CS,Shen T,Santo MA,Torrinhas RS,Waitzberg DL

更新日期：2020-06-30 00:00:00

abstract：:Although the power conversion efficiency (PCE) of perovskite solar cells (PSCs) reached up to 23%, their short lifetime and fast degradation still remain as the main challenges. In this work, a new facile optical method based on the high power UV-irradiation is presented for the recovery of the degraded PSCs. Addition...

journal_title：Scientific reports

authors： Arabpour Roghabadi F,Mansour Rezaei Fumani N,Alidaei M,Ahmadi V,Sadrameli SM

更新日期：2019-07-01 00:00:00

abstract：:Blockage of Delta-like 4 (DLL4)-directed Notch signaling induces excessive tip cell formation and endothelial proliferation resulting in dysfunctional angiogenesis in tumors. MMGZ01, as a murine anti-human DLL4 monoclonal antibody, specifically binds to human DLL4 and blocks Notch pathway. Here, the structure of MMGZ0...

journal_title：Scientific reports

authors： Jia X,Wang W,Xu Z,Wang S,Wang T,Wang M,Wu M

更新日期：2016-06-15 00:00:00

abstract：:Although several studies have investigated the association between C4, C4A, and C4B gene copy number variations (CNVs) and susceptibility to autoimmune diseases, the results remain inconsistency for those diseases. Thus, in this study, a comprehensive meta-analysis was conducted to assess the role of C4, C4A, and C4B ...

journal_title：Scientific reports

authors： Li N,Zhang J,Liao D,Yang L,Wang Y,Hou S

更新日期：2017-02-16 00:00:00

abstract：:The Simon effect refers to the acceleration of choice responses when the target position and response location are consistent compared with scenarios in which they are inconsistent, even if the target position is not relevant to the response. Here, we provide the first demonstration that the tactile Simon-like effect ...

journal_title：Scientific reports

authors： Zheng W,Chen L

更新日期：2018-06-08 00:00:00

abstract：:Rice black-streaked dwarf disease, caused by rice black-streaked dwarf virus (RBSDV), is transmitted by small brown planthoppers (Laodelphax striatellus Fallén, SBPH) and causes severe yield loss in epidemic years in China and other East Asian countries. Breeding for resistance to RBSDV is a promising strategy to cont...

journal_title：Scientific reports

authors： Zhou T,Du L,Wang L,Wang Y,Gao C,Lan Y,Sun F,Fan Y,Wang G,Zhou Y

更新日期：2015-07-22 00:00:00

abstract：:Orthographic regularity is important for processing Chinese characters. However, the issues how orthographic regularity influences the visual recognition of real Chinese characters and whether common processes related to the potential effect exist between successive (SUCC) and concurrent (CONC) conditions with asynchr...

journal_title：Scientific reports

authors： He W,Fan C,Ren J,Liu T,Zhang M,Luo W

更新日期：2016-03-23 00:00:00

abstract：:Pearl millet hybrids biofortified with iron (Fe) and zinc (Zn) promise to be part of a long-term strategy to combat micronutrient malnutrition in the arid and semi-arid tropical (SAT) regions of the world. Biofortification through molecular breeding is the way forward to achieving a rapid trait-based breeding strategy...

journal_title：Scientific reports

authors： Pujar M,Gangaprasad S,Govindaraj M,Gangurde SS,Kanatti A,Kudapa H

更新日期：2020-11-10 00:00:00

abstract：:We study localized photonic excitations in a quasi-two-dimensional non-ideal binary microcavity lattice with use of the virtual crystal approximation. The effect of point defects (vacancies) on the excitation spectrum is investigated by numerical modelling. We obtain the dispersion and the energy gap of the electromag...

journal_title：Scientific reports

authors： Rumyantsev V,Fedorov S,Gumennyk K,Sychanova M,Kavokin A

更新日期：2014-11-06 00:00:00

abstract：:Climate change is expected to have profound, partly unforeseeable effects on the composition of functional traits of complex ecosystems, such as coral reefs, and some ecosystem properties are at risk of disappearing. This study applies a novel spatially explicit, individual-based model to explore three critical life h...

journal_title：Scientific reports

authors： Kubicek A,Breckling B,Hoegh-Guldberg O,Reuter H

更新日期：2019-03-06 00:00:00

abstract：:SNPs may restrict cell detoxification activity and be a potential risk factor for cancer chemosensitivity. We evaluated the predictive value of these polymorphisms on the sensitivity of bladder cancer patients to epirubicin and mitomycin chemotherapy instillation as well as their toxicities. SNPs were analyzed by TaqM...

journal_title：Scientific reports

authors： Deng X,Yang X,Cheng Y,Liu X,Li X,Zhao R,Qin C,Lu Q,Yin C

更新日期：2015-09-10 00:00:00

abstract：:Periodontitis is a local and systemic inflammatory condition and a risk factor of atherosclerosis, but no studies investigated the effect of a statin on atherogenesis affected by severe periodontitis. In this study, we investigated the effect of rosuvastatin (RSV) on atherogenesis in Apolipoprotein E-deficient mice re...

journal_title：Scientific reports

authors： Suh JS,Lee SH,Fouladian Z,Lee JY,Kim T,Kang MK,Lusis AJ,Boström KI,Kim RH,Park NH

更新日期：2020-04-14 00:00:00

abstract：:A novel process to control light through the coupling modulation by surface acoustic wave (SAW) is presented in an optical micro resonator. An optical waveguide modulator of a racetrack resonator on silicon-on-insulator (SOI) technology is took as an example to explore the mechanism. A finite-difference time-domain (F...

journal_title：Scientific reports

authors： Fan G,Li Y,Hu C,Lei L,Guo Y

更新日期：2016-08-03 00:00:00

abstract：:Viral infection triggers a series of signaling cascades, which converge to activate the transcription factors nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3), thereby inducing the transcription of type I interferons (IFNs). Although not fully characterized, these innate antiviral responses are fine...

journal_title：Scientific reports

authors： Zhang H,Wang D,Zhong H,Luo R,Shang M,Liu D,Chen H,Fang L,Xiao S

更新日期：2015-06-10 00:00:00

abstract：:The PRL phosphatases are oncogenic when overexpressed but their in vivo biological function is less well understood. Previous gene deletion study revealed a role for PRL2 in spermatogenesis. We report here the first knockout mice lacking PRL1, the most related homolog of PRL2. We found that loss of PRL1 does not affec...

journal_title：Scientific reports

authors： Bai Y,Zhou HM,Zhang L,Dong Y,Zeng Q,Shou W,Zhang ZY

更新日期：2016-09-26 00:00:00

abstract：:The brain lacks a traditional lymphatic system for metabolite clearance. The existence of a "glymphatic system" where metabolites are removed from the brain's extracellular space by convective exchange between interstitial fluid (ISF) and cerebrospinal fluid (CSF) along the paravascular spaces (PVS) around cerebral bl...

journal_title：Scientific reports

authors： Kedarasetti RT,Drew PJ,Costanzo F

更新日期：2020-06-22 00:00:00

abstract：:High Resolution Melt (HRM) is a versatile and rapid post-PCR DNA analysis technique primarily used to differentiate sequence variants among only a few short amplicons. We recently developed a one-vs-one support vector machine algorithm (OVO SVM) that enables the use of HRM for identifying numerous short amplicon seque...

journal_title：Scientific reports

authors： Fraley SI,Athamanolap P,Masek BJ,Hardick J,Carroll KC,Hsieh YH,Rothman RE,Gaydos CA,Wang TH,Yang S

更新日期：2016-01-18 00:00:00

abstract：:Developing rationally controlled bottom-up device fabrication processes is essential for the achievement of high performance optimal devices. We report a controlled, seedless and site-selective hydrothermal technique to fabricate high-performance nanostructured ZnO UV-detectors directly on-chip. We demonstrate that by...

journal_title：Scientific reports

authors： Alenezi MR,Henley SJ,Silva SR

更新日期：2015-02-17 00:00:00

abstract：:Generation of multiple genomic alterations is currently a time consuming process. Here, a method was established that enables highly efficient and simultaneous deletion of multiple genes in Escherichia coli. A temperature sensitive plasmid containing arabinose inducible lambda Red recombineering genes and a rhamnose i...

journal_title：Scientific reports

authors： Jensen SI,Lennen RM,Herrgård MJ,Nielsen AT

更新日期：2015-12-08 00:00:00

abstract：:While previous studies separately demonstrate EEG spectral modulations during speech preparation and ERP responses to the listened speech, it is unclear whether these responses are related on a trial-by-trial basis between a speaker and listener. In order to determine whether these responses are related in real-time, ...

journal_title：Scientific reports

authors： Bridwell DA,Henderson S,Sorge M,Plis S,Calhoun VD

更新日期：2018-08-27 00:00:00

abstract：:Although the Guangxi region accounts for 10% of all HIV-1 cases new reported in 2011 in China, the sources of the transmitted HIV-1 strains are virtually unknown. To determine the extent to which recent HIV infections were derived from already circulating local strains as opposed to recently introduced strains, we per...

journal_title：Scientific reports

authors： Li J,Feng Y,Shen Z,Li Y,Tang Z,Xiong R,Zhang H,Wei J,Zhou X,Deng Y,Fang N,Lan G,Liang S,Zhu Q,Xing H,Ruan Y,Shao Y

更新日期：2018-08-27 00:00:00

abstract：:Although it has been reported that uterine signal transducer and activator of transcription 3 (STAT3) is essential for embryo implantation, the exact roles of uterine epithelial and stromal STAT3 on embryo implantation have not been elucidated. To address this issue, we generated Stat3-floxed/Ltf-iCre (Stat3-eKO), Sta...

journal_title：Scientific reports

authors： Hiraoka T,Hirota Y,Fukui Y,Gebril M,Kaku T,Aikawa S,Hirata T,Akaeda S,Matsuo M,Haraguchi H,Saito-Kanatani M,Shimizu-Hirota R,Takeda N,Yoshino O,Fujii T,Osuga Y

更新日期：2020-09-23 00:00:00