Abstract：
:Invasive infections caused by drug-resistant bacteria are frequently responsible for fatal sepsis, morbidity and mortality rates. In this work, we propose a new methodology based on nanosecond high frequency electric field bursts, which enables successful eradication of bacteria in vivo. High frequency (15 kHz) 15-25 kV/cm 300-900 ns pulsing bursts were used separately and in combination with acetic acid (0.1-1%) to treat Pseudomonas aeruginosa in a murine model. Acetic acid 1% alone was effective resulting in almost 10-fold reduction of bacteria viability, however combination of nanosecond electric field and acetic acid 1% treatment was the most successful showing almost full eradication (0.01% survival compared to control) of the bacteria in the contaminated area. The short duration of the pulses (sub-microsecond) and high frequency (kHz range) of the burst enabled reduction of the muscle contractions to barely detectable level while the proposed applicators ensured predominantly topical treatment, without electroporation of deeper tissues. The results of our study have direct application for treatment of wounds and ulcers when chemical treatment is no longer effective.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Novickij V,Zinkevičienė A,Perminaitė E,Čėsna R,Lastauskienė E,Paškevičius A,Švedienė J,Markovskaja S,Novickij J,Girkontaitė Idoi
10.1038/s41598-018-32783-7subject
Has Abstractpub_date
2018-09-28 00:00:00pages
14516issue
1issn
2045-2322pii
10.1038/s41598-018-32783-7journal_volume
8pub_type
杂志文章abstract：:Transcatheter arterial embolization (TAE), as an alternative to surgery for iatrogenic renal vascular injury (IRVI), may have unsatisfactory outcomes. Nonetheless, there is inadequate information regarding the predictors of TAE outcomes for IRVI in the literature. The aim of this retrospective study was to investigate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53561-z
更新日期：2019-11-19 00:00:00
abstract：:Glutamine (Gln) is converted to excitatory (glutamate, aspartate) and inhibitory (γ-amino butyric acid) amino acid neurotransmitters in brain, and is a source of energy during glucose deprivation. Current research utilized an Analytical Quality by Design approach to optimize levels and combinations of critical gas pre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64099-w
更新日期：2020-04-28 00:00:00
abstract：:In music, the perception of pitch is governed largely by its tonal function given the preceding harmonic structure of the music. While behavioral research has advanced our understanding of the perceptual representation of musical pitch, relatively little is known about its representational structure in the brain. Usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19222-3
更新日期：2018-01-16 00:00:00
abstract：:Growing evidences showed that a large number of miRNAs were abnormally expressed in cervical cancer tissues and played irreplaceable roles in tumorigenesis, progression and metastasis. The aim of the present study was to identify the differential miRNAs expression between cervical cancer and normal cervical tissues by...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06032-2
更新日期：2017-07-17 00:00:00
abstract：:Kohlschutter-Tönz syndrome (KTS) is a rare genetic disorder with neurological dysfunctions including seizure and intellectual impairment. Mutations at the Rogdi locus have been linked to development of KTS, yet the underlying mechanisms remain elusive. Here we demonstrate that a Drosophila homolog of Rogdi acts as a n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11941-3
更新日期：2017-09-12 00:00:00
abstract：:Lipidomic analyses address the problem of characterizing the lipid components of given cells, tissues and organisms by means of chromatographic separations coupled to high-resolution, tandem mass spectrometry analyses. A number of software tools have been developed to help in the daunting task of mass spectrometry sig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70259-9
更新日期：2020-08-07 00:00:00
abstract：:The neuropeptide oxytocin has been shown to affect social interaction. Meanwhile, the underlying mechanism remains highly debated. Using an interpersonal finger-tapping paradigm, we investigated whether oxytocin affects the ability to synchronise with and adapt to the behaviour of others. Dyads received either oxytoci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38416
更新日期：2016-12-08 00:00:00
abstract：:Switching magnetizations with femtosecond circularly polarized lasers may have revolutionary impacts on magnetic data storage and relevant applications. Achievements in ferrimagnetic and ferromagnetic materials of various structures strongly imply a general phenomenon of fundamental atom-laser interaction. Rotating an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41294
更新日期：2017-01-24 00:00:00
abstract：:Malaria is a fatal disease that displays a spectrum of symptoms and severity, which are determined by complex host-parasite interactions. It has been difficult to study the effects of parasite strains on disease severity in human infections, but the mechanisms leading to specific disease phenotypes can be investigated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10776-2
更新日期：2017-09-05 00:00:00
abstract：:Ginseng rusty root (GRR) symptom is one of the primary diseases of ginseng. There has been a problem of ginseng rusty root, leading to a severe decline in the quality of ginseng. To clarify the relationship between root symptoms of ginseng rust and soil, the physical and chemical properties, enzyme activity, community...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71024-8
更新日期：2020-09-25 00:00:00
abstract：:Intriguing experimental results raised the question about the fundamental mechanisms governing the electron-hole coupling induced bipolar thermal conduction in semiconductors. Our combined theoretical analysis and experimental measurements show that in semiconductors bipolar thermal transport is in general a "conducti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10136
更新日期：2015-05-13 00:00:00
abstract：:During pregnancy several maternal adaptations occur in order to support the growing fetus which are further exacerbated by gestational diabetes mellitus (GDM). Previously we developed a mouse model of GDM, however we did not evaluate alterations to energy and fat metabolism. We have also shown that alterations in lipi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77529-6
更新日期：2020-11-30 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62442-9
更新日期：2020-04-02 00:00:00
abstract：:The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specific antibodies have been shown to control virus clearance, but an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20305-4
更新日期：2018-01-30 00:00:00
abstract：:Spinal cord injury (SCI) leads to wide-spread neurodegeneration across the neuroaxis. We explored trajectories of surface morphology, demyelination and iron concentration within the basal ganglia-thalamic circuit over 2 years post-SCI. This allowed us to explore the predictive value of neuroimaging biomarkers and dete...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70805-5
更新日期：2020-08-24 00:00:00
abstract：:This study aimed to assess the validity and functional relevance of a standardized procedure to assess lower limb muscle power by means of the 30-s sit-to-stand (STS) test when compared to leg extension power (LEP), traditional STS performance and handgrip strength. A total of 628 community-dwelling older subjects (60...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73395-4
更新日期：2020-10-01 00:00:00
abstract：:Standard aquatic toxicity tests of chemicals are often limited by the chemicals' water solubility. Liposomes have been widely used in the pharmaceutical industry to overcome poor pharmacokinetics and biodistribution. In this work, liposomes were synthesized and used in an ecotoxicological context, as a tool to assure ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66694-3
更新日期：2020-06-16 00:00:00
abstract：:The endoplasmic reticulum (ER) is a multi functional organelle and plays a crucial role in protein folding and lipid biosynthesis. The SEC59 gene encodes dolichol kinase, required for protein glycosylation in the ER. The mutation of sec59-1 caused a protein N-glycosylation defect mediated ER stress resulting in increa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51054-7
更新日期：2019-10-09 00:00:00
abstract：:Alzheimer's disease (AD) is a severe neurodegenerative disorder for which identification of differentially expressed genes is one way to find new therapeutic targets. Here, we conducted analysis to identify age-independent, AD-specific genes. We found that the MET, WIF1, and NPTX2 genes are downregulated in AD. WIF1 a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21256-6
更新日期：2018-02-09 00:00:00
abstract：:Flexible thermoelectric generators (TEGs) can provide uninterrupted, green energy from body-heat, overcoming bulky battery configurations that limit the wearable-technologies market today. High-throughput production of flexible TEGs is currently dominated by printing techniques, limiting material choices and performan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41000-y
更新日期：2019-03-13 00:00:00
abstract：:Bioactive gibberellins (GAs) are essential phytohormones involved in the regulation of many aspects of plant development. GA receptors are crucial in GA signal transduction in plants. The GA receptor GoGID1 promotes plant elongation and improves biomass production when ectopically expressed in tobacco. Here, we discov...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41296
更新日期：2017-01-27 00:00:00
abstract：:Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and ana...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78832-y
更新日期：2020-12-17 00:00:00
abstract：:Frequency shifts in signals of bats flying near conspecifics have been interpreted as a spectral jamming avoidance response (JAR). However, several prerequisites supporting a JAR hypothesis have not been controlled for in previous studies. We recorded flight and echolocation behavior of foraging Pipistrellus pipistrel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30978
更新日期：2016-08-09 00:00:00
abstract：:Constrained layer dampers (CLD) are in widespread use for passive vibration damping, in applications including aerospace structures. However, the introducing of the damping layer can reduce the stiffness of the sandwich structures. A viscoelastic material filling (VMF) is chosen to balance structural and vibrational p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27963-4
更新日期：2018-06-25 00:00:00
abstract：:Lupus nephritis is a crucial complication of systemic lupus erythematosus. In this study, we investigated the roles of mouse natural killer T (NKT) cells in lupus nephritis. From 24 weeks of age, NZB/NZW F1 mice were injected with alpha-galactosylceramide (α-GalCer) or vehicle once a week for four weeks. In the α-GalC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26470-w
更新日期：2018-05-29 00:00:00
abstract：:Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09386-9
更新日期：2017-08-21 00:00:00
abstract：:Irreversible electroporation (IRE) as a non-thermal tumor ablation technology has been studied for the treatment of pancreatic carcinoma and has shown a significant survival benefit. We discovered that moderate heating (MH) at 43 °C for 1-2 minutes significantly enhanced ex vivo IRE tumor ablation of Pan02 cells by 5....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12227-4
更新日期：2017-09-18 00:00:00
abstract：:With Motor imagery (MI), movements are mentally rehearsed without overt actions; this procedure has been adopted in motor rehabilitation, primarily in brain-damaged patients. Here we rather tested the clinical potentials of MI in purely orthopaedic patients who, by definition, should maximally benefit of mental exerci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65820-5
更新日期：2020-06-02 00:00:00
abstract：:In order to study the molecular differences between type 2 diabetes mellitus (T2DM) and T2DM with depression (DD), we aimed to screen the differential expression of lncRNA, mRNA, and circRNA in the blood of patients with T2DM and DD. Based on the self-rating depression scale (SDS), patient health questionnaire 9 (PHQ9...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47077-9
更新日期：2019-07-24 00:00:00
abstract：:Sex steroids, such as estrogens and androgens, are important regulators of the humoral immune response. Studies in female mice have demonstrated that alteration of circulating estrogen concentration regulates antibody-mediated immunity. As males have normally little endogenous estrogen, we hypothesized that in males h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75059-9
更新日期：2020-10-27 00:00:00
