Abstract:
:Biomaterial injection is a novel therapy to treat ischemic heart failure (HF) that has shown to reduce remodeling and restore cardiac function in recent preclinical studies. While the effect of biomaterial injection in reducing mechanical wall stress has been recently demonstrated, the influence of biomaterials on the electrical behavior of treated hearts has not been elucidated. In this work, we developed computational models of swine hearts to study the electrophysiological vulnerability associated with biomaterial injection therapy. The propagation of action potentials on realistic biventricular geometries was simulated by numerically solving the monodomain electrophysiology equations on anatomically-detailed models of normal, HF untreated, and HF treated hearts. Heart geometries were constructed from high-resolution magnetic resonance images (MRI) where the healthy, peri-infarcted, infarcted and gel regions were identified, and the orientation of cardiac fibers was informed from diffusion-tensor MRI. Regional restitution properties in each case were evaluated by constructing a probability density function of the action potential duration (APD) at different cycle lengths. A comparative analysis of the ventricular fibrillation (VF) dynamics for every heart was carried out by measuring the number of filaments formed after wave braking. Our results suggest that biomaterial injection therapy does not affect the regional dispersion of repolarization when comparing untreated and treated failing hearts. Further, we found that the treated failing heart is more prone to sustain VF than the normal heart, and is at least as susceptible to sustained VF as the untreated failing heart. Moreover, we show that the main features of VF dynamics in a treated failing heart are not affected by the level of electrical conductivity of the biogel injectates. This work represents a novel proof-of-concept study demonstrating the feasibility of computer simulations of the heart in understanding the arrhythmic behavior in novel therapies for HF.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ramírez WA,Gizzi A,Sack KL,Guccione JM,Hurtado DEdoi
10.1038/s41598-020-69900-4subject
Has Abstractpub_date
2020-07-31 00:00:00pages
12990issue
1issn
2045-2322pii
10.1038/s41598-020-69900-4journal_volume
10pub_type
杂志文章abstract::Understanding and mitigating decoherence is a key challenge for quantum science and technology. The main source of decoherence for solid-state spin systems is the uncontrolled spin bath environment. Here, we demonstrate quantum control of a mesoscopic spin bath in diamond at room temperature that is composed of electr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00382
更新日期:2012-01-01 00:00:00
abstract::Chemical purity of RNA samples is important for high-precision studies of RNA folding and catalytic behavior, but photodamage accrued during ultraviolet (UV) shadowing steps of sample preparation can reduce this purity. Here, we report the quantitation of UV-induced damage by using reverse transcription and single-nuc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00517
更新日期:2012-01-01 00:00:00
abstract::The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the TARGT pipeline for...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64312-w
更新日期:2020-04-30 00:00:00
abstract::The use of metabolomic and lipidomic strategies for selecting potential biomarkers for obstructive sleep apnoea (OSA) has been little explored. We examined adult male patients with OSA (defined by an apnoea-hypopnoea index ≥15 events/hour), as well as age-, gender-, and fat-composition-matched volunteers without OSA. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29727-6
更新日期:2018-07-26 00:00:00
abstract::A three dimensional (3D) numerical solution of unsteady, Ag-MgO hybrid nanoliquid flow with heat and mass transmission caused by upward/downward moving of wavy spinning disk has been scrutinized. The magnetic field has been also considered. The hybrid nanoliquid has been synthesized in the presence of Ag-MgO nanoparti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75905-w
更新日期:2020-11-02 00:00:00
abstract::We demonstrate the capability of a novel Electron Backscatter Diffraction (EBSD) dictionary indexing (DI) approach by means of orientation mapping of a highly deformed graded microstructure in a shot peened Aluminium 7075-T651 alloy. A low microscope accelerating voltage was used to extract, for the first time from a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29315-8
更新日期:2018-07-20 00:00:00
abstract::This research aimed to assess the associations of 7 parkin RBR E3 ubiquitin protein ligase (PRKN) and 4 parkin coregulated gene (PACRG) single-nucleotide polymorphisms (SNPs), their haplotypes, gene-gene (G × G) and gene-environment (G × E) interactions with hyperlipidaemia in the Chinese Maonan minority. The genotype...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68826-1
更新日期:2020-08-03 00:00:00
abstract::Membrane fouling remains an obstacle to wide-spread applications of membrane bioreactors (MBRs) for wastewater treatment and reclamation. Herein, we report a simple method to prepare a composite conductive microfiltration (MF) membrane by introducing a stainless steel mesh into a polymeric MF membrane and to effective...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09268
更新日期:2015-03-18 00:00:00
abstract::Hominin dietary specialization is crucial to understanding the evolutionary changes of craniofacial biomechanics and the interaction of food processing methods' effects on teeth. However, the diet-related dental wear processes of the earliest European hominins remain unknown because most of the academic attention has ...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/srep43319
更新日期:2017-02-27 00:00:00
abstract::Our previous study suggested that microtubule network alteration affects the process of glycolysis in cardiomyocytes (CMs) via the regulation of hypoxia-inducible factor (HIF)-1α during the early stages of hypoxia. However, little is known regarding the underlying mechanisms of microtubule network alteration-induced c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09193
更新日期:2015-03-17 00:00:00
abstract::The immune checkpoint based therapy targeting the programmed death-1 (PD-1) receptor and its PD-L1 ligand has recently been approved for the therapy of different malignant conditions, but not yet for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). In this context, we evaluated the expression of PD-1 and PD-L1...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/s41598-018-36129-1
更新日期:2018-12-13 00:00:00
abstract::No licensed human vaccines are currently available against leishmaniasis. Several anti-leishmanial vaccines are currently undergoing testing, including genetically modified live-attenuated parasite vaccines. Studies with live attenuated Leishmania vaccines such as centrin deleted Leishmania donovani parasites (LdCen -...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05088-4
更新日期:2017-07-05 00:00:00
abstract::Halobacteria, a class of Euryarchaeota are extremely halophilic archaea that can adapt to a wide range of salt concentration generally from 10% NaCl to saturated salt concentration of 32% NaCl. It consists of the orders: Halobacteriales, Haloferaciales and Natriabales. Pan-genome analysis of class Halobacteria was don...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77723-6
更新日期:2020-12-03 00:00:00
abstract::Blueberry juice is a healthy and nutritious food that has become increasingly popular worldwide. However, little is known about the microbial groups of this juice that can cause its spoilage. This study aimed to identify the main spoilage microorganisms in blueberry juice and explore whether a microchip pulsed electri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26513-2
更新日期:2018-05-25 00:00:00
abstract::Hedgehog interacting protein (Hhip) is essential for islet formation and beta-cell proliferation during pancreatic development; abnormally elevated Hhip expression has been linked to human pancreatitis. Here, we investigate the role of Hhip in modulating insulin secretion in adult Hhip mice (Hhip +/- vs. Hhip+/+) fed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47633-3
更新日期:2019-08-01 00:00:00
abstract::Sex hormones influence the prevalence and the outcome of heart diseases. The conversion of testosterone to its more active metabolite dihydrotestosterone drives cardiac growth and dysfunction, while inhibition of this step by the anti-androgenic drug finasteride counteracts these pathological processes in preclinical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46640-8
更新日期:2019-07-12 00:00:00
abstract::Potential benefits of carbohydrate counting for glycemic control in patients with type 1 diabetes mellitus (T1DM) remain inconclusive. Our aim is to systematically assess the efficacy of carbohydrate counting in patients with T1DM. We searched PubMed, Embase, Web of Science, Cochrane Library and the Chinese Biology Me...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep37067
更新日期:2016-11-14 00:00:00
abstract::Human platelet antigens (HPAs) are membranous glycoproteins considered as alloantigens due to their polymorphisms. HPA-incompatibility in multiple pregnancies or blood transfusion can induce the development of alloantibodies leading to thrombocytopenia. The frequency of HPAs varies among populations, so that deep know...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64469-4
更新日期:2020-05-04 00:00:00
abstract::Aggressive interactions between groups are frequent in human societies and can bear significant fitness costs and benefits (e.g. death or access to resources). During between-group competitive interactions, more cohesive groups (i.e. groups formed by individuals who cooperate in group defence) should out-perform less ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43277
更新日期:2017-02-24 00:00:00
abstract::Blood platelets are instrumental in blood clotting and are thus heavily involved in early wound closure. After adhering to a substrate they spread by forming protrusions like lamellipodia and filopodia. However, the interaction of these protrusions with the physical environment of platelets while spreading is not full...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22357
更新日期:2016-03-03 00:00:00
abstract::Tuned gene expression is crucial to the proper growth and response to the environmental changes of an organism. To enable tunable gene expression as designed is desirable in both scientific research and industrial application. Here, we introduce a novel promoter switching method based on the DDI2 promoter (PDDI2) that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49000-8
更新日期:2019-08-29 00:00:00
abstract::Estimating the potential distribution of invasive species has been primarily achieved by employing species distribution models (SDM). Recently introduced joint species distribution models (JSDM) that include species interactions are expected to improve model output. Here we compare the predictive ability of SDM and JS...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52256-9
更新日期:2019-11-01 00:00:00
abstract::We set out to determine the usability of serum neurofilament light chain (sNfL), serum glial fibrillary acidic protein (sGFAP), and retinal parameters by using optical coherence tomography (OCT) as reliable biomarkers of the progression of oxaliplatin-induced peripheral neuropathy (OIPN). Forty-three patients schedule...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64511-5
更新日期:2020-05-14 00:00:00
abstract::Editor's Note: this Article has been retracted; the Retraction Note is available at https://www.nature.com/articles/s41598-020-77203-x. ...
journal_title:Scientific reports
pub_type: 已发布勘误,撤回出版物
doi:10.1038/s41598-020-77203-x
更新日期:2020-12-01 00:00:00
abstract::Oxalate decarboxylase (OXDC) enzyme has immense biotechnological applications due to its ability to decompose anti-nutrient oxalic acid. Flammulina velutipes, an edible wood rotting fungus responds to oxalic acid by induction of OXDC to maintain steady levels of pH and oxalate anions outside the fungal hyphae. Here, w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14578
更新日期:2015-10-12 00:00:00
abstract::Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants linked to PD in SNCA. However, the consequences of this genetic variabi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54865-w
更新日期:2019-12-05 00:00:00
abstract::Episodic memories are long lasting and full of detail, yet imperfect and malleable. We quantitatively evaluated recollection of short audiovisual segments from movies as a proxy to real-life memory formation in 161 subjects at 15 minutes up to a year after encoding. Memories were reproducible within and across individ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30175
更新日期:2016-09-30 00:00:00
abstract::Microbial rhodopsin is a photoreceptor protein found in various bacteria and archaea, and it is considered to be a light-utilization device unique to heterotrophs. Recent studies have shown that several cyanobacterial genomes also include genes that encode rhodopsins, indicating that these auxiliary light-utilizing pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73606-y
更新日期:2020-10-07 00:00:00
abstract::Natural and anthropogenic stressors can cause phase shifts from coral-dominated to algal-dominated states. In the Caribbean, over-fishing of large herbivorous fish and disease among the long-spined urchin, Diadema, have facilitated algal growth on degraded reefs. We found that diminutive species of urchin and parrotfi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39670
更新日期:2017-01-05 00:00:00
abstract::Inspired by the well-documented tumor protecting ability of paullones, recently, we synthesized novel paullone-like scaffolds, indole-fused benzo-oxazepines (IFBOs), and screened them against hepatocellular carcinoma (HCC) specific Hep-G2 cells. Three of the synthesized compounds significantly attenuated the progressi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24288-0
更新日期:2018-04-12 00:00:00