Abstract:
:The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the TARGT pipeline for targeted analysis of polymorphic loci from low-coverage shotgun sequence data. The pipeline was successfully applied to medieval aDNA samples and validated using both simulated aDNA and modern empirical sequence data from the 1000 Genomes Project. Thus the TARGT pipeline enables accurate analysis of HLA polymorphisms in historical (and modern) human populations.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pierini F,Nutsua M,Böhme L,Özer O,Bonczarowska J,Susat J,Franke A,Nebel A,Krause-Kyora B,Lenz TLdoi
10.1038/s41598-020-64312-wsubject
Has Abstractpub_date
2020-04-30 00:00:00pages
7339issue
1issn
2045-2322pii
10.1038/s41598-020-64312-wjournal_volume
10pub_type
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