Abstract：
:Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants linked to PD in SNCA. However, the consequences of this genetic variability are rather unclear. Herein, our analysis on selective single nucleotide polymorphisms (SNPs) which are highly associated with the PD susceptibility revealed that several SNP sites attribute to the nucleosomes and overlay with bivalent regions poised to adopt either active or repressed chromatin states. We also identified large number of transcription factor (TF) binding sites associated with these variants. In addition, we located two docking sites in the intron-1 methylation prone region of SNCA which are required for the putative interactions with DNMT1. Taken together, our analysis reflects an additional layer of epigenomic contribution for the regulation of the SNCA gene in PD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sharma A,Osato N,Liu H,Asthana S,Dakal TC,Ambrosini G,Bucher P,Schmitt I,Wüllner Udoi
10.1038/s41598-019-54865-wsubject
Has Abstractpub_date
2019-12-05 00:00:00pages
18464issue
1issn
2045-2322pii
10.1038/s41598-019-54865-wjournal_volume
9pub_type
杂志文章abstract：:3-D modeling of coupled thermo-hydro-mechanical (THM) processes in enhanced geothermal systems using the control volume finite element code was done. In a first, a comparative analysis on the effects of coupled processes, operational parameters and reservoir parameters on heat extraction was conducted. We found that s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14273-4
更新日期：2017-12-06 00:00:00
abstract：:Milk microbiota has a great influence on the safety and quality of dairy products. However, few studies have investigated the variations of bacterial composition in raw milk. In this study, raw milk samples were collected in 12 successive months, and their bacterial compositions were determined by 16 S rRNA gene seque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20862-8
更新日期：2018-02-05 00:00:00
abstract：:Laser has been widely used in many aspects, by now it is difficult to get each frequency that we want, and frequency conversion is an effective way to obtain different frequency laser through a nonlinear optical crystal. MgO-doped LiNbO3 (Mg:LN) crystal has usually been used for second harmonic generation (SHG) throug...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22205-z
更新日期：2018-03-01 00:00:00
abstract：:The Saccharomyces cerevisiae kinesin-5 Cin8 performs essential mitotic functions in spindle assembly and anaphase B spindle elongation. Recent work has shown that Cin8 is a bi-directional motor which moves towards the minus-end of microtubules (MTs) under high ionic strength (IS) conditions and changes directionality ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25597
更新日期：2016-05-24 00:00:00
abstract：:We assessed the Chinese version of the Drug Abuse Screening Test (DAST-10) for identifying illicit drug use during pregnancy among Chinese population. Chinese pregnant women attending their first antenatal visit or their first unbooked visit to the maternity ward were recruited during a 4-month study period in 2011. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11420
更新日期：2015-06-19 00:00:00
abstract：:Limited reference values exist for visceral adipose tissue (VAT) mass measured by DXA. The objectives of this study were to provide reference values for DXA-derived VAT mass and compare the association with anthropometry measures. The study cohort comprised 677 men and 738 women aged 18-65 years from Western Australia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73631-x
更新日期：2020-10-30 00:00:00
abstract：:We demonstrated tailored plasmon-induced transparency (PIT) in a metal (Au)-insulator (SiO2)-metal (Ag) (MIM) structure, where the Fano interference between the MIM waveguide mode and the surface plasmon polariton (SPP) resonance mode induced a transparency window in an otherwise opaque wavenumber (k) region. A series...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17847-4
更新日期：2017-12-19 00:00:00
abstract：:Auxin response factors (ARFs) are the transcription factors that regulate auxin responses in various aspects of plant growth and development. Although genome-wide analysis of ARF gene family has been done in some species, no information is available regarding ARF genes in chickpea. In this study, we identified 28 ARF ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11327-5
更新日期：2017-09-07 00:00:00
abstract：:Grapevine is an important and extensively grown fruit crop, which is severely hampered by drought worldwide. So, comprehending the impact of drought on grapevine genetic resources is necessary. In the present study, RNA-sequencing was executed using cDNA libraries constructed from both drought-stress and control plant...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13464-3
更新日期：2017-10-13 00:00:00
abstract：:The bacterial flagellar hook connects the helical flagellar filament to the rotary motor at its base. Bending flexibility of the hook allows the helical filaments to form a bundle behind the cell body to produce thrust for bacterial motility. The hook protein FlgE shows considerable sequence and structural similaritie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46723
更新日期：2017-04-21 00:00:00
abstract：:Multi-drug resistant efflux transporters found in Blood-Brain Barrier (BBB) acts as a functional barrier, by pumping out most of the drugs into the blood. Previous studies showed focused ultrasound (FUS) induced microbubble oscillation can disrupt the BBB by loosening the tight junctions in the brain endothelial cells...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31201
更新日期：2016-08-11 00:00:00
abstract：:To understand the ecosystem dynamics that underpin the year-round presence of a large generalist consumer, the Bryde's whale (Balaenoptera edeni brydei), we use a DNA metabarcoding approach and systematic zooplankton surveys to investigate seasonal and regional changes in zooplankton communities and if whale diet refl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36478-x
更新日期：2019-01-22 00:00:00
abstract：:The maternal environment can influence the intensity of seed dormancy and thus seasonal germination timing and post-germination life history traits. We tested the hypotheses that germination season influences phenotypic expression of post-germination life history traits in the cold desert annual Isatis violascens and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25076
更新日期：2016-04-27 00:00:00
abstract：:Invasive alien species are regarded a nuisance. This extends into a lack of conservation efforts in their native range. As a consequence, conservation of e.g. range-edge populations is neglected. Gobiidae have many representatives of alien species in European freshwaters, and therefore they have a bad reputation. Obje...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56264-7
更新日期：2019-12-23 00:00:00
abstract：:EU biodiversity conservation policy is based on the Habitats Directive (92/43/EC), which aims that habitat types and species of Community interest should reach 'favourable conservation status'. To this end, Member States are obliged to perform periodic assessment of species and habitat conservation status through biod...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09316-9
更新日期：2017-08-21 00:00:00
abstract：:To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick's limit. We find that in the biologically relevant range of parameters, if the imbalance between cell division and death is moderate or low (high de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17660
更新日期：2015-12-09 00:00:00
abstract：:Efficient interventions to reduce blood triglycerides are few; newer and more tolerable intervention targets are needed. Understanding the molecular mechanisms underlying blood triglyceride levels variation is key to identifying new therapies. To explore the role of epigenetic mechanisms on triglyceride levels, a bloo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09552-z
更新日期：2017-09-11 00:00:00
abstract：:Loss of olfactomedin 4 (OLFM4) gene expression is associated with the progression of human prostate cancer, but its role and the molecular mechanisms involved in this process have not been completely understood. In this study, we found that Olfm4-knockout mice developed prostatic intraepithelial neoplasia and prostati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16974
更新日期：2015-11-19 00:00:00
abstract：:Gallic acid is a trihydroxybenzoic acid found in tea leaves and some plants. Here, we report the effect of gallic acid on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure and in primary rat cardiac fibroblasts, and compare the effects of gallic acid with those of drugs used ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27599-4
更新日期：2018-06-18 00:00:00
abstract：:An intact cell wall is critical for cellular interactions with the environment and protecting the cell from environmental challenges. Signaling mechanisms are necessary to monitor cell wall integrity and to regulate cell wall production and remodeling during growth and division cycles. The green alga, Chlamydomonas, h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48523-4
更新日期：2019-08-21 00:00:00
abstract：:We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly, after injection of MSCs which had been pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24425-9
更新日期：2018-04-18 00:00:00
abstract：:Methylation of DNA CpG sites is a major mechanism of epigenetic gene silencing and plays important roles in cell division, development and carcinogenesis. One of its regulators is the 64-residue C-terminal Transcriptional Repressor Domain (the TRD) of MBD1, which recruits several repressor proteins such as MCAF1, HDAC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04896
更新日期：2014-05-09 00:00:00
abstract：:There is increasing evidence that extracellular cGMP modulates glutamatergic neurotransmission and some forms of learning. However, the underlying mechanisms remain unknown. We proposed the hypotheses that extracellular cGMP may regulate membrane expression of AMPA receptors. To do this extracellular cGMP should act o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18024-3
更新日期：2017-12-15 00:00:00
abstract：:We aimed to investigate the potential of preoperative mammographic breast density (MBD) as a prognostic factor in breast cancer. Data of 969 patients with primary breast cancer were analyzed. We defined low MBD as fatty or fibroglandular breast, and high MBD as heterogeneously dense or extremely dense breast, respecti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34297-8
更新日期：2018-10-30 00:00:00
abstract：:Wolfram syndrome (WS) is a recessive multisystem disorder defined by the association of diabetes mellitus and optic atrophy, reminiscent of mitochondrial diseases. The role played by mitochondria remains elusive, with contradictory results on the occurrence of mitochondrial dysfunction. We evaluated 13 recessive WS pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61735-3
更新日期：2020-03-16 00:00:00
abstract：:Early detection of breast cancer and its correct stage determination are important for prognosis and rendering appropriate personalized clinical treatment to breast cancer patients. However, despite considerable efforts and progress, there is a need to identify the specific genomic factors responsible for, or accompan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60740-w
更新日期：2020-03-05 00:00:00
abstract：:A composite of manganese monoxide loaded onto carbon nanotubes (CNTs@MnO) has been synthesized by a facile approach, in which the CNTs form a continuous conductive network connecting the electrocatalyst MnO nanoparticles together to facilitate good electrochemical performance. The electrocatalyst MnO shows favourable ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08012
更新日期：2015-01-30 00:00:00
abstract：:The shallow oxidized asthenosphere may contain a small fraction of potassic silicate melts that are enriched in incompatible trace elements and volatiles. Here, to determine the chemical composition of such melt, we analysed fossilized melt inclusions, preserved as multiphase solid inclusions, from an orogenic garnet ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28264-6
更新日期：2018-07-04 00:00:00
abstract：:The midline thalamus is reciprocally connected with the medial temporal lobe, where neural circuitry essential for spatial navigation and memory formation resides. Yet, little information is available on the dynamic relationship between activity patterns in the midline thalamus and medial temporal lobe. Here, we repor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29807
更新日期：2016-07-14 00:00:00
abstract：:Relative sea level rise at tide gauge Galveston Pier 21, Texas, is the combination of absolute sea level rise and land subsidence. We estimate subsidence rates of 3.53 mm/a during 1909-1937, 6.08 mm/a during 1937-1983, and 3.51 mm/a since 1983. Subsidence attributed to aquifer-system compaction accompanying groundwate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74696-4
更新日期：2020-10-21 00:00:00
