Abstract:
:The association between blood urea nitrogen to creatinine ratio (UCR) and survival is uncertain in hemodialysis patients. We examined the influence of UCR on mortality and morbidity in hemodialysis patients. A total of 3,401 hemodialysis patients were prospectively followed for 4 years. The association between UCR with overall survival was analyzed using a Cox regression model. During a 4-year follow-up period, 545 patients died from any cause and 582 experienced MACE, 392 with coronary heart disease (CHD), 114 with infection-related death, 77 with hemorrhagic stroke, 141 with ischemic stroke, and 107 with cancer death. Every 1 increase in UCR level was significantly associated with an increased risk for all-cause mortality (hazard ratio [HR] 1.07; 95% confidence interval [CI] 1.03-1.12), CHD (HR 1.08; 95% CI 1.02-1.14), and infection-related death (HR 1.11; 95% CI 1.02-1.21). There was no evidence of a significant association between UCR and death from cancer, and incidence of stroke. A high UCR was significantly associated with an increased risk for all-cause mortality, infection-related death and incidence of CHD in hemodialysis patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tanaka S,Ninomiya T,Taniguchi M,Tokumoto M,Masutani K,Ooboshi H,Kitazono T,Tsuruya Kdoi
10.1038/s41598-017-14205-2subject
Has Abstractpub_date
2017-11-02 00:00:00pages
14901issue
1issn
2045-2322pii
10.1038/s41598-017-14205-2journal_volume
7pub_type
杂志文章abstract::Prostate cancer (PCa) is the most common solid neoplasm diagnosed in developed countries. Nerve-sparing radical prostatectomy (NS-RP) has been widely accepted as the best choice treatment for localised PCa. However, erectile dysfunction (ED) and urinary incontinence are commonly observed after NS-RP. Using meta-analys...
journal_title:Scientific reports
pub_type: 杂志文章,评审
doi:10.1038/srep05801
更新日期:2014-07-23 00:00:00
abstract::Segmentation of the vertebrate hindbrain is an evolutionarily conserved process. Here, we identify the transcription factor early growth response 4 (egr4) as a novel regulator of posterior hindbrain development in Xenopus. egr4 is specifically and transiently expressed in rhombomeres 5 and 6 (r5/r6), and Egr4 knockdow...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07750
更新日期:2015-01-13 00:00:00
abstract::Two-dimensional (2D) acoustic vortex allows new physics and applications different from three-dimensional counterparts, yet existing mechanisms usually have to rely on active array composed of transducers which may result in complexity, high cost and, in particular, undesired spatial aliasing effect. We propose to gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60836-3
更新日期:2020-03-02 00:00:00
abstract::Metal-organic frameworks (MOFs) are intriguing host materials in composite electrolytes due to their ability for tailoring host-guest interactions by chemical tuning of the MOF backbone. Here, we introduce particularly high sodium ion conductivity into the zeolitic imidazolate framework ZIF-8 by impregnation with the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60198-w
更新日期:2020-02-26 00:00:00
abstract::Tuberculosis treatment includes broad-spectrum antibiotics such as rifampicin, streptomycin and fluoroquinolones, which are also used against other pathogenic bacteria. We developed Drug Resistance Associated Genes database (DRAGdb), a manually curated repository of mutational data of drug resistance associated genes ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65766-8
更新日期:2020-06-02 00:00:00
abstract::The purpose of this study was to investigate changes in peripapillary microvasculature using optical coherence tomography angiography (OCTA) in systemic hypertension (HTN) patients. This was a cross-sectional study. Based on the duration of HTN, seventy-eight HTN patients were divided into two groups. (HTN group 1: <1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63603-6
更新日期:2020-04-16 00:00:00
abstract::Specific HPV genotypes have been recognized as risk factors inducing head and neck cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect accurately High Risk HPV DNA in Formalin Fixed Paraffin Embedded (FFPE) and oral cytobrush samples and compare the results with conventional PCR. Repea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29790-z
更新日期:2018-07-27 00:00:00
abstract::The effects of dairy products on human health have been studied for years. However, the relationship between dairy products as well as calcium intake and the risk of lung cancer is still inconclusive. A total of 32 studies regarding this association were identified from the PubMed and Web of Science databases through ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep20624
更新日期:2016-02-15 00:00:00
abstract::Graphene grown by high temperature molecular beam epitaxy on hexagonal boron nitride (hBN) forms continuous domains with dimensions of order 20 μm, and exhibits moiré patterns with large periodicities, up to ~30 nm, indicating that the layers are highly strained. Topological defects in the moiré patterns are observed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22440
更新日期:2016-03-01 00:00:00
abstract::Studies reveal that there exists much interaction and communication between bacterial cells, with parts of these social behaviors depending on cell-cell contacts. The cell-cell contact has proved to be crucial for determining various biochemical processes. However, for cell culture with relatively low cell concentrati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01993
更新日期:2013-01-01 00:00:00
abstract::Anthurium amnicola Dressler possesses a number of desirable and novel ornamental traits such as a purple-colored upright spathe, profuse flowering, and floral scent, some of which have been introgressed into modern Anthurium cultivars. As a first step in identifying genes associated with these traits, the transcriptom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00808-2
更新日期:2017-05-04 00:00:00
abstract::An important property of spin-torque nano-oscillators (STNOs) is their ability to produce a frequency modulated (FM) signal, which is very critical for communication applications. We here demonstrate a novel single sideband (SSB) modulation phenomenon using a magnetic tunnel junction (MTJ)-based STNO, which saves tran...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13551-5
更新日期:2017-10-18 00:00:00
abstract::Dissection of the neural circuits of the cerebral cortex is essential for studying mechanisms underlying brain function. Herein, combining a retrograde rabies tracing system with fluorescent micro-optical sectional tomography, we investigated long-range input neurons of corticotropin-releasing hormone containing neuro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68115-x
更新日期:2020-07-22 00:00:00
abstract::We aimed to assess whether brain volumes may affect the results of deep brain stimulation (DBS) in patients with Parkinson's disease (PD). Eighty-one consecutive patients with PD (male:female 40:41), treated with DBS between June 2012 and December 2017, were enrolled. Total and regional brain volumes were measured usi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79138-9
更新日期:2020-12-16 00:00:00
abstract::The conformational landscapes of p53 peptide variants and phage derived peptide (12/1) variants, all known to bind to MDM2, are studied using hamiltonian replica exchange molecular dynamics simulations. Complementing earlier observations, the current study suggests that the p53 peptides largely follow the 'conformatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15930-4
更新日期:2017-11-15 00:00:00
abstract::The recombination is one of the most frequently identified drivers of double-stranded DNA viruses evolution. However, the recombination events in African swine fever virus (ASFV) genomes have been poorly annotated. We hypothesize that the genetic determinants of ASFV variability are potential hot-spots for recombinati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75377-y
更新日期:2020-10-28 00:00:00
abstract::Ecosystem carbon carrying capacity (CCC) is determined by prevailing climate and natural disturbance regimes, conditions that are projected to change significantly. The interaction of changing climate and its effects on disturbance regimes is expected to affect forest regeneration and growth, which may diminish forest...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02686-0
更新日期:2017-05-25 00:00:00
abstract::Environmental context strongly affects many host-pathogen interactions, but the underlying causes of these effects at the individual level are usually poorly understood. The amphibian chytrid fungus has caused amphibian population declines and extinctions in many parts of the world. Many amphibian species that have de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01515
更新日期:2013-01-01 00:00:00
abstract::Denitrification in coastal sediments can provide resilience to eutrophication in estuarine ecosystems, but this key ecosystem function is impacted directly and indirectly by increasing stressors. The erosion and loading of fine sediments from land, resulting in sedimentation and elevated sediment muddiness, presents a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54192-0
更新日期:2019-11-26 00:00:00
abstract::Field electron emission (FEE) properties of vertically aligned hexagonal boron nitride nanowalls (hBNNWs) grown on Si have been markedly enhanced through the use of nitrogen doped nanocrystalline diamond (nNCD) films as an interlayer. The FEE properties of hBNNWs-nNCD heterostructures show a low turn-on field of 15.2 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29444
更新日期:2016-07-11 00:00:00
abstract::Applications of biomaterials in cancer therapy has been limited to drug delivery systems and markers in radiation therapy. In this article, we introduce the concept of phase-functionalization of silicon to preferentially select cancer cell populations for survival in a catalyst and additive free approach. Silicon is p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10826
更新日期:2015-06-04 00:00:00
abstract::Dysfunction of cortical GABAergic interneurons are involved in numerous neurological disorders including epilepsy, schizophrenia and autism; and replenishment of these cells by transplantation strategy has proven to be a feasible and effective method to help revert the symptoms in several animal models. To develop met...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19003
更新日期:2016-01-11 00:00:00
abstract::Clonal cell analysis defines the potential of single cells and the diversity they can produce. To achieve this, we have developed a novel adaptation of the genetic tracing strategy, UbC-StarTrack, which attributes a specific and unique color-code to single neural precursors, allowing all their progeny to be tracked. W...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33896
更新日期:2016-09-22 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-55968-0
更新日期:2019-12-27 00:00:00
abstract::The (p)ppGpp signal molecules play a central role in the stringent response (SR) to adapt to nutrient starvation in bacteria, yet the carbohydrate starvation induced adaptive response and the roles of SR in this response is not well characterized, especially in Gram-positives. Here, two (p)ppGpp synthetases RelA and R...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27169
更新日期:2016-06-03 00:00:00
abstract::The functional heterogeneity of T cell responses to diverse antigens expressed at different stages of Mycobacterium tuberculosis (Mtb) infection, in particular early secreted versus dormancy related latency antigens expressed later, that distinguish subjects with latent (LTBI), pulmonary (PTB) or extrapulmonary (EPTB)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10773-5
更新日期:2017-09-20 00:00:00
abstract::By growing monolayer FeSe on SrTiO3(001) surface, researchers obtain the highest superconducting transition-temperature for iron-based superconductor. Here, we study the antiferromagnetic (AFM) checkerboard monolayer FeSe adsorbed on SrTiO3(001) surface. We show that the system has a considerable charge transfer from ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02213
更新日期:2013-01-01 00:00:00
abstract::The mandibular proximal ramus segments should be moved and rotated during orthognathic surgery-based skeletofacial reconstruction for the correction of challenging patients with facial asymmetry and malocclusion, but quantitative data regarding this rotation were not sufficient to date. This 3D computer-assisted study...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49946-9
更新日期:2019-09-16 00:00:00
abstract::Most of the human genome is non-coding. However, some of the non-coding part is transcriptionally active. In humans, the tandemly repeated (TR) pericentromeric non-coding DNA-human satellites 2 and 3 (HS2, HS3)-are transcribed in somatic cells. These transcripts are also found in pre- and post-implantation embryos. Th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76628-8
更新日期:2020-11-12 00:00:00
abstract::The macroscopically ordered structure of rod-like nanoapatites within the collagen matrix is of great significance for the mechanical performance of bones and teeth. However, the synthesis of macroscopically ordered nanoapatite remains a challenge. Inspired by the effect of citrate molecules on apatite crystals in nat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36843-w
更新日期:2019-01-24 00:00:00