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Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier.

Abstract：

:A weakening of the gut mucous barrier permits an increase in the access of intestinal luminal contents to the epithelial cells, which will trigger the inflammatory response. In inflammatory bowel diseases, there is an inappropriate and ongoing activation of the immune system, possibly because the intestinal mucus is less protective against the endogenous microflora. General strategies aimed at improving the protection of the intestinal epithelium are still missing. We generated a transgenic mouse that secreted a molecule consisting of 12 consecutive copies of a mucin domain into its intestinal mucus, which is believed to modify the mucus layer by establishing reversible interactions. We showed that the mucus gel was more robust and that mucin O-glycosylation was altered. Notably, the gut epithelium of transgenic mice housed a greater abundance of beneficial Lactobacillus spp. These modifications were associated with a reduced susceptibility of transgenic mice to chemically induced colitis. Furthermore, transgenic mice cleared faster Citrobacter rodentium bacteria which were orally given and mice were more protected against bacterial translocation induced by gavage with adherent-invasive Escherichia coli. Our data show that delivering the mucin CYS domain into the gut lumen strengthens the intestinal mucus blanket which is impaired in inflammatory bowel diseases.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Gouyer V,Dubuquoy L,Robbe-Masselot C,Neut C,Singer E,Plet S,Geboes K,Desreumaux P,Gottrand F,Desseyn JL

doi

10.1038/srep09577

subject

Has Abstract

pub_date

2015-05-14 00:00:00

pages

9577

issn

2045-2322

pii

srep09577

journal_volume

5

pub_type

杂志文章

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