Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity.

abstract：:The objective of this meta-analysis is to compare hybrid surgery (HS) and cervical discectomy and fusion (ACDF) for multilevel cervical degenerative disc diseases (DDD). Systematic searches of all published studies through March 2015 were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect, CNKI, ...

journal_title：Scientific reports

authors： Tian P,Fu X,Li ZJ,Sun XL,Ma XL

更新日期：2015-08-26 00:00:00

abstract：:Endonuclease V (EndoV) is a ubiquitous protein present in all three kingdoms of life, responsible for the specific cleavages at the second phosphodiester bond 3' to inosine. E. coli EndoV (EcEndoV) is the first member discovered in the EndoV family. It is a small protein with a compact gene organization, yet with a wi...

journal_title：Scientific reports

authors： Zhang Z,Jia Q,Zhou C,Xie W

更新日期：2015-08-05 00:00:00

abstract：:The knowledge of diffusion processes in semiconducting alloys is very important both technologically and from a theoretical point of view. Here we show that, self-diffusion in Si1-x Ge x alloys as a function of temperature and Ge concentration can be described by the cBΩ thermodynamic model. This model connects the ac...

journal_title：Scientific reports

authors： Saltas V,Chroneos A,Vallianatos F

更新日期：2017-05-02 00:00:00

abstract：:Hepatitis B is one of most etiologies of Liver cirrhosis in China, and clinically lacks the effective strategy for Hepatitis B caused cirrhosis (HBC) therapy. As a complementary and alternative medicine, Chinese Traditional Medicine (TCM) has special therapeutic effects for HBC. Here, we focus on the evolution process...

journal_title：Scientific reports

authors： Liu Y,Wang M,Luo Y,Chen J,Lu Y,Shi Y,Tang C,Zhou Q,Zhang H,Hu Y,Su S,Chen Q

更新日期：2017-09-08 00:00:00

abstract：:Gamma radiation is a commonly used adjuvant treatment for abdominally localized cancer. Since its therapeutic potential is limited due to gastrointestinal (GI) syndrome, elucidation of the regenerative response following radiation-induced gut injury is needed to develop a preventive treatment. Previously, we showed th...

journal_title：Scientific reports

authors： Orzechowska EJ,Katano T,Bialkowska AB,Yang VW

更新日期：2020-10-27 00:00:00

abstract：:The pectin methylesterase action is usually studied in a homogeneous aqueous medium in the presence of a large excess of soluble substrate and water. However in the cell wall, the water content is much lower, the substrate is cross-linked with itself or with other polymers, and the enzyme has to diffuse through the so...

journal_title：Scientific reports

authors： Bonnin E,Alvarado C,Crépeau MJ,Bouchet B,Garnier C,Jamme F,Devaux MF

更新日期：2019-08-29 00:00:00

abstract：:The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We foun...

journal_title：Scientific reports

authors： Liang Y,Zhu F,Zhang H,Chen D,Zhang X,Gao Q,Li Y

更新日期：2016-07-05 00:00:00

abstract：:Metabolomics has emerged as a powerful approach to comprehensively interrogate cellular biochemistry. As such, we applied an untargeted liquid chromatography-mass spectrometry metabolomic strategy to elucidate metabolome changes in the anthracnose-causing hemibiotrophic sorghum pathogen, Colletotrichum sublineolum. An...

journal_title：Scientific reports

authors： Tugizimana F,Djami-Tchatchou AT,Fahrmann JF,Steenkamp PA,Piater LA,Dubery IA

更新日期：2019-03-01 00:00:00

abstract：:The synthesis of highly biocompatible polymers is important for modern biotechnologies and medicine. Here, we report a unique process based on a two-step high-pressure ramp (HPR) for the ultrafast and efficient bulk polymerization of 2-(hydroxyethyl)methacrylate (HEMA) at room temperature without photo- and thermal ac...

journal_title：Scientific reports

authors： Evlyukhin E,Museur L,Traore M,Perruchot C,Zerr A,Kanaev A

更新日期：2015-12-16 00:00:00

abstract：:The present study aimed to evaluate the efficiency, effectiveness, and biocompatibility of two agents used for the chemomechanical removal of carious dentin. Sixty extracted carious human teeth were treated with a conventional bur (CBG) or chemomechanical agents - Papacarie Duo (PG) and Brix 3000 (BG). Treatment effic...

journal_title：Scientific reports

authors： Santos TML,Bresciani E,Matos FS,Camargo SEA,Hidalgo APT,Rivera LML,Bernardino ÍM,Paranhos LR

更新日期：2020-05-15 00:00:00

abstract：:Treatment of decompensated heart failure often includes administration of levosimendan. Myeloperoxidase (MPO) is released during polymorphonuclear neutrophil (PMN) degranulation, and mediates dysregulation of vascular tone in heart failure. We evaluated the effects of levosimendan-treatment on MPO in patients with acu...

journal_title：Scientific reports

authors： Adam M,Meyer S,Knors H,Klinke A,Radunski UK,Rudolph TK,Rudolph V,Spin JM,Tsao PS,Costard-Jäckle A,Baldus S

更新日期：2015-04-13 00:00:00

abstract：:Modern Computed Tomography (CT) scanners are capable of acquiring contrast dynamics of the whole brain, adding functional to anatomical information. Soft tissue segmentation is important for subsequent applications such as tissue dependent perfusion analysis and automated detection and quantification of cerebral patho...

journal_title：Scientific reports

authors： Manniesing R,Oei MTH,Oostveen LJ,Melendez J,Smit EJ,Platel B,Sánchez CI,Meijer FJA,Prokop M,van Ginneken B

更新日期：2017-03-09 00:00:00

abstract：:Overuse of antibiotics has caused serious problems, such as appearance of super bacteria, whose accumulation in the human body through the food chain is a concern. Kanamycin is a common antibiotic used to treat diverse infections; however, residual kanamycin can cause many side effects in humans. Thus, development of ...

journal_title：Scientific reports

authors： Ha NR,Jung IP,La IJ,Jung HS,Yoon MY

更新日期：2017-01-05 00:00:00

abstract：:Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of diastolic dysfunction. Increased cardiovascular risk associated with diabetes is more marked for women, but an understanding of the role of diastolic dysfunction in female susceptibility to diabetic cardiomyopathy is lacking. To invest...

journal_title：Scientific reports

authors： Chandramouli C,Reichelt ME,Curl CL,Varma U,Bienvenu LA,Koutsifeli P,Raaijmakers AJA,De Blasio MJ,Qin CX,Jenkins AJ,Ritchie RH,Mellor KM,Delbridge LMD

更新日期：2018-02-05 00:00:00

abstract：:In wild animal conservation, knowing the age of an individual animal is extremely beneficial. However, estimating the age is difficult for many species. Recently, epigenetics-based methods of estimating age have been reported. These studies were predominantly on humans with few reports on other animals, especially wil...

journal_title：Scientific reports

authors： Ito H,Udono T,Hirata S,Inoue-Murayama M

更新日期：2018-07-03 00:00:00

abstract：:Although recovery following a stroke is limited, undamaged neurons under the right conditions can establish new connections and take on-board lost functions. Sonic hedgehog (Shh) signaling is integral for developmental axon growth, but its role after injury has not been fully examined. To investigate the effects of Sh...

journal_title：Scientific reports

authors： Berretta A,Gowing EK,Jasoni CL,Clarkson AN

更新日期：2016-02-23 00:00:00

abstract：:Data on predictors of intraoperative cardiac arrest (ICA) outcomes are scarce in the literature. This study analysed predictors of poor outcome and their prognostic value after an ICA. Clinical and laboratory data before and 24 hours (h) after ICA were analysed as predictors for no return of spontaneous circulation (R...

journal_title：Scientific reports

authors： Vane MF,Carmona MJC,Pereira SM,Kern KB,Timerman S,Perez G,Vane LA,Otsuki DA,Auler JOC Jr

更新日期：2019-10-18 00:00:00

abstract：:Microalgae identification is extremely difficult. The efficiency of DNA barcoding in microalgae identification involves ideal gene markers and approaches employed, which however, is still under the way. Although Scenedesmus has obtained much research in producing lipids its identification is difficult. Here we present...

journal_title：Scientific reports

authors： Zou S,Fei C,Wang C,Gao Z,Bao Y,He M,Wang C

更新日期：2016-11-09 00:00:00

abstract：:Cosolvent Molecular Dynamics (MD) simulations are increasingly popular techniques developed for prediction and characterization of allosteric and cryptic binding sites, which can be rendered "druggable" by small molecule ligands. Despite their conceptual simplicity and effectiveness, the analysis of cosolvent MD traje...

journal_title：Scientific reports

authors： Sabanés Zariquiey F,de Souza JV,Bronowska AK

更新日期：2019-12-13 00:00:00

abstract：:We propose a scheme of designing polygonal rotator with homogenous materials by using linear coordinate transformation. Our strategy is available for both time-harmonic electromagnetic field case and static field case. In particular, we found that only one anisotropic material is needed in static field case, and the d...

journal_title：Scientific reports

authors： Gao W,Wang H,Yu F

更新日期：2019-10-22 00:00:00

abstract：:Sucralose is a widely-used artificial high-intensity sweetener. Although doubts have been raised about the safety of sucralose by several researchers, it can still be found in a broad range of foods and beverages worldwide, including in baked goods. Sucralose may decompose at high temperatures, and participate in chlo...

journal_title：Scientific reports

authors： Dong S,Liu G,Hu J,Zheng M

更新日期：2013-10-15 00:00:00

abstract：:Homogeneous target dose distribution in intensity-modulated radiotherapy (IMRT) for sinonasal cancer (SNC) is challenging to achieve. To solve this problem, we established and evaluated a basal-dose-compensation (BDC) optimization approach, in which the treatment plan is further optimized based on the initial plans. G...

journal_title：Scientific reports

authors： Lu JY,Zhang JY,Li M,Cheung ML,Li YK,Zheng J,Huang BT,Zhang WZ

更新日期：2015-10-26 00:00:00

abstract：:GABA counteracts wide range of stresses through regulation of GABA shunt pathway in plants. Although, GABA assisted tolerance against As toxicity in plants is still unexplored. We have examined GABA induced tolerance in rice seedlings with two exposure periods of GABA i.e., short term and long term. Results showed tha...

journal_title：Scientific reports

authors： Kumar N,Dubey AK,Upadhyay AK,Gautam A,Ranjan R,Srikishna S,Sahu N,Behera SK,Mallick S

更新日期：2017-08-18 00:00:00

abstract：:Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans. Their extensive use has led to the emergence of drug resistance, complicating antifungal therapy for yeast infections in critically ill patients. Combination therapy has become popular in clinical practice as a potential strateg...

journal_title：Scientific reports

authors： Shrestha SK,Fosso MY,Garneau-Tsodikova S

更新日期：2015-11-23 00:00:00

abstract：:Amazonian wildfires in 2019 have raised awareness about rainforest burning due to increased emissions of particulate matter and carbon. In the context of these emissions, by-products of lignin thermal degradation (i.e. methoxyphenols) are often neglected. Methoxyphenols entering the atmosphere may form intermediates w...

journal_title：Scientific reports

authors： Babić S,Čižmek L,Maršavelski A,Malev O,Pflieger M,Strunjak-Perović I,Popović NT,Čož-Rakovac R,Trebše P

更新日期：2021-01-28 00:00:00

abstract：:Glial cells actively maintain the homeostasis of brain parenchyma, regulating neuronal excitability and preserving the physiological composition of the extracellular milieu. Under pathological conditions, some functions of glial cells could be compromised, exacerbating the neurotoxic processes. We investigated if the ...

journal_title：Scientific reports

authors： Grimaldi A,D'Alessandro G,Di Castro MA,Lauro C,Singh V,Pagani F,Sforna L,Grassi F,Di Angelantonio S,Catacuzzeno L,Wulff H,Limatola C,Catalano M

更新日期：2018-05-16 00:00:00

abstract：:Mid-infrared quantum cascade lasers operating under external optical feedback and external periodic bias forcing are shown to exhibit a deterministic chaotic pattern composed of frequencies which are linked to the one of the forcing. Results also show that both the amplitude and the frequency of the forcing play a key...

journal_title：Scientific reports

authors： Spitz O,Wu J,Carras M,Wong CW,Grillot F

更新日期：2019-03-14 00:00:00

abstract：:In this study, dye-sensitized solar cells (DSSCs) has been assembled with poly(1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VAc)) gel polymer electrolytes (GPEs) which have been incorporated with binary salt and an ionic liquid. The potential of this combination was studied and reported. The binary salt system GPEs w...

journal_title：Scientific reports

authors： Ming NH,Ramesh S,Ramesh K

更新日期：2016-06-08 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are unlikely to respond to hormonal therapies and anti-HER2-targeted therapies. TNBCs overexpress EGFR and exhibit constitutive activation of the PI3K/AKT/mTOR signalling pathway. We hypothesized that simultaneously blocking EGFR and mTOR could be a potential therapeutic strategy ...

journal_title：Scientific reports

authors： El Guerrab A,Bamdad M,Bignon YJ,Penault-Llorca F,Aubel C

更新日期：2020-04-14 00:00:00

abstract：:Regulation of the chromatin state is crucial for biological processes such as the regulation of transcription, DNA replication, and DNA damage repair. Here we show that knockdown of the BRD8 bromodomain protein - a subunit of the p400/Tip60 complex - leads to p21 induction, and concomitant cell cycle arrest in G1/S. W...

journal_title：Scientific reports

authors： Lashgari A,Fauteux M,Maréchal A,Gaudreau L

更新日期：2018-09-20 00:00:00