Abstract:
:Sucralose is a widely-used artificial high-intensity sweetener. Although doubts have been raised about the safety of sucralose by several researchers, it can still be found in a broad range of foods and beverages worldwide, including in baked goods. Sucralose may decompose at high temperatures, and participate in chlorination reactions, generating highly toxic compounds. Here, we demonstrate that heating sucralose at high temperatures in stainless steel or other metal utensils in the presence of rust (Al2O3, Fe2O3, and CuO) produces polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). PCDD/Fs were found in smoke generated during the heating of sucralose and in the residues after heating. CuO enhanced the PCDD/F yield in comparison with Al2O3 and Fe2O3.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dong S,Liu G,Hu J,Zheng Mdoi
10.1038/srep02946subject
Has Abstractpub_date
2013-10-15 00:00:00pages
2946issn
2045-2322pii
srep02946journal_volume
3pub_type
杂志文章abstract::During the Final Eneolithic the Corded Ware Complex (CWC) emerges, chiefly identified by its specific burial rites. This complex spanned most of central Europe and exhibits demographic and cultural associations to the Yamnaya culture. To study the genetic structure and kin relations in CWC communities, we sequenced th...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-020-63138-w
更新日期:2020-04-14 00:00:00
abstract::Serotonin (5-HT) is an important neurotransmitter and neuromodulator that controls a variety of sensory and motor functions through 5-HT receptors (5-HTRs). The 5-HT4R subfamily is linked to Gs proteins, which activate adenylyl cyclases (ACs), and is involved in many responses in peripheral organs. In this study, the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40247
更新日期:2017-01-06 00:00:00
abstract::Channelopathy mutations prove informative on disease causing mechanisms and channel gating dynamics. We have identified a novel heterozygous mutation in the KCNA1 gene of a young proband displaying typical signs and symptoms of Episodic Ataxia type 1 (EA1). This mutation is in the S4 helix of the voltage-sensing domai...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03041-z
更新日期:2017-07-04 00:00:00
abstract::The nuclear receptor, farnesoid X receptor (FXR), has been recently considered as a tumor suppressor in HCC. IL-6/Janus kinase 2 (Jak-2)/signal transducer and activator of transcription 3 (STAT3) pathway has been implicated as a key player in many cancer types. This study aimed at investigating the potential effect of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12629-4
更新日期:2017-10-02 00:00:00
abstract::This prospective, single-blind, randomized study was designed to evaluate the effect of genotype-based warfarin dosing compared with standard warfarin dosing in Korean patients with mechanical cardiac valves. Patients were assigned to either the genotype-based dosing group or the standard dosing group using stratified...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-63985-7
更新日期:2020-04-24 00:00:00
abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41598-017-14994-6
更新日期:2017-12-19 00:00:00
abstract::The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection and apoptotic cell clearance by ac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07824
更新日期:2015-01-16 00:00:00
abstract::Current robots can manipulate only surface-attached cells seriously limiting the fields of their application for single cell handling. We developed a computer vision-based robot applying a motorized microscope and micropipette to recognize and gently isolate intact individual cells for subsequent analysis, e.g., DNA/R...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20375
更新日期:2016-02-09 00:00:00
abstract::Although diatoms have been extensively studied as bioreactors, only a limited number of efficient gene promoters are available. Therefore, the development of new endogenous promoters is important for the heterologous production of a variety of recombinant proteins. Herein, we identified the most abundant secreted prot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45786-9
更新日期:2019-07-09 00:00:00
abstract::Electron-hole exchange interaction in semiconductor quantum dots (QDs) splits the band-edge exciton manifold into optically active ("bright") and passive ("dark") states, leading to a complicated exciton fine structure. In the present work, we resolve by atomistic million-atom many-body pseudopotential calculations th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09812-y
更新日期:2017-08-24 00:00:00
abstract::Autonomic modulation and cardiorespiratory variables are influenced by numerous factors, including anthropometric variables. We investigated autonomic recovery following aerobic exercise in healthy men with different waist-stature ratio (WSR) values. The study was conducted with 52 healthy men aged 18 to 30 years, div...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-018-34246-5
更新日期:2018-10-31 00:00:00
abstract::Currently little is known about structure-function mappings in the human subcortex. Here we present a large-scale automated meta-analysis on the literature to understand the structure-function mapping in the human subcortex. The results provide converging evidence into unique large scale structure-function mappings of...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-33796-y
更新日期:2018-10-26 00:00:00
abstract::We examined whether alterations in body perception in EDs extend to the integration of exteroceptive visual and tactile information. Moreover, we investigated the effect of self-focused attention on the ability to correctly detect tactile stimuli. Twenty-seven women reporting low ED symptoms, versus 26 women reporting...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68500-6
更新日期:2020-07-15 00:00:00
abstract::Selective inhibition of function-specific β-GlcNAcase has great potential in terms of drug design and biological research. The symmetrical bis-naphthalimide M-31850 was previously obtained by screening for specificity against human glycoconjugate-lytic β-GlcNAcase. Using protein-ligand co-crystallization and molecular...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06188
更新日期:2014-08-26 00:00:00
abstract::Soil fauna are critical for ecosystem function and sensitive to the changes of soil fertility. The effects of fertilization on soil fauna communities, however, remain poorly understood. We examined the effects of fertilization form and quantity on the abundance, diversity and composition of soil fauna across an age-se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20816
更新日期:2016-02-09 00:00:00
abstract::Recent research in filamentous fungi has revealed that the motility of an endocytic organelle early endosome (EE) has a versatile role in many physiological functions. Here, to further examine the motility of EEs in the industrially important fungus Aspergillus oryzae, we visualized these organelles via the Rab5 homol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16163-1
更新日期:2017-11-17 00:00:00
abstract::A body with mechanical sensors may remotely detect particles suspended in the surrounding fluid via controlled agitation. Here we propose a sensory mode that relies on generating unsteady flow and sensing particle-induced distortions in the flow field. We demonstrate the basic physical principle in a simple analytical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58880-0
更新日期:2020-02-14 00:00:00
abstract::Supplementation of cattle diets with n-3-polyunsaturated fatty acids (PUFA) can improve reproductive efficiency. Conversely, short-term fluctuations in feed supply can impact pregnancy establishment. The objectives of this study were to examine the effects of (1) dietary supplementation with n-3-PUFA and (2) post-inse...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77604-y
更新日期:2020-11-27 00:00:00
abstract::Chiral optical response is an inherent property of molecules and nanostructures, which cannot be superimposed on their mirror images. In specific cases, optical chirality can be observed also for symmetric structures. This so-called extrinsic chirality requires that the mirror symmetry is broken by the geometry of the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41615-1
更新日期:2019-03-25 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-57442-8
更新日期:2020-01-15 00:00:00
abstract::A subset of the family of fluorescent proteins are the non-fluorescent chromoproteins which are promising probe molecules for use in photoacoustic imaging and as acceptor chromophores in Förster resonance energy transfer (FRET)-based biosensors. Typical approaches for fluorescent protein optimization by screening of l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22129
更新日期:2016-03-01 00:00:00
abstract::Development of conformal n-channel organic phototransistor (OPT) array is urgent for future applications of organic complementary circuits in portable and wearable electronics and optoelectronics. In this work, the ultrathin conformal OPT array based on air-stable n-type PTCDI-C13H27 was fabricated. The OPT array show...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35062-7
更新日期:2018-11-09 00:00:00
abstract::Controlled ovarian stimulation by exogenous gonadotrophins is a key procedure during the in vitro fertilization cycle to obtain a sufficient number of oocytes in humans. Previous studies demonstrated that repeated superovulation had deleterious effects on the ovaries. However, whether repeated superovulation adversely...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31368
更新日期:2016-10-04 00:00:00
abstract::Breast tissue heterogeneity is related to risk factors that lead to more aggressive tumour growth and worse prognosis, yet such heterogeneity has not been well characterized. The aim of this study is to reveal the heterogeneous signal patterns of the apparent diffusion coefficient (ADC) of a tumour and its surrounding...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03122-z
更新日期:2017-06-06 00:00:00
abstract::Grassland degradation due to overgrazing is common in many areas of the world. This study analyzed the potential of the stable carbon isotope (δ(13)C) value as a structural microcosmic index to monitor processes of grassland degradation. The δ(13)C values of plant leaves, roots and soils in non-grazed (NG) and over-gr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31399
更新日期:2016-08-16 00:00:00
abstract::Hypothalamic growth hormone-releasing hormone (GHRH) neurons orchestrate body growth/maturation and have been implicated in feeding responses and ageing. However, the electrical patterns that dictate GHRH neuron functions have remained elusive. Since the inhibitory neuropeptide somatostatin (SST) is considered to be a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24394
更新日期:2016-04-13 00:00:00
abstract::Nutrient inputs and ultraviolet radiation (UVR) are global factors affecting the structure and functioning of aquatic ecosystems, particularly clear-water ecosystems. We performed experiments in two model lakes highly exposed to UVR fluxes in order to test the effect that future increases in mineral nutrients transpor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06279-9
更新日期:2017-07-24 00:00:00
abstract::The G protein-coupled receptor opsin is a phospholipid scramblase that facilitates rapid transbilayer phospholipid exchange in liposomes. The mechanism by which opsin scrambles lipids is unknown. It has been proposed that lipid translocation may occur at protein-protein interfaces of opsin dimers. To test this possibi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16842-z
更新日期:2017-12-01 00:00:00
abstract::Lytic transglycosylases (LTs) catalyze the non-hydrolytic cleavage of the bacterial cell wall by an intramolecular transacetalization reaction. This reaction is critically and broadly important in modifications of the bacterial cell wall in the course of its biosynthesis, recycling, manifestation of virulence, inserti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22527-y
更新日期:2018-03-07 00:00:00
abstract::The green bacterial biosynthesis of lead sulfide nanocrystallites by L-cysteine-desulfurizing bacterium Lysinibacillus sphaericus SH72 was demonstrated in this work. Nanocrystals formed by this bacterial method were characterized using the mineralogical and morphological approaches. The results revealed that the micro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80450-7
更新日期:2021-01-13 00:00:00