Abstract:
:Currently little is known about structure-function mappings in the human subcortex. Here we present a large-scale automated meta-analysis on the literature to understand the structure-function mapping in the human subcortex. The results provide converging evidence into unique large scale structure-function mappings of the human subcortex based on their functional and anatomical similarity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Keuken MC,van Maanen L,Boswijk M,Forstmann BU,Steyvers Mdoi
10.1038/s41598-018-33796-ysubject
Has Abstractpub_date
2018-10-26 00:00:00pages
15854issue
1issn
2045-2322pii
10.1038/s41598-018-33796-yjournal_volume
8pub_type
杂志文章,meta分析abstract::This study aimed to investigate the prevalence, antibiogram of Pseudomonas aeruginosa (P. aeruginosa), and the distribution of virulence genes (oprL, exoS, phzM, and toxA) and the antibiotic-resistance genes (blaTEM, tetA, and blaCTX-M). A total of 285 fish (165 Oreochromis niloticus and 120 Clarias gariepinus) were c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72264-4
更新日期:2020-09-29 00:00:00
abstract::Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We hypothesized that high lipid levels and specific lipoproteins could significantly decrease adenoviral tr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00376-5
更新日期:2017-03-24 00:00:00
abstract::Evasion of the potent tumour suppressor activity of p53 is one of the hurdles that must be overcome for cancer cells to escape normal regulation of cellular proliferation and survival. In addition to frequent loss of function mutations, p53 wild-type activity can also be suppressed post-translationally through several...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28002-y
更新日期:2018-06-26 00:00:00
abstract::In order to design a painless and mechanically durable micro syringe-needle system for biomedical applications, the study of insect stingers is of interest because of their elegant structures and functionalities. In the present work, the structure, mechanical properties and the mechanical behavior during insertion of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33386-y
更新日期:2018-10-08 00:00:00
abstract::Sulfonylureas are commonly used to treat type 2 diabetes mellitus. Despite awareness of their effects on cardiac physiology, a knowledge gap exists regarding their effects on cardiovascular events in real-world populations. Prior studies reported sulfonylurea-associated cardiovascular death but not serious arrhythmoge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66668-5
更新日期:2020-06-22 00:00:00
abstract::Several epidemiological studies have found a positive association between diabetic retinopathy (DR) and subclinical hypothyroidism (SCH), but the findings are varied or even contradictory. In the work, we performed a meta-analysis to ascertain the relationship between DR and SCH. We searched relevant studies on the re...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep12212
更新日期:2015-07-20 00:00:00
abstract::An on-going debate concerning the dietary adaptations of archaic hominins and early Homo has been fuelled by contradictory inferences obtained using different methodologies. This work presents an extensive comparative sample of 30 extant primate species that was assembled to perform a morpho-functional comparison of t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63739-5
更新日期:2020-04-22 00:00:00
abstract::Diabetes is a chronic metabolic disease that causes blood glucose (BG) concentration to make dangerous excursions outside its physiological range. Measuring the fraction of time spent by BG outside this range, and, specifically, the time-below-range (TBR), is a clinically common way to quantify the effectiveness of th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75079-5
更新日期:2020-10-23 00:00:00
abstract::We propose the quantum simulation of the quantum Rabi model in all parameter regimes by means of detuned bichromatic sideband excitations of a single trapped ion. We show that current setups can reproduce, in particular, the ultrastrong and deep strong coupling regimes of such a paradigmatic light-matter interaction. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15472
更新日期:2015-10-20 00:00:00
abstract::Intercellular adhesion plays a major role in tissue development and homeostasis. Yet, technologies to measure mature cell-cell contacts are not available. We introduce a methodology based on fluidic probe force microscopy to assess cell-cell adhesion forces after formation of mature intercellular contacts in cell mono...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46152
更新日期:2017-04-10 00:00:00
abstract::The COVID-19 pandemic caused by the SARS-CoV-2 requires a fast development of antiviral drugs. SARS-CoV-2 viral main protease (Mpro, also called 3C-like protease, 3CLpro) is a potential target for drug design. Crystal and co-crystal structures of the SARS-CoV-2 Mpro have been solved, enabling the rational design of in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77794-5
更新日期:2020-11-30 00:00:00
abstract::Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a nov...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11030
更新日期:2015-06-05 00:00:00
abstract::Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes. Our data demonstrates that hypoxia controls the expression of RhoA in chondrocytes in a context...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09505-6
更新日期:2017-08-22 00:00:00
abstract::Obesity is characterized as the excessive accumulation of body fat and has a complex genetic foundation in humans including monogenic high-risk mutations and polygenic contributions. Domestic pigs represent a valuable model on an obesity-promoting high-caloric diet while constantly evaluated for body characteristics. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08961-4
更新日期:2017-08-22 00:00:00
abstract::Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in bra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25213-1
更新日期:2018-04-30 00:00:00
abstract::Accurate intraocular lens (IOL) power calculation is always a challenge in ophthalmology, and unoptimized process may lead to inaccurate refractive outcomes. Quality control circle (QCC) has shown its success in many fields as a process management tool. However, its efficacy in ophthalmology remains unclear. Here we u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14171-9
更新日期:2017-11-01 00:00:00
abstract::Early-life stress in adolescence has a long-lasting influence on brain function in adulthood, and it is mostly recognized as a predisposing factor for mental illnesses, such as anxiety and posttraumatic stress disorder. Previous studies also indicated that adolescent predictable chronic mild stress (PCMS) in early lif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08017-7
更新日期:2017-08-10 00:00:00
abstract::In this study, we demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function. Presently, skeletal muscle disease and dysfunction at the sarcomere level has been associated with mutatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34163
更新日期:2016-09-26 00:00:00
abstract::Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the phenotype of AMD to include another extracellular deposit, reticular pseudodruse...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66355-5
更新日期:2020-06-12 00:00:00
abstract::The effects of transcranial direct current stimulation (tDCS) on motor cortical excitability are highly variable between individuals. Inter-individual differences in the electric fields generated in the brain by tDCS might play a role in the variability. Here, we explored whether these fields are related to excitabili...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-018-37226-x
更新日期:2019-01-24 00:00:00
abstract::Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem cells may contribute to paracrine signaling. In this study, we inve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32993
更新日期:2016-09-12 00:00:00
abstract::Viruses induce double-stranded RNA (dsRNA) in the host cells. The mammalian system has developed dsRNA-dependent recognition receptors such as RLRs that recognize the long stretches of dsRNA as PAMPs to activate interferon-mediated antiviral pathways and apoptosis in severe infection. Here we report an efficient antiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22550
更新日期:2016-03-03 00:00:00
abstract::Stream microbes that occur in the Mediterranean Basin have been shown to possess heightened sensitivity to intensified water stress attributed to climate change. Here, we investigate the effects of long-term drought (150 days), storms and rewetting (7 days) on the diversity and composition of archaea, bacteria and fun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49832-4
更新日期:2019-09-18 00:00:00
abstract::Anxiety and depression are commonly found in patients with diabetes, but little is known about how the anxiety and depression symptoms of diabetes patients and the health-related quality of life (HRQoL) over time influence each other. Therefore, we conducted a survey among patients with diabetes (T1) and repeated the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57647-x
更新日期:2020-05-20 00:00:00
abstract::Nicotine is the psychoactive agent involved in nicotine dependence. However, nicotine as a drug, and its effects on human psychology are largely under-investigated in genetic studies. In this study, we recruited 208 current non-smokers to evaluate the effect of nicotine and its relationship to genetic risks to nicotin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09521
更新日期:2015-03-31 00:00:00
abstract::An effective method, involving time and frequency domains was developed to interpret seismic precursors by comparing groundwater-level fluctuations recorded immediately and long before the occurrence of a known earthquake. The proposed method, consisting of the pre-processing (3-point filtering, band-pass filtering, a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64586-0
更新日期:2020-05-12 00:00:00
abstract::We report here that CYB5D2 is associated with tumor suppression function in breast cancer (BC). CYB5D2 expression was significantly reduced in tamoxifen resistant MCF7 cells and in MCF7 cell-derived xenografts treated with TAM. CYB5D2 overexpression induced apoptosis in MCF7 cells; CYB5D2 knockdown enhanced MCF7 cell ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43006-y
更新日期:2019-04-29 00:00:00
abstract::Discriminating between inherited and non-inherited sporadic hearing loss is challenging. Here, we attempted to delineate genetic inheritance in simplex cases of severe-to-profound congenital hearing loss in Korean children. Variations in SLC26A4 and GJB2 in 28 children with bilateral severe-to-profound non-syndromic h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45973
更新日期:2017-04-06 00:00:00
abstract::Aphids are important agricultural pests causing major yield losses worldwide. Since aphids can rapidly develop resistance to chemical insecticides there is an urgent need to find alternative aphid pest management strategies. Despite the economic importance of bluegreen aphid (Acyrthosiphon kondoi), very few genetic re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58442-4
更新日期:2020-01-31 00:00:00
abstract::The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection and apoptotic cell clearance by ac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07824
更新日期:2015-01-16 00:00:00