当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia.

Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia.

Abstract：

:Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of diastolic dysfunction. Increased cardiovascular risk associated with diabetes is more marked for women, but an understanding of the role of diastolic dysfunction in female susceptibility to diabetic cardiomyopathy is lacking. To investigate the sex-specific relationship between systemic diabetic status and in vivo occurrence of diastolic dysfunction, diabetes was induced in male and female mice by streptozotocin (5x daily i.p. 55 mg/kg). Echocardiography was performed at 7 weeks post-diabetes induction, cardiac collagen content assessed by picrosirius red staining, and gene expression measured using qPCR. The extent of diabetes-associated hyperglycemia was more marked in males than females (males: 25.8 ± 1.2 vs 9.1 ± 0.4 mM; females: 13.5 ± 1.5 vs 8.4 ± 0.4 mM, p < 0.05) yet in vivo diastolic dysfunction was evident in female (E/E' 54% increase, p < 0.05) but not male diabetic mice. Cardiac structural abnormalities (left ventricular wall thinning, collagen deposition) were similar in male and female diabetic mice. Female-specific gene expression changes in glucose metabolic and autophagy-related genes were evident. This study demonstrates that STZ-induced diabetic female mice exhibit a heightened susceptibility to diastolic dysfunction, despite exhibiting a lower extent of hyperglycemia than male mice. These findings highlight the importance of early echocardiographic screening of asymptomatic prediabetic at-risk patients.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Chandramouli C,Reichelt ME,Curl CL,Varma U,Bienvenu LA,Koutsifeli P,Raaijmakers AJA,De Blasio MJ,Qin CX,Jenkins AJ,Ritchie RH,Mellor KM,Delbridge LMD

doi

10.1038/s41598-018-20703-8

subject

Has Abstract

pub_date

2018-02-05 00:00:00

pages

2346

issue

1

issn

2045-2322

pii

10.1038/s41598-018-20703-8

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Color image encryption based on chaotic compressed sensing and two-dimensional fractional Fourier transform.

    abstract：:Combining the advantages of structured random measurement matrix and chaotic structure, this paper introduces a color image encryption algorithm based on a structural chaotic measurement matrix and random phase mask. The Chebyshev chaotic sequence is used in the algorithm to generate the flip permutation matrix, the s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75562-z

    authors： Wang X,Su Y

    更新日期：2020-10-29 00:00:00

  • Direct observation of catalytic oxidation of particulate matter using in situ TEM.

    abstract：:The ability to observe chemical reactions at the molecular level convincingly demonstrates the physical and chemical phenomena occurring throughout a reaction mechanism. Videos obtained through in situ transmission electron microscopy (TEM) revealed the oxidation of catalytic soot under practical reaction conditions. ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10161

    authors： Kamatani K,Higuchi K,Yamamoto Y,Arai S,Tanaka N,Ogura M

    更新日期：2015-07-08 00:00:00

  • Profiling the MAPK/ERK dependent and independent activity regulated transcriptional programs in the murine hippocampus in vivo.

    abstract：:Activity-dependent alteration of the transcriptional program is central for shaping neuronal connectivity. Constitutively expressed transcription factors orchestrate the initial response to neuronal stimulation and serve as substrates for second messenger-regulated kinase signalling cascades. The mitogen-activated pro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45101

    authors： Blüthgen N,van Bentum M,Merz B,Kuhl D,Hermey G

    更新日期：2017-03-28 00:00:00

  • Gamma oryzanol impairs alcohol-induced anxiety-like behavior in mice via upregulation of central monoamines associated with Bdnf and Il-1β signaling.

    abstract：:Adolescent alcohol exposure may increase anxiety-like behaviors by altering central monoaminergic functions and other important neuronal pathways. The present study was designed to investigate the anxiolytic effect of 0.5% γ-oryzanol (GORZ) and its neurochemical and molecular mechanisms under chronic 10% ethanol consu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67689-w

    authors： Akter S,Uddin KR,Sasaki H,Lyu Y,Shibata S

    更新日期：2020-06-30 00:00:00

  • Real-time and ultrahigh accuracy image synthesis algorithm for full field of view imaging system.

    abstract：:In this paper, we propose a real time, ultrahigh accuracy and full-field-of-view (RUF) algorithm for full field of view (FOV) imaging system. The proposed algorithm combines rough matching and precise matching method to stitch multiple images with the whole FOV in short time and high imaging quality. In order to verif...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69353-9

    authors： Liu SB,Wang JH,Yuan RY,Zhao WX,Li L,Wang QH

    更新日期：2020-07-24 00:00:00

  • Spatial and temporal variations of air quality and six air pollutants in China during 2015-2017.

    abstract：:Air pollution has aroused significant public concern in China, therefore, long-term air-quality data with high temporal and spatial resolution are needed to understand the variations of air pollution in China. However, the yearly variations with high spatial resolution of air quality and six air pollutants are still u...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50655-6

    authors： Guo H,Gu X,Ma G,Shi S,Wang W,Zuo X,Zhang X

    更新日期：2019-10-23 00:00:00

  • Genomic Characterization of Diverse Gyroviruses Identified in the Feces of Domestic Cats.

    abstract：:Gyroviruses (GyVs) are small, single-stranded, circular DNA viruses in the genus Gyrovirus, which consists of the chicken anemia virus (CAV) prototype and nine other viral species. These different GyV species have been reported in chickens, humans, mice, and companion animals. To date, CAV has been identified in the f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49955-8

    authors： Niu JT,Yi SS,Dong GY,Guo YB,Zhao YL,Huang HL,Wang K,Hu GX,Dong H

    更新日期：2019-09-16 00:00:00

  • Precise Doppler shift compensation in the hipposiderid bat, Hipposideros armiger.

    abstract：:Bats of the Rhinolophidae and Hipposideridae families, and Pteronotus parnellii, compensate for Doppler shifts generated by their own flight movement. They adjust their call frequency such that the frequency of echoes coming from ahead fall in a specialized frequency range of the hearing system, the auditory fovea, to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22880-y

    authors： Schoeppler D,Schnitzler HU,Denzinger A

    更新日期：2018-03-15 00:00:00

  • Effects of surface defects on the mechanical properties of ZnO nanowires.

    abstract：:The elastic modulus of ZnO nanowires was measured using a resonance method based on laser Doppler effect and their fracture strains were determined via two-point bending with the aid of optical nanomanipulation. The elastic moduli of ZnO nanowires with diameters of 78 to 310 nm vary from 123 to 154 GPa, which are clos...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09843-5

    authors： Roy A,Mead J,Wang S,Huang H

    更新日期：2017-08-25 00:00:00

  • A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules.

    abstract：:The accelerated discovery of disease-related genes emerging from genomic studies has strained the capacity of traditional genetically engineered mouse models (GEMMs) to provide in-vivo validation. Direct, somatic, genetic engineering approaches allow for accelerated and flexible genetic manipulation and represent an a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11061

    authors： Espana-Agusti J,Tuveson DA,Adams DJ,Matakidou A

    更新日期：2015-06-05 00:00:00

  • Proteomic and metagenomic insights into prehistoric Spanish Levantine Rock Art.

    abstract：:The Iberian Mediterranean Basin is home to one of the largest groups of prehistoric rock art sites in Europe. Despite the cultural relevance of prehistoric Spanish Levantine rock art, pigment composition remains partially unknown, and the nature of the binders used for painting has yet to be disclosed. In this work, w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28121-6

    authors： Roldán C,Murcia-Mascarós S,López-Montalvo E,Vilanova C,Porcar M

    更新日期：2018-07-03 00:00:00

  • Conformational transitions induced by γ-amino butyrate binding in GabR, a bacterial transcriptional regulator.

    abstract：:GabR from Bacillus subtilis is a transcriptional regulator of the MocR subfamily of GntR regulators. The MocR architecture is characterized by the presence of an N-terminal winged-Helix-Turn-Helix domain and a C-terminal domain folded as the pyridoxal 5'-phosphate (PLP) dependent aspartate aminotransferase (AAT). The ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55581-1

    authors： Frezzini M,Guidoni L,Pascarella S

    更新日期：2019-12-17 00:00:00

  • Handheld Photoacoustic Microscopy Probe.

    abstract：:Optical resolution photoacoustic microscopy (OR-PAM) is a non-invasive, label-free method of in vivo imaging with microscopic resolution and high optical contrast. Based on intrinsic contrasts, OR-PAM has expanded to include in vivo vessel imaging, flow cytometry, physiological parameter analysis, and single-cell char...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13224-3

    authors： Park K,Kim JY,Lee C,Jeon S,Lim G,Kim C

    更新日期：2017-10-17 00:00:00

  • Earthquake impacts on microcrustacean communities inhabiting groundwater-fed springs alter species-abundance distribution patterns.

    abstract：:Earthquakes are important natural events, yet their impacts on animal communities are poorly known. Understanding earthquake impacts on groundwater communities is essential to assess their resilience and hence to perform conservation actions. We investigated how a 6.3 Mw earthquake that occurred in 2009 altered the co...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20011-1

    authors： Fattorini S,Di Lorenzo T,Galassi DMP

    更新日期：2018-01-24 00:00:00

  • Response of Human Osteoblast to n-HA/PEEK--Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite.

    abstract：:Nano-sized hydroxyapatite (n-HA) is considered as a bio-active material, which is often mixed into bone implant material, polyetheretherketone (PEEK). To reveal the global protein expression modulations of osteoblast in response to direct contact with the PEEK composite containing high level (40%) nano-sized hydroxyap...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22832

    authors： Zhao M,Li H,Liu X,Wei J,Ji J,Yang S,Hu Z,Wei S

    更新日期：2016-03-09 00:00:00

  • Assessing mutant p53 in primary high-grade serous ovarian cancer using immunohistochemistry and massively parallel sequencing.

    abstract：:The tumour suppressor p53 is mutated in cancer, including over 96% of high-grade serous ovarian cancer (HGSOC). Mutations cause loss of wild-type p53 function due to either gain of abnormal function of mutant p53 (mutp53), or absent to low mutp53. Massively parallel sequencing (MPS) enables increased accuracy of detec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26191

    authors： Cole AJ,Dwight T,Gill AJ,Dickson KA,Zhu Y,Clarkson A,Gard GB,Maidens J,Valmadre S,Clifton-Bligh R,Marsh DJ

    更新日期：2016-05-18 00:00:00

  • Immunological evidence for in vivo production of novel advanced glycation end-products from 1,5-anhydro-D-fructose, a glycogen metabolite.

    abstract：:The anhydrofructose pathway is an alternate pathway for glycogen degradation by α-1,4-glucan lyase. The sugar 1,5-anhydro-D-fructose (1,5-AF) acts as the central intermediate of this pathway, but its physiological role of in mammals is unclear. Glycation reactions forming advanced glycation end-products (AGEs) are imp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46333-2

    authors： Sakasai-Sakai A,Takata T,Suzuki H,Maruyama I,Motomiya Y,Takeuchi M

    更新日期：2019-07-15 00:00:00

  • A record of changes in the Gran Sasso groundwater before, during and after the 2016 Amatrice earthquake, central Italy.

    abstract：:We performed continuous recordings (May 2015 - January 2017) of hydraulic pressure and electrical conductivity of groundwater in the 190 m-long horizontal S13 borehole drilled next to the deep underground laboratories of Gran Sasso (LNGS-INFN), located in the core of the Gran Sasso carbonate aquifer (central Italy) at...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34444-1

    authors： De Luca G,Di Carlo G,Tallini M

    更新日期：2018-10-29 00:00:00

  • C-terminal intrinsically disordered region-dependent organization of the mycobacterial genome by a histone-like protein.

    abstract：:The architecture of the genome influences the functions of DNA from bacteria to eukaryotes. Intrinsically disordered regions (IDR) of eukaryotic histones have pivotal roles in various processes of gene expression. IDR is rare in bacteria, but interestingly, mycobacteria produce a unique histone-like protein, MDP1 that...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26463-9

    authors： Savitskaya A,Nishiyama A,Yamaguchi T,Tateishi Y,Ozeki Y,Nameta M,Kon T,Kaboso SA,Ohara N,Peryanova OV,Matsumoto S

    更新日期：2018-05-29 00:00:00

  • NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling.

    abstract：:Acute pancreatitis (AP) is a complicated disease without specific drug therapy. The cofactor nicotinamide adenine dinucleotide (NAD+) is an important regulator of cellular metabolism and homeostasis. However, it remains unclear whether modulation of NAD+ levels has an impact on caerulein-induced AP. Therefore, in this...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03418-0

    authors： Shen A,Kim HJ,Oh GS,Lee SB,Lee SH,Pandit A,Khadka D,Choe SK,Kwak SC,Yang SH,Cho EY,Kim HS,Kim H,Park R,Kwak TH,So HS

    更新日期：2017-06-07 00:00:00

  • Amaryllidaceae alkaloids: identification and partial characterization of montanine production in Rhodophiala bifida plant.

    abstract：:Rhodophiala bifida (R. bifida) is a representative of the Amaryllidaceae plant family and is rich in montanine, an alkaloid with high pharmaceutical potential. Despite the interest in these compounds, many steps of the biosynthetic pathway have not been elucidated. In this study, we identified the alkaloids produced i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44746-7

    authors： Reis A,Magne K,Massot S,Tallini LR,Scopel M,Bastida J,Ratet P,Zuanazzi JAS

    更新日期：2019-06-11 00:00:00

  • Extra-electron induced covalent strengthening and generalization of intrinsic ductile-to-brittle criterion.

    abstract：:Traditional strengthening ways, such as strain, precipitation, and solid-solution, come into effect by pinning the motion of dislocation. Here, through first-principles calculations we report on an extra-electron induced covalent strengthening mechanism, which alters chemical bonding upon the introduction of extra-val...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00718

    authors： Niu H,Chen XQ,Liu P,Xing W,Cheng X,Li D,Li Y

    更新日期：2012-01-01 00:00:00

  • Accumulation of organic C components in soil and aggregates.

    abstract：:To explore soil organic carbon (SOC) accumulation mechanisms, the dynamics of C functional groups and macroaggregation were studied synchronously through aggregate fractionation and (13)C NMR spectroscopy in sandy loam soil following an 18-year application of compost and fertilizer in China. Compared with no fertilize...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13804

    authors： Yu H,Ding W,Chen Z,Zhang H,Luo J,Bolan N

    更新日期：2015-09-11 00:00:00

  • In situ investigation of phase transformations in Ti-6Al-4V under additive manufacturing conditions combining laser melting and high-speed micro-X-ray diffraction.

    abstract：:We present combined in situ X-ray diffraction and high-speed imaging to monitor the phase evolution upon cyclic rapid laser heating and cooling mimicking the direct energy deposition of Ti-6Al-4V in real time. Additive manufacturing of the industrially relevant alloy Ti-6Al-4V is known to create a multitude of phases ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16760-0

    authors： Kenel C,Grolimund D,Li X,Panepucci E,Samson VA,Sanchez DF,Marone F,Leinenbach C

    更新日期：2017-11-27 00:00:00

  • Enzyme-guided DNA Sewing Architecture.

    abstract：:With the advent of nanotechnology, a variety of nanoarchitectures with varied physicochemical properties have been designed. Owing to the unique characteristics, DNAs have been used as a functional building block for novel nanoarchitecture. In particular, a self-assembly of long DNA molecules via a piece DNA staple ha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17722

    authors： Song IH,Shin SW,Park KS,Lansac Y,Jang YH,Um SH

    更新日期：2015-12-04 00:00:00

  • Helical organization of microtubules occurs in a minority of tunneling membrane nanotubes in normal and cancer urothelial cells.

    abstract：:Tunneling membrane nanotubes (TnTs) are membrane protrusions connecting nearby or distant cells in vitro and in vivo. Functions of TnTs in cellular processes are various and rely on TnT structure, which also depends on cytoskeletal composition. In the present study, we focused on the organization of microtubules (MTs)...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35370-y

    authors： Resnik N,Prezelj T,De Luca GMR,Manders E,Polishchuk R,Veranič P,Kreft ME

    更新日期：2018-11-20 00:00:00

  • Statistical Modeling of Heart Rate Variability to Unravel the Factors Affecting Autonomic Regulation in Preterm Infants.

    abstract：:Analyzing heart rate variability (HRV) in preterm infants can help track maturational changes and subclinical signatures of disease. We conducted an observational study to characterize the effect of demographic and cardiorespiratory factors on three features of HRV using a linear mixed-effects model. HRV-features were...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44209-z

    authors： Joshi R,Kommers D,Guo C,Bikker JW,Feijs L,van Pul C,Andriessen P

    更新日期：2019-05-22 00:00:00

  • The Sulfoquinovosyltransferase-like Enzyme SQD2.2 is Involved in Flavonoid Glycosylation, Regulating Sugar Metabolism and Seed Setting in Rice.

    abstract：:Seed setting is an important trait that contributes to seed yield and relies greatly on starch accumulation. In this study, a sulfoquinovosyl transferase-like protein, designated as SQD2.2 involved in seed setting and flavonoid accumulation, was identified and characterized in rice. Rice SQD2.2 is localized to the cyt...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04002-2

    authors： Zhan X,Shen Q,Wang X,Hong Y

    更新日期：2017-07-05 00:00:00

  • Accuracy of manual and automatic placement of an anatomical coordinate system for the full or partial radius in 3D space.

    abstract：:Accurate placement of a coordinate system on the radius is important to quantitatively report 3D surgical planning parameters or joint kinematics using 4D imaging techniques. In clinical practice, the scanned length of the radial shaft varies among scanning protocols and scientific studies. The error in positioning a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65060-7

    authors： de Roo MGA,Dobbe JGG,Peymani A,van der Made AD,Strackee SD,Streekstra GJ

    更新日期：2020-05-15 00:00:00

  • Formation of Biphasic Hydroxylapatite-Beta Magnesium Tricalcium Phosphate in Heat Treated Salmonid Vertebrae.

    abstract：:Ichthyoarchaeological evidence is uncommon at ancient hunter-gatherer sites from various regions and timeframes. This research contributes to the development of microarchaeological techniques useful for identifying fishing economies in situations where classifiable bones are unavailable. Specifically, traces of heat a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03737-2

    authors： Butler DH,Shahack-Gross R

    更新日期：2017-06-15 00:00:00