Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma.

abstract：:In the present study, a coarse grained AZ31 plate was refined by twin boundaries (TBs) and grain boundaries (GBs), respectively. A comparative study about the different effects of grain refinements by GBs and by TBs on tension-compression yield asymmetry was performed. Our results show that both the refinements by GBs...

journal_title：Scientific reports

authors： Yu H,Xin Y,Chapuis A,Huang X,Xin R,Liu Q

更新日期：2016-07-04 00:00:00

abstract：:Identifying the unintended effects of drugs (side effects) is a very important issue in pharmacological studies. The laboratory verification of associations between drugs and side effects requires costly, time-intensive research. Thus, an approach to predicting drug side effects based on known side effects, using a co...

journal_title：Scientific reports

authors： Timilsina M,Tandan M,d'Aquin M,Yang H

更新日期：2019-07-18 00:00:00

abstract：:Plant genomes encode several classes of small regulatory RNAs (sRNAs) that play critical roles in both development and stress responses. Panax notoginseng (Burk.) F.H. Chen (P. notoginseng) is an important traditional Chinese herbal medicinal plant species for its haemostatic effects. Therefore, the root yield of P. n...

journal_title：Scientific reports

authors： Zheng Y,Chen K,Xu Z,Liao P,Zhang X,Liu L,Wei K,Liu D,Li YF,Sunkar R,Cui X

更新日期：2017-08-25 00:00:00

abstract：:The Turin Shroud is traditionally considered to be the burial cloth in which the body of Jesus Christ was wrapped after his death approximately 2000 years ago. Here, we report the main findings from the analysis of genomic DNA extracted from dust particles vacuumed from parts of the body image and the lateral edge use...

journal_title：Scientific reports

authors： Barcaccia G,Galla G,Achilli A,Olivieri A,Torroni A

更新日期：2015-10-05 00:00:00

abstract：:Monitoring of disease/therapeutic conditions is an important application of circulating tumor DNA (ctDNA). We devised numerical indices, based on ctDNA dynamics, for therapeutic response and disease progression. 52 lung cancer patients subjected to the EGFR-TKI treatment were prospectively collected, and ctDNA levels ...

journal_title：Scientific reports

authors： Kato K,Uchida J,Kukita Y,Kumagai T,Nishino K,Inoue T,Kimura M,Oba S,Imamura F

更新日期：2016-07-06 00:00:00

abstract：:Metasurfaces, owing to their attractive features, provide a wide range of potential applications. Electromagnetic absorbers based on metasurfaces have significantly improved responses compared to the earlier absorbers made from composite materials. Active metasurfaces, in contrast to the passive designs, can exhibit m...

journal_title：Scientific reports

authors： Ghosh S,Lim S

更新日期：2018-07-05 00:00:00

abstract：:Nilaparvata lugens (Stål) (Hemiptera: Delphacidae) is a major rice pest that harbors an endosymbiont ascomycete fungus, Entomomyces delphacidicola str. NLU (also known as yeast-like symbiont, YLS). Driving by demand of novel population management tactics (e.g. RNAi), the importance of YLS has been studied and revealed...

journal_title：Scientific reports

authors： Wan PJ,Tang YH,Yuan SY,He JC,Wang WX,Lai FX,Fu Q

更新日期：2017-02-13 00:00:00

abstract：:The repressive activity of ancestral histone-like proteins helps integrate transcription of foreign genes with discrepant AT content into existing regulatory networks. Our investigations indicate that the AT-rich discriminator region located between the -10 promoter element and the transcription start site of the regu...

journal_title：Scientific reports

authors： Tapscott T,Kim JS,Crawford MA,Fitzsimmons L,Liu L,Jones-Carson J,Vázquez-Torres A

更新日期：2018-06-21 00:00:00

abstract：:This research utilized an external longitudinal dataset of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) to compare and validate various predictive models that support the current recommendations to select the most effective predictive risk models to estimate short- and long-term mortality and fa...

journal_title：Scientific reports

authors： Shen Y,Wang X,Zhang S,Qin G,Liu Y,Lu Y,Liang F,Zhuang X

更新日期：2016-09-16 00:00:00

abstract：:Monitoring one's actions is essential for goal-directed performance. In the event-related potential (ERP), errors are followed by fronto-centrally distributed negativities. These error(-related) negativity (Ne/ERN) amplitudes are often found to be attenuated in patients with Parkinson's disease (PD) compared to health...

journal_title：Scientific reports

authors： Seer C,Lange F,Loens S,Wegner F,Schrader C,Dressler D,Dengler R,Kopp B

更新日期：2017-01-24 00:00:00

abstract：:Homogeneously distributed zinc nanoparticles (NPs) on the glass substrate were investigated for the transmittance, mechanical durability, and antibacterial effect. The buffered Ti NPs between Zn NPs and glass substrate were studied for an enhancement of the transmittance and mechanical endurance. The Ti NPs buffered Z...

journal_title：Scientific reports

authors： Choi HJ,Choi JS,Park BJ,Eom JH,Heo SY,Jung MW,An KS,Yoon SG

更新日期：2014-09-03 00:00:00

abstract：:Mitochondria play an essential role in bioenergetics and cellular Ca[Formula: see text] handling. The mitochondrial permeability transition pore (mPTP) is a non-specific channel located in the inner mitochondrial membrane. Long-lasting openings of the pore allow the rapid passage of ions and large molecules, which can...

journal_title：Scientific reports

authors： Wacquier B,Combettes L,Dupont G

更新日期：2020-03-03 00:00:00

abstract：:Biomass waste treatment and detrimental dye adsorption are two of the crucial environmental issues nowadays. In this study, we investigate to simultaneously resolve the aforementioned issues by synthesizing chitosan sponges as adsorbents toward rose bengal (RB) dye adsorption. Through a temperature-controlled freeze-c...

journal_title：Scientific reports

authors： Wang M,Ma Y,Sun Y,Hong SY,Lee SK,Yoon B,Chen L,Ci L,Nam JD,Chen X,Suhr J

更新日期：2017-12-22 00:00:00

abstract：:Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1, PFI-1, and Bromos...

journal_title：Scientific reports

authors： Roberts TC,Etxaniz U,Dall'Agnese A,Wu SY,Chiang CM,Brennan PE,Wood MJA,Puri PL

更新日期：2017-07-21 00:00:00

abstract：:Insufficient glenoid fixation is one of the main reasons for failure in total shoulder arthroplasty. This is predominantly caused by the inert nature of the ultra-high molecular weight polyethylene (UHMWPE) used in the glenoid component of the implant, which makes it difficult to adhesively bind to bone cement or bone...

journal_title：Scientific reports

authors： Van Vrekhem S,Vloebergh K,Asadian M,Vercruysse C,Declercq H,Van Tongel A,De Wilde L,De Geyter N,Morent R

更新日期：2018-03-16 00:00:00

abstract：:NOTCH plays a pivotal role during normal development and in congenital disorders and cancer. γ-secretase inhibitors are commonly used to probe NOTCH function, but also block processing of numerous other proteins. We discovered a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ...

journal_title：Scientific reports

authors： Hurtado C,Safarova A,Smith M,Chung R,Bruyneel AAN,Gomez-Galeno J,Oswald F,Larson CJ,Cashman JR,Ruiz-Lozano P,Janiak P,Suzuki T,Mercola M

更新日期：2019-07-25 00:00:00

abstract：:Up to now, a very few catalysts have been developed approaching the heterogeneous catalytic degradation of Eosin Y and Chromotrope 2R dyes (Acid Red 29). The present study provides a complete perspective of recyclable nanocomposite Au(Salen)@CC for catalytic degradation of hazardous water pollutant dyes viz., Eosin Y ...

journal_title：Scientific reports

authors： Mayani VJ,Mayani SV,Kim SW

更新日期：2017-08-03 00:00:00

abstract：:Synapse and dendritic spine loss induced by amyloid-β oligomers is one of the main hallmarks of the early phases of Alzheimer's disease (AD) and is directly correlated with the cognitive decline typical of this pathology. The p75 neurotrophin receptor (p75NTR) binds amyloid-β oligomers in the nM range. While it was sh...

journal_title：Scientific reports

authors： Patnaik A,Zagrebelsky M,Korte M,Holz A

更新日期：2020-08-07 00:00:00

abstract：:This article presents the homodyne detection in a self-oscillation system, which represented by a short-range radar (SRR) circuit, that is analysed using a multi-time forced oscillator (MTFO) model. The MTFO model is based on a forced oscillation perspective with the signal and system theory, a second-order differenti...

journal_title：Scientific reports

authors： Kittipute K,Saratayon P,Srisook S,Wardkein P

更新日期：2017-03-02 00:00:00

abstract：:The effects of gradual vascular occlusion on the blood supply of perfused areas are poorly described. Information relating to the comparison of flap monitoring techniques is lacking. Varying stenotic conditions (0%, 25%, 50%, 75% and 100%) were generated on purpose at the A. and V. femoralis in the rat model. Analyses...

journal_title：Scientific reports

authors： Mücke T,Hapfelmeier A,Schmidt LH,Fichter AM,Kanatas A,Wolff KD,Ritschl LM

更新日期：2020-01-22 00:00:00

abstract：:Antimicrobial resistant infections are a serious public health threat worldwide. Whole genome sequencing approaches to rapidly identify pathogens and predict antibiotic resistance phenotypes are becoming more feasible and may offer a way to reduce clinical test turnaround times compared to conventional culture-based m...

journal_title：Scientific reports

authors： Nguyen M,Brettin T,Long SW,Musser JM,Olsen RJ,Olson R,Shukla M,Stevens RL,Xia F,Yoo H,Davis JJ

更新日期：2018-01-11 00:00:00

abstract：:Recent studies on next-generation permanent magnets have focused on filling in the gap between rare-earth magnets and rare-earth-free magnets, taking into account both the cost-effectiveness and magnetic performance of the magnetic materials. As an improved rare-earth-free magnet candidate, here, Ca-substituted M-type...

journal_title：Scientific reports

authors： Lee J,Lee EJ,Hwang TY,Kim J,Choa YH

更新日期：2020-09-28 00:00:00

abstract：:Amyloid-beta (Aβ)-induced neurotoxicity is a major contributor to the pathologies associated with Alzheimer's disease (AD). The formation of reactive oxygen species (ROS), an early response induced by the peptide and oligomeric derivatives of Aβ, plays a significant role in effecting cellular pathogenesis. Here we emp...

journal_title：Scientific reports

authors： Giordano CR,Terlecky LJ,Bollig-Fischer A,Walton PA,Terlecky SR

更新日期：2014-05-15 00:00:00

abstract：:Effective application of whole-cell devices in synthetic biology and biocatalysis will always require consideration of the uptake of molecules of interest into the cell. Here we demonstrate that the AlkL protein from Pseudomonas putida GPo1 is an alkane import protein capable of industrially relevant rates of uptake o...

journal_title：Scientific reports

authors： Grant C,Deszcz D,Wei YC,Martínez-Torres RJ,Morris P,Folliard T,Sreenivasan R,Ward J,Dalby P,Woodley JM,Baganz F

更新日期：2014-07-28 00:00:00

abstract：:Traditional strengthening ways, such as strain, precipitation, and solid-solution, come into effect by pinning the motion of dislocation. Here, through first-principles calculations we report on an extra-electron induced covalent strengthening mechanism, which alters chemical bonding upon the introduction of extra-val...

journal_title：Scientific reports

authors： Niu H,Chen XQ,Liu P,Xing W,Cheng X,Li D,Li Y

更新日期：2012-01-01 00:00:00

abstract：:Pancreas development requires restrained Hedgehog (Hh) signaling activation. While deregulated Hh signaling in the pancreatic mesenchyme has been long suggested to be detrimental for proper organogenesis, this association was not directly shown. Here, we analyzed the contribution of mesenchymal Hh signaling to pancrea...

journal_title：Scientific reports

authors： Hibsher D,Epshtein A,Oren N,Landsman L

更新日期：2016-11-28 00:00:00

abstract：:The Law of the Minimum is often implemented using t-norm or fuzzy intersection. We propose the use of t-conorm or fuzzy union for climate suitability assessment of a grass species using annual ryegrass (Lolium multiflorum Lam.) as an example and evaluate the performance for alfalfa (Medicago sativa L.) and sorghum (So...

journal_title：Scientific reports

authors： Kim H,Hyun SW,Hoogenboom G,Porter CH,Kim KS

更新日期：2018-07-05 00:00:00

abstract：:The current standard treatment for ovarian cancer is aggressive surgery followed by platinum-based combination chemotherapy. Recurrence and chemotherapeutic drug resistance are the two main factors that account for the high mortality of most ovarian cancers. Liposomal doxorubicin is primarily used for the treatment of...

journal_title：Scientific reports

authors： Li S,Cao J,Zhang W,Zhang F,Ni G,Luo Q,Wang M,Tao X,Xia H

更新日期：2016-11-11 00:00:00

abstract：:Enterococcus faecium is a commensal of the mammalian gastrointestinal tract, but is also found in non-enteric environments where it can grow between 10 °C and 45 °C. E. faecium has recently emerged as a multi-drug resistant nosocomial pathogen. We hypothesized that genes involved in the colonization and infection of m...

journal_title：Scientific reports

authors： Guzmán Prieto AM,Urbanus RT,Zhang X,Bierschenk D,Koekman CA,van Luit-Asbroek M,Ouwerkerk JP,Pape M,Paganelli FL,Wobser D,Huebner J,Hendrickx AP,Bonten MJ,Willems RJ,van Schaik W

更新日期：2015-12-17 00:00:00

abstract：:Recently, the first-order synchronization transition has been studied in systems of coupled phase oscillators. In this paper, we propose a framework to investigate the synchronization in the frequency-weighted Kuramoto model with all-to-all couplings. A rigorous mean-field analysis is implemented to predict the possib...

journal_title：Scientific reports

authors： Xu C,Sun Y,Gao J,Qiu T,Zheng Z,Guan S

更新日期：2016-02-23 00:00:00