Abstract：
:NOTCH plays a pivotal role during normal development and in congenital disorders and cancer. γ-secretase inhibitors are commonly used to probe NOTCH function, but also block processing of numerous other proteins. We discovered a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ, which is the main transcriptional effector of NOTCH signaling. RBPJ Inhibitor-1 (RIN1) also blocked the functional interaction of RBPJ with SHARP, a scaffold protein that forms a transcriptional repressor complex with RBPJ in the absence of NOTCH signaling. RIN1 induced changes in gene expression that resembled siRNA silencing of RBPJ rather than inhibition at the level of NOTCH itself. Consistent with disruption of NOTCH signaling, RIN1 inhibited the proliferation of hematologic cancer cell lines and promoted skeletal muscle differentiation from C2C12 myoblasts. Thus, RIN1 inhibits RBPJ in its repressing and activating contexts, and can be exploited for chemical biology and therapeutic applications.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hurtado C,Safarova A,Smith M,Chung R,Bruyneel AAN,Gomez-Galeno J,Oswald F,Larson CJ,Cashman JR,Ruiz-Lozano P,Janiak P,Suzuki T,Mercola Mdoi
10.1038/s41598-019-46948-5subject
Has Abstractpub_date
2019-07-25 00:00:00pages
10811issue
1issn
2045-2322pii
10.1038/s41598-019-46948-5journal_volume
9pub_type
杂志文章abstract：:The process of second-harmonic generation (SHG) in a finite one-dimensional nonlinear medium is analyzed in parallel by the Green-function technique and the Fourier-transform method. Considering the fundamental pump field propagating along a given direction and eliminating back-reflections at the boundaries the terms ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39260-9
更新日期：2019-03-20 00:00:00
abstract：:The white spot syndrome virus (WSSV) causes mass mortalities in the aquaculture of shrimps worldwide. The mud shrimp Austinogebia edulis (Ngoc-Ho & Chan, 1992) is an economically important sea food item occurring along the west coast of Taiwan. While the population of A. edulis began to decrease with some fluctuations...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54837-0
更新日期：2019-12-09 00:00:00
abstract：:Anserine/carnosine supplementation improves cerebral blood flow and verbal episodic memory in elderly people, as we previously reported. Anserine's buffering activity is superior to that of carnosine at neutral pH. In human sera, carnosine but not anserine is rapidly cleaved by carnosinase, limiting its effectiveness....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12785-7
更新日期：2017-10-03 00:00:00
abstract：:Nitric oxide (NO) signaling has been studied in the eye, including in the pathophysiology of some eye diseases. While NO production by nitric oxide synthase (NOS) enzymes in the eye has been characterized, the more recently described pathways of NO generation by nitrate (NO3-) and nitrite (NO2-) ions reduction has rec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69272-9
更新日期：2020-08-05 00:00:00
abstract：:Large spin splitting at Rashba interface, giving rise to strong spin-momentum locking, is essential for efficient spin-to-charge conversion. Recently, a Cu/Bismuth oxide (Bi2O3) interface has been found to exhibit an efficient spin-to-charge conversion similar to a Ag/Bi interface with large Rashba spin splitting. How...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23787-4
更新日期：2018-04-03 00:00:00
abstract：:Retinal diseases are frequently characterized by the accumulation of excessive scar tissue found throughout the neural retina. However, the pathophysiology of retinal fibrosis remains poorly understood, and the cell types that contribute to the fibrotic response are incompletely defined. Here, we show that myofibrobla...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72875-x
更新日期：2020-09-25 00:00:00
abstract：:Controlled surface wettability for oil has been intensively studied to remove industrial oil waste or oil spill pollution from seas or rivers. In particular, external stimuli-induced special wetting materials, such as photo-responsive TiO2, have attracted considerable attention for oil-water separation. In this study,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12908
更新日期：2015-08-11 00:00:00
abstract：:Myostatin (MSTN) is a dominant inhibitor of skeletal muscle development and growth. Mutations in MSTN gene can lead to muscle hypertrophy or double-muscled (DM) phenotype in cattle, sheep, dog and human. However, there has not been reported significant muscle phenotypes in pigs in association with MSTN mutations. Pigs...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14435
更新日期：2015-09-24 00:00:00
abstract：:In this study, we analyze the role of different structural variants of proteins in the speciation processes. We separate human and mouse proteomes (taken as a reference) into three previously defined variants of disorder: ordered proteins (ORDPs), structured proteins with intrinsically disordered protein regions (IDPR...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61466-5
更新日期：2020-03-11 00:00:00
abstract：:Short-wavelength luminescence is essential for high-performance optoelectronic device applications. There have been efforts to obtain intense ultraviolet (UV) emission by encapsulating ZnO one-dimensional (1D) nanostructures with materials such as ZnS. However, the encapsulation of ZnS 1D nanostructures with ZnO has n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13556-0
更新日期：2017-10-12 00:00:00
abstract：:The recent reported trapped "rainbow" storage of light using metamaterials and plasmonic graded surface gratings has generated considerable interest for on-chip slow light. The potential for controlling the velocity of broadband light in guided photonic structures opens up tremendous opportunities to manipulate light ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01249
更新日期：2013-01-01 00:00:00
abstract：:Microbial survival in dynamic environments requires the ability to successfully respond to abrupt changes in osmolarity. The mechanosensitive channel of large conductance (MscL) is a ubiquitous channel that facilitates the survival of bacteria and archaea under severe osmotic downshock conditions by relieving excess t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32536-6
更新日期：2018-10-01 00:00:00
abstract：:The intention of this observational study is to show the significant impact of comorbidities and smoking on the outcome in aneurysmal subarachnoid hemorrhage (SAH). During this observational study 203 cases of treatment of ruptured intracranial aneurysms were analyzed. We examined and classified prospectively the 12 m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30878-9
更新日期：2018-08-17 00:00:00
abstract：:Biology is adapted to Earth's gravity force, and the long-term effects of varying gravity on the development of animals is unclear. Previously, we reported that high gravity, called hypergravity, increases defects in the development of motor neuron axons in the nematode Caenorhabditis elegans. Here, we show that a mut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78414-y
更新日期：2020-12-03 00:00:00
abstract：:The family Trichomycteridae is one of the most diverse groups of freshwater catfishes in South and Central America with eight subfamilies, 41 genera and more than 300 valid species. Its members are widely distributed throughout South America, reaching Costa Rica in Central America and are recognized by extraordinary a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59519-w
更新日期：2020-02-14 00:00:00
abstract：:This is a systematical report on the potential health risk of heavy metals from the leather industries in Pakistan based on multiple biological matrices of the exposed workers and indoor dust samples. The adverse impacts of heavy metals on the oxidative enzyme and their risks to workers' health were also explored. Our...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09075-7
更新日期：2017-08-18 00:00:00
abstract：:Yeast Cdc48 is a well-conserved, essential chaperone of ATPases associated with diverse cellular activity (AAA) proteins, which recognizes substrate proteins and modulates their conformations to carry out many cellular processes. However, the fundamental mechanisms underlying the diverse pivotal roles of Cdc48 remain ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05806-y
更新日期：2017-07-14 00:00:00
abstract：:The mechanism by which the HIV-1 MPER epitope is recognized by the potent neutralizing antibody 10E8 at membrane interfaces remains poorly understood. To solve this problem, we have optimized a 10E8 peptide epitope and analyzed the structure and binding activities of the antibody in membrane and membrane-like environm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38177
更新日期：2016-12-01 00:00:00
abstract：:Rabies is still a public health threat in China. Evaluating the exposure history, clinical characteristics, and post-exposure prophylaxis (PEP) of the cases could help in identifying approaches to reducing the number of these preventable deaths. We analysed data collected from 10,971 case-investigations conducted in C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35158-0
更新日期：2018-11-21 00:00:00
abstract：:Human iPS cells hold great promise for disease modeling and treatment of degenerative disorders including muscular dystrophies. Although a few research groups have used them for skeletal muscle differentiation, most were based on gene over-expression or long-term mesenchymal differentiation and retrospective identific...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18759
更新日期：2016-01-05 00:00:00
abstract：:Vibrio vulnificus causes fatal infections in humans, and antibiotics are commonly used in treatment regimens against V. vulnificus infection. However, the therapeutic effects of antibiotics are limited by multidrug resistance. In this study, we demonstrated that an antimicrobial peptide (AMP), HPA3PHis, loaded onto a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14127-z
更新日期：2017-10-19 00:00:00
abstract：:Threat detection is essential for protecting individuals from adverse situations, in which a network of amygdala, limbic regions and dorsomedial prefrontal cortex (dmPFC) regions are involved in fear processing. Excitability regulation in the dmPFC might be crucial for fear processing, while abnormal patterns could le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32781-9
更新日期：2018-09-28 00:00:00
abstract：:Osteopontin (OPN), a multifunctional cytokine that controls liver glycerolipid metabolism, is involved in activation and proliferation of several liver cell types during regeneration, a condition of high metabolic demands. Here we investigated the role of OPN in modulating the liver lipidome during regeneration after ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32919-9
更新日期：2018-10-02 00:00:00
abstract：:Breast cancer is the most common cancer in women. However, it remains unproven whether psychological factors have an influence on breast cancer incidence. In our earlier study, subjects possessing two personality traits, decisiveness and "ikigai" (a Japanese word meaning something that makes one's life worth living), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32559
更新日期：2016-09-02 00:00:00
abstract：:Development of cost-effective counter electrode (CE) materials is a key issue for practical applications of photoelectrochemical solar energy conversion. Kesterite Cu2ZnSnS4 (CZTS) has been recognized as a potential CE material, but its electrocatalytic activity is still insufficient for the recovery of I-/I3- electro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26770-1
更新日期：2018-06-07 00:00:00
abstract：:Wetting failure is of vital importance to many physical phenomena, such as industrial coating and drop emission. Here we show when and how the surface roughness promotes the destabilization of a moving contact line on a hydrophilic surface. Beyond the balance of the driving force and viscous resistance where a stable ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05376
更新日期：2014-06-20 00:00:00
abstract：:Recently, the discovery of room temperature magnetoelectricity in organic charge transfer complexes has reignited interest in the multiferroic field. The solution processed, large-area and low cost organic semiconductor materials offer new possibilities for the functional all organic multiferroic devices. Here we repo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28656
更新日期：2016-06-23 00:00:00
abstract：:Alveolar type II epithelial cells (ATII) are instrumental in early wound healing in response to lung injury, restoring epithelial integrity through spreading and migration. We previously reported in separate studies that focal adhesion kinase-1 (FAK) and the chemokine receptor CXCR4 promote epithelial repair mechanism...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02204-2
更新日期：2017-05-19 00:00:00
abstract：:The surveillance of infectious diseases is of great importance for disease control and prevention, and more attention should be paid to the Class B notifiable diseases in China. Meanwhile, according to the International Monetary Fund (IMF), the annual growth of Chinese gross domestic product (GDP) would decelerate bel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-016-0020-5
更新日期：2016-12-23 00:00:00
abstract：:Tuberculosis (TB) is a leading infectious cause of death globally. Drug treatment and vaccination, in particular with Bacillus Calmette-Guérin (BCG), remain the main strategies to control TB. With the emergence of drug resistance, it has been proposed that a combination of TB vaccination with pharmacological treatment...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41008-4
更新日期：2019-03-19 00:00:00
