Abstract：
:Anserine/carnosine supplementation improves cerebral blood flow and verbal episodic memory in elderly people, as we previously reported. Anserine's buffering activity is superior to that of carnosine at neutral pH. In human sera, carnosine but not anserine is rapidly cleaved by carnosinase, limiting its effectiveness. This study examined the effects of anserine on AβPPswe/PSEN1dE9 Alzheimer's disease (AD) model mice over 18-months old, an age at which these mice exhibit detectable memory deficits. We found that 8 weeks of anserine treatment completely recovered the memory deficits, improved pericyte coverage on endothelial cells in the brain, and diminished chronic glial neuroinflammatory reactions in these mice. These results suggest that anserine (beta-alanyl-3-methyl-L-histidine) supplementation improved memory functions in AD-model mice by exerting a protective effect on the neurovascular units, which are composed of endothelial cells, pericytes, and supporting glial cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kaneko J,Enya A,Enomoto K,Ding Q,Hisatsune Tdoi
10.1038/s41598-017-12785-7subject
Has Abstractpub_date
2017-10-03 00:00:00pages
12571issue
1issn
2045-2322pii
10.1038/s41598-017-12785-7journal_volume
7pub_type
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