A heteromeric molecular complex regulates the migration of lung alveolar epithelial cells during wound healing.

abstract：:The P2X receptor family of ATP-gated cation channels are attractive drug targets for pain and inflammatory disease, but no subtype-selective agonists, and few partially selective agonists have been described to date. As proof-of-concept for the discovery of novel P2X receptor agonists, here we demonstrate the use of D...

journal_title：Scientific reports

authors： Grimes L,Griffiths J,Pasqualetto G,Brancale A,Kemp PJ,Young MT,van der Goes van Naters W

更新日期：2020-05-19 00:00:00

abstract：:The bioactive plant diterpene oridonin displays important pharmacological activities and is widely used in traditional Chinese medicine; however, its molecular mechanism of action is still incompletely described. In vitro and in vivo data have demonstrated anti-tumor activity of oridonin and its ability to interfere w...

journal_title：Scientific reports

authors： Vasaturo M,Cotugno R,Fiengo L,Vinegoni C,Dal Piaz F,De Tommasi N

更新日期：2018-11-13 00:00:00

abstract：:Expression profiling of multiple microRNAs (miRNAs) generally provides valuable information for understanding various biological processes. Thus, it is necessary to develop a sensitive and accurate miRNA assay suitable for multiplexing. Isothermal exponential amplification reaction (EXPAR) has received significant int...

journal_title：Scientific reports

authors： Na J,Shin GW,Son HG,Lee SV,Jung GY

更新日期：2017-09-12 00:00:00

abstract：:In this work, we report lateral heterojunction formation in as-exfoliated MoS2 flakes by thickness modulation. Kelvin probe force microscopy is used to map the surface potential at the monolayer-multilayer heterojunction, and consequently the conduction band offset is extracted. Scanning photocurrent microscopy is per...

journal_title：Scientific reports

authors： Tosun M,Fu D,Desai SB,Ko C,Kang JS,Lien DH,Najmzadeh M,Tongay S,Wu J,Javey A

更新日期：2015-06-30 00:00:00

abstract：:The association between cervical lymph node metastasis (LNM) and ultrasonographic features as well as BRAFV600E mutations in patients with papillary thyroid carcinoma (PTC) remained controversial. This study investigated the association between LNM and ultrasonographic features as well as BRAFV600E mutation in Chinese...

journal_title：Scientific reports

authors： Guo L,Ma YQ,Yao Y,Wu M,Deng ZH,Zhu FW,Luo YK,Tang J

更新日期：2019-01-11 00:00:00

abstract：:Mind wandering (MW) refers to the disengagement of attention from the external environment and the generation of thoughts unrelated to the task at hand. It is a ubiquitous cognitive process resulting in lapses of attention. MW imposes a negative impact on attention-based task performance, but also has been associated ...

journal_title：Scientific reports

authors： Leszczynski M,Chaieb L,Reber TP,Derner M,Axmacher N,Fell J

更新日期：2017-08-31 00:00:00

abstract：:Monocytes and macrophages are key players in maintaining immune homeostasis. Identifying strategies to manipulate their functions via gene delivery is thus of great interest for immunological research and biomedical applications. We set out to establish conditions for mRNA transfection in hard-to-transfect primary hum...

journal_title：Scientific reports

authors： Moradian H,Roch T,Lendlein A,Gossen M

更新日期：2020-03-06 00:00:00

abstract：:The molecular structure of the hole transporting material (HTM) play an important role in hole extraction in a perovskite solar cells. It has a significant influence on the molecular planarity, energy level, and charge transport properties. Understanding the relationship between the chemical structure of the HTM's and...

journal_title：Scientific reports

authors： Tiazkis R,Paek S,Daskeviciene M,Malinauskas T,Saliba M,Nekrasovas J,Jankauskas V,Ahmad S,Getautis V,Khaja Nazeeruddin M

更新日期：2017-03-10 00:00:00

abstract：:In this contribution, a semi-automatic segmentation algorithm for (medical) image analysis is presented. More precise, the approach belongs to the category of interactive contouring algorithms, which provide real-time feedback of the segmentation result. However, even with interactive real-time contouring approaches t...

journal_title：Scientific reports

authors： Egger J

更新日期：2014-06-04 00:00:00

abstract：:Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from Pub...

journal_title：Scientific reports

authors： Yamasue M,Komiya K,Usagawa Y,Umeki K,Nureki SI,Ando M,Hiramatsu K,Nagai H,Kadota JI

更新日期：2020-01-31 00:00:00

abstract：:Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, has numerous advantages to the rodent and marmoset that make it a superior and irreplaceable animal model for studying stroke in the brain. In the present study, after ma...

journal_title：Scientific reports

authors： Dai P,Huang H,Zhang L,He J,Zhao X,Yang F,Zhao N,Yang J,Ge L,Lin Y,Yu H,Wang J

更新日期：2017-03-30 00:00:00

abstract：:The mechanisms by which the airborne pathogen Mycobacterium tuberculosis spreads within the lung and leaves its primary niche to colonize other organs, thus inducing extrapulmonary forms of tuberculosis (TB) in humans, remains poorly understood. Herein, we used a transcriptomic approach to investigate the host cell ge...

journal_title：Scientific reports

authors： Polena H,Boudou F,Tilleul S,Dubois-Colas N,Lecointe C,Rakotosamimanana N,Pelizzola M,Andriamandimby SF,Raharimanga V,Charles P,Herrmann JL,Ricciardi-Castagnoli P,Rasolofo V,Gicquel B,Tailleux L

更新日期：2016-09-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Wang J,Sun P,Chen Y,Yao H,Wang S

更新日期：2019-12-19 00:00:00

abstract：:The structural, electronic, transport and optical properties of black phosphorus/MoS2 (BP/MoS2) van der Waals (vdw) heterostructure are investigated by using first principles calculations. The band gap of BP/MoS2 bilayer decreases with the applied normal compressive strain and a semiconductor-to-metal transition is ob...

journal_title：Scientific reports

authors： Huang L,Li Y,Wei Z,Li J

更新日期：2015-11-10 00:00:00

abstract：:The interaction of a mechanical oscillator with the operation actions and environment fields will give rise to the splitting of normal modes. In this study, we investigate the normal mode splitting behaviour of a moving-particles-pumped single-span clamped-hinged elastic homogeneous beam based on the proposed multi-oc...

journal_title：Scientific reports

authors： Sun Z

更新日期：2018-06-28 00:00:00

abstract：:At the present study, a one-dimensional model for the flat sheet direct contact membrane distillation (DCMD) for desalination purposes is proposed. Flows and membrane properties have been estimated by appropriate temperature-dependent correlations. Results show that the numerical model is in a very good agreement with...

journal_title：Scientific reports

authors： Keshavarzzadeh AH

更新日期：2020-10-08 00:00:00

abstract：:Nature disasters and terrorist attacks have occurred globally in recent years. Posttraumatic stress disorder (PTSD) has gained increasing attention, but its incidence and comorbidities in the general population are different from those inside the disaster areas. The present study estimated incident PTSD and comorbid d...

journal_title：Scientific reports

authors： Chang JC,Yen AM,Chen HH,Chen SL,Chiu SY,Fann JC,Lee CS

更新日期：2017-01-27 00:00:00

abstract：:Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models. Here, we proposed an appro...

journal_title：Scientific reports

authors： Kageyama T,Chun YS,Fukuda J

更新日期：2021-01-12 00:00:00

abstract：:It is usually assumed that metabolic constraints restrict deep-sea corals to cold-water habitats, with 'deep-sea' and 'cold-water' corals often used as synonymous. Here we report on the first measurements of biological characters of deep-sea corals from the central Red Sea, where they occur at temperatures exceeding 2...

journal_title：Scientific reports

authors： Roder C,Berumen ML,Bouwmeester J,Papathanassiou E,Al-Suwailem A,Voolstra CR

更新日期：2013-10-03 00:00:00

abstract：:A detailed characterisation of the molecular determinants of membrane binding by α-synuclein (αS), a 140-residue protein whose aggregation is associated with Parkinson's disease, is of fundamental significance to clarify the manner in which the balance between functional and dysfunctional processes are regulated for t...

journal_title：Scientific reports

authors： Fusco G,De Simone A,Arosio P,Vendruscolo M,Veglia G,Dobson CM

更新日期：2016-06-08 00:00:00

abstract：:Cryptochromes (CRYs) are an ubiquitously occurring class of photoreceptors, which are important for regulating the circadian rhythm of animals via a time-delayed transcription-translation feedback loop (TTFL). Due to their protein architecture and common FAD chromophore, they belong to the same superfamily as photolya...

journal_title：Scientific reports

authors： Franz-Badur S,Penner A,Straß S,von Horsten S,Linne U,Essen LO

更新日期：2019-07-09 00:00:00

abstract：:Dogs' attachment towards humans might be the core of their social skillset, yet the origins of their ability to build such a bond are still unclear. Here we show that adult, hand-reared wolves, similarly to dogs, form individualized relationship with their handler. During separation from their handler, wolves, much li...

journal_title：Scientific reports

authors： Lenkei R,Újváry D,Bakos V,Faragó T

更新日期：2020-10-14 00:00:00

abstract：:Sea ice is an important component of the global climate system and a key indicator of climate change. A decreasing trend in Arctic sea-ice concentration is evident in recent years, whereas Antarctic sea-ice concentration exhibits a generally increasing trend. Various studies have investigated the underlying causes of ...

journal_title：Scientific reports

authors： Yu L,Zhong S,Winkler JA,Zhou M,Lenschow DH,Li B,Wang X,Yang Q

更新日期：2017-04-05 00:00:00

abstract：:The heterogeneity of major depressive disorder (MDD) is attributed to the fact that diagnostic criteria (e.g., DSM-5) are only based on clinical symptoms. The discovery of blood biomarkers has the potential to change the diagnosis of MDD. The purpose of this study was to identify blood biomarkers of DNA methylation by...

journal_title：Scientific reports

authors： Yamagata H,Ogihara H,Matsuo K,Uchida S,Kobayashi A,Seki T,Kobayashi M,Harada K,Chen C,Miyata S,Fukuda M,Mikuni M,Hamamoto Y,Watanabe Y,Nakagawa S

更新日期：2021-01-27 00:00:00

abstract：:Pain is a harmful sensation that arises from noxious stimuli. Transient receptor potential ankyrin 1 (TRPA1) is one target for studying pain mechanisms. TRPA1 is activated by various stimuli such as noxious cold, pungent natural products and environmental irritants. Since TRPA1 is an attractive target for pain therapy...

journal_title：Scientific reports

authors： Gupta R,Saito S,Mori Y,Itoh SG,Okumura H,Tominaga M

更新日期：2016-11-22 00:00:00

abstract：:Electrochemically generated bactericidal compounds have been shown to eradicate bacterial lawn biofilms through electroceutical treatment. However, the ultrastructure of biofilms exposed to these species has not been studied. Moreover, it is unknown if the efficacy of electroceutical treatment extends to antibiotic-re...

journal_title：Scientific reports

authors： Lochab V,Jones TH,Dusane DH,Peters CW,Stoodley P,Wozniak DJ,Subramaniam VV,Prakash S

更新日期：2020-06-18 00:00:00

abstract：:Gliomas are the most common brain tumors affecting the central nervous system and are associated with a high mortality rate. DCF1 is a membrane protein that was previously found to play a role in neural stem cell differentiation. In the present study, we found that overexpression of dcf1 significantly inhibited cell p...

journal_title：Scientific reports

authors： Xie Y,Li Q,Yang Q,Yang M,Zhang Z,Zhu L,Yan H,Feng R,Zhang S,Huang C,Liu Z,Wen T

更新日期：2014-01-15 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is unclear. In this study, treatment with either of two BMP inhibitors reduced hepa...

journal_title：Scientific reports

authors： Thayer TE,Lino Cardenas CL,Martyn T,Nicholson CJ,Traeger L,Wunderer F,Slocum C,Sigurslid H,Shakartzi HR,O'Rourke C,Shelton G,Buswell MD,Barnes H,Neitzel LR,Ledsky CD,Li JP,Burke MF,Farber-Eger E,Perrien DS,Kumar R,

更新日期：2020-06-19 00:00:00

abstract：:YidC, a bacterial member of the YidC/Alb3/Oxa1 insertase family, mediates membrane protein assembly and insertion. Cytoplasmic loops are known to have functional significance in membrane proteins such as YidC. Employing microsecond-level molecular dynamics (MD) simulations, we show that the crystallographically unreso...

journal_title：Scientific reports

authors： Harkey T,Govind Kumar V,Hettige J,Tabari SH,Immadisetty K,Moradi M

更新日期：2019-10-08 00:00:00

abstract：:Early admission to the neurosciences intensive care unit (NSICU) is associated with improved patient outcomes. Natural language processing offers new possibilities for mining free text in electronic health record data. We sought to develop a machine learning model using both tabular and free text data to identify pati...

journal_title：Scientific reports

authors： Klang E,Kummer BR,Dangayach NS,Zhong A,Kia MA,Timsina P,Cossentino I,Costa AB,Levin MA,Oermann EK

更新日期：2021-01-14 00:00:00