Abstract：
:The heterogeneity of major depressive disorder (MDD) is attributed to the fact that diagnostic criteria (e.g., DSM-5) are only based on clinical symptoms. The discovery of blood biomarkers has the potential to change the diagnosis of MDD. The purpose of this study was to identify blood biomarkers of DNA methylation by strategically subtyping patients with MDD by onset age. We analyzed genome-wide DNA methylation of patients with adult-onset depression (AOD; age ≥ 50 years, age at depression onset < 50 years; N = 10) and late-onset depression (LOD; age ≥ 50 years, age at depression onset ≥ 50 years; N = 25) in comparison to that of 30 healthy subjects. The methylation profile of the AOD group was not only different from that of the LOD group but also more homogenous. Six identified methylation CpG sites were validated by pyrosequencing and amplicon bisulfite sequencing as potential markers for AOD in a second set of independent patients with AOD and healthy control subjects (N = 11). The combination of three specific methylation markers achieved the highest accuracy (sensitivity, 64%; specificity, 91%; accuracy, 77%). Taken together, our findings suggest that DNA methylation markers are more suitable for AOD than for LOD patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yamagata H,Ogihara H,Matsuo K,Uchida S,Kobayashi A,Seki T,Kobayashi M,Harada K,Chen C,Miyata S,Fukuda M,Mikuni M,Hamamoto Y,Watanabe Y,Nakagawa Sdoi
10.1038/s41598-021-81758-8subject
Has Abstractpub_date
2021-01-27 00:00:00pages
2296issue
1issn
2045-2322pii
10.1038/s41598-021-81758-8journal_volume
11pub_type
杂志文章abstract：:The ability of wild animals to respond flexibly to anthropogenic environmental changes, including agriculture, is critical to survival in human-impacted habitats. Understanding use of human foods by wildlife can shed light on the acquisition of novel feeding habits and how animals respond to human-driven land-use chan...
journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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