Abstract:
:Laser speckle flowmetry suffers from a debated quantification of the inverse relation between decorrelation time (τc) and blood flow velocity (V), i.e. 1/τc = αV. Using a modified microcirculation imager (integrated sidestream dark field - laser speckle contrast imaging [SDF-LSCI]), we experimentally investigate on the influence of the optical properties of scatterers on α in vitro and in vivo. We found a good agreement to theoretical predictions within certain limits for scatterer size and multiple scattering. We present a practical model-based scaling factor to correct for multiple scattering in microcirculatory vessels. Our results show that SDF-LSCI offers a quantitative measure of flow velocity in addition to vessel morphology, enabling the quantification of the clinically relevant blood flow, velocity and tissue perfusion.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nadort A,Kalkman K,van Leeuwen TG,Faber DJdoi
10.1038/srep25258subject
Has Abstractpub_date
2016-04-29 00:00:00pages
25258issn
2045-2322pii
srep25258journal_volume
6pub_type
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