Abstract:
:Epithelial-to-mesenchymal transition (EMT) is a biological process in which epithelial cells translate into a mesenchymal phenotype with invasive capacities, contributing to tumour progression, metastasis, and the acquisition of chemotherapy resistance. To identify new therapeutic targets for cancers, it is important to clarify the molecular mechanism of induction of EMT. We have previously reported that fad104, a positive regulator of adipocyte differentiation, suppressed the invasion and metastasis of melanoma and breast cancer cells. In this study, we showed that FAD104 functions as a novel suppressor of transforming growth factor-β (TGF-β)-mediated EMT in cervical cancer cells. Expression of FAD104 is upregulated during TGF-β-mediated EMT in human cervical cancer HeLa cells. Reduction of fad104 expression enhanced TGF-β-mediated EMT and migration in HeLa cells. Conversely, overexpression of FAD104 suppressed TGF-β-induced EMT. In addition, we showed that FAD104 negatively regulated phosphorylation of Smad2 and Smad3 but positively regulated phosphorylation of Smad1/5/8 via treatment with TGF-β. These findings demonstrate that FAD104 is a novel suppressor of TGF-β signalling and represses TGF-β-mediated EMT in cervical cancer cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Goto M,Osada S,Imagawa M,Nishizuka Mdoi
10.1038/s41598-017-16555-3subject
Has Abstractpub_date
2017-11-27 00:00:00pages
16365issue
1issn
2045-2322pii
10.1038/s41598-017-16555-3journal_volume
7pub_type
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