Engineering complex tissue-like microgel arrays for evaluating stem cell differentiation.

abstract：:Because of the small particle number of intracellular species participating in genetic circuits, stochastic fluctuations are inevitable. This intracellular noise is detrimental to precise regulation. To maintain the proper function of a cell, some natural motifs attenuate the noise at the protein level. In many biolog...

journal_title：Scientific reports

authors： Liu FY,Lo SC,Shu CC

更新日期：2019-03-04 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Lee TH,Lim HB,Nam KY,Kim K,Kim JY

更新日期：2020-03-11 00:00:00

abstract：:Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to present acyl substrates to a series of enzyme active sites. Many domains from the multimodular PKS that generates the toxin mycolactone display an unusually hi...

journal_title：Scientific reports

authors： Moretto L,Heylen R,Holroyd N,Vance S,Broadhurst RW

更新日期：2019-02-20 00:00:00

abstract：:A novel fungal species, Aspergillus labruscus sp. nov., has been found in Brazil during an investigation of the fungal species present on the surface of grape berries (Vitis labrusca L.) for use in the production of concentrated grape juice. It seems to be associated to V. labrusca, and has never been recovered from V...

journal_title：Scientific reports

authors： Fungaro MHP,Ferranti LS,Massi FP,da Silva JJ,Sartori D,Taniwaki MH,Frisvad JC,Iamanaka BT

更新日期：2017-07-24 00:00:00

abstract：:Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and fun...

journal_title：Scientific reports

authors： Si Y,Chen YB,Chen SJ,Zheng YQ,Liu X,Liu Y,Jiang HL,Xu G,Li ZH,Huang QH,Xiong H,Zhang ZG

更新日期：2015-12-07 00:00:00

abstract：:The vascular smooth muscle cells (VSMCs) are exposed to interstitial flow induced shear stress that may be sensed by the surface glycocalyx, a surface layer composed primarily of proteoglycans and glycoproteins, to mediate cell contraction during the myogenic response. We, therefore, attempted to elucidate the signal ...

journal_title：Scientific reports

authors： Kang H,Liu J,Sun A,Liu X,Fan Y,Deng X

更新日期：2017-02-13 00:00:00

abstract：:Pre-shared non-local entanglement dramatically simplifies and improves the performance of quantum error correction via entanglement-assisted quantum error-correcting codes (EAQECCs). However, even considering the noise in quantum communication only, the non-local sharing of a perfectly entangled pair is technically im...

journal_title：Scientific reports

authors： Wang Z,Yu S,Fan H,Oh CH

更新日期：2014-11-26 00:00:00

abstract：:KIBRA has been suggested as a key regulator of the hippo pathway, regulating organ size, cell contact inhibition as well as tissue regeneration and tumorigenesis. Recently, alterations of KIBRA expression caused by promotor methylation have been reported for several types of cancer. Our current study aimed to design a...

journal_title：Scientific reports

authors： Schelleckes K,Schmitz B,Lenders M,Mewes M,Brand SM,Brand E

更新日期：2018-03-09 00:00:00

abstract：:This paper illustrates the potential for seasonal prediction of wind and solar energy resources through a case study in the Yangtze River estuary. Sea surface temperature and geopotential height-based climate predictors, each with high correlation to ensuing seasonal wind speed and solar radiation at the Baoshan weath...

journal_title：Scientific reports

authors： Zeng P,Sun X,Farnham DJ

更新日期：2020-05-25 00:00:00

abstract：:A wide range of human diseases is associated with mutations that, destabilizing proteins native state, promote their aggregation. However, the mechanisms leading from folded to aggregated states are still incompletely understood. To investigate these mechanisms, we used a combination of NMR spectroscopy and molecular ...

journal_title：Scientific reports

authors： Camilloni C,Sala BM,Sormanni P,Porcari R,Corazza A,De Rosa M,Zanini S,Barbiroli A,Esposito G,Bolognesi M,Bellotti V,Vendruscolo M,Ricagno S

更新日期：2016-05-06 00:00:00

abstract：:Melanoma is the most lethal cutaneous cancer. New drugs have recently appeared; however, not all patients obtain a benefit of these new drugs. For this reason, it is still necessary to characterize melanoma at molecular level. The aim of this study was to explore the molecular differences between melanoma tumor subtyp...

journal_title：Scientific reports

authors： Trilla-Fuertes L,Gámez-Pozo A,Prado-Vázquez G,Zapater-Moros A,Díaz-Almirón M,Fortes C,Ferrer-Gómez M,López-Vacas R,Parra Blanco V,Márquez-Rodas I,Soria A,Fresno Vara JÁ,Espinosa E

更新日期：2019-05-10 00:00:00

abstract：:Human phosphoglucomutase 1 (PGM1) is an evolutionary conserved enzyme that belongs to the ubiquitous and ancient α-D-phosphohexomutases, a large enzyme superfamily with members in all three domains of life. PGM1 catalyzes the bi-directional interconversion between α-D-glucose 1-phosphate (G1P) and α-D-glucose 6-phosph...

journal_title：Scientific reports

authors： Backe PH,Laerdahl JK,Kittelsen LS,Dalhus B,Mørkrid L,Bjørås M

更新日期：2020-03-27 00:00:00

abstract：:Hepatitis E Virus-like particles self-assemble in to noninfectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery conditions. Previously, the nanocapsid was engineered to specifically bind and enter breast cancer cells, where successful tumor targeting was demonstrated in animal models. In the p...

journal_title：Scientific reports

authors： Stark MC,Baikoghli MA,Lahtinen T,Malola S,Xing L,Nguyen M,Nguyen M,Sikaroudi A,Marjomäki V,Häkkinen H,Cheng RH

更新日期：2017-12-06 00:00:00

abstract：:In this article a new spent catalyst sample preparation method was implemented for the purpose of molybdenum leaching in a single step. Further molybdenum and vanadium in the leach liquor were separated and their concentrations were enriched using the solvent extraction and stripping techniques. The impervious sulfur ...

journal_title：Scientific reports

authors： Pradhan D,Kim DJ,Sukla LB,Pattanaik A,Lee SW

更新日期：2020-02-06 00:00:00

abstract：:Stroke incidence is a multifactorial disease and especially hyperhomocysteinemia is associated with a higher risk of stroke. Previous studies have reported a folate metabolism disorder associated with the MTHFR gene. We investigated four single nucleotide polymorphisms in the MTHFR 3'-UTR [2572 C > A (rs4846049), 4869...

journal_title：Scientific reports

authors： Kim JO,Park HS,Ryu CS,Shin JW,Kim J,Oh SH,Kim OJ,Kim NK

更新日期：2017-09-29 00:00:00

abstract：:The lignite biodegradation procedure to produce water-soluble humic materials (WSHM) with a Penicillium stain was established by previous studies in our laboratory. This study researched the effects of WSHM on the growth of Bradyrhizobium liaoningense CCBAU05525 and its nodulation on soybean. Results showed that WSHM ...

journal_title：Scientific reports

authors： Guo Gao T,Yuan Xu Y,Jiang F,Zhen Li B,Shui Yang J,Tao Wang E,Li Yuan H

更新日期：2015-06-08 00:00:00

abstract：:The nutrient ecological stoichiometry of plants and soil is important for the growth and dynamics of species, but the stoichiometric relationships among leaf, litter, and soil remain poorly understood. We analyzed the carbon (C), nitrogen (N), and phosphorus (P) stoichiometry of the leaves, litter, and soil for 31 spe...

journal_title：Scientific reports

authors： Zhang G,Zhang P,Peng S,Chen Y,Cao Y

更新日期：2017-09-18 00:00:00

abstract：:Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the 'honey trap' during an economic exchange. Males tend to cooperate with physicall...

journal_title：Scientific reports

authors： Watabe M,Kato TA,Tsuboi S,Ishikawa K,Hashiya K,Monji A,Utsumi H,Kanba S

更新日期：2013-01-01 00:00:00

abstract：:The interaction of (quasi)particles with a periodic potential arises in various domains of science and engineering, such as solid-state physics, chemical physics, and communication theory. An attractive test ground to investigate this interaction is represented by superconductors with artificial pinning sites, where m...

journal_title：Scientific reports

authors： Dobrovolskiy OV,Huth M,Shklovskij VA,Vovk RV

更新日期：2017-10-23 00:00:00

abstract：:Sertoli cells are essential for regulating normal spermatogenesis. However, the mechanisms underlying human Sertoli cell development remain largely elusive. Here we examined the function and signaling pathways of BMP6 in regulating human Sertoli cells. RT-PCR, immunocytochemistry and Western blots revealed that BMP6 a...

journal_title：Scientific reports

authors： Wang H,Yuan Q,Sun M,Niu M,Wen L,Fu H,Zhou F,Chen Z,Yao C,Hou J,Shen R,Lin Q,Liu W,Jia R,Li Z,He Z

更新日期：2017-04-07 00:00:00

abstract：:Soybean is an important source of protein, oil and carbohydrates, as well as other beneficial nutrients. A major function of proteins in nutrition is to supply adequate amounts of amino acids. Although they are essential for human nutrition, the sulfur-containing amino acids cysteine (Cys) and methionine (Met) are oft...

journal_title：Scientific reports

authors： Malle S,Eskandari M,Morrison M,Belzile F

更新日期：2020-12-11 00:00:00

abstract：:In this report we have evaluated radiation effective dose received by patients during ECG-gated CCTA examinations based on gender, heart rate, tube voltage protocol and body mass index (BMI). A total of 1,824 patients were retrospectively recruited (1,139 men and 685 women) and they were divided into Group 1 (CCTA wit...

journal_title：Scientific reports

authors： Sabarudin A,Siong TW,Chin AW,Hoong NK,Karim MKA

更新日期：2019-03-13 00:00:00

abstract：:We reconstructed the radiological dose for birds observed at 300 census sites in the 50-km northwest area affected by the accident at the Fukushima Daiichi nuclear power plant over 2011-2014. Substituting the ambient dose rate measured at the census points (from 0.16 to 31 μGy h(-1)) with the dose rate reconstructed f...

journal_title：Scientific reports

authors： Garnier-Laplace J,Beaugelin-Seiller K,Della-Vedova C,Métivier JM,Ritz C,Mousseau TA,Møller AP

更新日期：2015-11-16 00:00:00

abstract：:Balance is a very important function that allows maintaining a stable stance needed for many daily life activities and for preventing falls. We investigated whether balance control could be improved by a placebo procedure consisting of verbal suggestion. Thirty healthy volunteers were randomized in two groups (placebo...

journal_title：Scientific reports

authors： Villa-Sánchez B,Emadi Andani M,Menegaldo G,Tinazzi M,Fiorio M

更新日期：2019-04-23 00:00:00

abstract：:Phylogenetic clustering approaches can elucidate HIV transmission dynamics. Comparisons across countries are essential for evaluating public health policies. Here, we used a standardised approach to compare the UK HIV Drug Resistance Database and the Swiss HIV Cohort Study while maintaining data-protection requirement...

journal_title：Scientific reports

authors： Ragonnet-Cronin ML,Shilaih M,Günthard HF,Hodcroft EB,Böni J,Fearnhill E,Dunn D,Yerly S,Klimkait T,Aubert V,Yang WL,Brown AE,Lycett SJ,Kouyos R,Brown AJ

更新日期：2016-09-19 00:00:00

abstract：:Bacteria belonging to the genus Acinetobacter have become of clinical importance over the last decade due to the development of a multi-resistant phenotype and their ability to survive under multiple environmental conditions. The development of these traits among Acinetobacter strains occurs frequently as a result of ...

journal_title：Scientific reports

authors： Salto IP,Torres Tejerizo G,Wibberg D,Pühler A,Schlüter A,Pistorio M

更新日期：2018-05-17 00:00:00

abstract：:Rhythmically bedded cherts are observed in both pelagic marine and lacustrine deposits, but the formation mechanism in the latter remains highly uncertain. Our study of alternating chert-dolomite beds in the Eocene Green River Formation, Utah, USA reveals dense accumulations of organic-matter spheres (30-50 μm diamete...

journal_title：Scientific reports

authors： Kuma R,Hasegawa H,Yamamoto K,Yoshida H,Whiteside JH,Katsuta N,Ikeda M

更新日期：2019-11-11 00:00:00

abstract：:Spotted seal (Phoca largha) is a critically endangered pinniped in China and South Korea. The conventional method to protect and maintain the P. largha population is to keep them captive in artificially controlled environments. However, little is known about the physiological differences between wild and captive P. la...

journal_title：Scientific reports

authors： Tian J,Du J,Han J,Bao X,Song X,Lu Z

更新日期：2020-10-30 00:00:00

abstract：:Current medications inadequately treat the symptoms of chronic pain experienced by over 50 million people in the United States, and may come with substantial adverse effects signifying the need to find novel treatments. One novel therapeutic target is the Transient Receptor Potential A1 channel (TRPA1), an ion channel...

journal_title：Scientific reports

authors： Ko MJ,Ganzen LC,Coskun E,Mukadam AA,Leung YF,van Rijn RM

更新日期：2019-02-20 00:00:00

abstract：:Hand preference is a conspicuous variation in human behaviour, with a worldwide proportion of around 90% of people preferring to use the right hand for many tasks, and 10% the left hand. We used the large cohort of the UK biobank (~500,000 participants) to study possible relations between early life factors and adult ...

journal_title：Scientific reports

authors： de Kovel CGF,Carrión-Castillo A,Francks C

更新日期：2019-01-24 00:00:00