Characterization of the electrical conductivity of bone and its correlation to osseous structure.

Abstract:

:The interaction of osseous tissue with electric fields is an important subject. The electrical stimulation of bone promotes osteogenesis, while bone impedance has been proposed as a measure of osteoporosis, to follow fracture healing, or as a method to improve safety of surgical procedures. However, a deeper understanding of the electrical properties of bone and their relation to the architecture of osseous tissue is required to extend the range of use of electrical measurements to clinical studies. In this paper we apply electrical impedance spectroscopy to study the conductivity of fresh bovine tibia and we correlate the measured conductivities with its structural properties. Impedance was measured using a custom-made cell and a potentiostat. Bone conductivity was determined at 100 kHz, where the phase shift was negligible. A good agreement (R2 = 0.83) was found between the measured conductivity and the bone volume fraction, determined on microCT images. Based on this relationship, an equivalent circuit model was created for bone samples. The results of this ex-vivo study are comparable to previous in-vivo observations reporting bone resistivity as a function of bone density. This information can be used to construct a map of the tissue resistivity directly derived from clinical images.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Balmer TW,Vesztergom S,Broekmann P,Stahel A,Büchler P

doi

10.1038/s41598-018-26836-0

subject

Has Abstract

pub_date

2018-06-05 00:00:00

pages

8601

issue

1

issn

2045-2322

pii

10.1038/s41598-018-26836-0

journal_volume

8

pub_type

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