к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling.

abstract：:The comet assay is an electrophoretic technique used to assess DNA damage, as a marker of genotoxicity and oxidative stress, in tissues and biological samples including peripheral blood mononuclear cells (PBMCs) and whole blood (WB). Although numerous studies are performed on stored samples, the impact of cryopreserva...

journal_title：Scientific reports

authors： Marino M,Gigliotti L,Møller P,Riso P,Porrini M,Del Bo C

更新日期：2021-01-11 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive. To study physiological role of LCN2 in energy homeostasis, we challenged female Lcn2 k...

journal_title：Scientific reports

authors： Ishii A,Katsuura G,Imamaki H,Kimura H,Mori KP,Kuwabara T,Kasahara M,Yokoi H,Ohinata K,Kawanishi T,Tsuchida J,Nakamoto Y,Nakao K,Yanagita M,Mukoyama M,Mori K

更新日期：2017-11-14 00:00:00

abstract：:Interleukin-6 (IL-6) overproduction has been involved in the pathogenesis of several chronic inflammatory diseases and the administration of an anti-IL-6 receptor monoclonal antibody has been proven clinically efficient to treat them. However, the drawbacks of monoclonal antibodies have led our group to develop an inn...

journal_title：Scientific reports

authors： Desallais L,Bouchez C,Mouhsine H,Moreau G,Ratsimandresy R,Montes M,Do H,Quintin-Colonna F,Zagury JF

更新日期：2016-01-19 00:00:00

abstract：:In many vertebrates, acoustic cues to body size are encoded in resonance frequencies of the vocal tract ("formants"), rather than in the rate of tissue vibration in the sound source ("pitch"). Anatomical constraints on the vocal tract's size render formants honest cues to size in many bird and mammal species, but it i...

journal_title：Scientific reports

authors： Reber SA,Janisch J,Torregrosa K,Darlington J,Vliet KA,Fitch WT

更新日期：2017-05-12 00:00:00

abstract：:The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be u...

journal_title：Scientific reports

authors： Akita M,Tak YS,Shimura T,Matsumoto S,Okuda-Shimizu Y,Shimizu Y,Nishi R,Saitoh H,Iwai S,Mori T,Ikura T,Sakai W,Hanaoka F,Sugasawa K

更新日期：2015-06-04 00:00:00

abstract：:Graphene grown directly on germanium is a possible route for the integration of graphene into nanoelectronic devices as well as it is of great interest for materials science. The morphology of the interface between graphene and germanium influences the electronic properties and has not already been completely elucidat...

journal_title：Scientific reports

authors： Mendoza CD,Figueroa NS,Maia da Costa MEH,Freire FL Jr

更新日期：2019-08-29 00:00:00

abstract：:Diagnosis of sleep apnea (SA) using simple tools has the potential to improve the efficacy of cardiac implants in the prevention of cardiac arrhythmias. The aim of the present study was to validate a transthoracic impedance sensor for SA diagnosis in patients with cardiac implants. We compared the apnea-hypopnea index...

journal_title：Scientific reports

authors： Defaye P,Mendelson M,Tamisier R,Jacon P,Venier S,Arnol N,Pépin JL

更新日期：2019-07-03 00:00:00

abstract：:ATM is an important cancer susceptibility gene that encodes a critical apical kinase of the DNA damage response (DDR) pathway. We show that a key nonsense-mediated RNA decay switch exon (NSE) in ATM is repressed by U2AF, PUF60 and hnRNPA1. The NSE activation was haplotype-specific and was most promoted by cytosine at ...

journal_title：Scientific reports

authors： Kralovicova J,Knut M,Cross NC,Vorechovsky I

更新日期：2016-01-06 00:00:00

abstract：:The intention of this observational study is to show the significant impact of comorbidities and smoking on the outcome in aneurysmal subarachnoid hemorrhage (SAH). During this observational study 203 cases of treatment of ruptured intracranial aneurysms were analyzed. We examined and classified prospectively the 12 m...

journal_title：Scientific reports

authors： Hammer A,Steiner A,Ranaie G,Yakubov E,Erbguth F,Hammer CM,Killer-Oberpfalzer M,Steiner H,Janssen H

更新日期：2018-08-17 00:00:00

abstract：:Ceramide is one of the most important intercellular components responsible for the barrier and moisture retention functions of the skin. Because of the risks involved with using products of animal origin and the low productivity of plants, the availability of ceramides is currently limited. In this study, we successfu...

journal_title：Scientific reports

authors： Murakami S,Shimamoto T,Nagano H,Tsuruno M,Okuhara H,Hatanaka H,Tojo H,Kodama Y,Funato K

更新日期：2015-11-17 00:00:00

abstract：:Cues previously paired with rewarding stimuli induce a time-dependent increase in the motivational craving state (incubation of craving). Whether there is an increase in craving for high-fat (HF) food over time, which may contribute to overeating and obesity, has not been determined. We hypothesized that cues paired w...

journal_title：Scientific reports

authors： Darling RA,Dingess PM,Schlidt KC,Smith EM,Brown TE

更新日期：2016-08-03 00:00:00

abstract：:In this study, 111 Cryptosporidium parvum IId isolates from several species of animals in China, Sweden, and Egypt were subtyped by multilocus sequence typing (MLST). One to eleven subtypes were detected at each of the 12 microsatellite, minisatellite, and single nucleotide polymorphism (SNP) loci, forming 25 MLST sub...

journal_title：Scientific reports

authors： Wang R,Zhang L,Axén C,Bjorkman C,Jian F,Amer S,Liu A,Feng Y,Li G,Lv C,Zhao Z,Qi M,Dong H,Wang H,Sun Y,Ning C,Xiao L

更新日期：2014-02-27 00:00:00

abstract：:The concept of substrate inhibition to prevent its phosphorylation has potential in drug discovery and is envisioned to treat the autoimmune disorder multiple sclerosis (MS). Glia maturation factor-β (GMF-β) Ser83 phosphorylation by protein kinase A (PKA) is pivotal in the activation of GMF-β-p38MAPK-NFκB biochemical ...

journal_title：Scientific reports

authors： Vattathara JJ,Prakash O,Subhramanian S,Satheeshkumar MK,Xavier T,Anil M,Pillai GS,Anandakuttan A,Radhakrishnan S,Sivanarayanan TB,Akk U,Mohan CG,Menon KN

更新日期：2020-03-02 00:00:00

abstract：:Expression of various molecules on the surface of cancer cells compared to normal cells creates a platform for the generation of various drug vehicles for targeted therapy. Multiple interactions between ligands and their receptors mediated by targeting peptide-modified polymer could enable simultaneous delivery of a d...

journal_title：Scientific reports

authors： Sarangthem V,Cho EA,Yi A,Kim SK,Lee BH,Park RW

更新日期：2018-03-01 00:00:00

abstract：:We propose a reflection type metal-insulator-metal (MIM) metasurface composed of hybrid nano-antennas for comprehensive spatial engineering of the properties of optical fields. The capability of such structure is illustrated in the design of a device that can be used to produce a radially polarized vectorial beam for ...

journal_title：Scientific reports

authors： Wang S,Zhan Q

更新日期：2016-07-15 00:00:00

abstract：:The identification of the most influential individuals in structured populations is an important research question, with many applications across the social and natural sciences. Here, we study this problem in evolutionary populations on static networks, where invading cheaters can lead to the collapse of cooperation....

journal_title：Scientific reports

authors： Yang G,Cavaliere M,Zhu C,Perc M

更新日期：2020-02-10 00:00:00

abstract：:Glutamate is an indispensable neurotransmitter, triggering postsynaptic signals upon recognition by postsynaptic receptors. We questioned the phylogenetic position and the molecular details of when and where glutamate recognition arose in the glutamate-gated chloride channels. Experiments revealed that glutamate recog...

journal_title：Scientific reports

authors： Lynagh T,Beech RN,Lalande MJ,Keller K,Cromer BA,Wolstenholme AJ,Laube B

更新日期：2015-02-24 00:00:00

abstract：:Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and fun...

journal_title：Scientific reports

authors： Si Y,Chen YB,Chen SJ,Zheng YQ,Liu X,Liu Y,Jiang HL,Xu G,Li ZH,Huang QH,Xiong H,Zhang ZG

更新日期：2015-12-07 00:00:00

abstract：:We report an experimental demonstration of positive-negative sub-wavelength interference without correlation. Typically, people can achieve sub-wavelength effects with correlation measurement no matter by using bi-photon or thermal light sources. In this paper, we adopt a thermal light source, and we count the realiza...

journal_title：Scientific reports

authors： Dou LY,Cao DZ,Xu DQ,Zhang AN,Song XB

更新日期：2021-01-28 00:00:00

abstract：:Melanoma is one of the most aggressive skin cancers and is well known for its high metastatic rate. Studies have shown that epithelial mesenchymal transition (EMT) is essential for melanoma cell metastasis. However, the molecular mechanisms underlying EMT are still not fully understood. We have shown that IRGM1, a mem...

journal_title：Scientific reports

authors： Tian L,Li L,Xing W,Li R,Pei C,Dong X,Fu Y,Gu C,Guo X,Jia Y,Wang G,Wang J,Li B,Ren H,Xu H

更新日期：2015-07-23 00:00:00

abstract：:Interleukin-10 (IL-10) plays a central role in regulation of intestinal mucosal homeostasis and prevention of inflammatory bowel disease (IBD). We previously reported that CD11b(hi) regulatory dendritic cells (DCs) can produce more IL-10, and CD11b can negatively regulate Toll-like receptors (TLRs)-induced inflammator...

journal_title：Scientific reports

authors： Hu X,Han C,Jin J,Qin K,Zhang H,Li T,Li N,Cao X

更新日期：2016-05-18 00:00:00

abstract：:Heat shock protein 90 (HSP90) inhibition is an attractive strategy for cancer treatment. Several HSP90 inhibitors have shown promising effects in clinical oncology trials. However, little is known about HSP90 inhibition-mediated bladder cancer therapy. Here, we report a quantitative proteomic study that evaluates alte...

journal_title：Scientific reports

authors： Li QQ,Hao JJ,Zhang Z,Krane LS,Hammerich KH,Sanford T,Trepel JB,Neckers L,Agarwal PK

更新日期：2017-03-15 00:00:00

abstract：:Recent technological advances in remote sensing sensors and platforms, such as high-resolution satellite imagers or unmanned aerial vehicles (UAV), facilitate the availability of fine-grained earth observation data. Such data reveal vegetation canopies in high spatial detail. Efficient methods are needed to fully harn...

journal_title：Scientific reports

authors： Kattenborn T,Eichel J,Fassnacht FE

更新日期：2019-11-27 00:00:00

abstract：:The morbidity and mortality rates of human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfection are higher than that of either infection alone. Outcomes and the virological response to antiretrovirals (combination antiretroviral therapy, cART) were explored in HIV/HBV subjects in a cohort of Italian patien...

journal_title：Scientific reports

authors： Malagnino V,Cerva C,Maffongelli G,Teti E,Foroghi Biland L,Cesta N,De Masi M,Stingone C,Armenia D,Svicher V,Salpini R,Andreoni M,Sarmati L

更新日期：2019-08-16 00:00:00

abstract：:The insect membrane-protein, Torso, is a member of the receptor-tyrosine-kinase family, and is activated by its ligand, prothoracicotropic hormone (PTTH). Although PTTH is one of the most important regulators of insect development, the mechanism of Torso activation by the hormone has remained elusive. In this study, u...

journal_title：Scientific reports

authors： Konogami T,Yang Y,Ogihara MH,Hikiba J,Kataoka H,Saito K

更新日期：2016-03-01 00:00:00

abstract：:Ischemia-reperfusion (I/R) injury model has been widely applied to the study of microcirculation disturbance. In this work, we used laser oblique scanning optical microscopy (LOSOM) to observe the microcirculation system in the mesentery of rat model. Utilizing a localized point-scanning detection scheme, high-contras...

journal_title：Scientific reports

authors： Ding Y,Zhang Y,Peng T,Lu Y,Jin D,Ren Q,Liu Y,Han J,Xi P

更新日期：2013-01-01 00:00:00

abstract：:Vertebral fractures are a common burden amongst elderly and late middle aged people. Vertebral cross-sectional area (CSA) is a major determinant of vertebral strength and thus associated with vertebral fracture risk. Previous studies suggest that physical activity affects vertebral CSA. We aimed to investigate the rel...

journal_title：Scientific reports

authors： Oura P,Paananen M,Niinimäki J,Tammelin T,Herrala S,Auvinen J,Korpelainen R,Junno JA,Karppinen J

更新日期：2016-06-10 00:00:00

abstract：:As the natural boundary between the Yunnan-Guizhou Plateau and the Hengduan Mountains in China, the large-scale prominent terrain of Ailaoshan Mountain leads to obvious regional differences in climate and vegetation. In this article, a comparative analysis is made on both species composition and floristic components o...

journal_title：Scientific reports

authors： He SN,Hao CY,Zhao W

更新日期：2019-08-19 00:00:00

abstract：:Forest cutting is a major anthropogenic disturbance that affects forest carbon (C) storage and fluxes. Yet its characteristics and impacts on C cycling are poorly understood over large areas. Using recent annualized forest inventory data, we estimated cutting-related loss of live biomass in the eastern United States w...

journal_title：Scientific reports

authors： Zhou D,Liu S,Oeding J,Zhao S

更新日期：2013-12-19 00:00:00

abstract：:Plastic represents 60-80% of litter in the ocean. Degradation of plastic to small fragments leads to the formation of microplastics (MPs <5 mm) and nanoplastics (NPs <1 µm). One of the most widely used and representative plastics found in the ocean is polystyrene (PS). Among marine organisms, the immune system of biva...

journal_title：Scientific reports

authors： Sendra M,Carrasco-Braganza MI,Yeste PM,Vila M,Blasco J

更新日期：2020-05-25 00:00:00