Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences.

abstract：:Native collagen is arranged in bundles of aligned fibrils to withstand in vivo mechanical loads. Reproducing such a process under in vitro conditions has not met with major success. Our approach has been to induce nanolinks, during the self-assembly process, leading to delayed rather than inhibited fibrillogenesis. Fo...

journal_title：Scientific reports

authors： Nidhin M,Vedhanayagam M,Sangeetha S,Kiran MS,Nazeer SS,Jayasree RS,Sreeram KJ,Nair BU

更新日期：2014-08-06 00:00:00

abstract：:Adverse maternal environments, such as diabetes and obesity, impair placental mitochondrial function, which affects fetal development and offspring long-term health. The underlying mechanisms and effective interventions to abrogate such effect remain unclear. Our previous studies demonstrated impaired mitochondrial bi...

journal_title：Scientific reports

authors： Jiang S,Teague AM,Tryggestad JB,Jensen ME,Chernausek SD

更新日期：2020-05-20 00:00:00

abstract：:Arterial stiffness index (ASI) is a non-invasive measure of arterial stiffness using infra-red finger sensors (photoplethysmography). It is a well-suited measure for large populations as it is relatively inexpensive to perform, and data can be acquired within seconds. These features raise interest in using ASI as a to...

journal_title：Scientific reports

authors： Fung K,Ramírez J,Warren HR,Aung N,Lee AM,Tzanis E,Petersen SE,Munroe PB

更新日期：2019-06-24 00:00:00

abstract：:The purpose of this paper is to develop a lightweight apron that will be used for shielding low intensity radiation in medical imaging radiography room and to apply it to a custom-made effective shielding. The quality of existing aprons made for protecting our bodies from direct radiation are improved so that they are...

journal_title：Scientific reports

authors： Kim SC,Choi JR,Jeon BK

更新日期：2016-07-27 00:00:00

abstract：:Connecting genome-wide association study (GWAS) to biological mechanisms underlying complex traits is a major challenge. Mastitis resistance and milk production are complex traits of economic importance in the dairy sector and are associated with intra-mammary infection (IMI). Here, we integrated IMI-relevant RNA-Seq ...

journal_title：Scientific reports

authors： Fang L,Sahana G,Su G,Yu Y,Zhang S,Lund MS,Sørensen P

更新日期：2017-03-30 00:00:00

abstract：:Width-controlled M-type hexagonal SrFe12O19 nanoribbons were synthesized for the first time via polyvinylpyrrolidone (PVP) sol assisted electrospinning followed by heat treatment in air, and their chemical composition, microstructure and magnetic performance were investigated. Results demonstrated that as-obtained SrF...

journal_title：Scientific reports

authors： Jing P,Du J,Wang J,Wei J,Pan L,Li J,Liu Q

更新日期：2015-10-14 00:00:00

abstract：:Land cover change analyses are common and, especially in the absence of explanatory variables, they are mainly carried out by employing qualitative methods such as transition matrices or raster operations. These methods do not provide any estimation of the statistical significance of the changes, or the uncertainty of...

journal_title：Scientific reports

authors： Dettori S,Filigheddu MR,Deplano G,Molgora JE,Ruiu M,Sedda L

更新日期：2018-11-16 00:00:00

abstract：:A novel NaAgMoO4 material with spinel-like structure was synthesized by using the solid state reaction method and the ceramic sample was well densified at an extreme low sintering temperature about 400°C. Rietveld refinement of the crystal structure was performed using FULLPROF program and the cell parameters are a = ...

journal_title：Scientific reports

authors： Di Z,Li-Xia P,Ze-Ming Q,Biao-Bing J,Xi Y

更新日期：2014-08-07 00:00:00

abstract：:New strategies are needed to develop better tools to control TB, including identification of novel antigens for vaccination. Such Mtb antigens must be expressed during Mtb infection in the major target organ, the lung, and must be capable of eliciting human immune responses. Using genome-wide transcriptomics of Mtb in...

journal_title：Scientific reports

authors： Coppola M,van Meijgaarden KE,Franken KL,Commandeur S,Dolganov G,Kramnik I,Schoolnik GK,Comas I,Lund O,Prins C,van den Eeden SJ,Korsvold GE,Oftung F,Geluk A,Ottenhoff TH

更新日期：2016-11-28 00:00:00

abstract：:Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides from bovine lactoferrin C-lobe are able to prevent both Influenza virus hemagglutination and cell infection. To deeper ...

journal_title：Scientific reports

authors： Scala MC,Sala M,Pietrantoni A,Spensiero A,Di Micco S,Agamennone M,Bertamino A,Novellino E,Bifulco G,Gomez-Monterrey IM,Superti F,Campiglia P

更新日期：2017-09-06 00:00:00

abstract：:This work describes a simple technique to produce porous ceramics with aligned porosity having very high permeability and specific surface area. SiOC-based compositions were processed from blends of three types of preceramic polymer and a catalyst, followed by curing and pyrolysis. The heating applied from the bottom ...

journal_title：Scientific reports

authors： Vakifahmetoglu C,Zeydanli D,Innocentini MD,Ribeiro FD,Lasso PR,Soraru GD

更新日期：2017-01-20 00:00:00

abstract：:In "classic" biomedical research, diseases have usually been studied individually. The pioneering human disease network (HDN) studies jointly consider a large number of diseases, analyse their interconnections, and provide a more comprehensive description of diseases. However, most of the existing HDN studies are base...

journal_title：Scientific reports

authors： Jiang Y,Ma S,Shia BC,Lee TS

更新日期：2018-03-14 00:00:00

abstract：:Terahertz (THz) technology has emerged recently as a potential novel imaging modality in biomedical fields, including ophthalmology. However, the ocular biological responses after THz electromagnetic exposure have not been investigated. We conducted a rabbit study to evaluate the safety profiles of THz scanning on eye...

journal_title：Scientific reports

authors： Liu YC,Ke L,Yang SWQ,Nan Z,Teo EPW,Lwin NC,Lin MT,Lee IXY,Chan AS,Schmetterer L,Mehta JS

更新日期：2021-01-28 00:00:00

abstract：:Wildfires burn large parts of the tropics every year, shaping ecosystem structure and functioning. Yet the complex interplay between climate, vegetation and human factors that drives fire dynamics is still poorly understood. Here we show that on all continents, except Australia, tropical fire regimes change drasticall...

journal_title：Scientific reports

authors： Hantson S,Scheffer M,Pueyo S,Xu C,Lasslop G,van Nes EH,Holmgren M,Mendelsohn J

更新日期：2017-10-30 00:00:00

abstract：:The role of the Androgen Receptor (AR) expression and its activity in the prognosis of hepatocellular carcinoma (HCC) remains inconclusive. The aim of this study is to analyze the role of the AR expression and its activity as prognostic biomarkers in HCC. Three-hundred and thirty-seven patients from The Cancer Genome ...

journal_title：Scientific reports

authors： Acosta-Lopez S,Diaz-Bethencourt D,Concepción-Massip T,Martin-Fernandez de Basoa MC,Plata-Bello A,Gonzalez-Rodriguez A,Perez-Hernandez F,Plata-Bello J

更新日期：2020-12-16 00:00:00

abstract：:The study of factors influencing animal intake can provide a better understanding of the dynamics of the pasture ecosystem and serve as a basis for managing livestock in a more efficient way. We measured different sward surface heights of tall fescue in the process of short-term intake rate of sheep. There was a signi...

journal_title：Scientific reports

authors： Szymczak LS,de Moraes A,Sulc RM,Monteiro ALG,Lang CR,Moraes RF,da Silva DFF,Bremm C,de Faccio Carvalho PC

更新日期：2020-07-16 00:00:00

abstract：:A series of La1-xCexCoO3 perovskite nanoparticles with rhombohedral phases was synthesized via sol-gel chemical process. X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), Electron Diffraction Spectroscopy (EDS), Thermogravimetric Analysis (TGA), UV-Vis spectroscopy, Fourier Transform Infrared spectra (F...

journal_title：Scientific reports

authors： Ansari AA,Adil SF,Alam M,Ahmad N,Assal ME,Labis JP,Alwarthan A

更新日期：2020-09-14 00:00:00

abstract：:The pine wood nematode, Bursaphelenchus xylophilus, is the causal agent of pine wilt disease that has devastated pine forests in Asia. Parasitic nematodes are known to have evolved antioxidant stress responses that defend against host plant defenses. In this study, the infestation of whitebark pine, Pinus bungean, wit...

journal_title：Scientific reports

authors： Li Z,Zhang Q,Zhou X

更新日期：2016-06-07 00:00:00

abstract：:The CRISPR system holds much promise for successful genome engineering, but therapeutic, industrial, and research applications will place high demand on improving the specificity and efficiency of this tool. CT-Finder (http://bioinfolab.miamioh.edu/ct-finder) is a web service to help users design guide RNAs (gRNAs) op...

journal_title：Scientific reports

authors： Zhu H,Misel L,Graham M,Robinson ML,Liang C

更新日期：2016-05-23 00:00:00

abstract：:Deformable elastomeric spheres are evaluated experimentally as they skip multiple times over a lake surface. Some spheres are embedded with small inertial measurement units to measure the acceleration experienced during water surface impact. A model for multiple impact events shows good agreement between measured acce...

journal_title：Scientific reports

authors： Hurd RC,Belden J,Bower AF,Holekamp S,Jandron MA,Truscott TT

更新日期：2019-04-15 00:00:00

abstract：:The voltage-gated sodium channel subtype NaV1.8 is expressed in the peripheral nervous system in primary afferent nociceptive C-fibers and is essential for noxious cold signaling. We utilized functional magnetic resonance imaging on NaV1.8-deficient (NaV1.8-/-) compared with wildtype (WT) mice to identify brain struct...

journal_title：Scientific reports

authors： Heindl-Erdmann C,Zimmermann K,Reeh P,Brune K,Hess A

更新日期：2017-04-03 00:00:00

abstract：:Rotator cuff tears are common and are associated with shoulder pain, disability, and dysfunction. Previous studies that have reported different arthroscopic techniques are controversial. A network meta-analysis with indirect and direct evidence was performed to compare the effectiveness of arthroscopic techniques for ...

journal_title：Scientific reports

authors： Xu B,Chen L,Zou J,Gu Y,Hao L,Peng K

更新日期：2019-03-11 00:00:00

abstract：:Radiation exposure severely damages the hematopoietic system. Although several radio-protectors have been proposed to prevent radiation-induced damage, most agents have limited efficacy. In the present study, we investigated whether mesenchymal stem cells (MSCs) could contribute to the expansion of hematopoietic cells...

journal_title：Scientific reports

authors： Kim A,Shim S,Kim MJ,Myung JK,Park S

更新日期：2018-06-18 00:00:00

abstract：:Dysfunction of cortical GABAergic interneurons are involved in numerous neurological disorders including epilepsy, schizophrenia and autism; and replenishment of these cells by transplantation strategy has proven to be a feasible and effective method to help revert the symptoms in several animal models. To develop met...

journal_title：Scientific reports

authors： Wang Q,Hong P,Gao H,Chen Y,Yang Q,Jiang M,Li H

更新日期：2016-01-11 00:00:00

abstract：:Two supramolecular complexes of trans-1⊂CB[8] and trans-2⊂CB[8] were successfully achieved by the controlled selective complexation process of cucurbit[8]uril (CB[8]) with hetero-guest pair containing azobenzene and bispyridinium moieties in aqueous solution, exhibiting the reversibly light-driven movements of CB[8] u...

journal_title：Scientific reports

authors： Cheng HB,Zhang YM,Xu C,Liu Y

更新日期：2014-02-27 00:00:00

abstract：:Leaf nutrient resorption is an important mechanism in adapting to adverse environments. However, few studies examine how nutrient resorption responds to phosphorus (P) and potassium (K) fertilization or to a shift in nutrient limitation due to water supply and fertilization. On the Loess Plateau of China, we treated l...

journal_title：Scientific reports

authors： Yang M,Lu J,Liu M,Lu Y,Yang H

更新日期：2020-06-29 00:00:00

abstract：:Nearly half of the world's population obtains its daily calories from rice grains, which lack or have insufficient levels of essential micronutrients. The deficiency of micronutrients vital for normal growth is a global health problem, and iron, zinc and vitamin A deficiencies are the most prevalent ones. We developed...

journal_title：Scientific reports

authors： Singh SP,Gruissem W,Bhullar NK

更新日期：2017-07-31 00:00:00

abstract：:Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vivo. In this study, a small-d...

journal_title：Scientific reports

authors： Pan Y,Zhou X,Wei Y,Zhang Q,Wang T,Zhu M,Li W,Huang R,Liu R,Chen J,Fan G,Wang K,Kong D,Zhao Q

更新日期：2017-06-15 00:00:00

abstract：:Administration of dibutyl phthalate (DBP) to pregnant rats causes reproductive disorders in male offspring, resulting from suppression of intratesticular testosterone, and is used as a model for human testicular dysgenesis syndrome (TDS). DBP exposure in pregnancy induces focal dysgenetic areas in fetal testes that ap...

journal_title：Scientific reports

authors： Lara NLM,van den Driesche S,Macpherson S,França LR,Sharpe RM

更新日期：2017-05-31 00:00:00

abstract：:Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in dopaminergic head neuron specification or differentiation, we isolated a new allele of the transcription factor HAM-1 [HSN (Hermaphro...

journal_title：Scientific reports

authors： Offenburger SL,Bensaddek D,Murillo AB,Lamond AI,Gartner A

更新日期：2017-06-28 00:00:00