Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors.

abstract：:Daily life stress is an omnipresent phenomenon in modern society. Research has linked prolonged activation of the hypothalamic-pituitary-adrenal axis to psychiatric and somatic diseases. Everyday stressors substantially contribute to these health risks. Despite the notion that the physiological stress response is high...

journal_title：Scientific reports

authors： Linz R,Singer T,Engert V

更新日期：2018-10-18 00:00:00

abstract：:Invariant natural killer T (iNKT) cells are a specialized subset of T cells contributing to both, the innate and adaptive immune responses. In contrast to conventional T lymphocytes they recognize lipid antigens. The aim of the project is to establish a novel model system, to study iNKT-TCR - ligand interaction. An iN...

journal_title：Scientific reports

authors： Humeniuk P,Geiselhart S,Battin C,Webb T,Steinberger P,Paster W,Hoffmann-Sommergruber K

更新日期：2019-05-15 00:00:00

abstract：:Results from live cell imaging of fluorescently tagged Cellulose Synthase (CESA) proteins in Cellulose Synthesis Complexes (CSCs) have enhanced our understanding of cellulose biosynthesis, including the mechanisms of action of cellulose synthesis inhibitors. However, this method has been applied only in Arabidopsis th...

journal_title：Scientific reports

authors： Tran ML,McCarthy TW,Sun H,Wu SZ,Norris JH,Bezanilla M,Vidali L,Anderson CT,Roberts AW

更新日期：2018-01-15 00:00:00

abstract：:In a previous study, we proposed that age-related mitochondrial respiration defects observed in elderly subjects are partially due to age-associated downregulation of nuclear-encoded genes, including serine hydroxymethyltransferase 2 (SHMT2), which is involved in mitochondrial one-carbon (1C) metabolism. This assertio...

journal_title：Scientific reports

authors： Tani H,Mito T,Velagapudi V,Ishikawa K,Umehara M,Nakada K,Suomalainen A,Hayashi JI

更新日期：2019-11-05 00:00:00

abstract：:Stroke is one of the main causes of human disabilities. Experimental observations indicate that several mechanisms are activated during the recovery of functional activity after a stroke. Here we unveil how the brain recovers by explaining the role played by three mechanisms: Plastic adaptation, hyperexcitability and ...

journal_title：Scientific reports

authors： Berger D,Varriale E,van Kessenich LM,Herrmann HJ,de Arcangelis L

更新日期：2019-11-01 00:00:00

abstract：:Caspases are proteases traditionally associated with inflammation and cell death. Recently, they have also been shown to modulate cell proliferation and differentiation. The aim of the current research was to search for osteogenic molecules affected by caspase inhibition and to specify the individual caspases critical...

journal_title：Scientific reports

authors： Kratochvílová A,Veselá B,Ledvina V,Švandová E,Klepárník K,Dadáková K,Beneš P,Matalová E

更新日期：2020-05-04 00:00:00

abstract：:HIV-exposed uninfected (HEU) infants are disproportionately at a higher risk of morbidity and mortality, as compared to HIV-unexposed uninfected (HUU) infants. Here, we used transcriptional profiling of peripheral blood mononuclear cells to determine immunological signatures of in utero HIV exposure. We identified 262...

journal_title：Scientific reports

authors： Musimbi ZD,Rono MK,Otieno JR,Kibinge N,Ochola-Oyier LI,de Villiers EP,Nduati EW

更新日期：2019-12-02 00:00:00

abstract：:The aims of this study were, firstly, to assess the effect of concurrent peripheral artery disease (PAD) on the health-related quality of life (QOL) of people diagnosed with a small abdominal aortic aneurysm (AAA); and secondly, to test whether the peroxisome proliferator-activated receptor α agonist fenofibrate impro...

journal_title：Scientific reports

authors： Golledge J,Pinchbeck J,Rowbotham SE,Yip L,Jenkins JS,Quigley F,Moxon JV

更新日期：2020-09-03 00:00:00

abstract：:A panel of 32 candidate reference genes was used to identify the most stable genes for gene normalisation in quantitative RT-PCR studies using endometrial biopsies obtained from women with endometrial cancer (type 1 or type 2) and without cancer (controls). RNA from the biopsies was isolated, examined for purity and q...

journal_title：Scientific reports

authors： Ayakannu T,Taylor AH,Konje JC

更新日期：2020-05-21 00:00:00

abstract：:Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission...

journal_title：Scientific reports

authors： Jiang Y,Su S,Borné Y

更新日期：2020-01-23 00:00:00

abstract：:Voice disorder such as vocal fatigue is a common and complex multifaceted clinical problem that presents a significant impact on quality of life. In this study, the functional near-infrared diffuse optical technique (fNIRS-DOT) was proposed as a novel approach for human vocal cords oxidative metabolism detection and a...

journal_title：Scientific reports

authors： Lin TC,Chen JC,Liu CH,Lee CY,Tsou YA,Chuang CC

更新日期：2017-12-05 00:00:00

abstract：:In this paper, we prepared a novel structure to enhance the electroluminescence intensity from Si quantum dots/SiO2multilayers. An amorphous Si/SiO2 multilayer film was fabricated by plasma-enhanced chemical vapor deposition on a Pt nanoparticle (NP)-coated Si nanopillar array substrate. By thermal annealing, an embed...

journal_title：Scientific reports

authors： Li W,Wang S,Hu M,He S,Ge P,Wang J,Guo YY,Zhaowei L

更新日期：2015-07-03 00:00:00

abstract：:The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental pathophysiology of diabe...

journal_title：Scientific reports

authors： Lee CS,Kim YG,Cho HJ,Park J,Jeong H,Lee SE,Lee SP,Kang HJ,Kim HS

更新日期：2016-07-06 00:00:00

abstract：:This study aimed to investigate changes in types of dental arch form during adolescence and explore adolescent changes in size and form of dental arch. Hong Kong Chinese were recruited and digital dental arch models were obtained at ages 12, 15, and 18 years. Geometric morphometrics was used to investigate adolescent ...

journal_title：Scientific reports

authors： Wen YF,Wong HM,Pei T,McGrath C

更新日期：2019-12-06 00:00:00

abstract：:Alternative tillage and rice establishment options should aim at less water and labor to produce similar or improved yields compared with traditional puddled-transplanted rice cultivation. The relative performance of these practices in terms of yield, water input, and economics varies across rice-growing regions. A gl...

journal_title：Scientific reports

authors： Chakraborty D,Ladha JK,Rana DS,Jat ML,Gathala MK,Yadav S,Rao AN,Ramesha MS,Raman A

更新日期：2017-08-24 00:00:00

abstract：:Naturally occurring metals and metalloids [metal(loid)s] are essential for the physiological functioning of wildlife; however, environmental contamination by metal(loid) and plastic pollutants is a health hazard. Metal(loid)s may interact with plastic in the environment and there is mixed evidence about whether plasti...

journal_title：Scientific reports

authors： Roman L,Kastury F,Petit S,Aleman R,Wilcox C,Hardesty BD,Hindell MA

更新日期：2020-10-22 00:00:00

abstract：:Oil repellent surface have lots of practical applications in many fields. Current oil repellent coating may suffer from limited liquid repellency to oils or environmental risks. In this work, we report an eco-friendly 'green' processes for preparing oil-repellent surface using a renewable and environmentally benign bi...

journal_title：Scientific reports

authors： Xu LP,Han D,Wu X,Zhang Q,Zhang X,Wang S

更新日期：2016-11-29 00:00:00

abstract：:In the present work, an attempt has been made to synthesize the 1,2,3-triazole derivatives resulting from the click reaction, in a mild and green environment using the new copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2 modified by isatoic anhydride. The structure of the catalyst has been determined by ...

journal_title：Scientific reports

authors： Rajabi-Moghaddam H,Naimi-Jamal MR,Tajbakhsh M

更新日期：2021-01-22 00:00:00

abstract：:A novel ignition hohlraum for indirect-drive inertial confinement fusion is proposed, which is named three-axis cylindrical hohlraum (TACH). TACH is a kind of 6 laser entrance holes (LEHs) hohlraum, which is orthogonally jointed of three cylindrical hohlraums. Laser beams are injected through every entrance hole with ...

journal_title：Scientific reports

authors： Kuang L,Li H,Jing L,Lin Z,Zhang L,Li L,Ding Y,Jiang S,Liu J,Zheng J

更新日期：2016-10-05 00:00:00

abstract：:This study presents analysis of four chimney samples in terms of glycerol dialkyl glycerol tetraether lipids (GDGTs), representing different growing stages of sulfide chimneys at the Deyin hydrothermal field, the southern mid-Atlantic ridge. The modified Bligh-Dyer method was used for lipid extraction and purification...

journal_title：Scientific reports

authors： Li H,Lü X,Tao C,Han T,Hu P,Zhang G,Yu Z,Dong C,Shao Z

更新日期：2018-05-23 00:00:00

abstract：:Brood is a very valuable part of an ant colony and behaviours increasing its number with minimum investment is expected to be favoured by natural selection. Brood theft has been well documented in ants belonging to the subfamilies Myrmicinae and Formicinae. In this study we report opportunistic brood theft in the cont...

journal_title：Scientific reports

authors： Paul B,Paul M,Annagiri S

更新日期：2016-10-31 00:00:00

abstract：:Ballooning degeneration (BD) of hepatocytes is a distinguishing histological feature associated with the progression of nonalcoholic fatty liver disease (NAFLD). Under the assumption that NAFLD severity is associated with metabolic-stress we explored the hypothesis that heat shock 27 kDa protein 1 (HSP27), a protein c...

journal_title：Scientific reports

authors： Sookoian S,Castaño GO,Scian R,San Martino J,Pirola CJ

更新日期：2016-03-03 00:00:00

abstract：:The major components of vitelline membrane (VM) are ovomucin, VM outer (VMO) I and VMO II. At present, the distribution pattern of maternal cells on the VM has not been described in detail. In this study, the existence and distribution characteristics of maternal cells on VM were observed. There were more than 3.2 × 1...

journal_title：Scientific reports

authors： Li Q,Li W,Li X,Liu L,Zhang Y,Guo Y,Chen X,Xu G,Zheng J

更新日期：2017-07-26 00:00:00

abstract：:Odors elicit complex patterns of activated olfactory sensory neurons. Knowing the complete olfactome, i.e. the responses in all sensory neurons for all relevant odorants, is desirable to understand olfactory coding. The DoOR project combines all available Drosophila odorant response data into a single consensus respon...

journal_title：Scientific reports

authors： Münch D,Galizia CG

更新日期：2016-02-25 00:00:00

abstract：:Bed bugs have shown a recent and rapid global expansion that has been suggested to be caused by cheap air travel. How a small, flightless and anachoretic insect that hides within its host's sleeping area manages to travel long distances is not yet clear. Bed bugs are attracted to the odour of sleeping humans and we su...

journal_title：Scientific reports

authors： Hentley WT,Webster B,Evison SEF,Siva-Jothy MT

更新日期：2017-09-28 00:00:00

abstract：:The original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant selenoenzyme that regulates cellul...

journal_title：Scientific reports

authors： Liu M,Gao L,Zhao L,He J,Yuan Q,Zhang P,Zhao Y,Gao X

更新日期：2017-03-09 00:00:00

abstract：:The newly sequenced mitochondrial genomes of 107 Asian swamp buffalo (Bubalus bubalis carabensis) allowed the reconstruction of the matrilineal divergence since ~900 Kya. Phylogenetic trees and Bayesian skyline plots suggest a role of the glacial periods in the demographic history of swamp buffalo. The ancestral swamp...

journal_title：Scientific reports

authors： Wang S,Chen N,Capodiferro MR,Zhang T,Lancioni H,Zhang H,Miao Y,Chanthakhoun V,Wanapat M,Yindee M,Zhang Y,Lu H,Caporali L,Dang R,Huang Y,Lan X,Plath M,Chen H,Lenstra JA,Achilli A,Lei C

更新日期：2017-07-05 00:00:00

abstract：:Metformin is one of the treatments used for PCOS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin's effects on lipid metabolism, a crucial process in PCOS pathology. We have employed a lipidomic approach to explore alterations in the plasma...

journal_title：Scientific reports

authors： Pradas I,Rovira-Llopis S,Naudí A,Bañuls C,Rocha M,Hernandez-Mijares A,Pamplona R,Victor VM,Jové M

更新日期：2019-11-05 00:00:00

abstract：:Filamentous fungi grow exclusively at their tips, where many growth-related fungal processes, such as enzyme secretion and invasion into host cells, take place. Hyphal tips are also a site of active metabolism. Understanding metabolic dynamics within the tip region is therefore important for biotechnology and medicine...

journal_title：Scientific reports

authors： Yasuda M,Takeshita N,Shigeto S

更新日期：2021-01-14 00:00:00

abstract：:Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impa...

journal_title：Scientific reports

authors： Barth C,Steele CJ,Mueller K,Rekkas VP,Arélin K,Pampel A,Burmann I,Kratzsch J,Villringer A,Sacher J

更新日期：2016-10-07 00:00:00