The anti-tumor diterpene oridonin is a direct inhibitor of Nucleolin in cancer cells.

abstract：:Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2) are ligands for Tie2, an endothelial-specific receptor tyrosine kinase that is an essential regulator of angiogenesis. Here we report the identification, via expression cloning, of thrombomodulin (TM) as another receptor for Ang1 and Ang2. Thrombomodulin is an endothelia...

journal_title：Scientific reports

authors： Daly C,Qian X,Castanaro C,Pasnikowski E,Jiang X,Thomson BR,Quaggin SE,Papadopoulos N,Wei Y,Rudge JS,Thurston G,Yancopoulos GD,Davis S

更新日期：2018-01-11 00:00:00

abstract：:CoO nanocrystal/graphene nanosheets (GNS) composites, consisting of a triangular CoO nanocrystal of 2~20 nm on the surface of GNS, are synthesized by a mild synthetic method. First, cobalt acetate tetrahydrate is recrystallized in the alcohol solution at a low temperature. Then, graphene oxide mixed with cobalt-precur...

journal_title：Scientific reports

authors： Guan Q,Cheng J,Li X,Wang B,Huang L,Nie F,Ni W

更新日期：2015-05-11 00:00:00

abstract：:Spontaneous activity found in neural networks usually results in a reduction of computational performance. As a consequence, artificial neural networks are often operated at the edge of chaos, where the network is stable yet highly susceptible to input information. Surprisingly, regular spontaneous dynamics in Neural ...

journal_title：Scientific reports

authors： Marquez BA,Larger L,Jacquot M,Chembo YK,Brunner D

更新日期：2018-02-20 00:00:00

abstract：:Propylea japonica (Thunberg) (Coleoptera: Coccinellidae) is a prevalent pollen consumer in corn fields and is therefore exposed to insecticidal proteins contained in the pollen of insect-resistant transgenic corn cultivars expressing Cry proteins derived from Bacillus thuringiensis (Bt). In the present study, the pote...

journal_title：Scientific reports

authors： Liu Y,Liu Q,Wang Y,Chen X,Song X,Romeis J,Li Y,Peng Y

更新日期：2016-03-23 00:00:00

abstract：:The mitochondrial genome almost exclusively encodes a handful of transmembrane constituents of the oxidative phosphorylation (OXPHOS) system. Coordinated expression of these genes ensures the correct stoichiometry of the system's components. Translation initiation in mitochondria is assisted by two general initiation ...

journal_title：Scientific reports

authors： Kuzmenko A,Derbikova K,Salvatori R,Tankov S,Atkinson GC,Tenson T,Ott M,Kamenski P,Hauryliuk V

更新日期：2016-01-05 00:00:00

abstract：:The original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant selenoenzyme that regulates cellul...

journal_title：Scientific reports

authors： Liu M,Gao L,Zhao L,He J,Yuan Q,Zhang P,Zhao Y,Gao X

更新日期：2017-03-09 00:00:00

abstract：:Herbicide resistance has been observed in Chloris truncata, an Australian native C4 grass and a summer-fallow weed, which is common in no-till agriculture situations where herbicides are involved in crop management. To investigate the role of drought and increased atmospheric carbon dioxide (CO2) in determining weed g...

journal_title：Scientific reports

authors： Weller SL,Florentine SK,Mutti NK,Jha P,Chauhan BS

更新日期：2019-07-24 00:00:00

abstract：:We tested the hypothesis that epigenetic mechanisms in the brain and the immune system are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post nerve-injury (SNI) and Sham rats, in the prefrontal cortex (PFC) as well as in T cells revealed a vast difference in the DNA methylation landsca...

journal_title：Scientific reports

authors： Massart R,Dymov S,Millecamps M,Suderman M,Gregoire S,Koenigs K,Alvarado S,Tajerian M,Stone LS,Szyf M

更新日期：2016-01-28 00:00:00

abstract：:The attenuated Sabin strains contained in the oral poliomyelitis vaccine are genetically unstable, and their circulation in poorly immunized populations can lead to the emergence of pathogenic circulating vaccine-derived polioviruses (cVDPVs). The recombinant nature of most cVDPV genomes and the preferential presence ...

journal_title：Scientific reports

authors： Bessaud M,Joffret ML,Blondel B,Delpeyroux F

更新日期：2016-12-13 00:00:00

abstract：:Inosine-5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using the enzyme from the industria...

journal_title：Scientific reports

authors： Buey RM,Fernández-Justel D,Marcos-Alcalde Í,Winter G,Gómez-Puertas P,de Pereda JM,Luis Revuelta J

更新日期：2017-06-01 00:00:00

abstract：:The distribution of corals in Japan covers a wide range of latitudes, encompassing tropical to temperate zones. However, coral communities in temperate zones contain only a small subset of species. Among the parameters that determine the distribution of corals, temperature plays an important role. We tested the resili...

journal_title：Scientific reports

authors： Higuchi T,Agostini S,Casareto BE,Suzuki Y,Yuyama I

更新日期：2015-12-18 00:00:00

abstract：:Amorphous silicon oxycarbide (SiOC) is of great technological interest. However, its atomic-level structure is not well understood. Using density functional theory calculations, we show that the clustering tendency of C atoms in SiOC is extremely sensitive to hydrogen (H): without H, the C-C interaction is attractive,...

journal_title：Scientific reports

authors： Ding H,Demkowicz MJ

更新日期：2015-08-13 00:00:00

abstract：:Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple different MPSs linked together physiologically on re-useable, open-syste...

journal_title：Scientific reports

authors： Edington CD,Chen WLK,Geishecker E,Kassis T,Soenksen LR,Bhushan BM,Freake D,Kirschner J,Maass C,Tsamandouras N,Valdez J,Cook CD,Parent T,Snyder S,Yu J,Suter E,Shockley M,Velazquez J,Velazquez JJ,Stockdale L,Papps J

更新日期：2018-03-14 00:00:00

abstract：:The endoplasmic reticulum (ER) is a multi functional organelle and plays a crucial role in protein folding and lipid biosynthesis. The SEC59 gene encodes dolichol kinase, required for protein glycosylation in the ER. The mutation of sec59-1 caused a protein N-glycosylation defect mediated ER stress resulting in increa...

journal_title：Scientific reports

authors： William James A,Ravi C,Srinivasan M,Nachiappan V

更新日期：2019-10-09 00:00:00

abstract：:As a two-dimensional material, graphene has attracted increasing attention as heat dissipation material owing to its excellent thermal transport property. In this work, we fabricated sisal nanocrystalline cellulose/functionalized graphene papers (NPGs) with high thermal conductivity by vacuum-assisted self-assembly me...

journal_title：Scientific reports

authors： Ren L,Wang M,Lu S,Pan L,Xiong Z,Zhang Z,Peng Q,Li Y,Yu J

更新日期：2019-03-14 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) are expected to be both a revolutionary cell source for regenerative medicine and a powerful tool to investigate the molecular mechanisms underlying human cell development in vitro. In the present study, we tried to elucidate the steroidogenic differentiation processes usi...

journal_title：Scientific reports

authors： Matsuo K,Sone M,Honda-Kohmo K,Toyohara T,Sonoyama T,Taura D,Kojima K,Fukuda Y,Ohno Y,Inoue M,Ohta A,Osafune K,Nakao K,Inagaki N

更新日期：2017-11-09 00:00:00

abstract：:Laminotomy and transforaminal lumbar interbody fusion (TLIF) is usually used to treat unstable spinal stenosis. Minimally invasive surgery (MIS) can cause less muscle injury than conventional open surgery (COS). The purpose of this study was to compare the degree of postoperative fatty degeneration in the paraspinal m...

journal_title：Scientific reports

authors： Fu CJ,Chen WC,Lu ML,Cheng CH,Niu CC

更新日期：2020-09-03 00:00:00

abstract：:Lung cancer (LC) is the leading cause of cancer-related deaths. Downregulation of CDK1, 4 and 6, key regulators of cell cycle progression, correlates with decreased LC cell proliferation. Enforced expression of miRNAs (miRs) is a promising approach to regulate genes. Here, we study the combinatorial treatment of miR-1...

journal_title：Scientific reports

authors： Hossian AKMN,Sajib MS,Tullar PE,Mikelis CM,Mattheolabakis G

更新日期：2018-07-12 00:00:00

abstract：:Obesity causes low-grade inflammation that is involved in male infertility. Interleukin 1 beta (IL1β) plays an important role in this process. A high-fat diet (HFD) is the most common cause of obesity. However, the effect of a HFD on IL1β and its consequence in reproduction remain unclear. We established a HFD model i...

journal_title：Scientific reports

authors： Zhang J,Li K,Yuan M,Zhang J,Huang G,Ao J,Tan H,Li Y,Gong D,Li J,Kang L,An N,Li F,Lin P,Huang L

更新日期：2017-04-03 00:00:00

abstract：:In the present study, we tested whether the volatile metabolome was altered by mutations of the Alzheimer's disease (AD)-implicated amyloid precursor protein gene (APP) and comprehensively examined urinary volatiles that may potentially serve as candidate biomarkers of AD. Establishing additional biomarkers in screeni...

journal_title：Scientific reports

authors： Kimball BA,Wilson DA,Wesson DW

更新日期：2016-01-14 00:00:00

abstract：:Free carriers, polarons (P), in conjugated polymers play a key role in the performance of optoelectronic devices. Here, we present solid evidence that P can be predominantly generated from polaron pairs (PP) in a poly(3-hexylthiophene) (P3HT) film under zero electric field. P formation from PP strongly depends on temp...

journal_title：Scientific reports

authors： Ogata Y,Kawaguchi D,Tanaka K

更新日期：2015-02-13 00:00:00

abstract：:Nanofabrication has seen an increasing demand for applications in many fields of science and technology, but its production still requires relatively difficult, time-consuming, and expensive processes. Here we report a simple but very effective one dimensional (1D) nano-patterning technology that suggests a new nanofa...

journal_title：Scientific reports

authors： Nam KH,Suh YD,Yeo J,Woo D

更新日期：2016-01-04 00:00:00

abstract：:The starch granule is Nature's way to store energy in green plants over long periods. Irrespective of their origins, starches display distinct structural features that are the fingerprints of levels of organization over six orders of magnitude. We hypothesized that Nature retains hierarchical material structures at al...

journal_title：Scientific reports

authors： Spinozzi F,Ferrero C,Perez S

更新日期：2020-11-18 00:00:00

abstract：:Relative permeability and capillary pressure are the governing parameters that characterize multiphase fluid flow in porous media for diverse natural and industrial applications, including surface water infiltration into the ground, CO2 sequestration, and hydrocarbon enhanced recovery. Although the drastic effects of ...

journal_title：Scientific reports

authors： Haghi AH,Chalaturnyk R,Talman S

更新日期：2019-10-18 00:00:00

abstract：:Host-genetic control of influenza virus infection has been the object of little attention. In this study we determined that two inbred lines of chicken differing in their genetic background , Lines 0 and C-B12, were respectively relatively resistant and susceptible to infection with the low pathogenicity influenza vir...

journal_title：Scientific reports

authors： Ruiz-Hernandez R,Mwangi W,Peroval M,Sadeyen JR,Ascough S,Balkissoon D,Staines K,Boyd A,McCauley J,Smith A,Butter C

更新日期：2016-06-09 00:00:00

abstract：:BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of long-term heroin use. Thus, we investigated the relationships between brain-derived neurotrophic factor (BDNF) plasma concentrations and the BDNF Val66Met nucleotide polymor...

journal_title：Scientific reports

authors： Chen SL,Lee SY,Chang YH,Wang TY,Chen SH,Chu CH,Chen PS,Yang YK,Hong JS,Lu RB

更新日期：2015-02-02 00:00:00

abstract：:Early treatment of single sided deafness in children has been recommended to protect from neurodevelopmental preference for the better hearing ear and from social and educational deficits. A fairly homogeneous group of five young children (≤3.6 years of age) with normal right sided hearing who received a cochlear impl...

journal_title：Scientific reports

authors： Polonenko MJ,Gordon KA,Cushing SL,Papsin BC

更新日期：2017-12-04 00:00:00

abstract：:High-Q microresonator is perceived as a promising platform for optical frequency comb generation, via dissipative soliton formation. In order to achieve a higher quality factor and obtain the necessary anomalous dispersion, multi-mode waveguides were previously implemented in Si3N4 microresonators. However, coupling b...

journal_title：Scientific reports

authors： Huang SW,Liu H,Yang J,Yu M,Kwong DL,Wong CW

更新日期：2016-05-16 00:00:00

abstract：:Neutron grating interferometry (nGI) is a unique technique allowing to probe magnetic and nuclear properties of materials not accessible in standard neutron imaging. The signal-to-noise ratio of an nGI setup is strongly dependent on the achievable visibility. Hence, for analysis of weak signals or short measurement ti...

journal_title：Scientific reports

authors： Neuwirth T,Backs A,Gustschin A,Vogt S,Pfeiffer F,Böni P,Schulz M

更新日期：2020-02-04 00:00:00

abstract：:Leaf functional traits have attracted the attention of ecologists for several decades, but few studies have systematically assessed leaf morphological traits (termed "economic traits"), stomatal (termed "hydraulic"), and anatomical traits of entire forest communities, thus it is unclear whether their relationships are...

journal_title：Scientific reports

authors： Liu C,Li Y,Xu L,Chen Z,He N

更新日期：2019-04-09 00:00:00