Abstract:
:Early treatment of single sided deafness in children has been recommended to protect from neurodevelopmental preference for the better hearing ear and from social and educational deficits. A fairly homogeneous group of five young children (≤3.6 years of age) with normal right sided hearing who received a cochlear implant to treat deafness in their left ears were studied. Etiology of deafness was largely cytomegalovirus (n = 4); one child had an enlarged vestibular aqueduct. Multi-channel electroencephalography of cortical evoked activity was measured repeatedly over time at: 1) acute (0.5 ± 0.7 weeks); 2) early chronic (1.1 ± 0.2 months); and 3) chronic (5.8 ± 3.4 months) cochlear implant stimulation. Results indicated consistent responses from the normal right ear with marked changes in activity from the implanted left ear. Atypical distribution of peak amplitude activity from the implanted ear at acute stimulation marked abnormal lateralization of activity to the ipsilateral left auditory cortex and recruitment of extra-temporal areas including left frontal cortex. These abnormalities resolved with chronic implant use and contralateral aural preference emerged in both auditory cortices. These findings indicate that early implantation in young children with single sided deafness can rapidly restore bilateral auditory input to the cortex needed to improve binaural hearing.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Polonenko MJ,Gordon KA,Cushing SL,Papsin BCdoi
10.1038/s41598-017-17129-zsubject
Has Abstractpub_date
2017-12-04 00:00:00pages
16900issue
1issn
2045-2322pii
10.1038/s41598-017-17129-zjournal_volume
7pub_type
杂志文章abstract::INK4 locus at chromosome 9p21 has been reported to be associated with primary open angle glaucoma (POAG) and its subtypes along with the associated optic disc parameters across the populations of European, Japanese and African ancestries. The locus encodes three tumor suppressor genes namely CDKN2A, ARF, CDKN2B and a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05115
更新日期:2014-05-30 00:00:00
abstract::Flubendiamide (FD), the first commercial phthalic acid diamide that targets insect ryanodine receptor (RyRs), has played an important role in pest management. With its extensive worldwide application, a rapid and convenient method to detect its existence in the environment is necessary. In this study, an indirect comp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38649-w
更新日期:2019-02-14 00:00:00
abstract::Under specific reaction conditions, levansucrase from Bacillus subtilis (SacB) catalyzes the synthesis of a low molecular weight levan through the non-processive elongation of a great number of intermediates. To deepen understanding of the polymer elongation mechanism, we conducted a meticulous examination of the fruc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32872-7
更新日期:2018-10-09 00:00:00
abstract::This study assessed cortical tracking of temporal information in incoming natural speech in seven-month-old infants. Cortical tracking refers to the process by which neural activity follows the dynamic patterns of the speech input. In adults, it has been shown to involve attentional mechanisms and to facilitate effect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32150-6
更新日期:2018-09-13 00:00:00
abstract::Sufficient tissue oxygenation is required for regular brain function; thus oxygen supply must be tightly regulated to avoid hypoxia and irreversible cell damage. If hypoxia occurs the transcription factor complex hypoxia-inducible factor (HIF) will accumulate and coordinate adaptation of cells to hypoxia. However, eve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75838-4
更新日期:2020-11-05 00:00:00
abstract::microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we rep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02535
更新日期:2013-01-01 00:00:00
abstract::This study described the results of environmental enterovirus surveillance conducted in Shandong Province of China in 2013. Altogether 39 sewage samples were collected and 873 enterovirus isolates (including 334 polioviruses) belonging to 22 serotypes were obtained. Echovirus (E) -7, coxsackievirus (CV) -B5, E-11, E-6...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31474
更新日期:2016-08-11 00:00:00
abstract::Understanding the molecular mechanisms underlying Alzheimer's disease (AD) is necessary for the diagnosis and treatment of this neurodegenerative disorder. It is therefore important to detect the most important genes and miRNAs, which are associated with molecular events, and studying their interactions for recognitio...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-20959-0
更新日期:2018-03-19 00:00:00
abstract::Compact and power-efficient plastic electronic synapses are of fundamental importance to overcoming the bottlenecks of developing a neuromorphic chip. Memristor is a strong contender among the various electronic synapses in existence today. However, the speeds of synaptic events are relatively slow in most attempts at...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01619
更新日期:2013-01-01 00:00:00
abstract::Hereditary Parkinson's disease is commonly caused by mutations in the protein kinase PINK1 or the E3 ubiquitin ligase Parkin, which function together to eliminate damaged mitochondria. PINK1 phosphorylates both Parkin and ubiquitin to stimulate ubiquitination of dozens of proteins on the surface of the outer mitochond...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33019
更新日期:2016-09-08 00:00:00
abstract::Hyperuricemia is an abnormal metabolic condition characterized by an increase in uric acid levels in the blood. It is the cause of gout, manifested by inflammatory arthritis, pain and disability. This study examined the possible ameliorative impacts of parsley (PAR) and celery (CEL) as hypouricemic agents at biochemic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66205-4
更新日期:2020-06-11 00:00:00
abstract::In this paper, we investigate the high frequency performance of Co90Zr10/SiO2/Co90Zr10 trilayers. It is demonstrated that the in-plane isotropic microwave performance is theoretically derived from the solution of the Landau-Lifshitz-Gilbert equation and experimentally achieved in that sandwich structured film. The val...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21327
更新日期:2016-02-17 00:00:00
abstract::This corrects the article DOI: 10.1038/srep31347. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/srep46979
更新日期:2018-05-11 00:00:00
abstract::Lead germanate-graphene nanosheets (PbGeO3-GNS) composites have been prepared by an efficient one-step, in-situ hydrothermal method and were used as anode materials for Li-ion batteries (LIBs). The PbGeO3 nanowires, around 100-200 nm in diameter, are highly encapsulated in a graphene matrix. The lithiation and de-lith...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07030
更新日期:2014-11-13 00:00:00
abstract::Treponema pallidum subsp. pallidum, the causative agent of syphilis, is a highly invasive spirochete pathogen that uses the vasculature to disseminate throughout the body. Identification of bacterial factors promoting dissemination is crucial for syphilis vaccine development. An important step in dissemination is bact...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01589-4
更新日期:2017-05-08 00:00:00
abstract::Plasmodium vivax, a major agent of malaria in both temperate and tropical climates, has been thought to be unable to infect humans lacking the Duffy (Fy) blood group antigen because this receptor is critical for erythrocyte invasion. Recent surveys in various endemic regions, however, have reported P. vivax infections...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35581
更新日期:2016-10-19 00:00:00
abstract::Macrophages and resident microglia play an import role in the secondary neuroinflammation response following spinal cord injury. Reprogramming of macrophage/microglia polarization is an import strategy for spinal cord injury restoration. Low-level laser therapy (LLLT) is a noninvasive treatment that has been widely us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00553-6
更新日期:2017-04-04 00:00:00
abstract::Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with gold-standard methodology to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79540-3
更新日期:2021-01-11 00:00:00
abstract::Previous etiologic studies have indicated that both environmental and genetic factors play important roles in the occurrence and development of chronic Achilles tendinopathy (AT). A recent study documented the results of the largest genome-wide association study for chronic AT to date, indicating that MPP7, TIMP2 and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54097-y
更新日期:2019-11-26 00:00:00
abstract::Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is thought to be a pure genetic form of subcortical vascular cognitive impairment (SVCI). The aim of this study was to compare white matter integrity and cortical thickness between typical CADASIL, a genetic form, and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36580-0
更新日期:2019-01-28 00:00:00
abstract::We here develop a three-dimensional DMF (3D DMF) platform with patterned electrodes submerged in an oil medium to provide fundamental solutions to the technical limitations of 2D DMF platforms and water-air systems. 3D droplet manipulation on patterned electrodes is demonstrated by programmably controlling electrical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10685
更新日期:2015-06-02 00:00:00
abstract::A new fluorine-substituted ligand, compound 1 (CB251), with a very high affinity (Ki = 0.27 ± 0.09 nM) and selectivity for the 18-kDa translocator protein (TSPO), is presented as an attractive biomarker for the diagnosis of neuroinflammation, neurodegeneration and tumour progression. To test compound 1 as a TSPO PET i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20422
更新日期:2016-02-08 00:00:00
abstract::Chronic suppurative otitis media (CSOM) is one of the most common infectious diseases of the middle ear especially affecting children, leading to delay in language development and communication. Although Staphylococcus aureus is the most common pathogen associated with CSOM, its interaction with middle ear epithelial ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47079-7
更新日期:2019-07-25 00:00:00
abstract::Advances in Virtual Reality (VR) technologies allow the investigation of simulated moral actions in visually immersive environments. Using a robotic manipulandum and an interactive sculpture, we now also incorporate realistic haptic feedback into virtual moral simulations. In two experiments, we found that participant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13909-9
更新日期:2017-10-24 00:00:00
abstract::Angiotensin-converting enzyme (ACE) is an evolutionarily conserved peptidyl dipeptidase. Mammalian ACE converts angiotensin I to the active vasoconstrictor angiotensin II, thus playing a critical role for homeostasis of the renin-angiotensin system. In Drosophila, the ACE homolog Ance is expressed in specific regions ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13487-w
更新日期:2017-10-13 00:00:00
abstract::Human fetuin-B plays a key physiological role in human fertility through its inhibitory action on ovastacin, a member of the astacin family of metallopeptidases. The inhibitor consists of tandem cystatin-like domains (CY1 and CY2), which are connected by a linker containing a "CPDCP-trunk" and followed by a C-terminal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51095-y
更新日期:2019-10-11 00:00:00
abstract::This study evaluated the 4-year results of 32 patients with T1N0 low-lying rectal adenocarcinoma treated solely with californium-252 (Cf-252) neutron intracavity brachytherapy (ICBT). Patients were solicited into the study from January 2008 to June 2011. All the patients had refused surgery or surgery was contraindica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40619
更新日期:2017-01-17 00:00:00
abstract::Riemerella anatipestifer is a major pathogenic microorganism in poultry causing serositis with significant mortality. Serotype 1 and 2 were most pathogenic, prevalent, and liable over the world. In this study, the intracellular metabolites in R. anatipestifer strains RA-CH-1 (serotype 1) and RA-CH-2 (serotype 2) were ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79733-w
更新日期:2021-01-12 00:00:00
abstract::Magnetoelectric (ME) thin film composites consisting of sputtered piezoelectric (PE) and magnetostrictive (MS) layers enable for measurements of magnetic fields passively, i.e. an AC magnetic field directly generates an ME voltage by mechanical coupling of the MS deformation to the PE phase. In order to achieve high f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52657-w
更新日期:2019-11-08 00:00:00
abstract::The purpose of the present study was to assess the differential intraocular pressure response (IOP) to dexamethasone (DEX) treatment at two dose levels (100 or 500 nM) in perfusion cultured Indian cadaveric eyes to investigate glucocorticoid (GC) responsiveness. In a human organ-cultured anterior segment (HOCAS) set-u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80112-8
更新日期:2021-01-12 00:00:00