Abstract：
:BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of long-term heroin use. Thus, we investigated the relationships between brain-derived neurotrophic factor (BDNF) plasma concentrations and the BDNF Val66Met nucleotide polymorphism (SNP) in heroin-dependent patients. The pretreatment expression levels of plasma BDNF and the BDNF Val66Met SNP in 172 heroin-dependent patients and 102 healthy controls were checked. BDNF levels were significantly lower in patients (F = 52.28, p < 0.0001), but the distribution of the SNP was not significantly different. Nor were plasma BDNF levels significantly different between Met/Met, Met/Val, and Val/Val carriers in each group, which indicated that the BDNF Val66Met SNP did not affect plasma BDNF levels in our participants. In heroin-dependent patients, plasma BDNF levels were negatively correlated with the length of heroin dependency. Long-term (>15 years) users had significantly lower plasma BDNF levels than did short-term (<5 years) users. We conclude that plasma BDNF concentration in habitual heroin users are not affected by BDNF Val66Met gene variants, but by the length of the heroin dependency.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen SL,Lee SY,Chang YH,Wang TY,Chen SH,Chu CH,Chen PS,Yang YK,Hong JS,Lu RBdoi
10.1038/srep08148subject
Has Abstractpub_date
2015-02-02 00:00:00pages
8148issn
2045-2322pii
srep08148journal_volume
5pub_type
杂志文章abstract：:Toxins are believed to play a crucial role in Burkholderia pseudomallei pathogenicity, however to date, only a few have been identified. The discovery of additional toxic molecules is limited by the lack of a sensitive indicator of B. pseudomallei toxicity. Previously, from a whole genome transcriptome analysis of B. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27475
更新日期：2016-06-07 00:00:00
abstract：:Currently, a comprehensive assessment between mitochondrial DNA (mtDNA) content and cancer risk is lacking. We designed this meta-analysis to test the hypothesis that altered mtDNA copy number might influence genetic susceptibility to some specific types of cancer. The processes of literature search, eligibility appra...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep10039
更新日期：2015-05-08 00:00:00
abstract：:Oxidative stress due to hypobaric hypoxia at extreme altitudes causes severe neuronal damage and irreversible cognitive loss. Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract of Ganoderma lucidum (GLAQ) and underlying neuroprote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65812-5
更新日期：2020-06-02 00:00:00
abstract：:We investigated the relationship between aqueous cytokine levels, changes in ocular blood flow, and morphological and functional improvements after intravitreal ranibizumab injection (IRI) in treatment-naïve eyes with center-involving diabetic macular edema (DME). Thirty-three eligible patients with DME (33 eyes) were...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78792-3
更新日期：2020-12-10 00:00:00
abstract：:NGS (Next Generation Sequencing) technologies allows us to determine key gene expression signatures that correlate with resistance (and responsiveness) to anti-cancer therapeutics. We have undertaken a transcriptomic and chromatin immunoprecipitation followed by sequencing (ChIP-seq) approach to describe differences i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41672-6
更新日期：2019-03-26 00:00:00
abstract：:Stryphnodendron adstringens is a medicinal plant belonging to the Leguminosae family, and it is commonly found in the southeastern savannas, endemic to the Cerrado biome. The goal of this study was to assemble and annotate the chloroplast genome of S. adstringens and to compare it with previously known genomes of the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50620-3
更新日期：2019-10-02 00:00:00
abstract：:The aim of the current manuscript was to test the applicability of a nanocomposite system of penetration enhancer vesicles (PEVs) within polymeric in situ forming gel network composed of poloxamer and hyaluronic acid for the intranasal delivery of the antiemetic dimenhydrinate (DMH). PEVs were prepared using phospholi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10032-7
更新日期：2017-08-30 00:00:00
abstract：:Early-life social experiences cause lasting changes in behavior and health for a variety of animals including humans, but it is not well understood how social information ''gets under the skin'' resulting in these effects. Adult honey bees (Apis mellifera) exhibit socially coordinated collective nest defense, providin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15572
更新日期：2015-10-23 00:00:00
abstract：:This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Two multiple logistic regression models ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/srep38844
更新日期：2016-12-19 00:00:00
abstract：:The existing acoustic emission (AE) source location methods assume that acoustic waves propagate along straight lines, and the source location is determined by average wave velocity. Because of the heterogeneity of materials, location results often fail to meet the accuracy requirement. For this reason, an AE source l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07371-w
更新日期：2017-08-07 00:00:00
abstract：:We investigated how skeletal muscle mass (SMM) affects spinal sagittal balance (radiographic parameters) in symptomatic spinal patients. The first purpose of this study was to evaluate the body composition and the spinal sagittal alignment in symptomatic spinal patients. The second purpose of this study was to compare...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33867-0
更新日期：2018-10-19 00:00:00
abstract：:The development of artificial intelligence has led researchers to study the ethical principles that should guide machine behavior. The challenge in building machine morality based on people's moral decisions, however, is accounting for the biases in human moral decision-making. In seven studies, this paper investigate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49411-7
更新日期：2019-09-11 00:00:00
abstract：:Hypoplastic left heart syndrome (HLHS) is a fatal congenital heart disease in which the left side of the heart is underdeveloped, impairing the systemic circulation. Underdeveloped left ventricle exerts biomechanical stress on the right ventricle that can progress into heart failure. Genome-wide transcriptome changes ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30896
更新日期：2016-08-03 00:00:00
abstract：:This study evaluated the impact of mechanically stimulated saliva on initial bacterial colonization. Interaction between oral bacteria and both unstimulated and stimulated saliva was examined in vitro by laying labeled bacteria over SDS-PAGE-separated salivary proteins. The effects of chewing on in vivo biofilm, micro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48211-3
更新日期：2019-08-14 00:00:00
abstract：:Numerous studies have been conducted to examine the molecular mechanism of Haemophilus parasuis resistance to antibiotic, but rarely to tildipirosin. In the current study, transcriptional profiling was applied to analyse the variation in gene expression of JS0135 and tildipirosin-resistant JS32. The growth curves show...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07972-5
更新日期：2017-08-08 00:00:00
abstract：:The core of the Vibrio Harveyi clade contains V. harveyi, V. campbellii, V. owensii, V. jasicida, and V. rotiferianus. They are well recognized aquatic animal pathogens, but misclassification has been common due to similarities in their rDNA sequences and phenotypes. To better understand their evolutionary relationshi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41394
更新日期：2017-02-01 00:00:00
abstract：:The magnetization process is a very important probe to study magnetic materials, particularly in search of spin-liquid states in quantum spin systems. Regrettably, however, progress of the theoretical analysis has been unsatisfactory, mostly because it is hard to obtain sufficient numerical data to support the theory....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70389-0
更新日期：2020-08-26 00:00:00
abstract：:Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and Alzheimer's disease (AD). Therefore, we have formulated the first western-style diet that mimics the fat, carbohydrate, protein, vitamin and mineral levels of wester...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21568
更新日期：2016-02-18 00:00:00
abstract：:Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models. Inherent challenges, however, are the pluripotency of IVIG and its xenogeneicity in animals. IVIG can alter the viability of human neutrophils v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01404-0
更新日期：2017-05-02 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-31948-8
更新日期：2018-09-12 00:00:00
abstract：:The dugong (Dugong dugon Müller) is recognized as an endangered marine mammal. There is limited available anatomical data on the dugong's skeletal system, while what is available has not been well established due to the limited number of archived samples and limited access to them. Importantly, there are certain key q...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76545-w
更新日期：2020-11-09 00:00:00
abstract：:This is the first study to investigate the impact of a second fibula flap or a soft tissue flap combined with bridging plate for a repeated segmental mandibulectomy reconstruction on flap outcomes in head and neck cancer patients. A retrospective comparative analysis (2007-2016) of 61 patients who underwent a second s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44467-x
更新日期：2019-05-28 00:00:00
abstract：:The purpose of this study was to analyze spatiotemporal parameters of gait in children using varyingly loaded Backpacks(BP). This cross-sectional study examined 231 schoolchildren (118 boys, 113 girls) aged six to 12 years, carrying a traditional BP to manipulate loading (Crossing Backpack Children Arpenaz 7 Litres, J...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48675-3
更新日期：2019-08-21 00:00:00
abstract：:The scale-eating cichlid Perissodus microlepis exhibits significant lateralised predation behaviour using an asymmetric mouth. But how the acquisition of the behavioural laterality depends, if at all, on experience during development remains obscure. Here, naïve juveniles were tested in a series of predation sessions....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09342-7
更新日期：2017-08-21 00:00:00
abstract：:Chemical chaperones including arginine and its derivatives are widely used by biochemists working on the design of agents, which are able to efficiently suppress protein aggregation. To elucidate the mechanisms of anti-aggregation activity of chemical chaperones, methods based on registration of the increment in light...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04409-x
更新日期：2017-06-21 00:00:00
abstract：:The gradient relationship between mean corpuscular volume (MCV) and mortality due to ischemic vascular disease has not been researched using a large-scale population-based study. This study evaluated the association between MCV and death attributable to cerebrovascular disease (CVD) and cardiovascular disease (CAD) in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34403-w
更新日期：2018-11-08 00:00:00
abstract：:Tin selenide has attracted much research interest due to its unprecedentedly high thermoelectric figure of merit (ZT). For real applications, it is desirable to increase the ZT value in the lower-temperature range, as the peak ZT value currently exists near the melting point. It is shown in this paper that the structu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26193
更新日期：2016-05-19 00:00:00
abstract：:Homogeneously distributed zinc nanoparticles (NPs) on the glass substrate were investigated for the transmittance, mechanical durability, and antibacterial effect. The buffered Ti NPs between Zn NPs and glass substrate were studied for an enhancement of the transmittance and mechanical endurance. The Ti NPs buffered Z...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06271
更新日期：2014-09-03 00:00:00
abstract：:Distillers grains are co-products of the corn ethanol industry widely used in animal feed. We examined the effects of erythromycin, penicillin, and virginiamycin at low concentrations reflective of those detected in distillers grains on bacterial resistance selection. At 0.1 µg/ml erythromycin, macrolide-resistant mut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09593-4
更新日期：2017-09-08 00:00:00
abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that thrives in diverse environments and causes a variety of human infections. Pseudomonas aeruginosa AG1 (PaeAG1) is a high-risk sequence type 111 (ST-111) strain isolated from a Costa Rican hospital in 2010. PaeAG1 has both blaVIM-2 and blaIMP-18 genes encoding for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70581-2
更新日期：2020-08-13 00:00:00
