Intranasally administered in situ gelling nanocomposite system of dimenhydrinate: preparation, characterization and pharmacodynamic applicability in chemotherapy induced emesis model.

abstract：:Fat character is an important index in duck culture that linked to local flavor, feed cost and fat intake for costumers. Since the regulation networks in duck lipid metabolism had not been reported very clearly, we aimed to explore the potential miRNA-mRNA pairs and their regulatory roles in duck lipid metabolism. Her...

journal_title：Scientific reports

authors： He J,Wang W,Lu L,Tian Y,Niu D,Ren J,Dong L,Sun S,Zhao Y,Chen L,Shen J,Li X

更新日期：2016-06-08 00:00:00

abstract：:Direct measures of energy expenditure are difficult to obtain in marine mammals, and accelerometry may be a useful proxy. Recently its utility has been questioned as some analyses derived their measure of activity level by calculating the sum of accelerometry-based values and then comparing this summation to summed (t...

journal_title：Scientific reports

authors： Ladds MA,Rosen DAS,Slip DJ,Harcourt RG

更新日期：2017-09-18 00:00:00

abstract：:Co-existing infection/inflammation and birth asphyxia potentiate the risk of developing neonatal encephalopathy (NE) and adverse outcome. In a newborn piglet model we assessed the effect of E. coli lipopolysaccharide (LPS) infusion started 4 h prior to and continued for 48 h after hypoxia on brain cell death and syste...

journal_title：Scientific reports

authors： Martinello KA,Meehan C,Avdic-Belltheus A,Lingam I,Ragab S,Hristova M,Tann CJ,Peebles D,Hagberg H,Wolfs TGAM,Klein N,Tachtsidis I,Golay X,Kramer BW,Fleiss B,Gressens P,Robertson NJ

更新日期：2019-07-15 00:00:00

abstract：:The enrichment of viable cells is an essential step to obtain effective products for cell therapy. While procedures exist to characterize the viability of cells, most methods to exclude nonviable cells require the use of density gradient centrifugation or antibody-based cell sorting with molecular labels of cell viabi...

journal_title：Scientific reports

authors： Islam M,Brink H,Blanche S,DiPrete C,Bongiorno T,Stone N,Liu A,Philip A,Wang G,Lam W,Alexeev A,Waller EK,Sulchek T

更新日期：2017-05-17 00:00:00

abstract：:In this paper we report a low complexity compression method that is suitable for compact optical scanning holography (OSH) systems with different optical settings. Our proposed method can be divided into 2 major parts. First, an automatic decision maker is applied to select the rows of holographic pixels to be scanned...

journal_title：Scientific reports

authors： Tsang PW,Poon TC,Liu JP,Kim T,Kim YS

更新日期：2016-10-06 00:00:00

abstract：:Breast cancer transcriptome acquires a myriad of regulation changes, and splicing is critical for the cell to "tailor-make" specific functional transcripts. We systematically revealed splicing signatures of the three most common types of breast tumors using RNA sequencing: TNBC, non-TNBC and HER2-positive breast cance...

journal_title：Scientific reports

authors： Eswaran J,Horvath A,Godbole S,Reddy SD,Mudvari P,Ohshiro K,Cyanam D,Nair S,Fuqua SA,Polyak K,Florea LD,Kumar R

更新日期：2013-01-01 00:00:00

abstract：:Surface-enhanced Raman spectroscopy (SERS) has attracted a lot of attention in molecular sensing because of the remarkable ability of plasmonic metal nanostructures to enhance the weak Raman scattering process. On the other hand, coherent vibrational spectroscopy triggered by impulsive excitation using ultrafast laser...

journal_title：Scientific reports

authors： Du J,Harra J,Virkki M,Mäkelä JM,Leng Y,Kauranen M,Kobayashi T

更新日期：2016-11-04 00:00:00

abstract：:Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized medicine. Here we investigate the theranostic properties of topological insulator bismuth selenide (Bi2Se3) in in vivo and in vitro system for the ...

journal_title：Scientific reports

authors： Li J,Jiang F,Yang B,Song XR,Liu Y,Yang HH,Cao DR,Shi WR,Chen GN

更新日期：2013-01-01 00:00:00

abstract：:Muscle attachment sites (entheses) on dry bones are regularly used by paleontologists to infer soft tissue anatomy and to reconstruct behaviors of extinct organisms. This method is commonly applied to fossil hominin hand bones to assess their abilities to participate in Paleolithic stone tool behaviors. Little is know...

journal_title：Scientific reports

authors： Williams-Hatala EM,Hatala KG,Hiles S,Rabey KN

更新日期：2016-06-23 00:00:00

abstract：:Terrestrial plants typically take up nutrients through roots or mycorrhizae while freshwater plants additionally utilize leaves. Their nutrient uptake may be enhanced by root hairs whose occurrence is often negatively correlated with mycorrhizal colonization. Seagrasses utilize both leaves and roots and often form roo...

journal_title：Scientific reports

authors： Borovec O,Vohník M

更新日期：2018-07-17 00:00:00

abstract：:Histone deacetylase inhibition (HDACi) has been suggested as a promising approach to bolster TLR-mediated induction of antimicrobial peptides such as human β-defensin 2 (hBD2). In inflammatory bowel disease (IBD), Crohn's disease (CD) patients display an attenuated expression of hBD2 as compared to ulcerative colitis ...

journal_title：Scientific reports

authors： Stebe-Frick S,Ostaff MJ,Stange EF,Malek NP,Wehkamp J

更新日期：2018-08-27 00:00:00

abstract：:We describe a technique for imaging single mRNAs in living cells based on fluorescent protein (FP) complementation. We employ the high affinity interaction between the bacterial phage MS2/PP7 coat proteins and their respective RNA binding motifs as an RNA scaffold to bring two halves of a split-FP together to image si...

journal_title：Scientific reports

authors： Wu B,Chen J,Singer RH

更新日期：2014-01-09 00:00:00

abstract：:The coiled-coil domain containing 50 (CCDC50) protein is a phosphotyrosine-dependent signalling protein stimulated by epidermal growth factor. It is highly expressed in neuronal cells in the central nervous system; however, the roles of CCDC50 in neuronal development are largely unknown. In this study, we showed that ...

journal_title：Scientific reports

authors： Min JS,Halder D,Yoon JY,Jeon SJ,Jun SY,Lee JR,Lee JJ,Choi MH,Jung CR,Lee D,Kim BJ,Kim NS

更新日期：2020-12-04 00:00:00

abstract：:In plants, the shikimate pathway generally occurs in plastids and leads to the biosynthesis of aromatic amino acids. Chorismate synthase (CS) catalyses the last step of the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to chorismate, but the role of CS in the metabolism of higher plants has not been reported...

journal_title：Scientific reports

authors： Zhong S,Chen Z,Han J,Zhao H,Liu J,Yu Y

更新日期：2020-07-02 00:00:00

abstract：:A novel linear polarization converter operating in C- and X-bands with high polarization conversion ratio is described and demonstrated based on frequency selective surface. The building element is a planar-dipole pair, which is orthogonally printed on a double-layer substrate and vertically connected by a pair of thr...

journal_title：Scientific reports

authors： Wang SY,Liu W,Geyi W

更新日期：2018-02-28 00:00:00

abstract：:Somatic mutations of many cancer genes tend to co-occur (termed co-mutations) in certain patterns during tumor initiation and progression. However, the genetic and epigenetic mechanisms that contribute to the co-mutations of these cancer genes have yet to be explored. Here, we systematically investigated the associati...

journal_title：Scientific reports

authors： Shi Y,Su XB,He KY,Wu BH,Zhang BY,Han ZG

更新日期：2016-10-20 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Yoshitake R,Saeki K,Eto S,Shinada M,Nakano R,Sugiya H,Endo Y,Fujita N,Nishimura R,Nakagawa T

更新日期：2020-10-28 00:00:00

abstract：:Overexposure to intense noise can destroy the synapses between auditory nerve fibers and their hair cell targets without destroying the hair cells themselves. In adult mice, this synaptopathy is immediate and largely irreversible, whereas, in guinea pigs, counts of immunostained synaptic puncta can recover with increa...

journal_title：Scientific reports

authors： Hickman TT,Hashimoto K,Liberman LD,Liberman MC

更新日期：2020-11-17 00:00:00

abstract：:Most enzymes that act on carbohydrates include non-catalytic carbohydrate-binding modules (CBMs) that recognize and target carbohydrates. CBMs bring their appended catalytic modules into close proximity with the target substrate and increase the hydrolytic rate of enzymes acting on insoluble substrates. We previously ...

journal_title：Scientific reports

authors： Duan CJ,Feng YL,Cao QL,Huang MY,Feng JX

更新日期：2016-01-14 00:00:00

abstract：:Given that many fundamental questions in neuroscience are still open, it seems pertinent to explore whether the brain might use other physical modalities than the ones that have been discovered so far. In particular it is well established that neurons can emit photons, which prompts the question whether these biophoto...

journal_title：Scientific reports

authors： Kumar S,Boone K,Tuszyński J,Barclay P,Simon C

更新日期：2016-11-07 00:00:00

abstract：:Procalcitonin (PCT) is a useful marker for the diagnosis of systemic inflammatory response syndrome. In addition, PCT is affected by renal function. However, few studies have investigated the relationship between PCT and the development of acute kidney injury (AKI). Hence, we investigated whether serum PCT levels at t...

journal_title：Scientific reports

authors： Chun K,Chung W,Kim AJ,Kim H,Ro H,Chang JH,Lee HH,Jung JY

更新日期：2019-03-18 00:00:00

abstract：:The development of metal-based agents has had a tremendous role in the present progress in cancer chemotherapy. One well-known example of metal-based agents is Schiff based metal complexes, which hold great promise for cancer therapy. Based on the potential of Schiff based complexes for the induction of apoptosis, thi...

journal_title：Scientific reports

authors： Hajrezaie M,Paydar M,Looi CY,Moghadamtousi SZ,Hassandarvish P,Salga MS,Karimian H,Shams K,Zahedifard M,Majid NA,Ali HM,Abdulla MA

更新日期：2015-03-13 00:00:00

abstract：:We investigated the extent to which pre-pregnancy obesity mediates the association between maternal place of birth and severe pre-eclampsia in the PreCARE cohort of pregnant women in Paris (n = 9,579). Adjusted path analysis logistic regression models were used to assess the role of pre-pregnancy obesity as a mediator...

journal_title：Scientific reports

authors： Siddiqui A,Deneux-Tharaux C,Luton D,Schmitz T,Mandelbrot L,Estellat C,Howell EA,Khoshnood B,Bertille N,Azria E

更新日期：2020-03-23 00:00:00

abstract：:Elevated nitrogen associated with global change is believed to promote the invasion of many vigorous exotic plants. However, it is unclear how a weak exotic plant will respond to elevated nitrogen in the future. In this study, the competitive outcome of a weak invasive plant (Galinsoga quadriradiata) and two non-invas...

journal_title：Scientific reports

authors： Liu G,Yang YB,Zhu ZH

更新日期：2018-02-16 00:00:00

abstract：:The bald eagle (Haliaeetus leucocephalus) once experienced near-extinction but has since rebounded. For decades, bald eagles near the Wisconsin River, USA, have experienced a lethal syndrome with characteristic clinical and pathological features but unknown etiology. Here, we describe a novel hepacivirus-like virus (F...

journal_title：Scientific reports

authors： Goldberg TL,Sibley SD,Pinkerton ME,Dunn CD,Long LJ,White LC,Strom SM

更新日期：2019-10-18 00:00:00

abstract：:The spectral distribution of light emitted from a scanning tunnelling microscope junction not only bears its intrinsic plasmonic signature but is also imprinted with the characteristics of optical frequency fluc- tuations of the tunnel current. Experimental spectra from gold-gold tunnel junctions are presented that sh...

journal_title：Scientific reports

authors： Kalathingal V,Dawson P,Mitra J

更新日期：2017-06-14 00:00:00

abstract：:Routers, switches, and repeaters are essential components of modern information-processing systems. Similar devices will be needed in future superconducting quantum computers. In this work we investigate experimentally the time evolution of Autler-Townes splitting in a superconducting phase qubit under the application...

journal_title：Scientific reports

authors： Li J,Paraoanu GS,Cicak K,Altomare F,Park JI,Simmonds RW,Sillanpää MA,Hakonen PJ

更新日期：2012-01-01 00:00:00

abstract：:Alternate bearing (AB) refers to the tendency of trees to have an irregular crop load from 1 year (ON) to the next year (OFF). Despite its economic importance, it is not fully understood how gene networks and their related metabolic pathways may influence the irregular bearing in olive trees. To unravel molecular mech...

journal_title：Scientific reports

authors： Dastkar E,Soleimani A,Jafary H,de Dios Alche J,Bahari A,Zeinalabedini M,Salami SA

更新日期：2020-09-25 00:00:00

abstract：:Increasing evidence suggest that the glucose-lowering drug metformin exerts a valuable anti-senescence role. The ability of metformin to affect the biogenesis of selected microRNAs (miRNAs) was recently suggested. MicroRNA isoforms (isomiRs) are distinct variations of miRNA sequences, harboring addition or deletion of...

journal_title：Scientific reports

authors： Giuliani A,Londin E,Ferracin M,Mensà E,Prattichizzo F,Ramini D,Marcheselli F,Recchioni R,Rippo MR,Bonafè M,Rigoutsos I,Olivieri F,Sabbatinelli J

更新日期：2020-12-11 00:00:00

abstract：:One of the potential antibiofilm strategies is to use lytic phages and phage-derived polysaccharide depolymerases. The idea is to uncover bacteria embedded in the biofilm matrix making them accessible and vulnerable to antibacterials and the immune system. Here we present the antibiofilm efficiency of lytic phage KP34...

journal_title：Scientific reports

authors： Latka A,Drulis-Kawa Z

更新日期：2020-11-23 00:00:00