Identification of a novel family of carbohydrate-binding modules with broad ligand specificity.

abstract：:Non-alcoholic fatty liver disease (NAFLD), the most predominant liver disease worldwide, is a progressive condition that encompasses a spectrum of disorders ranging from steatosis to steatohepatitis, and, ultimately, cirrhosis and hepatocellular carcinoma. Although the underlying mechanism is complex and multifactoria...

journal_title：Scientific reports

authors： de Freitas Carvalho MM,Lage NN,de Souza Paulino AH,Pereira RR,de Almeida LT,da Silva TF,de Brito Magalhães CL,de Lima WG,Silva ME,Pedrosa ML,da Costa Guerra JF

更新日期：2019-05-30 00:00:00

abstract：:Natural medicines (i.e., herbal medicines, traditional formulas) are useful for treatment of multifactorial and chronic diseases. Here, we present KampoDB ( http://wakanmoview.inm.u-toyama.ac.jp/kampo/ ), a novel platform for the analysis of natural medicines, which provides various useful scientific resources on Japa...

journal_title：Scientific reports

authors： Sawada R,Iwata M,Umezaki M,Usui Y,Kobayashi T,Kubono T,Hayashi S,Kadowaki M,Yamanishi Y

更新日期：2018-07-25 00:00:00

abstract：:Platelet-derived growth factor receptor beta (PDGFRβ) affects in numerous human cancers and has been recognized as a promising molecular target for cancer therapies. The overexpression of PDGFRβ could be a biomarker for cancer diagnosis. Radiolabeled ligands having high affinity for the molecular target could be usefu...

journal_title：Scientific reports

authors： Effendi N,Mishiro K,Takarada T,Makino A,Yamada D,Kitamura Y,Shiba K,Kiyono Y,Odani A,Ogawa K

更新日期：2018-07-10 00:00:00

abstract：:Actinobacillus pleuropneumoniae (App) is the causative agent of porcine pleuropneumonia. Although App produces several virulence factors, Apx toxins, the primary App virulence factors, have been the focus of numerous studies. However, the host response against the Apx toxins has not been elucidated at the transcriptom...

journal_title：Scientific reports

authors： Kim S,Oh MW,Bin Park W,Yoo HS

更新日期：2019-03-27 00:00:00

abstract：:Understanding the genetic basis of phenotypic diversity is a challenge in contemporary biology. Domestication provides a model for unravelling aspects of the genetic basis of stress sensitivity. The ancestral Red Junglefowl (RJF) exhibits greater fear-related behaviour and a more pronounced HPA-axis reactivity than it...

journal_title：Scientific reports

authors： Fallahsharoudi A,de Kock N,Johnsson M,Ubhayasekera SJ,Bergquist J,Wright D,Jensen P

更新日期：2015-10-16 00:00:00

abstract：:High-throughput technologies have identified significant changes in patterns of mRNA expression over cancer development but the functional significance of these changes often rests upon the assumption that observed changes in levels of mRNA accurately reflect changes in levels of their encoded proteins. We systematica...

journal_title：Scientific reports

authors： Zhang M,Matyunina LV,Walker LD,Chen W,Xiao H,Benigno BB,Wu R,McDonald JF

更新日期：2017-08-15 00:00:00

abstract：:Current etching routes to process large graphene sheets into nanoscale graphene so as to open up a bandgap tend to produce structures with rough and disordered edges. This leads to detrimental electron scattering and reduces carrier mobility. In this work, we present a novel yet simple direct-growth strategy to yield ...

journal_title：Scientific reports

authors： Wang M,Fu L,Gan L,Zhang C,Rümmeli M,Bachmatiuk A,Huang K,Fang Y,Liu Z

更新日期：2013-01-01 00:00:00

abstract：:Symbiodinium is a dinoflagellate that plays an important role in the physiology of the symbiotic relationships of Cnidarians such as corals and sea anemones. However, it is very difficult to cultivate free-living dinoflagellates after being isolated from the host, as they are very sensitive to environmental changes. H...

journal_title：Scientific reports

authors： Pasaribu B,Weng LC,Lin IP,Camargo E,Tzen JT,Tsai CH,Ho SL,Lin MR,Wang LH,Chen CS,Jiang PL

更新日期：2015-10-20 00:00:00

abstract：:Pyrosomes are tunicates in the phylum Chordata, which also contains vertebrates. Their gigantic blooms play important ecological and biogeochemical roles in oceans. Pyrosoma, meaning "fire-body", derives from their brilliant bioluminescence. The biochemistry of this light production is unknown, but has been hypothesiz...

journal_title：Scientific reports

authors： Tessler M,Gaffney JP,Oliveira AG,Guarnaccia A,Dobi KC,Gujarati NA,Galbraith M,Mirza JD,Sparks JS,Pieribone VA,Wood RJ,Gruber DF

更新日期：2020-10-20 00:00:00

abstract：:Food webs in high-latitude oceans are dominated by relatively few species. Future ocean and sea-ice changes affecting the distribution of such species will impact the structure and functioning of whole ecosystems. Antarctic krill (Euphausia superba) is a key species in Southern Ocean food webs, but there is little und...

journal_title：Scientific reports

authors： Murphy EJ,Thorpe SE,Tarling GA,Watkins JL,Fielding S,Underwood P

更新日期：2017-07-31 00:00:00

abstract：:Recently, development of Adeno-associated virus (AAV) vectors has been focusing on expanding the genetic diversity of vectors from existing sequences via directed evolution or epitope remapping. Apart from intelligent design, AAV isolation from natural sources remains an important source of new AAVs with unique biolog...

journal_title：Scientific reports

authors： Bello A,Chand A,Aviles J,Soule G,Auricchio A,Kobinger GP

更新日期：2014-10-22 00:00:00

abstract：:The extraction and encoding of acoustical temporal regularities are fundamental for human cognitive auditory abilities such as speech or beat entrainment. Because the comparison of the neural sensitivity to temporal regularities between human and animals is fundamental to relate non-invasive measures of auditory proce...

journal_title：Scientific reports

authors： Ayala YA,Lehmann A,Merchant H

更新日期：2017-11-30 00:00:00

abstract：:Injection of pure spin current using a nonlocal geometry is a promising method for controlling magnetization in spintronic devices from the viewpoints of increasing freedom in device structure and avoiding problems related to charge current. Here, we report an experimental demonstration of magnetization switching of a...

journal_title：Scientific reports

authors： Suto H,Nagasawa T,Kanao T,Yamada K,Mizushima K

更新日期：2019-12-20 00:00:00

abstract：:Channelopathy mutations prove informative on disease causing mechanisms and channel gating dynamics. We have identified a novel heterozygous mutation in the KCNA1 gene of a young proband displaying typical signs and symptoms of Episodic Ataxia type 1 (EA1). This mutation is in the S4 helix of the voltage-sensing domai...

journal_title：Scientific reports

authors： Hasan S,Bove C,Silvestri G,Mantuano E,Modoni A,Veneziano L,Macchioni L,Hunter T,Hunter G,Pessia M,D'Adamo MC

更新日期：2017-07-04 00:00:00

abstract：:Molybdenum disulfide (MoS2) has been attracting much attentions due to its excellent electrical and optical properties. We report here the synthesis of large-scale and uniform MoS2 nanosheets with vertically standing morphology using chemical vapor deposition method. TEM observations clearly reveal the growth mechanis...

journal_title：Scientific reports

authors： Li H,Wu H,Yuan S,Qian H

更新日期：2016-02-18 00:00:00

abstract：:The fusion of villous cytotrophoblasts into the multinucleated syncytiotrophoblast is critical for the essential functions of the mammalian placenta. Using RNA-Seq gene expression and quantitative protein expression, we identified genes and their cognate proteins which are coordinately up- or down-regulated in two cel...

journal_title：Scientific reports

authors： Azar C,Valentine M,Trausch-Azar J,Druley T,Nelson DM,Schwartz AL

更新日期：2018-03-23 00:00:00

abstract：:An investigation was carried out to assess the effect of the P content on the microstructure and mechanical properties of ZCuPb20Sn5 alloy. Alloys of various compositions, (0.05, 0.1, 0.2, 0.3, 0.5% wt.% P) were melted in a melting furnace under 1200 °C and cast into metal mould, the hardness, strength and elongation ...

journal_title：Scientific reports

authors： Ren XY,Zhang X,Hong X,Ren J

更新日期：2019-09-16 00:00:00

abstract：:Micro/nanophotonic structures that are capable of optical wave-front shaping are implemented in optical waveguides and passive optical devices to alter the phase of the light propagating through them. The beam division directions and beam power distribution depend on the design of the micro/nanostructures. The ultimat...

journal_title：Scientific reports

authors： Li P,Han Y,Wang W,Liu Y,Jin P,Leng J

更新日期：2017-03-09 00:00:00

abstract：:People who used illicit drugs (PWUDs) represent an important population group for acquisition and viral dispersion. In Brazil, high rates of the human T lymphotropic virus 1 (HTLV-1) and 2 (HTLV-2) have been reported in epidemiological studies. However, the epidemiological scenario of HTLV-1/2 infections in PWUDs is s...

journal_title：Scientific reports

authors： Oliveira-Filho AB,Araújo APS,Souza APC,Gomes CM,Silva-Oliveira GC,Martins LC,Fischer B,Machado LFA,Vallinoto ACR,Ishak R,Lemos JAR,Kupek E

更新日期：2019-10-14 00:00:00

abstract：:Ultrafast thermomechanical responses and spallation behaviours of monocrystal copper films irradiated by femtosecond laser pulse are investigated using molecular dynamics simulation (MDS). Films with 〈100〉, 〈110〉 and 〈111〉 crystal orientations along the thickness direction were studied. The results show that the cryst...

journal_title：Scientific reports

authors： Xiong QL,Li Z,Kitamura T

更新日期：2017-08-23 00:00:00

abstract：:Semisynthetic cephalosporins are widely used antibiotics currently produced by different chemical steps under harsh conditions, which results in a considerable amount of toxic waste. Biocatalytic synthesis by the cephalosporin acylase from Pseudomonas sp. strain N176 is a promising alternative. Despite intensive engin...

journal_title：Scientific reports

authors： Ferrario V,Fischer M,Zhu Y,Pleiss J

更新日期：2019-08-27 00:00:00

abstract：:CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to...

journal_title：Scientific reports

authors： Li S,Lu H,Sella R,Zhang W,Dong H,Guo C,Afshari NA,Pan Z,Jie Y

更新日期：2018-05-22 00:00:00

abstract：:Uterus transplantation (UTx) is a potential option for women with uterine factor infertility to have a child. The clinical features indicating irreversible rejection of the uterus are unknown. In our experimental series of allogeneic UTx in cynomolgus macaques, six female macaques were retrospectively examined, which ...

journal_title：Scientific reports

authors： Kisu I,Emoto K,Masugi Y,Yamada Y,Matsubara K,Obara H,Matoba Y,Banno K,Kato Y,Saiki Y,Itagaki I,Kawamoto I,Iwatani C,Murase M,Nakagawa T,Tsuchiya H,Ishigaki H,Urano H,Ema M,Ogasawara K,Aoki D,Nakagawa K,Shiina

更新日期：2020-08-17 00:00:00

abstract：:We adopted a vision-based tracking system for augmented reality (AR), and evaluated whether it helped surgeons to localize the recurrent laryngeal nerve (RLN) during robotic thyroid surgery. We constructed an AR image of the trachea, common carotid artery, and RLN using CT images. During surgery, an AR image of the tr...

journal_title：Scientific reports

authors： Lee D,Yu HW,Kim S,Yoon J,Lee K,Chai YJ,Choi JY,Kong HJ,Lee KE,Cho HS,Kim HC

更新日期：2020-05-21 00:00:00

abstract：:Virtual-hand-illusion studies often use explicit and implicit measures of body ownership but no agreed-on implicit measure of agency exists. We investigated whether the Intentional Binding (IB) effect could serve as such a measure. A pilot study confirmed that current consistency increases both perceived agency and IB...

journal_title：Scientific reports

authors： Ma K,Hommel B,Chen H

更新日期：2019-03-07 00:00:00

abstract：:Diarrheagenic Escherichia coli (DEC) causes human diarrhea symptom in both healthy and immunocompromised individuals. An auto-microfluidic thin-film chip (AMTC) instrument integrating one-step multiplex PCR (mPCR) with reverse dot blot hybridization (RDBH) was developed for high-throughput detection of DEC. The novel ...

journal_title：Scientific reports

authors： Yun Z,Zeng L,Huang W,Wu Q,Fan Y,Zheng S,Peng L,Han J,Huang Y,Zhou H,Chen H

更新日期：2018-08-27 00:00:00

abstract：:A typical assumption made in the existing opinion formation models is that two individuals can communicate with each other only if the distance between their opinions is less than a threshold called bound of confidence. However, in the real world it is quite possible that people may also have a few friends with quite ...

journal_title：Scientific reports

authors： Liu Q,Wang X

更新日期：2013-10-17 00:00:00

abstract：:CD47 is overexpressed in many human cancers, its level positively correlates with tumor invasion and metastasis. However, it is largely unknown whether CD47 overexpression drives metastasis and how CD47 lead to tumor metastasis in non-small cell lung cancer (NSCLC). In this study, we analyzed NSCLC specimens and cell ...

journal_title：Scientific reports

authors： Zhao H,Wang J,Kong X,Li E,Liu Y,Du X,Kang Z,Tang Y,Kuang Y,Yang Z,Zhou Y,Wang Q

更新日期：2016-07-14 00:00:00

abstract：:Very recently, we postulated that the incorporation of citral into nanostructured lipid carrier (NLC-Citral) improves solubility and delivery of the citral without toxic effects in vivo. Thus, the objective of this study is to evaluate anti-cancer effects of NLC-Citral in MDA MB-231 cells in vitro through the Annexin ...

journal_title：Scientific reports

authors： Nordin N,Yeap SK,Rahman HS,Zamberi NR,Abu N,Mohamad NE,How CW,Masarudin MJ,Abdullah R,Alitheen NB

更新日期：2019-02-07 00:00:00

abstract：:This study examines the analytical and numerical solution of electromagnetic surface waves supported by a resistive metasurface-covered grounded metamaterial structure. To simulate the metamaterial, the Kramers-Kronig relation based on the causality principle is used, while the modeling of the resistive metasurface ha...

journal_title：Scientific reports

authors： Yaqoob MZ,Ghaffar A,Alkanhal MAS,Naz MY,Alqahtani AH,Khan Y

更新日期：2020-09-23 00:00:00