Abstract：
:The coiled-coil domain containing 50 (CCDC50) protein is a phosphotyrosine-dependent signalling protein stimulated by epidermal growth factor. It is highly expressed in neuronal cells in the central nervous system; however, the roles of CCDC50 in neuronal development are largely unknown. In this study, we showed that the depletion of CCDC50-V2 impeded the neuronal development process, including arbor formation, spine density development, and axonal outgrowth, in primary neurons. Mechanistic studies revealed that CCDC50-V2 positively regulated the nerve growth factor receptor, while it downregulated the epidermal growth factor receptor pathway. Importantly, JNK/c-Jun activation was found to be induced by the CCDC50-V2 overexpression, in which the interaction between CCDC50-V2 and JNK2 was also observed. Overall, the present study demonstrates a novel mechanism of CCDC50 function in neuronal development and provides new insight into the link between CCDC50 function and the aetiology of neurological disorders.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Min JS,Halder D,Yoon JY,Jeon SJ,Jun SY,Lee JR,Lee JJ,Choi MH,Jung CR,Lee D,Kim BJ,Kim NSdoi
10.1038/s41598-020-78304-3subject
Has Abstractpub_date
2020-12-04 00:00:00pages
21295issue
1issn
2045-2322pii
10.1038/s41598-020-78304-3journal_volume
10pub_type
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