Abstract:
:The excessive release and accumulation of glutamate in the brain is known to be associated with excitotoxicity. CE, an extract derived from the plant Coeloglossum viride var. Bracteatum, exerted neuroprotective effects against amyloid toxicity and oxidative stress in cortical neurons. The aims of this study are to examine whether CE also attenuates glutamate neurotoxicity in rat primary cultured cortical neurons and to determine the effect of CE in vivo. According to the results of MTT, LDH release, and TUNEL assays, the CE treatment significantly reduced glutamate-induced neurotoxicity in a dose-dependent manner. Moreover, the protective effects of CE were blocked by an Akt inhibitor, LY294002, suggesting that the PI3K/Akt signalling pathway is involved in the neuroprotective effects of CE. In addition, CE might regulate the PKC-GluA2 axis to prevent neuronal apoptosis. CE also protected against dopaminergic neuronal loss in a mouse model of MPTP-induced PD. Based on our results, CE exerted neuroprotective effects both in vitro and in vivo, thus providing a potential therapeutic target for the treatment or prevention of neurodegeneration.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pan RY,Ma J,Wu HT,Liu QS,Qin XY,Cheng Ydoi
10.1038/s41598-017-08957-0subject
Has Abstractpub_date
2017-08-23 00:00:00pages
9209issue
1issn
2045-2322pii
10.1038/s41598-017-08957-0journal_volume
7pub_type
杂志文章abstract::Novel mesoporous silicas rolled with silica sheets with 2D regular spacing were prepared using a self-assembled graphene oxide (GO) template formed by mixing GO with Pluronic123 (P123). Self-assembled GO templated mesoporous silicas (SGT-PMS) showed well-developed X-ray diffraction peaks with d-spacings of 9.8-10.8 nm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63017-4
更新日期:2020-04-10 00:00:00
abstract::The incidence and mortality of primary liver cancer are very high and resection of tumor is the most crucial treatment for it. We aimed to assess the efficacy and safety of combined use of transversus abdominis plane (TAP) block and laryngeal mask airway (LMA) during implementing Enhanced Recovery After Surgery (ERAS)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71477-x
更新日期:2020-09-10 00:00:00
abstract::Plasmodium falciparum merozoite invasion into erythrocytes is an essential step of the blood-stage cycle, survival of parasites, and malaria pathogenesis. P. falciparum merozoite Rh5 interacting protein (PfRipr) forms a complex with Rh5 and CyRPA in sequential molecular events leading to erythrocyte invasion. Recently...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63611-6
更新日期:2020-04-20 00:00:00
abstract::Transcription activator-like effector (TALE) nuclease (TALEN) is a site-specific nuclease, which can be freely designed and easily constructed. Numerous methods of constructing TALENs harboring different TALE scaffolds and repeat variants have recently been reported. However, the functionalities of structurally differ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03379
更新日期:2013-11-29 00:00:00
abstract::Silver nanorod arrays prepared by oblique angle deposition (AgOADs) represent versatile, simple and inexpensive substrates for high sensitivity surface enhanced Raman scattering (SERS) applications. Their anisotropic nature suggests that their optical responses such as the SERS signal, the depolarization ratio, reflec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04565-0
更新日期:2017-06-27 00:00:00
abstract::The ongoing global intensification of wheat production will likely be accompanied by a rising pressure of Fusarium diseases. While utmost attention was given to Fusarium head blight (FHB) belowground plant infections of the pathogen have largely been ignored. The current knowledge about the impact of soil borne Fusari...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31544-w
更新日期:2018-09-03 00:00:00
abstract::Diabetes mellitus accelerates vascular calcification (VC) and increases the risk of end-stage renal disease (ESRD). Nevertheless, the impact of VC in renal disease progression in type 2 diabetes mellitus (T2DM) is poorly understood. We addressed the effect of VC and mechanisms involved in renal dysfunction in a murine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55501-3
更新日期:2020-01-09 00:00:00
abstract::Glioblastomas are highly malignant brain tumors. Knowledge of growth rates and growth patterns is useful for understanding tumor biology and planning treatment logistics. Based on untreated human glioblastoma data collected in Trondheim, Norway, we first fit the average growth to a Gompertz curve, then find a best fit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63394-w
更新日期:2020-04-20 00:00:00
abstract::Chronic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney disease (CKD). The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model. Nuclear factor erythroid 2-related factor 2 (Nrf...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08054-2
更新日期:2017-08-18 00:00:00
abstract::Underutilization due to performance limitations imposed by species and charge transports is one of the key issues that persist with various lithium-ion batteries. To elucidate the relevant mechanisms, two groups of characteristic parameters were proposed. The first group contains three characteristic time parameters, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32639
更新日期:2016-09-07 00:00:00
abstract::Incorporation of Zn atoms into a nanosize Cu lattice is known to alter the electronic properties of Cu, improving catalytic performance in a number of industrially important reactions. However the structural influence of Zn on the Cu phase is not well studied. Here, we show that Cu nano-clusters modified with increasi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20527
更新日期:2016-02-09 00:00:00
abstract::N-doped carbon nanosheets/vanadium nitride nanoparticles (N-CNS/VNNPs) are synthesized via a novel method combining surface-initiated in-situ intercalative polymerization and thermal-treatment process in NH3/N2 atmosphere. The pH value of the synthesis system plays a critical role in constructing the structure and enh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21082-w
更新日期:2018-02-13 00:00:00
abstract::Medicinal herbs belonging to the same genus are always easily confused due to their extremely similar morphology and metabolites. Previously, to differentiate them, inherently specific biomarkers were screened out via intuitive comparison of their metabolite profiles. Unfortunately, the selected biomarkers have worked...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04712-7
更新日期:2017-07-04 00:00:00
abstract::The two most important and studied phytocannabinoids present in Cannabis sativa L. are undoubtedly cannabidiol (CBD), a non-psychotropic compound, but with other pharmacological properties, and Δ9-tetrahydrocannabinol (Δ9-THC), which instead possesses psychotropic activity and is responsible for the recreative use of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79042-2
更新日期:2020-12-16 00:00:00
abstract::Little is known about the combined effects of stressors on social immunity of honey bees (Apis mellifera) and related gene expression. The interaction between sublethal doses of a neurotoxin, clothianidin, and the ectoparasite, Varroa destructor, was examined by measuring differentially expressed genes (DEGs) in brain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41365-0
更新日期:2019-03-26 00:00:00
abstract::Pedobacter schmidteae sp. nov. strain EGT (Collection de Souches de l'Unité des Rickettsie CSUR P6417 = Colección Española de Cultivos Tipo CECT 9771) is a new Pedobacter species isolated from the planarian Schmidtea mediterranea. Schmidtea mediterranea are flatworms living in freshwater and exhibiting an unusual abil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62985-x
更新日期:2020-04-09 00:00:00
abstract::The prognosis of patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) remains unsatisfactory and, despite major advances in genomic studies, the biological mechanisms underlying chemoresistance are still poorly understood. We conducted for the first time a large-scale differential multi-omics ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37273-4
更新日期:2019-01-29 00:00:00
abstract::Multinational corporations use highly complex structures of parents and subsidiaries to organize their operations and ownership. Offshore Financial Centers (OFCs) facilitate these structures through low taxation and lenient regulation, but are increasingly under scrutiny, for instance for enabling tax avoidance. There...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06322-9
更新日期:2017-07-24 00:00:00
abstract::Dopamine is a key neurotransmitter in the retina and plays a central role in the light adaptive processes of the visual system. The sole source of retinal dopamine is dopaminergic amacrine cells (DACs). We and others have previously demonstrated that DACs are activated by rods, cones, and intrinsically photosensitive ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28916
更新日期:2016-06-30 00:00:00
abstract::Increasingly, in vivo imaging holds a strategic position in bio-pharmaceutical innovation. We will present the implementation of an integrated multimodal imaging setup enabling the assessment of multiple, complementary parameters. The system allows the fusion of information provided by: Near infrared fluorescent bioma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59561-8
更新日期:2020-02-14 00:00:00
abstract::Biological invasions are a major threat to biodiversity and ecosystem functioning. Successful invasions depend on the interplay of multiple abiotic and biotic factors, however, the process of the invasion itself is often overlooked. The temporal variation of environmental factors suggests that a 'window of opportunity...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44737-8
更新日期:2019-06-05 00:00:00
abstract:ABSTARCT:The relationship between chronic kidney disease (CKD), which is defined by declined estimated glomerular filtration rate (eGFR) and/or proteinuria, and asymptomatic intracranial arterial stenosis (ICAS) is largely unknown. We conducted a population-based, cross-sectional study by recruiting 5209 participants f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04549-0
更新日期:2017-07-04 00:00:00
abstract::cAMP is one of the most important second messengers in biological processes. Cellular dynamics of cAMP have been investigated using a series of fluorescent indicators; however, their sensitivity was sub-optimal for detecting cAMP dynamics at a low concentration range, due to a low ligand affinity and/or poor dynamic r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20251-1
更新日期:2018-01-30 00:00:00
abstract::Most of the artificial low-pressure plasmas contact with physical walls in laboratories; the plasma loss at the wall significantly affects the plasma device performance, e.g., an electric propulsion device. Near the surface of the wall, ions are spontaneously accelerated by a sheath and deliver their momentum and ener...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58022-6
更新日期:2020-01-23 00:00:00
abstract::To manage health conditions of farmed fish and other living creatures, a simple method to measure bioelectric signals of the creatures in seawater is expected. A novel method to measure bioelectric signals by utilizing the conductivity of seawater surrounding the entire body of a fish is proposed. As for the proposed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73485-3
更新日期:2020-10-01 00:00:00
abstract::Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in prostate cancer cell lines, PC-3 and DU 145, respectively. Cell homeostasis disruption was demonstrated upon treatment, as shown by the increase i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57781-6
更新日期:2020-01-22 00:00:00
abstract::Accurate species identification is fundamental when recording ecological data. However, the ability to correctly identify organisms visually is rarely questioned. We investigated how experts and non-experts compared in the identification of bumblebees, a group of insects of considerable conservation concern. Experts a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33634
更新日期:2016-09-20 00:00:00
abstract::Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon completion of NHEJ,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36235-0
更新日期:2018-12-17 00:00:00
abstract::The 70-kD heat shock proteins (Hsp70s) are highly conserved molecular chaperones that play essential roles in cellular processes including abiotic stress responses. Physcomitrella patens serves as a representative of the first terrestrial plants and can recover from serious dehydration. To assess the possible relation...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33650
更新日期:2016-09-20 00:00:00
abstract::Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and segregation. Egg-laying mammals (monotremes) feature an unusually complex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04560-5
更新日期:2017-06-26 00:00:00