Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.

abstract：:The spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA), has shortened the useful life of anti-staphylococcal drugs enormously. Two approaches can be followed to address this problem: screening various sources for new leads for antibiotics or finding ways to di...

journal_title：Scientific reports

authors： Abreu AC,Coqueiro A,Sultan AR,Lemmens N,Kim HK,Verpoorte R,van Wamel WJB,Simões M,Choi YH

更新日期：2017-06-19 00:00:00

abstract：:New clinical trials for diabetic macular oedema (DMO) are being designed to prove superiority over aflibercept when this agent is already very effective in improving visual acuity (VA) and DMO. The aim of this study was to determine the optimal inclusion-exclusion criteria for trials to aim for superiority in visual o...

journal_title：Scientific reports

authors： Halim S,Gurudas S,Chandra S,Greenwood J,Sivaprasad S

更新日期：2020-10-05 00:00:00

abstract：:The coherent state preparation and control of single quantum systems is an important prerequisite for the implementation of functional quantum devices. Prominent examples for such systems are semiconductor quantum dots, which exhibit a fine structure split single exciton state and a V-type three level structure, given...

journal_title：Scientific reports

authors： Mantei D,Förstner J,Gordon S,Leier YA,Rai AK,Reuter D,Wieck AD,Zrenner A

更新日期：2015-05-22 00:00:00

abstract：:Dark septate endophytes (DSE) are a form-group of root endophytic fungi with elusive functions. Here, the genomes of two common DSE of semiarid areas, Cadophora sp. and Periconia macrospinosa were sequenced and analyzed with another 32 ascomycetes of different lifestyles. Cadophora sp. (Helotiales) and P. macrospinosa...

journal_title：Scientific reports

authors： Knapp DG,Németh JB,Barry K,Hainaut M,Henrissat B,Johnson J,Kuo A,Lim JHP,Lipzen A,Nolan M,Ohm RA,Tamás L,Grigoriev IV,Spatafora JW,Nagy LG,Kovács GM

更新日期：2018-04-20 00:00:00

abstract：:Low intensity transcranial focused ultrasound (LIFU) is a promising method of non-invasive neuromodulation that uses mechanical energy to affect neuronal excitability. LIFU confers high spatial resolution and adjustable focal lengths for precise neuromodulation of discrete regions in the human brain. Before the full p...

journal_title：Scientific reports

authors： Legon W,Adams S,Bansal P,Patel PD,Hobbs L,Ai L,Mueller JK,Meekins G,Gillick BT

更新日期：2020-03-27 00:00:00

abstract：:Paclitaxel drug coated balloons (DCBs) should provide optimal drug transfer exclusively to the target tissue. The aim of this study was to evaluate the particle loss by handling during angioplasty. A robotic arm was developed for systematic and reproducible drug abrasion experiments. The contact force on eight differe...

journal_title：Scientific reports

authors： Heinrich A,Engler MS,Güttler FV,Matthäus C,Popp J,Teichgräber UK

更新日期：2020-10-14 00:00:00

abstract：:We provide a proof for the necessity of quantizing fundamental interactions demonstrating that a quantum version is needed for any non trivial conservative interaction whose strength depends on the relative distance between two objects. Our proof is based on a consistency argument that in the presence of a classical f...

journal_title：Scientific reports

authors： Giampaolo SM,Macrì T

更新日期：2019-08-06 00:00:00

abstract：:Golden snub-nosed monkey (Rhinopithecus roxellana) is one of the most endangered primate species found in China, exhibiting multilevel society consisting of several one-male-females together with their offspring units (OMU), and all-male units (AMU). Female dispersal patterns of the species within herd have been well ...

journal_title：Scientific reports

authors： Huang ZP,Bian K,Liu Y,Pan RL,Qi XG,Li BG

更新日期：2017-05-11 00:00:00

abstract：:The atomic-scale response of dielectrics/ferroelectrics to electric fields is central to their functionality. Here we introduce an in situ characterization method that reveals changes in the local atomic structure in polycrystalline materials under fields. The method employs atomic pair distribution functions (PDFs), ...

journal_title：Scientific reports

authors： Usher TM,Levin I,Daniels JE,Jones JL

更新日期：2015-10-01 00:00:00

abstract：:All species face the important adaptive problem of efficiently locating high-quality nutritional resources. We explored whether human spatial cognition is enhanced for high-calorie foods, in a large multisensory experiment that covertly tested the location memory of people who navigated a maze-like food setting. We fo...

journal_title：Scientific reports

authors： de Vries R,Morquecho-Campos P,de Vet E,de Rijk M,Postma E,de Graaf K,Engel B,Boesveldt S

更新日期：2020-10-08 00:00:00

abstract：:The majority of colorectal cancer (CRC) arises from precursor lesions known as polyps. The molecular determinants that distinguish benign from malignant polyps remain unclear. To molecularly characterize polyps, we utilized Cancer Adjacent Polyp (CAP) and Cancer Free Polyp (CFP) patients. CAPs had tissues from the res...

journal_title：Scientific reports

authors： Druliner BR,Wang P,Bae T,Baheti S,Slettedahl S,Mahoney D,Vasmatzis N,Xu H,Kim M,Bockol M,O'Brien D,Grill D,Warner N,Munoz-Gomez M,Kossick K,Johnson R,Mouchli M,Felmlee-Devine D,Washechek-Aletto J,Smyrk T,Oberg A,

更新日期：2018-02-16 00:00:00

abstract：:Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and ana...

journal_title：Scientific reports

authors： Reimann H,Stopper H,Polak T,Lauer M,Herrmann MJ,Deckert J,Hintzsche H

更新日期：2020-12-17 00:00:00

abstract：:Geriatric trauma is a major socio-economic problem, especially among the aging Japanese society. Geriatric people are more vulnerable to trauma than younger people; thus, their outcomes are often severe. This study evaluates the characteristics of geriatric trauma divided by age in the Japanese population. We evaluate...

journal_title：Scientific reports

authors： Miyoshi Y,Kondo Y,Hirano Y,Ishihara T,Sueyoshi K,Okamoto K,Tanaka H

更新日期：2020-11-05 00:00:00

abstract：:Recently, structural colour formation and light control by accumulated guanine crystals were reported. However, the relationship between light interference by guanine platelets and light intensity in an individual platelet must be examined further. This study presents experimental evidence that the guanine crystal pla...

journal_title：Scientific reports

authors： Iwasaka M,Asada H

更新日期：2018-11-19 00:00:00

abstract：:Autosomal dominant North Carolina macular dystrophy (NCMD) is believed to represent a failure of macular development. The disorder has been linked to two loci, MCDR1 (chromosome 6q16) and MCDR3 (chromosome 5p15-p13). Recently, non-coding variants upstream of PRDM13 (MCDR1) and a duplication including IRX1 (MCDR3) have...

journal_title：Scientific reports

authors： Cipriani V,Silva RS,Arno G,Pontikos N,Kalhoro A,Valeina S,Inashkina I,Audere M,Rutka K,Puech B,Michaelides M,van Heyningen V,Lace B,Webster AR,Moore AT

更新日期：2017-08-08 00:00:00

abstract：:A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and signage through a scalable gravure printing method. By proximity of 13.56 MHz RF reader, the printed CV tag generates 320 mHz of triangular sweep ...

journal_title：Scientific reports

authors： Jung Y,Park H,Park JA,Noh J,Choi Y,Jung M,Jung K,Pyo M,Chen K,Javey A,Cho G

更新日期：2015-01-29 00:00:00

abstract：:Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate in Type 2 diabetes (T2D) and Alzheimer's disease (AD) brains and evidence suggests that interaction between the two amyloidogenic proteins can lead to the formation of heterocomplex aggregates. However, the structure and consequenc...

journal_title：Scientific reports

authors： Bharadwaj P,Solomon T,Sahoo BR,Ignasiak K,Gaskin S,Rowles J,Verdile G,Howard MJ,Bond CS,Ramamoorthy A,Martins RN,Newsholme P

更新日期：2020-06-25 00:00:00

abstract：:Macrophages play an important role in the inflammatory process that contributes to the development of abdominal aortic aneurysm (AAA). Studies of human and mouse AAA tissue reveal expanded populations of macrophages producing an abundance of pro-inflammatory cytokines, including TNF-α, IL-12p40 and high level of metal...

journal_title：Scientific reports

authors： Yan H,Hu Y,Akk A,Ye K,Bacon J,Pham CTN

更新日期：2019-07-18 00:00:00

abstract：:Maintaining balance while walking on a narrow beam is a challenging motor task. One important factor is that the foot's ability to exert torque on the support surface is limited by the beam width. Still, the feet serve as a critical interface between the body and the external environment, and it is unclear how the mec...

journal_title：Scientific reports

authors： Huber ME,Chiovetto E,Giese M,Sternad D

更新日期：2020-05-06 00:00:00

abstract：:The production of tuberous roots is usually reduced by vigorous vegetative growth because of the competition for resource between the vegetative parts and reproductive organs. In this study, we conducted root pruning to examine the vigorous vegetative growth by regulating root growth, subsequently limiting vegetative ...

journal_title：Scientific reports

authors： Gao K,Zhu T,Wang L,Gao Y

更新日期：2018-03-13 00:00:00

abstract：:Previous studies have discussed the relationship between simple renal cysts (SRC) and serum uric acid level in healthy individuals. We performed a cross-sectional study to evaluate the association between serum uric acid level and fractional excretion of uric acid (FEUA) and simple renal cysts in males and postmenopau...

journal_title：Scientific reports

authors： Han Y,Zhang M,Lu J,Zhang L,Han J,Zhao F,Chen H,Bao Y,Jia W

更新日期：2017-06-19 00:00:00

abstract：:Mutations at positions 70 and/or 91 in the core protein of genotype-1b, hepatitis C virus (HCV) are associated with hepatocellular carcinoma (HCC) risk in Asian patients. To evaluate this in a US population, the relationship between the percentage of 70 and/or 91 mutant HCV quasispecies in baseline serum samples of ch...

journal_title：Scientific reports

authors： El-Shamy A,Pendleton M,Eng FJ,Doyle EH,Bashir A,Branch AD

更新日期：2016-06-01 00:00:00

abstract：:With the increasing amount of research work in surface studies, a more effective method of producing patterned microstructures is highly desired due to the geometric limitations and complex fabricating process of current techniques. This paper presents an efficient and cost-effective method to generate customizable mi...

journal_title：Scientific reports

authors： He R,Wang S,Andrews G,Shi W,Liu Y

更新日期：2016-02-23 00:00:00

abstract：:Network robustness represents the ability of networks to withstand failures and perturbations. In social networks, maintenance of individual activities, also called persistence, is significant towards understanding robustness. Previous works usually consider persistence on pre-generated network structures; while in so...

journal_title：Scientific reports

authors： Jin X,Jin C,Huang J,Min Y

更新日期：2017-02-21 00:00:00

abstract：:The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating neurological diseases. κOR selective 6'-GNTI was proved to be a G-protein biased agonist, whereas 5'-GNTI acts as an antagonist. To investigate the molecular mechanism of how these two liga...

journal_title：Scientific reports

authors： Cheng J,Sun X,Li W,Liu G,Tu Y,Tang Y

更新日期：2016-01-08 00:00:00

abstract：:Mortuary practices in human evolution record cognitive, social changes and technological innovations. The Neolithic Revolution in the Levant was a watershed in this domain that has long fascinated the archaeological community. Plaster modelled skulls are well known at Jericho and several other Neolithic sites, and in ...

journal_title：Scientific reports

authors： Solazzo C,Courel B,Connan J,van Dongen BE,Barden H,Penkman K,Taylor S,Demarchi B,Adam P,Schaeffer P,Nissenbaum A,Bar-Yosef O,Buckley M

更新日期：2016-08-09 00:00:00

abstract：:We report that misfolded cytosolic proteins can be cleared from mammalian cells by directing them to endoplasmic reticulum (ER). NAT1 R64W and Parkin R42P are naturally occurring misfolded variants of cytosolic enzymes that acetylate arylamines and ubiquitinate proteins, respectively. We demonstrate that proteasome in...

journal_title：Scientific reports

authors： Liu F,Koepp DM,Walters KJ

更新日期：2015-07-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Rogawa A,Ogata S,Mougi A

更新日期：2019-10-15 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs that regulate a variety of biological processes. Recently, human liver-specific miRNA miR-122 has been reported to facilitate hepatitis C virus (HCV) replication in liver cells. HCV is one of the leading causes of liver diseases worldwide. In Pakistan, the estimated preval...

journal_title：Scientific reports

authors： Butt AM,Raja AJ,Siddique S,Khan JS,Shahid M,Tayyab GU,Minhas Z,Umar M,Idrees M,Tong Y

更新日期：2016-02-22 00:00:00

abstract：:The association between cervical lymph node metastasis (LNM) and ultrasonographic features as well as BRAFV600E mutations in patients with papillary thyroid carcinoma (PTC) remained controversial. This study investigated the association between LNM and ultrasonographic features as well as BRAFV600E mutation in Chinese...

journal_title：Scientific reports

authors： Guo L,Ma YQ,Yao Y,Wu M,Deng ZH,Zhu FW,Luo YK,Tang J

更新日期：2019-01-11 00:00:00